BRPI0922033A2 - composições e métodos de uso de variantes de trombomodulina - Google Patents

composições e métodos de uso de variantes de trombomodulina

Info

Publication number
BRPI0922033A2
BRPI0922033A2 BRPI0922033A BRPI0922033A BRPI0922033A2 BR PI0922033 A2 BRPI0922033 A2 BR PI0922033A2 BR PI0922033 A BRPI0922033 A BR PI0922033A BR PI0922033 A BRPI0922033 A BR PI0922033A BR PI0922033 A2 BRPI0922033 A2 BR PI0922033A2
Authority
BR
Brazil
Prior art keywords
compositions
methods
thrombomodulin
variants
thrombomodulin variants
Prior art date
Application number
BRPI0922033A
Other languages
English (en)
Inventor
Akanksha Gupta
Brian William Grinnel
David Thompson Berg
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of BRPI0922033A2 publication Critical patent/BRPI0922033A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A61K38/366—Thrombomodulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/7455—Thrombomodulin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
BRPI0922033A 2008-11-12 2009-10-21 composições e métodos de uso de variantes de trombomodulina BRPI0922033A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11380108P 2008-11-12 2008-11-12
PCT/US2009/061407 WO2010056472A2 (en) 2008-11-12 2009-10-21 Compositions and methods of use for thrombomodulin variants

Publications (1)

Publication Number Publication Date
BRPI0922033A2 true BRPI0922033A2 (pt) 2015-12-15

Family

ID=42111790

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0922033A BRPI0922033A2 (pt) 2008-11-12 2009-10-21 composições e métodos de uso de variantes de trombomodulina

Country Status (21)

Country Link
US (1) US20110207670A1 (pt)
EP (1) EP2355839A2 (pt)
JP (1) JP2012508742A (pt)
KR (1) KR20110083665A (pt)
CN (1) CN102216326A (pt)
AU (1) AU2009314413A1 (pt)
BR (1) BRPI0922033A2 (pt)
CA (1) CA2743141A1 (pt)
CL (1) CL2011001065A1 (pt)
CO (1) CO6362021A2 (pt)
CR (1) CR20110239A (pt)
DO (1) DOP2011000133A (pt)
EA (1) EA201170679A1 (pt)
EC (1) ECSP11011049A (pt)
IL (1) IL212209A0 (pt)
MA (1) MA32775B1 (pt)
MX (1) MX2011005005A (pt)
SV (1) SV2011003904A (pt)
TN (1) TN2011000206A1 (pt)
WO (1) WO2010056472A2 (pt)
ZA (1) ZA201103179B (pt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014020183A1 (de) * 2012-08-03 2014-02-06 Ici Immunochemical Intelligence Gmbh In-vitro-assay zur diagnose von störungen der hämostase
WO2021126822A1 (en) * 2019-12-20 2021-06-24 Blue Blood Biotech Corp. Thrombomodulin functional domains for use in promoting osteoblast functions and bone healing

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3189052B2 (ja) * 1990-06-27 2001-07-16 持田製薬株式会社 抗血液凝固活性を有するポリペプチド
EP0689843B1 (en) * 1993-12-17 2003-09-10 Mochida Pharmaceutical Co., Ltd. Composition containing soluble thrombomodulins
US5916874A (en) * 1994-04-20 1999-06-29 Asahi Kasei Kogyo Kabushiki Kaisha Method for treating liver injury
US5639625A (en) * 1994-09-26 1997-06-17 Oklahoma Medical Research Foundation Method for detecting antibodies to thrombomodulin in patients
WO2004050844A2 (en) * 2002-12-02 2004-06-17 Biovec Llc Ex vivo and in vivo expression of the thrombomodulin gene for the treatment of cardiovascular and peripheral vascular diseases
CA2515916A1 (en) * 2003-02-25 2004-09-10 Biovec B.V. Therapeutic applications of thrombomodulin gene via viral and non-viral vectors
ES2360610T3 (es) * 2005-10-13 2011-06-07 Eli Lilly And Company Tratamiento de la insuficiencia renal aguda con trombomodulina soluble.
RU2433829C2 (ru) * 2006-10-06 2011-11-20 Асахи Касеи Фарма Корпорейшн Средство для лечения и/или улучшения состояния при диссеминированном внутрисосудистом свертывании
US8076298B2 (en) * 2006-12-12 2011-12-13 Eli Lilly And Company Treating acute renal failure with soluble thrombomodulin variants

Also Published As

Publication number Publication date
KR20110083665A (ko) 2011-07-20
MX2011005005A (es) 2011-05-25
CN102216326A (zh) 2011-10-12
TN2011000206A1 (en) 2012-12-17
ECSP11011049A (es) 2011-06-30
AU2009314413A1 (en) 2010-05-20
CL2011001065A1 (es) 2011-10-07
DOP2011000133A (es) 2011-06-30
CO6362021A2 (es) 2012-01-20
CA2743141A1 (en) 2010-05-20
CR20110239A (es) 2011-06-09
IL212209A0 (en) 2011-06-30
EA201170679A1 (ru) 2012-04-30
WO2010056472A2 (en) 2010-05-20
EP2355839A2 (en) 2011-08-17
WO2010056472A3 (en) 2010-08-19
US20110207670A1 (en) 2011-08-25
ZA201103179B (en) 2012-10-31
JP2012508742A (ja) 2012-04-12
SV2011003904A (es) 2011-07-06
MA32775B1 (fr) 2011-11-01

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Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]