BRPI0922033A2 - composições e métodos de uso de variantes de trombomodulina - Google Patents

composições e métodos de uso de variantes de trombomodulina

Info

Publication number
BRPI0922033A2
BRPI0922033A2 BRPI0922033A BRPI0922033A BRPI0922033A2 BR PI0922033 A2 BRPI0922033 A2 BR PI0922033A2 BR PI0922033 A BRPI0922033 A BR PI0922033A BR PI0922033 A BRPI0922033 A BR PI0922033A BR PI0922033 A2 BRPI0922033 A2 BR PI0922033A2
Authority
BR
Brazil
Prior art keywords
compositions
methods
thrombomodulin
variants
thrombomodulin variants
Prior art date
Application number
BRPI0922033A
Other languages
English (en)
Inventor
Akanksha Gupta
Brian William Grinnel
David Thompson Berg
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of BRPI0922033A2 publication Critical patent/BRPI0922033A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A61K38/366—Thrombomodulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/7455—Thrombomodulin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
BRPI0922033A 2008-11-12 2009-10-21 composições e métodos de uso de variantes de trombomodulina BRPI0922033A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11380108P 2008-11-12 2008-11-12
PCT/US2009/061407 WO2010056472A2 (en) 2008-11-12 2009-10-21 Compositions and methods of use for thrombomodulin variants

Publications (1)

Publication Number Publication Date
BRPI0922033A2 true BRPI0922033A2 (pt) 2015-12-15

Family

ID=42111790

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0922033A BRPI0922033A2 (pt) 2008-11-12 2009-10-21 composições e métodos de uso de variantes de trombomodulina

Country Status (21)

Country Link
US (1) US20110207670A1 (pt)
EP (1) EP2355839A2 (pt)
JP (1) JP2012508742A (pt)
KR (1) KR20110083665A (pt)
CN (1) CN102216326A (pt)
AU (1) AU2009314413A1 (pt)
BR (1) BRPI0922033A2 (pt)
CA (1) CA2743141A1 (pt)
CL (1) CL2011001065A1 (pt)
CO (1) CO6362021A2 (pt)
CR (1) CR20110239A (pt)
DO (1) DOP2011000133A (pt)
EA (1) EA201170679A1 (pt)
EC (1) ECSP11011049A (pt)
IL (1) IL212209A0 (pt)
MA (1) MA32775B1 (pt)
MX (1) MX2011005005A (pt)
SV (1) SV2011003904A (pt)
TN (1) TN2011000206A1 (pt)
WO (1) WO2010056472A2 (pt)
ZA (1) ZA201103179B (pt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014020183A1 (de) * 2012-08-03 2014-02-06 Ici Immunochemical Intelligence Gmbh In-vitro-assay zur diagnose von störungen der hämostase
EP4076491A4 (en) * 2019-12-20 2024-02-07 Blue Blood Biotech Corp. FUNCTIONAL AREAS OF THROMBOMODULIN INTENDED FOR USE TO PROMOTE OSTEOBLAST FUNCTIONS AND BONE HEALING

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU643306B2 (en) * 1990-06-27 1993-11-11 Mochida Pharmaceutical Co., Ltd. Anticoagulant polypeptides
EP0689843B1 (en) * 1993-12-17 2003-09-10 Mochida Pharmaceutical Co., Ltd. Composition containing soluble thrombomodulins
US5916874A (en) * 1994-04-20 1999-06-29 Asahi Kasei Kogyo Kabushiki Kaisha Method for treating liver injury
US5639625A (en) * 1994-09-26 1997-06-17 Oklahoma Medical Research Foundation Method for detecting antibodies to thrombomodulin in patients
US7179459B2 (en) * 2002-12-02 2007-02-20 Biovec, Llc Ex vivo and in vivo expression of the thrombomodulin gene for the treatment of cardiovascular and peripheral vascular diseases
US20050106124A1 (en) * 2003-02-25 2005-05-19 Sehgal Lakshman R. Therapeutic applications of thrombomodulin gene via viral and non-viral vectors
JP5405829B2 (ja) * 2005-10-13 2014-02-05 インディアナ・ユニバーシティ・リサーチ・アンド・テクノロジー・コーポレイション トロンボモジュリン変異体を用いた急性障害の治療方法
CN101522206B (zh) * 2006-10-06 2013-03-27 旭化成制药株式会社 弥散性血管内凝血综合征的治疗剂和/或改善剂
EP2754447A3 (en) * 2006-12-12 2014-11-12 Indiana University Research and Technology Corporation Treating acute renal failure with soluble thrombomodulin variants

Also Published As

Publication number Publication date
CA2743141A1 (en) 2010-05-20
DOP2011000133A (es) 2011-06-30
US20110207670A1 (en) 2011-08-25
WO2010056472A2 (en) 2010-05-20
WO2010056472A3 (en) 2010-08-19
KR20110083665A (ko) 2011-07-20
EA201170679A1 (ru) 2012-04-30
AU2009314413A1 (en) 2010-05-20
MA32775B1 (fr) 2011-11-01
SV2011003904A (es) 2011-07-06
CL2011001065A1 (es) 2011-10-07
CO6362021A2 (es) 2012-01-20
CR20110239A (es) 2011-06-09
JP2012508742A (ja) 2012-04-12
TN2011000206A1 (en) 2012-12-17
ZA201103179B (en) 2012-10-31
ECSP11011049A (es) 2011-06-30
EP2355839A2 (en) 2011-08-17
CN102216326A (zh) 2011-10-12
IL212209A0 (en) 2011-06-30
MX2011005005A (es) 2011-05-25

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Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]