BRPI0922457A2 - forma polimórfica de ácido 1-(4-{1-[(e)-4-ciclo-hexil-3-trifluormetil-benziloxi-imino]-etil)-2-etil-benzil)-azetidino-3-carboxílico" - Google Patents

forma polimórfica de ácido 1-(4-{1-[(e)-4-ciclo-hexil-3-trifluormetil-benziloxi-imino]-etil)-2-etil-benzil)-azetidino-3-carboxílico"

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Publication number
BRPI0922457A2
BRPI0922457A2 BRPI0922457A BRPI0922457A BRPI0922457A2 BR PI0922457 A2 BRPI0922457 A2 BR PI0922457A2 BR PI0922457 A BRPI0922457 A BR PI0922457A BR PI0922457 A BRPI0922457 A BR PI0922457A BR PI0922457 A2 BRPI0922457 A2 BR PI0922457A2
Authority
BR
Brazil
Prior art keywords
ethyl
azetidine
benzyloxy
imino
trifluoromethyl
Prior art date
Application number
BRPI0922457A
Other languages
English (en)
Inventor
Dimitris Papoutsakis
Elizabeth Roddy
Yugang Liu
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of BRPI0922457A2 publication Critical patent/BRPI0922457A2/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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BRPI0922457A 2008-12-18 2009-12-17 forma polimórfica de ácido 1-(4-{1-[(e)-4-ciclo-hexil-3-trifluormetil-benziloxi-imino]-etil)-2-etil-benzil)-azetidino-3-carboxílico" BRPI0922457A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20305208P 2008-12-18 2008-12-18
PCT/US2009/068346 WO2010071794A1 (en) 2008-12-18 2009-12-17 New polymorphic form of 1- (4- { l- [ (e) -4-cyclohexyl--3-trifluoromethyl-benzyloxyimino] -ethyl) -2-ethyl-benzy l) -azetidine-3-carboxylic

Publications (1)

Publication Number Publication Date
BRPI0922457A2 true BRPI0922457A2 (pt) 2015-12-15

Family

ID=41566356

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0922457A BRPI0922457A2 (pt) 2008-12-18 2009-12-17 forma polimórfica de ácido 1-(4-{1-[(e)-4-ciclo-hexil-3-trifluormetil-benziloxi-imino]-etil)-2-etil-benzil)-azetidino-3-carboxílico"

Country Status (12)

Country Link
US (2) US8173634B2 (pt)
EP (1) EP2379498B1 (pt)
JP (1) JP2012512884A (pt)
KR (1) KR20110112352A (pt)
CN (1) CN102256942B (pt)
AU (1) AU2009327405A1 (pt)
BR (1) BRPI0922457A2 (pt)
CA (1) CA2746764A1 (pt)
ES (1) ES2531831T3 (pt)
MX (1) MX2011006610A (pt)
RU (1) RU2011129230A (pt)
WO (1) WO2010071794A1 (pt)

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CN110776450B (zh) * 2018-07-27 2022-09-27 广东东阳光药业有限公司 一种辛波莫德晶型及其制备方法
CN111484434A (zh) * 2019-01-29 2020-08-04 东莞市东阳光仿制药研发有限公司 一种辛波莫德晶型及其制备方法
WO2020173346A1 (zh) * 2019-02-25 2020-09-03 广东东阳光药业有限公司 一种辛波莫德的制备方法
WO2020174408A1 (en) * 2019-02-27 2020-09-03 Dr. Reddy's Laboratories Limited Solid state forms of siponimod
EP3947348A1 (en) * 2019-03-29 2022-02-09 Synthon B.V. Process for making siponimod and intermediate thereof
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JP7749552B2 (ja) 2019-10-31 2025-10-06 イドルシア・ファーマシューティカルズ・リミテッド Ｃｘｃｒ７アンタゴニストのｓ１ｐ１受容体調節剤との合剤
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US8173634B2 (en) 2012-05-08
CN102256942B (zh) 2013-07-24
RU2011129230A (ru) 2013-01-27
ES2531831T3 (es) 2015-03-20
EP2379498A1 (en) 2011-10-26
CA2746764A1 (en) 2010-06-24
KR20110112352A (ko) 2011-10-12
EP2379498B1 (en) 2015-01-21
WO2010071794A1 (en) 2010-06-24
JP2012512884A (ja) 2012-06-07
AU2009327405A1 (en) 2011-06-30
MX2011006610A (es) 2011-06-30
US20120122836A1 (en) 2012-05-17

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