BRPI0922664A2 - derivados de imidazol bicílicos substituídos como moduladores de gama secretase - Google Patents

derivados de imidazol bicílicos substituídos como moduladores de gama secretase

Info

Publication number: BRPI0922664A2
Authority: BR; Brazil
Prior art keywords: imidazole derivatives; gamma secretase; substituted bicyclic; secretase modulators; bicyclic imidazole
Prior art date: 2008-12-18

Application number

BRPI0922664A

Other languages

English (en)

Inventor

Andrés Avelino Trabanco-Suarez

Didier Jean-Claude Berthelot

François Paul Bischoff

Gary John Tresadern

Greogor James Macdonald

Henricus Jacobus Maria Gijsen

Sven Franciscus Anna Brandt

Original Assignee

Ortho Mcneil Janssen Pharm

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-12-18

Filing date

2009-12-16

Publication date

2016-01-05

2009-12-16 Application filed by Ortho Mcneil Janssen Pharm filed Critical Ortho Mcneil Janssen Pharm

2016-01-05 Publication of BRPI0922664A2 publication Critical patent/BRPI0922664A2/pt

Links

VHNYOQKVZQVBLC-RTCGXNAVSA-N (4r,7e,9as)-7-[[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]methylidene]-4-(3,4,5-trifluorophenyl)-1,3,4,8,9,9a-hexahydropyrido[2,1-c][1,4]oxazin-6-one Chemical compound C1([C@@H]2COC[C@@H]3CC\C(C(N32)=O)=C/C=2C=C(C(=CC=2)N2C=C(C)N=C2)OC)=CC(F)=C(F)C(F)=C1 VHNYOQKVZQVBLC-RTCGXNAVSA-N 0.000 title 1
-1 bicyclic imidazole derivatives Chemical class 0.000 title 1
229940079865 intestinal antiinfectives imidazole derivative Drugs 0.000 title 1
229940124648 γ-Secretase Modulator Drugs 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/02—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing not further condensed quinolizine ring systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Biomedical Technology (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Psychology (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

BRPI0922664A 2008-12-18 2009-12-16 derivados de imidazol bicílicos substituídos como moduladores de gama secretase BRPI0922664A2 (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP08172202		2008-12-18
PCT/EP2009/067321 WO2010070008A1 (en)	2008-12-18	2009-12-16	Substituted bicyclic imidazole derivatives as gamma secretase modulators

Publications (1)

Publication Number	Publication Date
BRPI0922664A2 true BRPI0922664A2 (pt)	2016-01-05

Family

ID=40451180

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0922664A BRPI0922664A2 (pt)	2008-12-18	2009-12-16	derivados de imidazol bicílicos substituídos como moduladores de gama secretase

Country Status (21)

Country	Link
US (1)	US8546440B2 (pt)
EP (1)	EP2379552B1 (pt)
JP (2)	JP2012512831A (pt)
KR (1)	KR20110102455A (pt)
CN (1)	CN102256974B (pt)
AP (1)	AP2011005692A0 (pt)
AR (1)	AR074771A1 (pt)
AU (1)	AU2009327103B2 (pt)
BR (1)	BRPI0922664A2 (pt)
CA (1)	CA2742914A1 (pt)
EA (1)	EA018625B1 (pt)
ES (1)	ES2460642T3 (pt)
IL (1)	IL213563A (pt)
MX (1)	MX2011006543A (pt)
NZ (1)	NZ594036A (pt)
PA (1)	PA8854101A1 (pt)
SG (1)	SG172213A1 (pt)
TW (1)	TWI438203B (pt)
UA (1)	UA104151C2 (pt)
WO (1)	WO2010070008A1 (pt)
ZA (1)	ZA201104504B (pt)

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2009
- 2009-12-15 PA PA20098854101A patent/PA8854101A1/es unknown
- 2009-12-16 AP AP2011005692A patent/AP2011005692A0/xx unknown
- 2009-12-16 ES ES09797025.5T patent/ES2460642T3/es active Active
- 2009-12-16 EA EA201170829A patent/EA018625B1/ru not_active IP Right Cessation
- 2009-12-16 BR BRPI0922664A patent/BRPI0922664A2/pt not_active IP Right Cessation
- 2009-12-16 JP JP2011541412A patent/JP2012512831A/ja active Pending
- 2009-12-16 SG SG2011044310A patent/SG172213A1/en unknown
- 2009-12-16 UA UAA201105485A patent/UA104151C2/ru unknown
- 2009-12-16 KR KR1020117016065A patent/KR20110102455A/ko not_active Ceased
- 2009-12-16 US US13/133,027 patent/US8546440B2/en not_active Expired - Fee Related
- 2009-12-16 NZ NZ594036A patent/NZ594036A/xx not_active IP Right Cessation
- 2009-12-16 CA CA2742914A patent/CA2742914A1/en not_active Abandoned
- 2009-12-16 WO PCT/EP2009/067321 patent/WO2010070008A1/en not_active Ceased
- 2009-12-16 MX MX2011006543A patent/MX2011006543A/es active IP Right Grant
- 2009-12-16 EP EP09797025.5A patent/EP2379552B1/en active Active
- 2009-12-16 CN CN200980151827.XA patent/CN102256974B/zh not_active Expired - Fee Related
- 2009-12-16 AU AU2009327103A patent/AU2009327103B2/en not_active Ceased
- 2009-12-17 AR ARP090104939A patent/AR074771A1/es not_active Application Discontinuation
- 2009-12-17 TW TW098143263A patent/TWI438203B/zh not_active IP Right Cessation
2011
- 2011-06-15 IL IL213563A patent/IL213563A/en not_active IP Right Cessation
- 2011-06-17 ZA ZA2011/04504A patent/ZA201104504B/en unknown
2015
- 2015-06-25 JP JP2015127609A patent/JP2015164969A/ja active Pending

Also Published As

Publication number	Publication date
EA018625B1 (ru)	2013-09-30
US8546440B2 (en)	2013-10-01
CA2742914A1 (en)	2010-06-24
TW201035093A (en)	2010-10-01
CN102256974B (zh)	2014-07-30
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