BRPI0923346A2 - Proteinas em super-helice antiparalela de cadeia simples - Google Patents

Proteinas em super-helice antiparalela de cadeia simples

Info

Publication number
BRPI0923346A2
BRPI0923346A2 BRPI0923346A BRPI0923346A BRPI0923346A2 BR PI0923346 A2 BRPI0923346 A2 BR PI0923346A2 BR PI0923346 A BRPI0923346 A BR PI0923346A BR PI0923346 A BRPI0923346 A BR PI0923346A BR PI0923346 A2 BRPI0923346 A2 BR PI0923346A2
Authority
BR
Brazil
Prior art keywords
proteins
superhelic
hrs3
hrs2
hrs1
Prior art date
Application number
BRPI0923346A
Other languages
English (en)
Inventor
Loverix Stefan
Desmet Johan
Lasters Ignace
Original Assignee
Complix Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Complix Nv filed Critical Complix Nv
Publication of BRPI0923346A2 publication Critical patent/BRPI0923346A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1075—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of amino acids or peptide residues
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2318/00—Antibody mimetics or scaffolds
    • C07K2318/20—Antigen-binding scaffold molecules wherein the scaffold is not an immunoglobulin variable region or antibody mimetics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Analytical Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Food Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

PROTEÍNAS EM SUPER-HÉLICE ANTIPARALELA DE CADEIA SIMPLES. A presente invenção se refere a proteínas de cadeia simples de fórmula HRS1-L1-HRS2-L2-HRS3, em que HRS1, HRS2 E HRS3 são seqüências de hepta repetições e L1 e L2 são seqüências de ligante (linker) estruturalmente flexíveis, e em que HRS1, HRS2 e HRS3 formam uma estrutura em super-hélice de alfa-hélice antiparalela de fita tripla termodinamicamente estável em solução aquosa. A invenção também se refere a variantes de seqüência de aminoácidos, condições e métodos para obter tais proteínas e variantes, e usos dos mesmo, especialmente seu uso como armações e como produtos terapêuticos.
BRPI0923346A 2008-12-08 2009-12-08 Proteinas em super-helice antiparalela de cadeia simples BRPI0923346A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12064208P 2008-12-08 2008-12-08
PCT/EP2009/066640 WO2010066740A1 (en) 2008-12-08 2009-12-08 Single-chain antiparallel coiled coil proteins

Publications (1)

Publication Number Publication Date
BRPI0923346A2 true BRPI0923346A2 (pt) 2017-07-11

Family

ID=41571709

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0923346A BRPI0923346A2 (pt) 2008-12-08 2009-12-08 Proteinas em super-helice antiparalela de cadeia simples

Country Status (10)

Country Link
US (2) US20110294983A1 (pt)
EP (1) EP2367840B1 (pt)
JP (1) JP2012510806A (pt)
CN (1) CN102245623A (pt)
AU (1) AU2009326075B2 (pt)
BR (1) BRPI0923346A2 (pt)
CA (1) CA2749558C (pt)
DK (1) DK2367840T3 (pt)
ES (1) ES2547121T3 (pt)
WO (1) WO2010066740A1 (pt)

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Also Published As

Publication number Publication date
JP2012510806A (ja) 2012-05-17
WO2010066740A1 (en) 2010-06-17
US20160039867A1 (en) 2016-02-11
CN102245623A (zh) 2011-11-16
EP2367840A1 (en) 2011-09-28
CA2749558A1 (en) 2010-06-17
EP2367840B1 (en) 2015-08-12
DK2367840T3 (en) 2015-10-12
ES2547121T3 (es) 2015-10-01
CA2749558C (en) 2019-01-15
AU2009326075A1 (en) 2011-06-30
AU2009326075B2 (en) 2014-06-05
US20110294983A1 (en) 2011-12-01

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Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NAO 10196/2001, QUE MODIFICOU A LEI NAO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUAANCIA PRA VIA DA ANVISA. CONSIDERANDO A APROVAA AO DOS TERMOS DO PARECER NAO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NAO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDAANCIAS CABA-VEIS.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements