BRPI0923393A2 - Processos e intermediários para preparar um inibidor de protease de hcv macrocíclico - Google Patents

Processos e intermediários para preparar um inibidor de protease de hcv macrocíclico

Info

Publication number
BRPI0923393A2
BRPI0923393A2 BRPI0923393-8A BRPI0923393A BRPI0923393A2 BR PI0923393 A2 BRPI0923393 A2 BR PI0923393A2 BR PI0923393 A BRPI0923393 A BR PI0923393A BR PI0923393 A2 BRPI0923393 A2 BR PI0923393A2
Authority
BR
Brazil
Prior art keywords
intermediates
preparing
processes
protease inhibitor
hcv protease
Prior art date
Application number
BRPI0923393-8A
Other languages
English (en)
Inventor
Andras Horvath
Dominic John Ormerod
Dominique Paul Michel Depré
Véronique Cerpentier
Original Assignee
Ortho Mcneil Janssen Pharm
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Mcneil Janssen Pharm filed Critical Ortho Mcneil Janssen Pharm
Publication of BRPI0923393A2 publication Critical patent/BRPI0923393A2/pt
Publication of BRPI0923393B1 publication Critical patent/BRPI0923393B1/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/40—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/475—Preparation of carboxylic acid esters by splitting of carbon-to-carbon bonds and redistribution, e.g. disproportionation or migration of groups between different molecules
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/32—Oxygen atoms
    • C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C07D453/04—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems having a quinolyl-4, a substituted quinolyl-4 or a alkylenedioxy-quinolyl-4 radical linked through only one carbon atom, attached in position 2, e.g. quinine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Furan Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
BRPI0923393-8A 2008-12-23 2009-12-22 "processos para preparar um inibidor de protease de hcv macrocíclico e intermediários e uso". BRPI0923393B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP08172691.1 2008-12-23
EP08172691 2008-12-23
PCT/EP2009/067715 WO2010072742A1 (en) 2008-12-23 2009-12-22 Processes and intermediates for preparing a macrocyclic protease inhibitor of hcv

Publications (2)

Publication Number Publication Date
BRPI0923393A2 true BRPI0923393A2 (pt) 2015-07-28
BRPI0923393B1 BRPI0923393B1 (pt) 2018-06-19

Family

ID=40548041

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0923393-8A BRPI0923393B1 (pt) 2008-12-23 2009-12-22 "processos para preparar um inibidor de protease de hcv macrocíclico e intermediários e uso".

Country Status (22)

Country Link
US (2) US8927722B2 (pt)
EP (1) EP2382198B1 (pt)
JP (1) JP5687631B2 (pt)
KR (1) KR101734507B1 (pt)
CN (1) CN102264715B (pt)
AR (1) AR074863A1 (pt)
AU (1) AU2009331530B2 (pt)
BR (1) BRPI0923393B1 (pt)
CA (1) CA2745565C (pt)
CY (1) CY1114488T1 (pt)
DK (1) DK2382198T3 (pt)
ES (1) ES2429013T3 (pt)
HR (1) HRP20130906T1 (pt)
IL (1) IL213246A (pt)
MX (1) MX2011006764A (pt)
PL (1) PL2382198T3 (pt)
PT (1) PT2382198E (pt)
RU (1) RU2016120007A (pt)
SI (1) SI2382198T1 (pt)
SM (1) SMT201300116B (pt)
TW (1) TWI461424B (pt)
WO (1) WO2010072742A1 (pt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL2382198T3 (pl) 2008-12-23 2013-11-29 Janssen Pharmaceuticals Inc Sposoby i półprodukty do otrzymywania makrocyklicznego inhibitora proteazy HCV
EP2758386A1 (en) * 2011-09-22 2014-07-30 Janssen Pharmaceuticals, Inc. Processes and intermediates for preparing a macrocyclic protease inhibitor of hcv
BR112014009849A2 (pt) 2011-10-28 2016-07-05 Janssen Pharmaceuticals Inc processo melhorado para preparação de intermediário do inibidor de protease macrocíclico tmc 435
CN103387509B (zh) * 2012-05-11 2016-06-08 重庆博腾制药科技股份有限公司 一种hcv蛋白酶抑制剂中间体的制备方法
KR20150040265A (ko) 2012-06-08 2015-04-14 길리애드 사이언시즈, 인코포레이티드 플라비비리대 바이러스의 마크로시클릭 저해제
PL2859009T3 (pl) 2012-06-08 2018-03-30 Gilead Sciences, Inc. Makrocykliczne inhibitory wirusów flaviviridae
AR091279A1 (es) * 2012-06-08 2015-01-21 Gilead Sciences Inc Inhibidores macrociclicos de virus flaviviridae
UA119315C2 (uk) 2012-07-03 2019-06-10 Гіліад Фармассет Елелсі Інгібітори вірусу гепатиту с
KR102215400B1 (ko) 2013-03-15 2021-02-10 길리애드 사이언시즈, 인코포레이티드 C형 간염 바이러스의 마크로시클릭 및 비시클릭 억제제
WO2015180253A1 (zh) * 2014-05-29 2015-12-03 杭州普晒医药科技有限公司 丙型肝炎药物的晶型及其制备方法、其药物组合物和用途
MA41812A (fr) 2015-03-27 2018-01-30 Janssen Pharmaceuticals Inc Procédés et intermédiaires pour la préparation d'un inhibiteur de protéase macrocyclique du vhc

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL8300536A (nl) 1983-02-14 1984-09-03 Oce Andeno Bv Optisch actief alfa-azido-p-hydroxyfenylazijnzuur en zijn zouten alsmede de bereiding daarvan.
JPS6124539A (ja) * 1984-07-11 1986-02-03 Sagami Chem Res Center 光学活性（ｒ）−２，５，１２−トリヒドロキシ−１，２，３，４−テトラヒドロナフタセン−６，１１−ジオン−２−カルボン酸の取得方法
JP4218040B2 (ja) * 1997-12-26 2009-02-04 曽田香料株式会社 有機酸とアミンの複合塩の製造法
JP3844112B2 (ja) 2000-08-23 2006-11-08 高砂香料工業株式会社 ３，５，６−トリヒドロキシヘキサン酸アンモニウム塩誘導体、及びその製造方法
DE602005017582D1 (en) 2004-01-30 2009-12-24 Medivir Ab Hcv ns-3 serine protease inhibitoren
CN101146794A (zh) 2005-01-21 2008-03-19 阿斯泰克斯治疗有限公司 用于抑制cdk和gsk的吡唑衍生物
PE20070211A1 (es) 2005-07-29 2007-05-12 Medivir Ab Compuestos macrociclicos como inhibidores del virus de hepatitis c
WO2007014921A1 (en) * 2005-07-29 2007-02-08 Tibotec Pharmaceuticals Ltd. Macrocyclic inhibitors of hepatitis c virus
EP2121674B1 (en) * 2007-02-01 2010-05-12 Tibotec Pharmaceuticals Processes and intermediates for preparing a macrocyclic protease inhibitor of hcv
DK2111396T3 (da) * 2007-02-08 2013-11-04 Janssen R & D Ireland HCV-Inhiberende makrocykliske phenylcarbamater
PL2382198T3 (pl) 2008-12-23 2013-11-29 Janssen Pharmaceuticals Inc Sposoby i półprodukty do otrzymywania makrocyklicznego inhibitora proteazy HCV

Also Published As

Publication number Publication date
US20150080577A1 (en) 2015-03-19
TW201033205A (en) 2010-09-16
PT2382198E (pt) 2013-10-01
CA2745565C (en) 2017-03-07
US20110257403A1 (en) 2011-10-20
SI2382198T1 (sl) 2013-11-29
DK2382198T3 (da) 2013-09-30
CY1114488T1 (el) 2016-10-05
PL2382198T3 (pl) 2013-11-29
BRPI0923393B1 (pt) 2018-06-19
HK1164839A1 (zh) 2012-09-28
ES2429013T3 (es) 2013-11-12
EP2382198A1 (en) 2011-11-02
KR20110099048A (ko) 2011-09-05
US9115077B2 (en) 2015-08-25
AU2009331530A1 (en) 2011-06-23
EP2382198B1 (en) 2013-07-10
SMT201300116B (it) 2013-11-08
AR074863A1 (es) 2011-02-16
HRP20130906T1 (hr) 2013-10-25
MX2011006764A (es) 2011-08-03
JP5687631B2 (ja) 2015-03-18
JP2012513381A (ja) 2012-06-14
WO2010072742A1 (en) 2010-07-01
CN102264715B (zh) 2015-12-02
RU2011130895A (ru) 2013-01-27
AU2009331530B2 (en) 2015-04-09
CA2745565A1 (en) 2010-07-01
IL213246A (en) 2017-10-31
US8927722B2 (en) 2015-01-06
KR101734507B1 (ko) 2017-05-11
TWI461424B (zh) 2014-11-21
IL213246A0 (en) 2011-07-31
RU2016120007A (ru) 2018-11-13
CN102264715A (zh) 2011-11-30

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Legal Events

Date Code Title Description
B65X Notification of requirement for priority examination of patent application
B65Y Grant of priority examination of the patent application (request complies with dec. 132/06 of 20061117)
B153 Others concerning applications: republication [chapter 15.33 patent gazette]

Free format text: REPUBLICADO O DESPACHO 15.24.2 PUBLICADO NA RPI 2380 DE 16/08/2016, HAJA VISTA EXISTENCIA DE ERRO MATERIAL NO TEOR DO DESPACHO. ONDE SE LE " PI1008918-7", LEIA-SE " PI0923393-8".

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]
B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE A 10A ANUIDADE.

B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2545 DE 15-10-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.