BRPI1001959A2 - Nanocarreadores coloidais para ativos hidrofílicos e processo de produção - Google Patents
Nanocarreadores coloidais para ativos hidrofílicos e processo de produção Download PDFInfo
- Publication number
- BRPI1001959A2 BRPI1001959A2 BRPI1001959-6A BRPI1001959A BRPI1001959A2 BR PI1001959 A2 BRPI1001959 A2 BR PI1001959A2 BR PI1001959 A BRPI1001959 A BR PI1001959A BR PI1001959 A2 BRPI1001959 A2 BR PI1001959A2
- Authority
- BR
- Brazil
- Prior art keywords
- hydrophilic
- assets
- phase
- production process
- colloidal
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 3
- 239000002539 nanocarrier Substances 0.000 abstract 4
- 239000012071 phase Substances 0.000 abstract 4
- 238000000034 method Methods 0.000 abstract 3
- 238000009472 formulation Methods 0.000 abstract 2
- 229920001477 hydrophilic polymer Polymers 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 239000004094 surface-active agent Substances 0.000 abstract 2
- 239000013543 active substance Substances 0.000 abstract 1
- 239000003905 agrochemical Substances 0.000 abstract 1
- 239000012736 aqueous medium Substances 0.000 abstract 1
- 239000008346 aqueous phase Substances 0.000 abstract 1
- 239000012620 biological material Substances 0.000 abstract 1
- 239000000470 constituent Substances 0.000 abstract 1
- 238000013270 controlled release Methods 0.000 abstract 1
- 239000002537 cosmetic Substances 0.000 abstract 1
- 238000006731 degradation reaction Methods 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000000839 emulsion Substances 0.000 abstract 1
- 239000008393 encapsulating agent Substances 0.000 abstract 1
- 239000003337 fertilizer Substances 0.000 abstract 1
- 239000012467 final product Substances 0.000 abstract 1
- 150000002433 hydrophilic molecules Chemical class 0.000 abstract 1
- 238000010348 incorporation Methods 0.000 abstract 1
- 239000002609 medium Substances 0.000 abstract 1
- 239000007908 nanoemulsion Substances 0.000 abstract 1
- 239000002105 nanoparticle Substances 0.000 abstract 1
- 239000002245 particle Substances 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 239000000047 product Substances 0.000 abstract 1
- 239000003981 vehicle Substances 0.000 abstract 1
- -1 veterinary Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Inorganic Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
Abstract
NANOCARREADORES COLOIDAIS PARA ATIVOS HIDROFILICOS E PROCESSO DE PRODUÇçO pertence ao setor de preparações para finalidades médicas, odontológicas ou de higiene caracterizado por serem estruturas formadas por polímeros hidrofílicos contendo ativos hidrofílicos, envoltos por uma fase não hidrofílica e tensoativos que possuem atração pelos componentes, formando uma emulsão inversa, que permite a incorporação e veiculação controlada de ativos h idrofílicos, conferindo-lhe propriedades como proteção contra processos de degradação, melhoria da compatibilidade com os outros constituintes da formulação do produto final, aumento da disponibilidade e/ou biodisponibilidade do ativo para o meio de interesse (incluindo melhorias em processos de permeação em materiais biológicos, redução da exposição e volatilização do ativo para o meio) e liberação controlada do(s) ativo(s). O nanocarreador obtido por este processo, denominado de Nanocarreadores Coloidais (NCs), pode ser aplicado em áreas diversas como farmacêutica (incluindo dermatológica), cosmética, produtos de higiene pessoal, veterinária, agroquímica e fertilizantes, alimentos e outros afins. "NANOCARREADORES COLOIDAIS PARA ATIVOS HIDROFILICOS E PROCESSO DE PRODUÇçO" apresenta um sistema cineticamente estável e eficiente quanto à nanoestrutura, que consiste em nanocarreadores formados por polímeros emulsificados em um meio não aquoso, na presença de um tensoativo que possui atração pelas duas fases (meio dispersante e agente encapsulante). Este sistema é obtido por meio da nanoemulsificação de uma fase aquosa de polímeros hidrofílicos, emulsificados em uma fase não hidrofílica (lipofílica ou silofílica) contendo o tensoativo destacando-se pela aplicação de dois conceitos que abrangem a geração de uma nanoemulsão inversa e de nanopartículas poliméricas. A formulação gera o efeito técnico novo de um veículo polimérico nanoestruturado para veiculação de moléculas hidrofílicas suspenso em fase não hidrofílica, passível de controle de tamanho de partícula em escala nanométrica e de modulação da estabilidade coloidal através de parâmetros de processo.
Priority Applications (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BRPI1001959-6A BRPI1001959A2 (pt) | 2010-06-15 | 2010-06-15 | Nanocarreadores coloidais para ativos hidrofílicos e processo de produção |
| US13/704,382 US20130197100A1 (en) | 2010-06-15 | 2011-06-14 | Colloidal nanoscale carriers for active hydrophilic substances and method for producing same |
| PCT/BR2011/000185 WO2011156880A1 (pt) | 2010-06-15 | 2011-06-14 | Nanocarreadores coloidais para ativos hidrofílicos e processo de produção |
| JP2013514500A JP2013530168A (ja) | 2010-06-15 | 2011-06-14 | 親水性活性物質のためのコロイド状ナノスケールキャリア及びその製造方法 |
| EP11794970.1A EP2583671A4 (en) | 2010-06-15 | 2011-06-14 | COLLOIDAL NANOSCAL CARRIER FOR ACTIVE HYDROPHILIC SUBSTANCES AND METHOD FOR THE PRODUCTION THEREOF |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BRPI1001959-6A BRPI1001959A2 (pt) | 2010-06-15 | 2010-06-15 | Nanocarreadores coloidais para ativos hidrofílicos e processo de produção |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI1001959A2 true BRPI1001959A2 (pt) | 2012-03-06 |
Family
ID=45347600
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI1001959-6A BRPI1001959A2 (pt) | 2010-06-15 | 2010-06-15 | Nanocarreadores coloidais para ativos hidrofílicos e processo de produção |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20130197100A1 (pt) |
| EP (1) | EP2583671A4 (pt) |
| JP (1) | JP2013530168A (pt) |
| BR (1) | BRPI1001959A2 (pt) |
| WO (1) | WO2011156880A1 (pt) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015123745A1 (pt) * | 2014-02-18 | 2015-08-27 | Instituto De Pesquisas Tecnologicas | Método de nanoencapsulação de ativos em dupla emulsão inversa e produtos resultantes |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10258698B2 (en) | 2013-03-14 | 2019-04-16 | Modernatx, Inc. | Formulation and delivery of modified nucleoside, nucleotide, and nucleic acid compositions |
| AU2014315287A1 (en) | 2013-09-03 | 2015-03-12 | Moderna Therapeutics, Inc. | Chimeric polynucleotides |
| EP3041938A1 (en) | 2013-09-03 | 2016-07-13 | Moderna Therapeutics, Inc. | Circular polynucleotides |
| EP3052521A1 (en) | 2013-10-03 | 2016-08-10 | Moderna Therapeutics, Inc. | Polynucleotides encoding low density lipoprotein receptor |
| US10537860B2 (en) | 2014-06-23 | 2020-01-21 | Massachusetts Institute Of Technology | Emulsions by condensation |
| EP3169693B1 (en) | 2014-07-16 | 2022-03-09 | ModernaTX, Inc. | Chimeric polynucleotides |
| EP3171895A1 (en) | 2014-07-23 | 2017-05-31 | Modernatx, Inc. | Modified polynucleotides for the production of intrabodies |
| MA47016A (fr) | 2015-10-22 | 2018-08-29 | Modernatx Inc | Vaccins contre les virus respiratoires |
| LT3394093T (lt) | 2015-12-23 | 2022-04-25 | Modernatx, Inc. | Ox40 ligandus koduojančių polinukleotidų naudojimo būdai |
| EP3400023A1 (en) | 2016-01-10 | 2018-11-14 | ModernaTX, Inc. | Therapeutic mrnas encoding anti ctla-4 antibodies |
| US11541105B2 (en) | 2018-06-01 | 2023-01-03 | The Research Foundation For The State University Of New York | Compositions and methods for disrupting biofilm formation and maintenance |
| KR102170764B1 (ko) * | 2018-11-06 | 2020-10-27 | 주식회사 코리아나화장품 | 나노구조 지질 전달체로 안정화된 유효성분을 함유하는 화장료 조성물 |
| EP4482962A1 (en) | 2022-02-24 | 2025-01-01 | IO Biotech ApS | Nucleotide delivery of cancer therapy |
| EP4520345A1 (en) | 2023-09-06 | 2025-03-12 | Myneo Nv | Product |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2608942B1 (fr) * | 1986-12-31 | 1991-01-11 | Centre Nat Rech Scient | Procede de preparation de systemes colloidaux dispersibles d'une substance, sous forme de nanocapsules |
| JP2657504B2 (ja) * | 1988-01-12 | 1997-09-24 | 株式会社資生堂 | 油中水型乳化組成物 |
| PT100723A (pt) * | 1991-07-26 | 1993-08-31 | Smithkline Beecham Corp | Microemulsoes de agua em oleo,auto-emulsionantes, estaveis e farmaceuticamente aceitaveis e seu uso |
| FR2711530B1 (fr) * | 1993-10-29 | 1995-12-01 | Oreal | Emulsion eau dans huile contenant des polyols et son utilisation en cosmétologie. |
| US5447354A (en) * | 1993-11-10 | 1995-09-05 | Delp; Melvin D. | Children's wagon top conversion assembly |
| JPH1066855A (ja) * | 1996-08-26 | 1998-03-10 | Lion Corp | Ｗ／ｏ型乳化組成物並びに食品用及び医薬品用基剤 |
| JPH1129432A (ja) * | 1997-07-04 | 1999-02-02 | Shiseido Co Ltd | 油中水型乳化組成物 |
| JPH11188256A (ja) * | 1997-12-26 | 1999-07-13 | Nisshin Oil Mills Ltd:The | 油性組成物及びその製造方法 |
| JP2004043383A (ja) * | 2002-07-12 | 2004-02-12 | Kao Corp | 油中水型乳化化粧料 |
| JP4397170B2 (ja) * | 2003-03-12 | 2010-01-13 | 株式会社Ａｄｅｋａ | 油中水型可塑性乳化油脂組成物 |
| US20050175651A1 (en) * | 2004-01-09 | 2005-08-11 | L'oreal | Aqueous dispersion of nanocapsules with an oily core |
| US7597907B2 (en) | 2004-11-05 | 2009-10-06 | Trustees Of The University Of Pennsylvania | Antioxidant polymer nanocarriers for use in preventing oxidative injury |
| JP2006232755A (ja) * | 2005-02-25 | 2006-09-07 | Dai Ichi Kogyo Seiyaku Co Ltd | 油中水型マイクロエマルション |
| EP1940355B1 (en) | 2005-09-30 | 2012-12-19 | Auburn University | Targeted drug delivery nanocarrier comprising a targeting landscape phage protein assembly |
| JP4840995B2 (ja) * | 2007-01-17 | 2011-12-21 | ハイモ株式会社 | 油中水型分散液の希釈液、その調製方法及びその使用方法 |
| JP2010522196A (ja) * | 2007-03-22 | 2010-07-01 | アルカームズ，インコーポレイテッド | コアセルベーション工程 |
| EP1972651B1 (en) * | 2007-03-23 | 2012-12-26 | Universität Ulm | Nanocapsules and process for their production |
| RU2362544C2 (ru) * | 2007-04-09 | 2009-07-27 | Закрытое акционерное общество "Санкт-Петербургский институт фармации" | Наноэмульсия с биологически активными веществами |
| KR100868724B1 (ko) | 2007-05-30 | 2008-11-13 | 한국생산기술연구원 | 가역적 온도감응성을 가지는 자기집합성 나노운반체의제조방법 |
| US7927629B2 (en) | 2007-10-27 | 2011-04-19 | The Trustees Of The University Of Pennsylvania | Method and compositions for polymer nanocarriers containing therapeutic molecules |
| WO2009123934A2 (en) | 2008-03-29 | 2009-10-08 | Emory University | Branched multifunctional nanoparticle conjugates and their use |
| CA2720474A1 (en) | 2008-04-04 | 2009-10-08 | Rutgers University | Nanocarrier and nanogel compositions |
| EP2123304A1 (en) | 2008-05-23 | 2009-11-25 | Freie Universität Berlin | Compounds suited as nanocarriers for active agents and their use |
-
2010
- 2010-06-15 BR BRPI1001959-6A patent/BRPI1001959A2/pt not_active Application Discontinuation
-
2011
- 2011-06-14 JP JP2013514500A patent/JP2013530168A/ja active Pending
- 2011-06-14 EP EP11794970.1A patent/EP2583671A4/en not_active Withdrawn
- 2011-06-14 WO PCT/BR2011/000185 patent/WO2011156880A1/pt not_active Ceased
- 2011-06-14 US US13/704,382 patent/US20130197100A1/en not_active Abandoned
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015123745A1 (pt) * | 2014-02-18 | 2015-08-27 | Instituto De Pesquisas Tecnologicas | Método de nanoencapsulação de ativos em dupla emulsão inversa e produtos resultantes |
Also Published As
| Publication number | Publication date |
|---|---|
| EP2583671A4 (en) | 2014-08-06 |
| US20130197100A1 (en) | 2013-08-01 |
| JP2013530168A (ja) | 2013-07-25 |
| EP2583671A1 (en) | 2013-04-24 |
| WO2011156880A1 (pt) | 2011-12-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B03A | Publication of a patent application or of a certificate of addition of invention [chapter 3.1 patent gazette] | ||
| B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
| B04C | Request for examination: application reinstated [chapter 4.3 patent gazette] | ||
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS. |
|
| B07G | Grant request does not fulfill article 229-c lpi (prior consent of anvisa) [chapter 7.7 patent gazette] | ||
| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
| B11B | Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements |