BRPI1004899A2 - composto, composição farmacêutica, método para tratar uma doença ou distúrbio relacionado a pi3k em um indivíduo necessitando do mesmo, método para tratar uma doença mediada por mtor, método para tratar ambas as doenças mediadas por pi3k e hdac - Google Patents

composto, composição farmacêutica, método para tratar uma doença ou distúrbio relacionado a pi3k em um indivíduo necessitando do mesmo, método para tratar uma doença mediada por mtor, método para tratar ambas as doenças mediadas por pi3k e hdac

Info

Publication number: BRPI1004899A2
Authority: BR; Brazil
Prior art keywords: treating; pi3k; mediated; disease; hdac
Prior art date: 2009-01-08

Application number

BRPI1004899A

Other languages

English (en)

Inventor

Changgeng Qian

Cheng-Jung Lai

Haixiao Zhai

Xiong Cai

Original Assignee

Curis Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2009-01-08

Filing date

2010-01-08

Publication date

2016-04-05

2010-01-08 Application filed by Curis Inc filed Critical Curis Inc

2016-04-05 Publication of BRPI1004899A2 publication Critical patent/BRPI1004899A2/pt

2020-08-18 Publication of BRPI1004899B1 publication Critical patent/BRPI1004899B1/pt

2021-05-25 Publication of BRPI1004899B8 publication Critical patent/BRPI1004899B8/pt

Links

208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 4
201000010099 disease Diseases 0.000 title 3
230000001404 mediated effect Effects 0.000 title 2
101150097381 Mtor gene Proteins 0.000 title 1
150000001875 compounds Chemical class 0.000 title 1
208000035475 disorder Diseases 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Urology & Nephrology (AREA)
Endocrinology (AREA)
Dermatology (AREA)
Gastroenterology & Hepatology (AREA)
Oncology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Diabetes (AREA)
Hematology (AREA)
Reproductive Health (AREA)
Pulmonology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

BRPI1004899A 2009-01-08 2010-01-08 composto inibidor de fosfoinositida 3-quinase, composição farmacêutica e uso de um composto BRPI1004899B8 (pt)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
US14327109P	2009-01-08	2009-01-08
US61/143,271		2009-01-08
US17258009P	2009-04-24	2009-04-24
US61/172,580		2009-04-24
PCT/US2010/020495 WO2010080996A1 (en)	2009-01-08	2010-01-08	Phosphoinositide 3-kinase inhibitors with a zinc binding moiety

Publications (3)

Publication Number	Publication Date
BRPI1004899A2 true BRPI1004899A2 (pt)	2016-04-05
BRPI1004899B1 BRPI1004899B1 (pt)	2020-08-18
BRPI1004899B8 BRPI1004899B8 (pt)	2021-05-25

Family

ID=42316830

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI1004899A BRPI1004899B8 (pt)	2009-01-08	2010-01-08	composto inibidor de fosfoinositida 3-quinase, composição farmacêutica e uso de um composto

Country Status (25)

Country	Link
US (11)	US8367663B2 (pt)
EP (1)	EP2385832B1 (pt)
JP (3)	JP5452617B2 (pt)
KR (2)	KR101430424B1 (pt)
CN (1)	CN102341108B (pt)
AU (1)	AU2010203512C1 (pt)
BR (1)	BRPI1004899B8 (pt)
CA (1)	CA2749228C (pt)
CY (1)	CY1116797T1 (pt)
DK (1)	DK2385832T3 (pt)
EA (1)	EA024252B1 (pt)
ES (1)	ES2550032T3 (pt)
HR (1)	HRP20150947T1 (pt)
HU (1)	HUE027615T2 (pt)
IL (2)	IL213976A (pt)
ME (1)	ME02230B (pt)
MX (1)	MX2011007326A (pt)
PL (1)	PL2385832T3 (pt)
PT (1)	PT2385832E (pt)
RS (1)	RS54230B1 (pt)
SG (2)	SG172908A1 (pt)
SI (1)	SI2385832T1 (pt)
SM (1)	SMT201500226B (pt)
TW (1)	TWI558710B (pt)
WO (1)	WO2010080996A1 (pt)

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EP2385832A1 (en)	2011-11-16
JP5762520B2 (ja)	2015-08-12
ME02230B (me)	2016-02-20
JP5452617B2 (ja)	2014-03-26
IL213976A0 (en)	2011-08-31
AU2010203512B2 (en)	2013-03-14
US8906909B2 (en)	2014-12-09
IL237727A0 (en)	2015-05-31
US20230227467A1 (en)	2023-07-20
IL213976A (en)	2015-03-31
KR101430424B1 (ko)	2014-08-14
KR20110112404A (ko)	2011-10-12
TW201030009A (en)	2010-08-16
CA2749228C (en)	2016-05-17
AU2010203512A1 (en)	2011-08-11
KR20140094590A (ko)	2014-07-30
CN102341108A (zh)	2012-02-01
DK2385832T3 (en)	2015-09-21
US20120088764A1 (en)	2012-04-12
HRP20150947T1 (hr)	2015-10-09
US10894795B2 (en)	2021-01-19
BRPI1004899B8 (pt)	2021-05-25
CA2749228A1 (en)	2010-07-15
US8367663B2 (en)	2013-02-05
US20100222343A1 (en)	2010-09-02
AU2010203512C1 (en)	2013-10-17
EP2385832A4 (en)	2012-07-25
WO2010080996A1 (en)	2010-07-15
JP2015187145A (ja)	2015-10-29
CY1116797T1 (el)	2018-03-07
MX2011007326A (es)	2011-10-19
US20150203509A1 (en)	2015-07-23
US10336770B2 (en)	2019-07-02
TWI558710B (zh)	2016-11-21
US11261195B2 (en)	2022-03-01
BRPI1004899B1 (pt)	2020-08-18
US9725461B2 (en)	2017-08-08
JP2012514650A (ja)	2012-06-28
US20140155595A1 (en)	2014-06-05
US20220402934A1 (en)	2022-12-22
US20210214370A1 (en)	2021-07-15
RS54230B1 (sr)	2015-12-31
PL2385832T3 (pl)	2016-01-29
US10676482B2 (en)	2020-06-09
HUE027615T2 (en)	2016-10-28
SG172908A1 (en)	2011-08-29
US8461157B2 (en)	2013-06-11
HK1164113A1 (en)	2012-09-21
EA024252B1 (ru)	2016-08-31
PT2385832E (pt)	2015-11-02
US11597732B2 (en)	2023-03-07
US20200339593A1 (en)	2020-10-29
JP2014058571A (ja)	2014-04-03
CN102341108B (zh)	2015-05-27
US20250230169A1 (en)	2025-07-17
EA201101053A1 (ru)	2012-02-28
SMT201500226B (it)	2015-10-30
US20170362251A1 (en)	2017-12-21
ES2550032T3 (es)	2015-11-04
US20190352310A1 (en)	2019-11-21
SG196815A1 (en)	2014-02-13
SI2385832T1 (sl)	2015-10-30
EP2385832B1 (en)	2015-07-15

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