BRPI1006443A2 - proteína ou peptídeo de fusão de meia-vida aumentada in vivo mantidos por liberação sustentada in vivo, e método para aumentar a meia-vida in vivo usando os mesmos. - Google Patents

proteína ou peptídeo de fusão de meia-vida aumentada in vivo mantidos por liberação sustentada in vivo, e método para aumentar a meia-vida in vivo usando os mesmos.

Info

Publication number
BRPI1006443A2
BRPI1006443A2 BRPI1006443A BRPI1006443A BRPI1006443A2 BR PI1006443 A2 BRPI1006443 A2 BR PI1006443A2 BR PI1006443 A BRPI1006443 A BR PI1006443A BR PI1006443 A BRPI1006443 A BR PI1006443A BR PI1006443 A2 BRPI1006443 A2 BR PI1006443A2
Authority
BR
Brazil
Prior art keywords
life
vivo
vivo half
increasing
increased
Prior art date
Application number
BRPI1006443A
Other languages
English (en)
Inventor
Hye-Shin Chung
Sang Mee Lee
Seung Bum Yoo
Original Assignee
Alteogen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alteogen Inc filed Critical Alteogen Inc
Publication of BRPI1006443A2 publication Critical patent/BRPI1006443A2/pt
Publication of BRPI1006443B1 publication Critical patent/BRPI1006443B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8121—Serpins
    • C07K14/8125—Alpha-1-antitrypsin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
BRPI1006443-5A 2009-04-22 2010-04-22 Proteína ou peptídeo de fusão e método para aumentar a meia-vida in vivo de uma proteína ou peptídeo BRPI1006443B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR20090035190 2009-04-22
KR10-2009-0035190 2009-04-22
PCT/KR2010/002520 WO2010123290A2 (ko) 2009-04-22 2010-04-22 체내 지속성을 유지함으로 체내 반감기가 증가된 단백질 또는 펩티드 융합체, 및 이를 이용하여 체내 반감기를 증가시키는 방법

Publications (2)

Publication Number Publication Date
BRPI1006443A2 true BRPI1006443A2 (pt) 2016-09-27
BRPI1006443B1 BRPI1006443B1 (pt) 2021-05-25

Family

ID=43011621

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI1006443-5A BRPI1006443B1 (pt) 2009-04-22 2010-04-22 Proteína ou peptídeo de fusão e método para aumentar a meia-vida in vivo de uma proteína ou peptídeo

Country Status (11)

Country Link
US (1) US9012606B2 (pt)
EP (1) EP2423233B1 (pt)
JP (1) JP5727459B2 (pt)
KR (1) KR101183262B1 (pt)
CN (1) CN102439044B (pt)
AU (1) AU2010239861B2 (pt)
BR (1) BRPI1006443B1 (pt)
CA (1) CA2758445C (pt)
MX (1) MX2011011130A (pt)
RU (1) RU2503688C2 (pt)
WO (1) WO2010123290A2 (pt)

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US9932381B2 (en) 2014-06-18 2018-04-03 Sanofi Exendin-4 derivatives as selective glucagon receptor agonists
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WO2016102580A1 (en) * 2014-12-22 2016-06-30 Novo Nordisk A/S Alpha-1-antitrypsin (a1at) fusion proteins and uses thereof
CN104645317B (zh) * 2015-01-28 2020-04-17 中国科学院天津工业生物技术研究所 一种多肽复合物作为多肽或蛋白质药物载体的应用、方法及其融合蛋白复合物
US10993993B2 (en) * 2015-05-28 2021-05-04 Immunoforge Co., Ltd. Pharmaceutical composition for treating muscle atrophy or sarcopenia including glucagon-like peptide (GLP-1) or GLP-1 receptor agonist
AR105319A1 (es) 2015-06-05 2017-09-27 Sanofi Sa Profármacos que comprenden un conjugado agonista dual de glp-1 / glucagón conector ácido hialurónico
WO2017003270A1 (ko) * 2015-07-02 2017-01-05 주식회사 녹십자 헌터증후군 치료제 및 치료방법
KR20170004814A (ko) 2015-07-02 2017-01-11 주식회사 녹십자 헌터증후군 치료제
TW201706291A (zh) 2015-07-10 2017-02-16 賽諾菲公司 作為選擇性肽雙重ｇｌｐ－１／升糖素受體促效劑之新毒蜥外泌肽（ｅｘｅｎｄｉｎ－４）衍生物
US10654912B2 (en) * 2015-09-08 2020-05-19 Jcr Pharmaceuticals Co., Ltd. Human serum albumin mutant
WO2018071528A1 (en) * 2016-10-11 2018-04-19 University Of Georgia Research Foundation, Inc. Proteins and method for treating obesity and associated comorbidities
WO2018185756A1 (en) 2017-04-02 2018-10-11 B. G. Negev Technologies And Applications Ltd., At Ben-Gurion University Mutant alpha-1-antitrypsin compositions and use thereof
KR101964376B1 (ko) 2017-09-29 2019-04-01 주식회사 나이벡 부갑상선호르몬(parathyroid hormone, PTH)에 골조직 선택성 펩타이드가 결합되어 있는 융합 펩타이드를 포함하는 약학 조성물 및 생체재료
KR102167827B1 (ko) * 2017-12-20 2020-10-20 주식회사 알테오젠 신규한 성장 호르몬 수용체 길항제 및 이의 융합 단백질
CN107916257B (zh) * 2018-01-09 2020-07-28 华南理工大学 T1脂肪酶突变体和应用
WO2019222435A1 (en) 2018-05-16 2019-11-21 Halozyme, Inc. Methods of selecting subjects for combination cancer therapy with a polymer-conjugated soluble ph20
EP3802587A4 (en) * 2018-06-07 2022-03-23 Prottech Inc. PHARMACEUTICAL COMPOSITION WITH A FUSION PROTEIN AND THEIR USE
EP3848388B1 (en) * 2018-09-05 2025-08-20 LG Chem, Ltd. Fusion polypeptide comprising polypeptide region that can be o-glycosylated
WO2020092448A1 (en) 2018-10-29 2020-05-07 Spin Therapeutics, Llc Compositions and methods for alpha-1-antitrypsin disorders
CN114573715A (zh) * 2022-03-14 2022-06-03 江苏雅酶医药科技有限公司 一种重组长效人透明质酸酶及其生产方法和应用
CN117186237A (zh) * 2022-05-29 2023-12-08 中国医学科学院药物研究所 一种含有糜蛋白酶抑制肽的胰岛素杂交肽及其应用
US12233115B2 (en) 2022-09-30 2025-02-25 Extend Biosciences, Inc. Long-acting parathyroid hormone

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Also Published As

Publication number Publication date
BRPI1006443B1 (pt) 2021-05-25
RU2011147216A (ru) 2013-05-27
WO2010123290A3 (ko) 2011-03-03
CN102439044B (zh) 2014-08-13
WO2010123290A2 (ko) 2010-10-28
AU2010239861A1 (en) 2011-10-27
EP2423233A4 (en) 2012-09-26
RU2503688C2 (ru) 2014-01-10
CN102439044A (zh) 2012-05-02
KR101183262B1 (ko) 2012-09-14
KR20100116558A (ko) 2010-11-01
US20120094356A1 (en) 2012-04-19
CA2758445A1 (en) 2010-10-28
US9012606B2 (en) 2015-04-21
EP2423233A2 (en) 2012-02-29
AU2010239861B2 (en) 2013-07-11
MX2011011130A (es) 2011-11-18
EP2423233B1 (en) 2015-03-11
CA2758445C (en) 2016-02-16
JP2012524062A (ja) 2012-10-11
JP5727459B2 (ja) 2015-06-03

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Legal Events

Date Code Title Description
B06T Formal requirements before examination [chapter 6.20 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B07E Notice of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B07A Technical examination (opinion): publication of technical examination (opinion) [chapter 7.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 22/04/2010, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF