BRPI1007721B1 - composição de vacina para uso na indução de uma resposta imunológica contra um rotavírus em um indivíduo, cepa de rotavírus isolado de cdc-9 e cepa de rotavírus isolado de cdc-66 - Google Patents

composição de vacina para uso na indução de uma resposta imunológica contra um rotavírus em um indivíduo, cepa de rotavírus isolado de cdc-9 e cepa de rotavírus isolado de cdc-66 Download PDF

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Publication number
BRPI1007721B1
BRPI1007721B1 BRPI1007721A BRPI1007721A BRPI1007721B1 BR PI1007721 B1 BRPI1007721 B1 BR PI1007721B1 BR PI1007721 A BRPI1007721 A BR PI1007721A BR PI1007721 A BRPI1007721 A BR PI1007721A BR PI1007721 B1 BRPI1007721 B1 BR PI1007721B1
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BR
Brazil
Prior art keywords
cdc
rotavirus
strain isolated
inducing
immune response
Prior art date
Application number
BRPI1007721A
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English (en)
Inventor
Jiang Baoming
Gentsch Jon
I Glass Roger
Wang Yuhuan
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The Government Of The Us Secretary Department Of Health And Human Services Centers For Disease Contr
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by The Government Of The Us Secretary Department Of Health And Human Services Centers For Disease Contr filed Critical The Government Of The Us Secretary Department Of Health And Human Services Centers For Disease Contr
Publication of BRPI1007721A2 publication Critical patent/BRPI1007721A2/pt
Publication of BRPI1007721B1 publication Critical patent/BRPI1007721B1/pt

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/15—Reoviridae, e.g. calf diarrhea virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5252—Virus inactivated (killed)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5254—Virus avirulent or attenuated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A61K2039/542—Mucosal route oral/gastrointestinal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2720/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsRNA viruses
    • C12N2720/00011—Details
    • C12N2720/12011—Reoviridae
    • C12N2720/12311—Rotavirus, e.g. rotavirus A
    • C12N2720/12334—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2720/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsRNA viruses
    • C12N2720/00011—Details
    • C12N2720/12011—Reoviridae
    • C12N2720/12311—Rotavirus, e.g. rotavirus A
    • C12N2720/12361—Methods of inactivation or attenuation

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

composição de vacina para uso na indução de uma resposta imunológica contra um rotavírus em um indivíduo, cepa de rotavírus isolado de cdc-9 e cepa de rotavírus isolado de cdc-66 uma composição de vacina e método para vacinação são providas úteis para imunização de um indivíduo contra um rotavírus. as vacinas incluem cepas de rotavírus cdc-9 e cdc-66, fragmentos dos mesmos, homólogos dos mesmos, ou combinações dos mesmos. as vacinas da invenção podem incluir um fragmento de cdc-9, cdc-66, homólogos dos mesmos, ou combinações dos mesmos. métodos para induzir uma resposta imunológica são providos através da administração de uma vacina da invenção.
BRPI1007721A 2009-05-12 2010-05-12 composição de vacina para uso na indução de uma resposta imunológica contra um rotavírus em um indivíduo, cepa de rotavírus isolado de cdc-9 e cepa de rotavírus isolado de cdc-66 BRPI1007721B1 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17739309P 2009-05-12 2009-05-12
PCT/US2010/034537 WO2010132561A2 (en) 2009-05-12 2010-05-12 New human rotavirus strains and vaccines

Publications (2)

Publication Number Publication Date
BRPI1007721A2 BRPI1007721A2 (pt) 2016-02-16
BRPI1007721B1 true BRPI1007721B1 (pt) 2020-04-28

Family

ID=43085559

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI1007721A BRPI1007721B1 (pt) 2009-05-12 2010-05-12 composição de vacina para uso na indução de uma resposta imunológica contra um rotavírus em um indivíduo, cepa de rotavírus isolado de cdc-9 e cepa de rotavírus isolado de cdc-66

Country Status (8)

Country Link
US (6) US8822192B2 (pt)
EP (2) EP3427750A1 (pt)
CN (2) CN102695522B (pt)
AU (1) AU2010249103B2 (pt)
BR (1) BRPI1007721B1 (pt)
CA (3) CA3121471A1 (pt)
ES (1) ES2723776T3 (pt)
WO (1) WO2010132561A2 (pt)

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CA2698392C (en) * 2007-09-04 2019-12-03 Baoming Jiang Thermal inactivation of rotavirus
CN102695522B (zh) 2009-05-12 2016-10-19 美国政府(由卫生和人类服务部、疾病控制和预防中心的部长所代表) 新的人轮状病毒株和疫苗
NZ631348A (en) * 2012-08-27 2017-02-24 Murdoch Childrens Res Inst Modified human rotaviruses and uses therefor
CN103316336B (zh) * 2013-05-31 2015-01-28 北京科兴中维生物技术有限公司 一种适于口服的轮状病毒疫苗
CN106167518B (zh) 2015-05-21 2021-01-15 厦门大学 截短的轮状病毒vp4蛋白及其用途
EP3359651A1 (en) 2015-10-05 2018-08-15 THE UNITED STATES OF AMERICA, represented by the S Human rota virus g9p[6]strain and use as a vaccine
EP3373965A1 (en) * 2015-11-09 2018-09-19 CureVac AG Rotavirus vaccines
CN106916791B (zh) * 2015-12-25 2021-05-04 中国医学科学院医学生物学研究所 人轮状病毒毒种ztr-18毒株及其分离，培养及鉴定
MY191163A (en) * 2016-08-26 2022-06-03 The Centers For Disease Control And Prevention Cdc Multivalent vaccine composition
EP3986452A1 (en) * 2019-06-18 2022-04-27 CureVac AG Rotavirus mrna vaccine
CN113480617A (zh) * 2021-07-09 2021-10-08 山东威高利彤生物制品有限公司 轮状病毒毒株及其作为疫苗的用途
CN114940706B (zh) * 2022-04-20 2023-08-15 中国疾病预防控制中心病毒病预防控制所 一种人轮状病毒毒株、分离培养方法、鉴定及用途
CN117899207A (zh) * 2023-12-12 2024-04-19 中国医学科学院医学生物学研究所 一种轮状病毒mRNA疫苗及其制备方法和应用
CN118345054B (zh) * 2024-04-07 2025-03-04 兰州生物制品研究所有限责任公司 一种人-羊轮状病毒基因重配减毒株及应用

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Also Published As

Publication number Publication date
CN102695522A (zh) 2012-09-26
WO2010132561A8 (en) 2011-03-03
US20120121629A1 (en) 2012-05-17
US9498526B2 (en) 2016-11-22
EP3427750A1 (en) 2019-01-16
US8822192B2 (en) 2014-09-02
ES2723776T3 (es) 2019-09-02
WO2010132561A2 (en) 2010-11-18
US11065327B2 (en) 2021-07-20
US20170173144A1 (en) 2017-06-22
US11786589B2 (en) 2023-10-17
US20200054735A1 (en) 2020-02-20
EP2429577A4 (en) 2013-11-06
CA3121654A1 (en) 2010-11-18
CA2763359A1 (en) 2010-11-18
BRPI1007721A2 (pt) 2016-02-16
US20150079122A1 (en) 2015-03-19
CA2763359C (en) 2021-07-27
AU2010249103A2 (en) 2012-03-01
AU2010249103A1 (en) 2012-01-12
US20210308254A1 (en) 2021-10-07
WO2010132561A3 (en) 2011-06-16
EP2429577B1 (en) 2019-01-30
CN102695522B (zh) 2016-10-19
US20180236060A1 (en) 2018-08-23
AU2010249103B2 (en) 2015-02-26
US9974851B2 (en) 2018-05-22
CA3121471A1 (en) 2010-11-18
US10500269B2 (en) 2019-12-10
CN106421772A (zh) 2017-02-22
EP2429577A2 (en) 2012-03-21

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