BRPI1007940A2 - "peptídeos relacionados ao colágeno e usos dos mesmos e substratos de espumas hemostáticas" - Google Patents

"peptídeos relacionados ao colágeno e usos dos mesmos e substratos de espumas hemostáticas"

Info

Publication number
BRPI1007940A2
BRPI1007940A2 BRPI1007940A BRPI1007940A BRPI1007940A2 BR PI1007940 A2 BRPI1007940 A2 BR PI1007940A2 BR PI1007940 A BRPI1007940 A BR PI1007940A BR PI1007940 A BRPI1007940 A BR PI1007940A BR PI1007940 A2 BRPI1007940 A2 BR PI1007940A2
Authority
BR
Brazil
Prior art keywords
collagen
related peptides
foam substrates
hemostatic foam
hemostatic
Prior art date
Application number
BRPI1007940A
Other languages
English (en)
Inventor
Chunlin Yang
Thomas Matalenas
Thoppil Mathew John
Original Assignee
Ethicon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ethicon Inc filed Critical Ethicon Inc
Publication of BRPI1007940A2 publication Critical patent/BRPI1007940A2/pt
Publication of BRPI1007940B1 publication Critical patent/BRPI1007940B1/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A61L24/0036—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/046—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/10—Polypeptides; Proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/04—Materials for stopping bleeding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/22—Haematology
    • G01N2800/224—Haemostasis or coagulation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/24—Structurally defined web or sheet [e.g., overall dimension, etc.]
    • Y10T428/24479—Structurally defined web or sheet [e.g., overall dimension, etc.] including variation in thickness
    • Y10T428/24496—Foamed or cellular component

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Urology & Nephrology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Materials Engineering (AREA)
  • General Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Toxicology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Dispersion Chemistry (AREA)
  • Vascular Medicine (AREA)
BRPI1007940-8A 2009-01-30 2010-01-29 Método para fabricação de um substrato de espuma hemostática BRPI1007940B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12/362,908 2009-01-30
US12/362,908 US20100021527A1 (en) 2008-07-25 2009-01-30 Collagen-related peptides and uses thereof and hemostatic foam substrates
PCT/US2010/022517 WO2010088469A2 (en) 2009-01-30 2010-01-29 Collagen-related peptides and uses thereof and hemostatic foam substrates

Publications (2)

Publication Number Publication Date
BRPI1007940A2 true BRPI1007940A2 (pt) 2016-07-26
BRPI1007940B1 BRPI1007940B1 (pt) 2018-07-03

Family

ID=41568857

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI1007940-8A BRPI1007940B1 (pt) 2009-01-30 2010-01-29 Método para fabricação de um substrato de espuma hemostática

Country Status (9)

Country Link
US (1) US20100021527A1 (pt)
EP (1) EP2391393A2 (pt)
JP (1) JP5583695B2 (pt)
KR (1) KR101620878B1 (pt)
CN (1) CN102369026B (pt)
AU (1) AU2010208150B2 (pt)
BR (1) BRPI1007940B1 (pt)
CA (1) CA2751132C (pt)
WO (1) WO2010088469A2 (pt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201101740D0 (en) 2011-02-01 2011-03-16 Haemostatix Ltd Therapeutic agents with improved fibrinogen binding
GB201201751D0 (en) * 2012-02-01 2012-03-14 Haemostatix Ltd Haemostatic wound dressing
CN103665110B (zh) * 2013-12-06 2015-10-28 华南理工大学 半程电荷互补型手性自组装短肽纳米生物医药材料及应用
GB201400292D0 (en) 2014-01-08 2014-02-26 Haemostatix Ltd Peptide dendrimers and agents
WO2016098816A1 (ja) * 2014-12-17 2016-06-23 国立大学法人 九州工業大学 生体成分含有溶液の製造方法及び生体成分含有物
GB201508024D0 (en) 2015-05-11 2015-06-24 Haemostatix Ltd Haemostatic compositions
US9896560B2 (en) 2015-06-02 2018-02-20 Ethicon, Inc. Lyophilized foams of end block containing absorbable polymers
US20200282100A1 (en) * 2016-06-01 2020-09-10 3-D Matrix, Ltd. Hemostatic Dressings with Self-Assembling Peptide Hydrogels
MA46239A (fr) 2016-09-14 2019-07-24 Ethicon Inc Mousse pharmaceutique stable
IL247810A0 (en) 2016-09-14 2017-01-31 Omrix Biopharmaceuticals Ltd Stable pharmaceutical foam
US11484564B2 (en) * 2017-10-20 2022-11-01 Otsuka Pharmaceutical Factory, Inc. Adhesion prevention material
WO2025133607A1 (en) * 2023-12-21 2025-06-26 Pplus Skin Care Limited Collagen related peptide
CN120837708B (zh) * 2025-09-22 2025-12-30 浙江珂瑞康生物医疗科技有限公司 一种絮状蓬松胶原止血材料及其制备方法和应用

Family Cites Families (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US850A (en) 1838-07-24 Apparatus for propelling boats by the action of air
US5645A (en) 1848-06-20 Improvement in water-wheels
US4208511A (en) * 1977-01-19 1980-06-17 Ethicon, Inc. Isomorphic copolyoxalates and sutures thereof
US4141087A (en) * 1977-01-19 1979-02-27 Ethicon, Inc. Isomorphic copolyoxalates and sutures thereof
US4105034A (en) * 1977-06-10 1978-08-08 Ethicon, Inc. Poly(alkylene oxalate) absorbable coating for sutures
US4205399A (en) * 1977-06-13 1980-06-03 Ethicon, Inc. Synthetic absorbable surgical devices of poly(alkylene oxalates)
US4140678A (en) * 1977-06-13 1979-02-20 Ethicon, Inc. Synthetic absorbable surgical devices of poly(alkylene oxalates)
US4130639A (en) * 1977-09-28 1978-12-19 Ethicon, Inc. Absorbable pharmaceutical compositions based on isomorphic copolyoxalates
US5274074A (en) * 1987-12-17 1993-12-28 United States Surgical Corporation Medical devices fabricated from homopolymers and copolymers having recurring carbonate units
US4960594A (en) * 1988-09-22 1990-10-02 Derma-Lock Medical Corporation Polyurethane foam dressing
GB8928250D0 (en) 1989-12-14 1990-02-21 Erba Carlo Spa Use of supercritical fluids to obtain porous sponges of biodegradable polymers
US5117009A (en) * 1990-08-31 1992-05-26 University Of Minnesota Xanthenylamide handle for use in peptide synthesis
US5196566A (en) * 1990-08-31 1993-03-23 Regents Of The University Of Minnesota Hypersensitive acid-labile handle for solid-phase peptide synthesis
GB9123707D0 (en) * 1991-11-07 1992-01-02 Johnson & Johnson Medical Ltd Polyurethane foam
GB9123708D0 (en) * 1991-11-07 1992-01-02 Johnson & Johnson Medical Ltd Method of making polyurethane foam
US6326410B1 (en) * 1992-11-04 2001-12-04 Johnson & Johnson Medical, Inc. Wound dressing comprising polyurethane foam
US5468253A (en) * 1993-01-21 1995-11-21 Ethicon, Inc. Elastomeric medical device
US5597579A (en) * 1995-03-06 1997-01-28 Ethicon, Inc. Blends of absorbable polyoxaamides
US5607687A (en) * 1995-03-06 1997-03-04 Ethicon, Inc. Polymer blends containing absorbable polyoxaesters
US5648088A (en) * 1995-03-06 1997-07-15 Ethicon, Inc. Blends of absorbable polyoxaesters containing amines and/or amide groups
US5859150A (en) * 1995-03-06 1999-01-12 Ethicon, Inc. Prepolymers of absorbable polyoxaesters
US5464929A (en) * 1995-03-06 1995-11-07 Ethicon, Inc. Absorbable polyoxaesters
US5618552A (en) * 1995-03-06 1997-04-08 Ethicon, Inc. Absorbable polyoxaesters
US5595751A (en) * 1995-03-06 1997-01-21 Ethicon, Inc. Absorbable polyoxaesters containing amines and/or amido groups
US5698213A (en) * 1995-03-06 1997-12-16 Ethicon, Inc. Hydrogels of absorbable polyoxaesters
US5700583A (en) * 1995-03-06 1997-12-23 Ethicon, Inc. Hydrogels of absorbable polyoxaesters containing amines or amido groups
US6096710A (en) * 1995-11-17 2000-08-01 The Regents Of The University Of California Collagen-like peptoid residue-containing structures
US6096863A (en) * 1996-08-23 2000-08-01 Regents Of The University Of Minnesota Self-assembling amphiphiles for construction of peptide secondary structures
DE69828387T2 (de) * 1997-01-28 2005-12-08 United States Surgical Corp., Norwalk Polyesteramid, seine darstellung und daraus fabrizierte chirurgische artikel
JP2001527451A (ja) 1997-05-16 2001-12-25 ノバルティス アクチエンゲゼルシャフト 細胞結合活性を有するコラーゲン様ポリマー
US5973112A (en) 1997-08-25 1999-10-26 Wisconsin Alumni Research Foundation Collagen mimics
US20050147690A1 (en) * 1998-09-25 2005-07-07 Masters David B. Biocompatible protein particles, particle devices and methods thereof
US6325810B1 (en) * 1999-06-30 2001-12-04 Ethicon, Inc. Foam buttress for stapling apparatus
US6306424B1 (en) * 1999-06-30 2001-10-23 Ethicon, Inc. Foam composite for the repair or regeneration of tissue
US6669980B2 (en) * 2001-09-18 2003-12-30 Scimed Life Systems, Inc. Method for spray-coating medical devices
JP5070442B2 (ja) 2002-02-28 2012-11-14 株式会社Ｐｈｇ 新規なポリペプチドおよびその製造方法
JP2005053878A (ja) 2003-08-07 2005-03-03 Masao Tanihara 新規なポリペプチドおよびその製造方法
JP2005060315A (ja) 2003-08-13 2005-03-10 Masao Tanihara 製剤組成物
JP2005060314A (ja) 2003-08-13 2005-03-10 Masao Tanihara 化粧料
JP2005058499A (ja) 2003-08-13 2005-03-10 Masao Tanihara 生体材料
JP2005060550A (ja) 2003-08-13 2005-03-10 Masao Tanihara 被膜形成組成物
JP4115361B2 (ja) 2003-08-13 2008-07-09 株式会社Ｐｈｇ 食用組成物
EP1660013A4 (en) * 2003-08-26 2011-07-20 Gel Del Technologies Inc BIOMATERIAL AND PROTEIN BIOCOACERVATES, METHODS OF MAKING AND USING THEM
JP2005126360A (ja) 2003-10-23 2005-05-19 Masao Tanihara 新規なポリペプチドで構成されたコラゲナーゼ阻害剤
JP4303137B2 (ja) 2004-01-23 2009-07-29 株式会社Ｐｈｇ 新規なポリペプチド及びその製造方法
US11395865B2 (en) * 2004-02-09 2022-07-26 DePuy Synthes Products, Inc. Scaffolds with viable tissue
WO2007044026A2 (en) 2004-11-23 2007-04-19 The Johns Hopkins University Compositions comprising modified collagen and uses therefore
US7772352B2 (en) * 2005-01-28 2010-08-10 Bezwada Biomedical Llc Bioabsorbable and biocompatible polyurethanes and polyamides for medical devices
EP1859818B1 (en) 2005-03-15 2013-05-29 National University Corporation Nara Institute of Science and Technology Composite for biocompatible material and process for production thereof
WO2007017671A1 (en) 2005-08-09 2007-02-15 Cambridge Enterprise Limited Collagen peptides, methods and uses
GB0522748D0 (en) 2005-11-07 2005-12-14 Univ Cambridge Tech Collagen peptides, methods and uses
WO2007075807A2 (en) 2005-12-20 2007-07-05 Es Cell International Pte Ltd. Methods for the directed differentiation of embryonic stem cell
US20090004271A1 (en) * 2007-06-29 2009-01-01 Brown Laura J Morselized foam for wound treatment
US20090004253A1 (en) * 2007-06-29 2009-01-01 Brown Laura J Composite device for the repair or regeneration of tissue
JP5566885B2 (ja) * 2007-08-01 2014-08-06 エシコン・インコーポレイテッド コラーゲン関連ペプチド及びその使用

Also Published As

Publication number Publication date
EP2391393A2 (en) 2011-12-07
WO2010088469A2 (en) 2010-08-05
CN102369026A (zh) 2012-03-07
CA2751132A1 (en) 2010-08-05
CA2751132C (en) 2017-12-12
JP5583695B2 (ja) 2014-09-03
BRPI1007940B1 (pt) 2018-07-03
JP2012516219A (ja) 2012-07-19
KR20110124248A (ko) 2011-11-16
AU2010208150A1 (en) 2011-08-11
AU2010208150B2 (en) 2013-08-15
WO2010088469A3 (en) 2011-01-06
CN102369026B (zh) 2014-12-17
KR101620878B1 (ko) 2016-05-13
US20100021527A1 (en) 2010-01-28

Similar Documents

Publication Publication Date Title
BRPI1007940A2 (pt) "peptídeos relacionados ao colágeno e usos dos mesmos e substratos de espumas hemostáticas"
BRPI0922790A2 (pt) peptídeos de ligação sparc e usos dos mesmos
BRPI0912225A2 (pt) peptídeos de direcionamento lisossomais e usos dos mesmos
BRPI0923283A2 (pt) conjugados terapêuticos de peptídeo e usos dos mesmos
BRPI1009455A2 (pt) anticorpos anti-c40 e usos dos mesmos
BR112012006501A2 (pt) polipeptídios e usos dos mesmos
BRPI1012340A (pt) proteínas de ligação específica e usos das mesmas
BRPI0912198A2 (pt) anticorpos anti-fn14 e usos dos mesmos
EP2371333A4 (en) THIN CLEANER ARTICLE
BRPI0821658A2 (pt) Anticorpos contra nkg2d humano e usos dos mesmos
DE602007002740D1 (de) Trokar und Behandlungssystem
GB0912577D0 (en) Surgical antenna and electrosurgical system using the same
BRPI1005292A2 (pt) composição de decapagem e uso da composição
EP2571439A4 (en) SYSTEMS AND METHOD FOR TISSUE ABLATION
BRPI0819909A2 (pt) anticorpos antimesotelina e usos dos mesmos
BRPI0920927A2 (pt) derivados de azaquinolinona e usos dos mesmos
BRPI0913574A2 (pt) composição de tratamento de acne compreendendo nanoprata e usos
EP2064300A4 (en) ADHESIVE FABRIC COMPOSITIONS AND RELATED METHODS
EP2288324A4 (en) ABSORBENT HYGIENE WITH DISPENSER
BR112012004731A2 (pt) peptídeos derivados de wnt10 e uso dos mesmos
PT2291654T (pt) Preparação e composição de proteínas inibidoras de interalfa do sangue
GB0706304D0 (en) Liquid healing vessels
BR112012002072A2 (pt) polipeptídeos de fator ix modificados e usos dos mesmos
EP2098233A4 (en) PREPARATION OF SKIN ADHESIVE COMPRISING DERESEPZIL STABILIZED
BRPI0907750A2 (pt) Variantes de alfa-amilase de bacillus stearothermophilus e usos dos mesmos

Legal Events

Date Code Title Description
B06T Formal requirements before examination [chapter 6.20 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]
B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE A 11A ANUIDADE.

B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2616 DE 23-02-2021 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.