BRPI1008232A2 - derivados de 6-(6-o-substituído- triazolo piridazina-sulfanil) benzotiazóis e benzimidazóis: preparo, aplicação como medicamentos e utilização como inibidores de met - Google Patents

derivados de 6-(6-o-substituído- triazolo piridazina-sulfanil) benzotiazóis e benzimidazóis: preparo, aplicação como medicamentos e utilização como inibidores de met

Info

Publication number: BRPI1008232A2
Authority: BR; Brazil
Prior art keywords: benzothiazoles; sulfanyl; medicaments; substituted; preparation
Prior art date: 2009-02-06

Application number

BRPI1008232A

Other languages

English (en)

Inventor

Antonio Ugolini

Conception Nemecek

Bacque Dominique

Eric Bacque

Sylvie Wentzler

Original Assignee

Sanofi Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2009-02-06

Filing date

2010-02-04

Publication date

2016-03-08

2010-02-04 Application filed by Sanofi Sa filed Critical Sanofi Sa

2016-03-08 Publication of BRPI1008232A2 publication Critical patent/BRPI1008232A2/pt

Links

229940058303 antinematodal benzimidazole derivative Drugs 0.000 title 1
125000003785 benzimidazolyl group Chemical class N1=C(NC2=C1C=CC=C2)* 0.000 title 1
IOJUPLGTWVMSFF-UHFFFAOYSA-N benzothiazole Chemical class C1=CC=C2SC=NC2=C1 IOJUPLGTWVMSFF-UHFFFAOYSA-N 0.000 title 1
239000003814 drug Substances 0.000 title 1
239000003112 inhibitor Substances 0.000 title 1
239000002184 metal Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D277/82—Nitrogen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Diabetes (AREA)
Pulmonology (AREA)
Urology & Nephrology (AREA)
Hematology (AREA)
Immunology (AREA)
Endocrinology (AREA)
Physical Education & Sports Medicine (AREA)
Heart & Thoracic Surgery (AREA)
Neurology (AREA)
Cardiology (AREA)
Dermatology (AREA)
Obesity (AREA)
Orthopedic Medicine & Surgery (AREA)
Rheumatology (AREA)
Oncology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Ophthalmology & Optometry (AREA)
Pain & Pain Management (AREA)
Emergency Medicine (AREA)
Gastroenterology & Hepatology (AREA)
Vascular Medicine (AREA)
Reproductive Health (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

BRPI1008232A 2009-02-06 2010-02-04 derivados de 6-(6-o-substituído- triazolo piridazina-sulfanil) benzotiazóis e benzimidazóis: preparo, aplicação como medicamentos e utilização como inibidores de met BRPI1008232A2 (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR0900512A FR2941950B1 (fr)	2009-02-06	2009-02-06	Derives de 6-(6-o-substitue-triazolopyridazine-sulfanyl) benzothiazoles et benzimidazoles : preparation, application comme medicaments et utilisation comme inhibiteurs de met.
PCT/FR2010/050178 WO2010089507A1 (fr)	2009-02-06	2010-02-04	Derives de 6-(6-o-substitue-triazolopyridazine-sulfanyl) benzothiazoles et benzimidazoles : preparation, application comme medicaments et utilisation comme inhibiteurs de met

Publications (1)

Publication Number	Publication Date
BRPI1008232A2 true BRPI1008232A2 (pt)	2016-03-08

Family

ID=40872767

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI1008232A BRPI1008232A2 (pt)	2009-02-06	2010-02-04	derivados de 6-(6-o-substituído- triazolo piridazina-sulfanil) benzotiazóis e benzimidazóis: preparo, aplicação como medicamentos e utilização como inibidores de met

Country Status (19)

Country	Link
EP (1)	EP2393791A1 (pt)
JP (1)	JP2012517408A (pt)
KR (1)	KR20110132560A (pt)
CN (1)	CN102378759A (pt)
AR (1)	AR075249A1 (pt)
AU (1)	AU2010212232A1 (pt)
BR (1)	BRPI1008232A2 (pt)
CA (1)	CA2750875A1 (pt)
CL (1)	CL2011001879A1 (pt)
CO (1)	CO6400223A2 (pt)
EA (1)	EA201171011A1 (pt)
FR (1)	FR2941950B1 (pt)
IL (1)	IL214406A0 (pt)
MA (1)	MA33107B1 (pt)
MX (1)	MX2011008319A (pt)
SG (1)	SG173559A1 (pt)
TW (1)	TW201031670A (pt)
UY (1)	UY32420A (pt)
WO (1)	WO2010089507A1 (pt)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU2012310168B2 (en)	2011-09-15	2015-07-16	Novartis Ag	6 - substituted 3 - (quinolin- 6 - ylthio) - [1,2,4] triazolo [4, 3 -a] pyradines as tyrosine kinase
WO2013045519A1 (en) *	2011-09-27	2013-04-04	Genfit	Derivatives of 6-substituted triazolopyridazines as rev-erb agonists
GB201321745D0 (en) *	2013-12-09	2014-01-22	Ucb Pharma Sa	Therapeutic agents
AU2024241633A1 (en)	2023-03-30	2025-11-06	Revolution Medicines, Inc.	Compositions for inducing ras gtp hydrolysis and uses thereof
WO2024229406A1 (en)	2023-05-04	2024-11-07	Revolution Medicines, Inc.	Combination therapy for a ras related disease or disorder
US20250049810A1 (en)	2023-08-07	2025-02-13	Revolution Medicines, Inc.	Methods of treating a ras protein-related disease or disorder
TW202530228A (zh)	2023-10-12	2025-08-01	美商銳新醫藥公司	Ｒａｓ抑制劑
WO2025171296A1 (en)	2024-02-09	2025-08-14	Revolution Medicines, Inc.	Ras inhibitors
TW202547461A (zh)	2024-05-17	2025-12-16	美商銳新醫藥公司	Ｒａｓ抑制劑
WO2025255438A1 (en)	2024-06-07	2025-12-11	Revolution Medicines, Inc.	Methods of treating a ras protein-related disease or disorder
WO2025265060A1 (en)	2024-06-21	2025-12-26	Revolution Medicines, Inc.	Therapeutic compositions and methods for managing treatment-related effects
WO2026006747A1 (en)	2024-06-28	2026-01-02	Revolution Medicines, Inc.	Ras inhibitors
WO2026015801A1 (en)	2024-07-12	2026-01-15	Revolution Medicines, Inc.	Methods of treating a ras related disease or disorder
WO2026015825A1 (en)	2024-07-12	2026-01-15	Revolution Medicines, Inc.	Use of ras inhibitor for treating pancreatic cancer
WO2026015790A1 (en)	2024-07-12	2026-01-15	Revolution Medicines, Inc.	Methods of treating a ras related disease or disorder
WO2026015796A1 (en)	2024-07-12	2026-01-15	Revolution Medicines, Inc.	Methods of treating a ras related disease or disorder
WO2026050446A1 (en)	2024-08-29	2026-03-05	Revolution Medicines, Inc.	Ras inhibitors

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1298125A1 (en)	2001-09-26	2003-04-02	Aventis Pharma S.A.	Substituted benzimidazole compounds and their use for the treatment of cancer
WO2007064797A2 (en) *	2005-11-30	2007-06-07	Vertex Pharmaceuticals Incorporated	Inhibitors of c-met and uses thereof
PT1966214T (pt) *	2005-12-21	2017-02-03	Janssen Pharmaceutica Nv	Triazolpiridazinas como moduladores de tirosina quinase
CA2651979A1 (en) *	2006-05-30	2007-12-06	Pfizer Products Inc.	Triazolopyridazine derivatives
PE20080403A1 (es) *	2006-07-14	2008-04-25	Amgen Inc	Derivados heterociclicos fusionados y metodos de uso
BRPI0717320A2 (pt) *	2006-10-23	2013-10-22	Sgx Pharmaceuticals Inc	Triazóis bicíclicos como moduladores de proteína cinase
PA8792501A1 (es) *	2007-08-09	2009-04-23	Sanofi Aventis	Nuevos derivados de 6-triazolopiridacina-sulfanil benzotiazol y bencimidazol,su procedimiento de preparación,su aplicación como medicamentos,composiciones farmacéuticas y nueva utilización principalmente como inhibidores de met.

2009
- 2009-02-06 FR FR0900512A patent/FR2941950B1/fr not_active Expired - Fee Related
2010
- 2010-02-04 CA CA2750875A patent/CA2750875A1/fr not_active Abandoned
- 2010-02-04 SG SG2011056488A patent/SG173559A1/en unknown
- 2010-02-04 EA EA201171011A patent/EA201171011A1/ru unknown
- 2010-02-04 MX MX2011008319A patent/MX2011008319A/es not_active Application Discontinuation
- 2010-02-04 AU AU2010212232A patent/AU2010212232A1/en not_active Abandoned
- 2010-02-04 MA MA34152A patent/MA33107B1/fr unknown
- 2010-02-04 WO PCT/FR2010/050178 patent/WO2010089507A1/fr not_active Ceased
- 2010-02-04 JP JP2011548751A patent/JP2012517408A/ja not_active Withdrawn
- 2010-02-04 BR BRPI1008232A patent/BRPI1008232A2/pt not_active IP Right Cessation
- 2010-02-04 CN CN2010800155375A patent/CN102378759A/zh active Pending
- 2010-02-04 KR KR1020117020677A patent/KR20110132560A/ko not_active Withdrawn
- 2010-02-04 EP EP10708278A patent/EP2393791A1/fr not_active Withdrawn
- 2010-02-05 AR ARP100100317A patent/AR075249A1/es unknown
- 2010-02-05 UY UY0001032420A patent/UY32420A/es not_active Application Discontinuation
- 2010-02-05 TW TW099103579A patent/TW201031670A/zh unknown
2011
- 2011-08-02 IL IL214406A patent/IL214406A0/en unknown
- 2011-08-04 CL CL2011001879A patent/CL2011001879A1/es unknown
- 2011-08-05 CO CO11099127A patent/CO6400223A2/es not_active Application Discontinuation

Also Published As

Publication number	Publication date
CO6400223A2 (es)	2012-03-15
WO2010089507A1 (fr)	2010-08-12
UY32420A (es)	2010-09-30
FR2941950B1 (fr)	2011-04-01
KR20110132560A (ko)	2011-12-08
FR2941950A1 (fr)	2010-08-13
CA2750875A1 (fr)	2010-08-12
TW201031670A (en)	2010-09-01
AR075249A1 (es)	2011-03-16
CL2011001879A1 (es)	2012-01-06
SG173559A1 (en)	2011-09-29
EA201171011A1 (ru)	2012-03-30
CN102378759A (zh)	2012-03-14
AU2010212232A1 (en)	2011-08-25
JP2012517408A (ja)	2012-08-02
IL214406A0 (en)	2011-09-27
MX2011008319A (es)	2012-01-25
MA33107B1 (fr)	2012-03-01
EP2393791A1 (fr)	2011-12-14

Legal Events

Date	Code	Title	Description
2016-09-20	B08F	Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]	Free format text: REFERENTE AS 4A, 5A E 6A ANUIDADES.
2017-01-10	B08K	Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]	Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2385 DE 20-09-2016 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.

Publication	Publication Date	Title
BRPI1008232A2 (pt)	2016-03-08	derivados de 6-(6-o-substituído- triazolo piridazina-sulfanil) benzotiazóis e benzimidazóis: preparo, aplicação como medicamentos e utilização como inibidores de met
CY2019031I2 (el)	2019-11-27	Αναπνευστικη απελευθερωση ενεργων παραγοντων
SG11201401189WA (en)	2014-09-26	Benzothiazol- 6 -yl acetic acid derivatives and their use for treating an hiv infection
IT1396269B1 (it)	2012-11-16	Procedimento per fabbricare un pezzo da lavorare, pezzo da lavorare ed utilizzo di un pezzo da lavorare
PT2504005E (pt)	2014-01-10	Utilização de derivados de 1,3-difenilprop-2-en-1-ona para tratamento de doenças hepáticas
IL214098A (en)	2015-05-31	Derivatives of 2– (pyrolidine – 2 – il) - h1– benzimidazole, pharmaceutical preparations containing them and their use in the preparation of drugs
IL210802A0 (en)	2011-04-28	Purin derivatives for use in the treatment of fab-related diseases
BRPI1011046A2 (pt)	2016-03-15	derivados de isoquinolin-1 (2h)-ona como inibidores de parp-i
EP2471546A4 (en)	2013-02-20	THERAPEUTIC ACTIVE AGAINST RHINITIS
EP2740728A4 (en)	2015-04-01	URACIL DERIVATIVE AND ITS USE FOR MEDICAL PURPOSES
EP2305237A4 (en)	2013-06-12	THERAPEUTIC AGENT FOR MALE STERILITY
IL251177B (en)	2018-03-29	Parasitic preparations containing benzaimidazole history, methods and uses
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EP2614824A4 (en)	2014-02-12	THERAPEUTIC AGENT AGAINST PAIN
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