BRPI1008396A2 - sal de tosilato de um derivado de 5-pirazolil-2-piridona, útil no tratamento de copd - Google Patents
sal de tosilato de um derivado de 5-pirazolil-2-piridona, útil no tratamento de copdInfo
- Publication number
- BRPI1008396A2 BRPI1008396A2 BRPI1008396A BRPI1008396A BRPI1008396A2 BR PI1008396 A2 BRPI1008396 A2 BR PI1008396A2 BR PI1008396 A BRPI1008396 A BR PI1008396A BR PI1008396 A BRPI1008396 A BR PI1008396A BR PI1008396 A2 BRPI1008396 A2 BR PI1008396A2
- Authority
- BR
- Brazil
- Prior art keywords
- pyrazolyl
- tosylate salt
- derivative useful
- treating copd
- pyridone derivative
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Inorganic Chemistry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15409909P | 2009-02-20 | 2009-02-20 | |
| US61/154,099 | 2009-02-20 | ||
| PCT/GB2010/050271 WO2010094964A1 (en) | 2009-02-20 | 2010-02-18 | Tosylate salt of a 5-pyrazolyl-2-pyridone derivative, useful in the treatment of copd |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BRPI1008396A2 true BRPI1008396A2 (pt) | 2017-06-27 |
| BRPI1008396B1 BRPI1008396B1 (pt) | 2020-11-10 |
| BRPI1008396B8 BRPI1008396B8 (pt) | 2021-05-25 |
Family
ID=42046174
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI1008396A BRPI1008396B8 (pt) | 2009-02-20 | 2010-02-18 | composto de sal de tosilato de um derivado de 5-pirazolil-2-piridona, composição farmacêutica, uso e processo para preparação do dito composto |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US8232296B2 (pt) |
| EP (1) | EP2398792B1 (pt) |
| JP (1) | JP5543982B2 (pt) |
| KR (1) | KR20110127158A (pt) |
| CN (1) | CN102405219B (pt) |
| AR (1) | AR075523A1 (pt) |
| AU (1) | AU2010215269B2 (pt) |
| BR (1) | BRPI1008396B8 (pt) |
| CA (1) | CA2752319C (pt) |
| ES (1) | ES2469916T3 (pt) |
| MX (1) | MX2011008389A (pt) |
| RU (1) | RU2526038C2 (pt) |
| TW (1) | TW201036957A (pt) |
| UY (1) | UY32461A (pt) |
| WO (1) | WO2010094964A1 (pt) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE0302486D0 (sv) | 2003-09-18 | 2003-09-18 | Astrazeneca Ab | Novel compounds |
| TW200808763A (en) * | 2006-05-08 | 2008-02-16 | Astrazeneca Ab | Novel compounds I |
| TW200808771A (en) * | 2006-05-08 | 2008-02-16 | Astrazeneca Ab | Novel compounds II |
| MX2010004673A (es) * | 2007-11-06 | 2010-05-27 | Astrazeneca Ab | Algunos derivados de 2-pirazinona y su uso como inhibidores de elastasa de los neutrofilos. |
| EP2671614A1 (en) * | 2007-12-21 | 2013-12-11 | University of Rochester | Molecular Targets for Treatment of Inflammation |
| TW201036957A (en) * | 2009-02-20 | 2010-10-16 | Astrazeneca Ab | Novel salt 628 |
| CN102639505A (zh) * | 2009-10-02 | 2012-08-15 | 阿斯利康(瑞典)有限公司 | 用作嗜中性白细胞弹性蛋白酶抑制剂的吡啶-2-酮化合物 |
| US9475041B2 (en) * | 2012-04-24 | 2016-10-25 | Basf Se | Zeolitic materials and methods for their preparation using alkenyltrialkylammonium compounds |
| US20140057926A1 (en) | 2012-08-23 | 2014-02-27 | Boehringer Ingelheim International Gmbh | Substituted 4-pyridones and their use as inhibitors of neutrophil elastase activity |
| US20140057920A1 (en) | 2012-08-23 | 2014-02-27 | Boehringer Ingelheim International Gmbh | Substituted 4-pyridones and their use as inhibitors of neutrophil elastase activity |
| US9102624B2 (en) | 2012-08-23 | 2015-08-11 | Boehringer Ingelheim International Gmbh | Substituted 4-pyridones and their use as inhibitors of neutrophil elastase activity |
| AU2012391395B2 (en) * | 2012-09-26 | 2016-10-27 | Dalian Institute Of Chemical Physics, Chinese Academy Of Sciences | SAPO-34 molecular sieves and synthesis method thereof |
| SG11201501834YA (en) * | 2012-09-26 | 2015-05-28 | Dalian Chemical Physics Inst | Sapo-34 molecular sieve and synthesis method thereof |
| SG11201506392VA (en) * | 2013-03-06 | 2015-09-29 | Novartis Ag | Formulations of organic compounds |
| RU2542100C1 (ru) * | 2013-12-24 | 2015-02-20 | Федеральное государственное бюджетное учреждение науки Институт химии растворов им. Г.А. Крестова Российской Академии Наук (ИХС РАН) | Сокристаллическая форма теофиллина с дифлунисалом или диклофенаком |
| US9221807B2 (en) * | 2014-02-21 | 2015-12-29 | Boehringer Ingelheim International Gmbh | Substituted pyridones and pyrazinones and their use as inhibitors of neutrophil elastase activity |
| US10556801B2 (en) * | 2015-02-12 | 2020-02-11 | Basf Se | Process for the preparation of a dealuminated zeolitic material having the BEA framework structure |
| US20160257573A1 (en) * | 2015-03-03 | 2016-09-08 | Uop Llc | High surface area pentasil zeolite and process for making same |
| KR102509478B1 (ko) * | 2016-10-28 | 2023-03-10 | 아스트라제네카 아베 | (1r,2r)-2-[4-(3-메틸-1h-피라졸-5-일)벤조일]-n-(4-옥소-4,5,6,7-테트라하이드로피라졸로[1,5-a]피라진-3-일)사이클로헥산카복스아미드의 결정형 |
| BR112022004861A2 (pt) * | 2019-09-17 | 2022-06-07 | Univ Duke | Alvelestat para uso no tratamento de rejeição de transplante, síndrome de bronquiolite obliterante e doença de transplante versus hospedeiro |
| CN112851643B (zh) * | 2019-11-28 | 2024-01-16 | 广东东阳光药业股份有限公司 | 嘧啶苯甲酰胺化合物的盐酸盐及其用途 |
| SI4106757T1 (sl) * | 2020-04-16 | 2023-11-30 | Mereo Biopharma 4 Limited | Postopki, ki vključujejo zaviralec nevtrofilne elastaze alvelestat, za zdravljenje bolezni dihal, ki jo sproži pomanjkanje antitripsina alfa-1 |
| WO2022033471A1 (zh) * | 2020-08-10 | 2022-02-17 | 上海润石医药科技有限公司 | 含邻氨基吡啶炔基的化合物的盐及其制备方法和应用 |
| MX2023008755A (es) * | 2021-01-27 | 2023-08-02 | Intra Cellular Therapies Inc | Cristales de sal. |
| IL312002A (en) | 2021-10-20 | 2024-06-01 | Mereo Biopharma 4 Ltd | Neutrophil elastase inhibitors for use in the treatment of fibrosis |
| WO2023115795A1 (zh) * | 2021-12-23 | 2023-06-29 | 深圳安泰维生物医药有限公司 | 一种核苷类化合物的晶型 |
| WO2025078838A1 (en) | 2023-10-11 | 2025-04-17 | Mereo Biopharma 4 Limited | Alvelestat and alpha- 1 antitrypsin for treating respiratory disorders |
| WO2025133628A1 (en) | 2023-12-21 | 2025-06-26 | Mereo Biopharma 4 Limited | Use of alvelestat in specific patients |
| GB202319953D0 (en) | 2023-12-22 | 2024-02-07 | Mereo Biopharma 4 Ltd | Tablet formulations involving alvelestat |
Family Cites Families (72)
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|---|---|---|---|---|
| FR2358891A1 (fr) | 1976-07-22 | 1978-02-17 | Yamanouchi Pharma Co Ltd | Composes heterocycliques contenant un azote, utilise comme agents analgesiques et anti-inflammatoires |
| DE2706977A1 (de) | 1977-02-18 | 1978-08-24 | Hoechst Ag | Benzoesaeuren und deren derivate sowie verfahren zu ihrer herstellung |
| EP0008864A1 (en) | 1978-08-15 | 1980-03-19 | FISONS plc | Pyridopyrazine and quinoxaline derivatives, processes for their preparation, and pharmaceutical compositions containing them |
| JPH02152966A (ja) | 1988-12-05 | 1990-06-12 | Otsuka Pharmaceut Co Ltd | ４−ヒドロキシカルボスチリル誘導体 |
| US5521179A (en) | 1991-04-18 | 1996-05-28 | Zeneca Limited | Heterocyclic amides |
| US5441960A (en) | 1992-04-16 | 1995-08-15 | Zeneca Limited | 1-pyrimidinylacetamide human leukocyte elastate inhibitors |
| BR9713863A (pt) | 1996-12-05 | 2000-03-14 | Amgen Inc | Composto ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, processos de profilaxia ou tratamento, para abaixar as concentrações no plasma, para diminuir a produção de prostaglandinas, e, para diminuir a atividade de enzima ciclooxigenase |
| JPH1171351A (ja) | 1997-08-29 | 1999-03-16 | Ss Pharmaceut Co Ltd | 置換キノロン誘導体及びこれを含有する医薬 |
| MXPA02012314A (es) | 2000-06-12 | 2004-09-06 | Eisai Co Ltd | Compuestos de 1,2-dihidropiridina, metodo de fabricacion y utilizacion de los mismos. |
| DE60139506D1 (de) | 2000-12-28 | 2009-09-17 | Shionogi & Co | 2-pyridonderivate mit affinität für den cannabinoid-typ-2-rezeptor |
| US6627646B2 (en) * | 2001-07-17 | 2003-09-30 | Sepracor Inc. | Norastemizole polymorphs |
| KR100894167B1 (ko) | 2001-08-14 | 2009-04-22 | 토야마 케미칼 컴퍼니 리미티드 | 신규의 바이러스 증식저해 ·살바이러스방법 및 신규의피라진뉴클레오티드 ·피라진뉴클레오시드 유사체 |
| GB0129260D0 (en) | 2001-12-06 | 2002-01-23 | Eisai London Res Lab Ltd | Pharmaceutical compositions and their uses |
| SE0104251D0 (sv) | 2001-12-14 | 2001-12-14 | Astrazeneca Ab | Novel compounds |
| GB2383326A (en) | 2001-12-20 | 2003-06-25 | Bayer Ag | Antiinflammatory dihydropyridines |
| MXPA03000145A (es) | 2002-01-07 | 2003-07-15 | Pfizer | Compuestos de oxo u oxi-piridina como moduladores de receptores 5-ht4. |
| US20050101590A1 (en) | 2002-02-19 | 2005-05-12 | Kiyoshi Yasui | Antipruritics |
| JP4619122B2 (ja) | 2002-08-27 | 2011-01-26 | バイエル・シェーリング・ファルマ・アクチェンゲゼルシャフト | Ｈｎｅインヒビターとしてのジヒドロピリジノン誘導体 |
| GB2392910A (en) | 2002-09-10 | 2004-03-17 | Bayer Ag | 2-Oxopyrimidine derivatives and their use as human leukocyte elastase inhibitors |
| TW200500341A (en) | 2002-11-12 | 2005-01-01 | Astrazeneca Ab | Novel compounds |
| UA82867C2 (en) | 2003-02-13 | 2008-05-26 | Banyu Pharma Co Ltd | 2-pyridinecarboxamide derivatives |
| PE20040950A1 (es) | 2003-02-14 | 2005-01-01 | Theravance Inc | DERIVADOS DE BIFENILO COMO AGONISTAS DE LOS RECEPTORES ADRENERGICOS ß2 Y COMO ANTAGONISTAS DE LOS RECEPTORES MUSCARINICOS |
| JP4767842B2 (ja) | 2003-04-01 | 2011-09-07 | セラヴァンス， インコーポレーテッド | β２アドレナリン作用性レセプターアゴニスト活性およびムスカリン性レセプターアンタゴニスト活性を有するジアリールメチル化合物および関連化合物 |
| EP1626970B1 (en) | 2003-05-28 | 2009-07-08 | Theravance, Inc. | Azabicycloalkane compounds as muscarinic receptor antagonists |
| SE0302324D0 (sv) | 2003-08-28 | 2003-08-28 | Astrazeneca Ab | Novel compounds |
| SE0302323D0 (sv) | 2003-08-28 | 2003-08-28 | Astrazeneca Ab | Novel compounds |
| SE0302486D0 (sv) * | 2003-09-18 | 2003-09-18 | Astrazeneca Ab | Novel compounds |
| SE0302487D0 (sv) | 2003-09-18 | 2003-09-18 | Astrazeneca Ab | Novel compounds |
| JP4851937B2 (ja) | 2003-11-21 | 2012-01-11 | セラヴァンス， インコーポレーテッド | β２アドレナリン作動性受容体作動薬活性およびムスカリン受容体拮抗薬活性を有する化合物 |
| US8097629B2 (en) | 2004-02-19 | 2012-01-17 | Bayer Pharma Aktiengesellschaft | Dihydropyridinone derivatives |
| ES2394177T3 (es) | 2004-02-26 | 2013-01-23 | Bayer Intellectual Property Gmbh | 1,4-diaril-dihidropirimidin-2-onas y su uso como inhibidores de elastasa de neutrófilos humanos |
| DE102004024453A1 (de) | 2004-05-14 | 2006-01-05 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue langwirksame Bronchodilatoren zur Behandlung von Atemwegserkrankungen |
| US7745621B2 (en) | 2004-05-14 | 2010-06-29 | Boehringer Ingelheim International Gmbh | Long acting bronchodilators for the treatment of respiratory diseases |
| US7439246B2 (en) | 2004-06-28 | 2008-10-21 | Bristol-Myers Squibb Company | Fused heterocyclic kinase inhibitors |
| US7173031B2 (en) | 2004-06-28 | 2007-02-06 | Bristol-Myers Squibb Company | Pyrrolotriazine kinase inhibitors |
| EP1778626A1 (en) | 2004-08-16 | 2007-05-02 | Theravance, Inc. | Compounds having beta2 adrenergic receptor agonist and muscarinic receptor antagonist activity |
| EP1833822A2 (en) | 2004-08-16 | 2007-09-19 | Theravance, Inc. | Compounds having beta2 adrenergic receptor agonist and muscarinic receptor antagonist activity |
| EP1786813A2 (en) | 2004-09-03 | 2007-05-23 | Plexxikon, Inc. | Bicyclic heteroaryl pde4b inhibitors |
| GB0420722D0 (en) | 2004-09-17 | 2004-10-20 | Addex Pharmaceuticals Sa | Novel allosteric modulators |
| TWI360539B (en) | 2004-10-28 | 2012-03-21 | Shionogi & Co | 3-carbamoyl-2-pyridone derivatives |
| GB0502258D0 (en) | 2005-02-03 | 2005-03-09 | Argenta Discovery Ltd | Compounds and their use |
| TW200700392A (en) | 2005-03-16 | 2007-01-01 | Astrazeneca Ab | Novel compounds |
| JO2787B1 (en) | 2005-04-27 | 2014-03-15 | امجين إنك, | Alternative amide derivatives and methods of use |
| GB0512940D0 (en) | 2005-06-24 | 2005-08-03 | Argenta Discovery Ltd | Compounds and their use |
| RU2442771C2 (ru) | 2005-08-08 | 2012-02-20 | Арджента Дискавери Лтд | Производные бицикло[2,2,1]гепт-7-иламина и их применения |
| GB0516313D0 (en) | 2005-08-08 | 2005-09-14 | Argenta Discovery Ltd | Azole derivatives and their uses |
| GB0605469D0 (en) | 2006-03-17 | 2006-04-26 | Argenta Discovery Ltd | Multimers of heterocyclic compounds and their use |
| EA016203B1 (ru) | 2006-03-20 | 2012-03-30 | Пфайзер Лимитед | Производные амина |
| DE602007009095D1 (de) | 2006-05-04 | 2010-10-21 | Pulmagen Therapeutics Inflamma | Tetrahydropyrrolopyrimidindione und ihre verwendung als inhibitoren der humanen neutrophilen elastase |
| TW200808771A (en) | 2006-05-08 | 2008-02-16 | Astrazeneca Ab | Novel compounds II |
| TW200808763A (en) | 2006-05-08 | 2008-02-16 | Astrazeneca Ab | Novel compounds I |
| GB0613154D0 (en) | 2006-06-30 | 2006-08-09 | Novartis Ag | Organic Compounds |
| BRPI0714409A2 (pt) | 2006-07-14 | 2013-03-12 | Novartis Ag | derivados de pirimidina como inibidores de alk-5 |
| TW200821316A (en) | 2006-07-19 | 2008-05-16 | Astrazeneca Ab | Novel compounds 243 |
| EP2064184A1 (en) | 2006-09-04 | 2009-06-03 | AstraZeneca AB | Multimeric heterocyclic compounds useful as neutrophil elastase inhibitors |
| BRPI0719270A2 (pt) | 2006-10-04 | 2014-03-11 | Pfizer Ltd | Derivados de sulfonamida como agonistas adrenérgicos e antagonistas muscarínicos |
| TW200825084A (en) | 2006-11-14 | 2008-06-16 | Astrazeneca Ab | New compounds 521 |
| WO2008075005A1 (en) | 2006-12-19 | 2008-06-26 | Astrazeneca Ab | Quinuclidinol derivatives as muscarinic receptor antagonists |
| TW200833670A (en) | 2006-12-20 | 2008-08-16 | Astrazeneca Ab | Novel compounds 569 |
| SA08280783B1 (ar) | 2007-01-11 | 2011-04-24 | استرازينيكا ايه بي | مشتقات بيريدوبيريميدين كمثبطات pde4 |
| CA2675629A1 (en) | 2007-02-07 | 2008-08-14 | Argenta Discovery Ltd | New salt |
| GB0702456D0 (en) | 2007-02-08 | 2007-03-21 | Astrazeneca Ab | New combination |
| JP2010519193A (ja) | 2007-02-15 | 2010-06-03 | アージェンタ ディスカバリー リミテッド | Ｍ３ムスカリン受容体としての複素環式誘導体 |
| WO2008104752A1 (en) | 2007-02-26 | 2008-09-04 | Astrazeneca Ab | Dihydropyridones as elastase inhibitors |
| JP5140154B2 (ja) | 2007-06-27 | 2013-02-06 | アストラゼネカ・アクチエボラーグ | ピラジノン誘導体および肺疾患の処置におけるそれらの使用 |
| WO2009058076A1 (en) | 2007-11-02 | 2009-05-07 | Astrazeneca Ab | 2-pyrazinone derivatives and their use as inhibitors of neutrophile elastase |
| MX2010004673A (es) | 2007-11-06 | 2010-05-27 | Astrazeneca Ab | Algunos derivados de 2-pirazinona y su uso como inhibidores de elastasa de los neutrofilos. |
| PT2242759E (pt) | 2008-02-06 | 2012-12-17 | Astrazeneca Ab | Compostos |
| WO2009138707A1 (en) | 2008-05-13 | 2009-11-19 | Astrazeneca Ab | Quinuclidine derivatives as muscarinic m3 receptor antagonists |
| GB0811099D0 (en) | 2008-06-17 | 2008-07-23 | Astrazeneca Ab | New combination 376 |
| US7862384B2 (en) * | 2008-07-07 | 2011-01-04 | Myers Kelly H | Repair adapter for a modular plug |
| TW201036957A (en) | 2009-02-20 | 2010-10-16 | Astrazeneca Ab | Novel salt 628 |
-
2010
- 2010-02-12 TW TW099104696A patent/TW201036957A/zh unknown
- 2010-02-16 US US12/706,313 patent/US8232296B2/en active Active
- 2010-02-18 AR ARP100100488A patent/AR075523A1/es unknown
- 2010-02-18 WO PCT/GB2010/050271 patent/WO2010094964A1/en not_active Ceased
- 2010-02-18 RU RU2011135627/04A patent/RU2526038C2/ru active
- 2010-02-18 KR KR1020117019327A patent/KR20110127158A/ko not_active Ceased
- 2010-02-18 AU AU2010215269A patent/AU2010215269B2/en active Active
- 2010-02-18 ES ES10705178.1T patent/ES2469916T3/es active Active
- 2010-02-18 CN CN2010800174198A patent/CN102405219B/zh active Active
- 2010-02-18 EP EP10705178.1A patent/EP2398792B1/en active Active
- 2010-02-18 JP JP2011550649A patent/JP5543982B2/ja active Active
- 2010-02-18 MX MX2011008389A patent/MX2011008389A/es active IP Right Grant
- 2010-02-18 CA CA2752319A patent/CA2752319C/en active Active
- 2010-02-18 BR BRPI1008396A patent/BRPI1008396B8/pt active IP Right Grant
- 2010-02-19 UY UY0001032461A patent/UY32461A/es unknown
-
2012
- 2012-06-27 US US13/534,687 patent/US20120269872A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP2012518623A (ja) | 2012-08-16 |
| HK1162498A1 (en) | 2012-08-31 |
| BRPI1008396B8 (pt) | 2021-05-25 |
| AU2010215269A1 (en) | 2011-08-25 |
| ES2469916T3 (es) | 2014-06-20 |
| US20120269872A1 (en) | 2012-10-25 |
| CN102405219A (zh) | 2012-04-04 |
| EP2398792B1 (en) | 2014-04-09 |
| JP5543982B2 (ja) | 2014-07-09 |
| WO2010094964A1 (en) | 2010-08-26 |
| UY32461A (es) | 2010-09-30 |
| AU2010215269B2 (en) | 2013-06-27 |
| MX2011008389A (es) | 2011-09-01 |
| KR20110127158A (ko) | 2011-11-24 |
| US20100216843A1 (en) | 2010-08-26 |
| CA2752319C (en) | 2016-10-04 |
| AR075523A1 (es) | 2011-04-06 |
| EP2398792A1 (en) | 2011-12-28 |
| RU2011135627A (ru) | 2013-03-27 |
| CA2752319A1 (en) | 2010-08-26 |
| RU2526038C2 (ru) | 2014-08-20 |
| US8232296B2 (en) | 2012-07-31 |
| CN102405219B (zh) | 2013-11-06 |
| TW201036957A (en) | 2010-10-16 |
| BRPI1008396B1 (pt) | 2020-11-10 |
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