BRPI1009215A2 - "tratamento de câncer com poliptídeos derivados de hiv tat imunoestimulante" - Google Patents
"tratamento de câncer com poliptídeos derivados de hiv tat imunoestimulante"Info
- Publication number
- BRPI1009215A2 BRPI1009215A2 BRPI1009215A BRPI1009215A BRPI1009215A2 BR PI1009215 A2 BRPI1009215 A2 BR PI1009215A2 BR PI1009215 A BRPI1009215 A BR PI1009215A BR PI1009215 A BRPI1009215 A BR PI1009215A BR PI1009215 A2 BRPI1009215 A2 BR PI1009215A2
- Authority
- BR
- Brazil
- Prior art keywords
- cancer treatment
- hiv tat
- derived polypeptides
- immunostimulatory
- immunostimulatory hiv
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title 1
- 201000011510 cancer Diseases 0.000 title 1
- 230000003308 immunostimulating effect Effects 0.000 title 1
- 229920001184 polypeptide Polymers 0.000 title 1
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16311—Human Immunodeficiency Virus, HIV concerning HIV regulatory proteins
- C12N2740/16322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Virology (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16260509P | 2009-03-23 | 2009-03-23 | |
| US30627810P | 2010-02-19 | 2010-02-19 | |
| US31022110P | 2010-03-03 | 2010-03-03 | |
| PCT/US2010/028347 WO2010111292A1 (en) | 2009-03-23 | 2010-03-23 | Treatment of cancer with immunostimulatory hiv tat derivative polypeptides |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BRPI1009215A2 true BRPI1009215A2 (pt) | 2016-03-15 |
| BRPI1009215B1 BRPI1009215B1 (pt) | 2019-10-29 |
Family
ID=42246045
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI1009215-3A BRPI1009215B1 (pt) | 2009-03-23 | 2010-03-23 | composição farmacêutica compreendendo uma sequência de aminoácidos modificada da proteína trans-ativadora de transcrição (tat) do vírus da imunodeficiência humana (hiv) e uso de um polipeptídeo derivado de tat para tratar câncer |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US8530431B2 (pt) |
| EP (1) | EP2411043B1 (pt) |
| JP (1) | JP5692933B2 (pt) |
| CN (1) | CN102405057B (pt) |
| AU (1) | AU2010230073B2 (pt) |
| BR (1) | BRPI1009215B1 (pt) |
| CA (1) | CA2755897C (pt) |
| DK (1) | DK2411043T3 (pt) |
| ES (1) | ES2432863T3 (pt) |
| IL (1) | IL215316A (pt) |
| NZ (1) | NZ595060A (pt) |
| WO (1) | WO2010111292A1 (pt) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2411043B1 (en) | 2009-03-23 | 2013-07-31 | PIN Pharma, Inc. | Treatment of cancer with immunostimulatory hiv tat derivative polypeptides |
| US20120150598A1 (en) * | 2010-09-02 | 2012-06-14 | Alfred William Griggs | Social retail referral control apparatuses, methods and systems |
| RU2653754C2 (ru) * | 2012-12-06 | 2018-05-14 | Пин Фарма, Инк. | Лечение воспалительных, аутоиммунных и нейродегенеративных нарушений иммуннодепрессивными полипетидами, являющимися производными тат |
| CN105705164A (zh) * | 2013-10-04 | 2016-06-22 | 品诺制药公司 | 用于癌症治疗的免疫刺激性hiv tat衍生多肽 |
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| US5804604A (en) | 1989-12-21 | 1998-09-08 | Biogen, Inc. | Tat-derived transport polypeptides and fusion proteins |
| US5670617A (en) | 1989-12-21 | 1997-09-23 | Biogen Inc | Nucleic acid conjugates of tat-derived transport polypeptides |
| US6316003B1 (en) | 1989-12-21 | 2001-11-13 | Whitehead Institute For Biomedical Research | Tat-derived transport polypeptides |
| AU7677891A (en) | 1990-03-30 | 1991-10-30 | Smithkline Beecham Corporation | Inhibition of disease associated with immunodeficiency virus infection |
| WO1991018454A1 (en) | 1990-05-18 | 1991-11-28 | Centre National De La Recherche Scientifique | Compositions capable of blocking cytotoxicity of viral regulatory proteins and neurotoxic symptoms associated with retroviral infection |
| US5219990A (en) | 1991-01-28 | 1993-06-15 | Biogen, Inc. | Papillomavirus e2 trans-activation repressors |
| RO116459B1 (ro) | 1991-07-25 | 2001-02-28 | Idec Pharma Corp | Compozitie imunogena |
| US5350835A (en) | 1991-11-05 | 1994-09-27 | Board Of Regents, University Of Texas | Cellular nucleic acid binding protein and uses thereof in regulating gene expression and in the treatment of aids |
| WO1994015634A1 (en) | 1992-12-30 | 1994-07-21 | Matthias Rath | Tat and rev oligopeptides in hiv treatment |
| FR2700169B1 (fr) | 1993-01-04 | 1995-03-24 | Transgene Sa | Nouveaux variants trans-dominants TAT du virus de l'immunodéficience humaine. |
| US6228369B1 (en) | 1993-12-13 | 2001-05-08 | Transgene S.A. | Composition of trans-dominant variants of viral proteins for obtaining an anti-viral effect |
| US5981258A (en) | 1993-12-13 | 1999-11-09 | Transgene S.A. | Composition of trans-dominant variants of viral proteins for obtaining an antiviral effect |
| US5817308A (en) | 1994-02-14 | 1998-10-06 | University Of Rochester | Tolerogenic fusion proteins of immunoglobulins and methods for inducing and maintaining tolerance |
| DE4405810A1 (de) | 1994-02-23 | 1995-08-24 | Behringwerke Ag | Von einem Retrovirus aus der HIV-Gruppe abgeleitete Peptide und deren Verwendung |
| WO1995031999A1 (en) | 1994-05-23 | 1995-11-30 | Immunogiology Research Institute, Inc. | Compositions of transactivating proteins of human immunodeficiency virus |
| US6207646B1 (en) | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| US6239116B1 (en) | 1994-07-15 | 2001-05-29 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| EP1167379A3 (en) | 1994-07-15 | 2004-09-08 | University Of Iowa Research Foundation | Immunomodulatory oligonucleotides |
| ATE196255T1 (de) | 1995-03-08 | 2000-09-15 | Neovacs | Von einem retroviralen regulationsprotein abstammende, detoxifierte immunogene, dagegen gerichtete antikörper, verfahren zur deren herstellung und diese immunogene oder antikörper enthaltende, pharmazeutische zusammensetzungen. |
| US6846493B2 (en) | 1995-09-01 | 2005-01-25 | Millenium Biologix Inc. | Synthetic biomaterial compound of calcium phosphate phases particularly adapted for supporting bone cell activity |
| US5976786A (en) | 1995-12-29 | 1999-11-02 | National Jewish Medical And Research Center | Screening methods for the identification of compounds that modulate apoptosis in immunodeficiency virus infected cells |
| US6200575B1 (en) | 1996-03-07 | 2001-03-13 | Neovacs | Non-toxic immunogens derived from a retroviral regulatory protein antibodies preparation process and pharmaceutical compositions comprising them |
| EP0834569A1 (en) | 1996-10-03 | 1998-04-08 | Roche Diagnostics GmbH | Thermostable DNA polymerase from carboxydothermus hydrogenoformans |
| US6686333B1 (en) | 1996-10-04 | 2004-02-03 | The United States Of America As Represented By The Department Of Health And Human Resources | Inhibition of HIV replication using soluble Tat peptide analogs |
| US6024965A (en) | 1996-10-18 | 2000-02-15 | Erasums University Rotterdam | Induction of REV and TAT specific cytotoxic T-cells for prevention and treatment of human immunodeficiency virus (HIV) infection |
| US6406705B1 (en) | 1997-03-10 | 2002-06-18 | University Of Iowa Research Foundation | Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant |
| US6271354B1 (en) | 1997-04-03 | 2001-08-07 | Thomas Jefferson University | Chimeric viral proteins |
| US20010007659A1 (en) | 1997-04-17 | 2001-07-12 | The University Of California | Use of lentiviral vectors for antigen presentation in dendritic cells |
| EP1003531B1 (en) | 1997-05-20 | 2007-08-22 | Ottawa Health Research Institute | Processes for preparing nucleic acid constructs |
| CN1263473A (zh) | 1997-05-21 | 2000-08-16 | 利兰·斯坦福青年大学托管委员会 | 增加跨生物膜转运的组合物和方法 |
| US5891994A (en) | 1997-07-11 | 1999-04-06 | Thymon L.L.C. | Methods and compositions for impairing multiplication of HIV-1 |
| NZ538399A (en) | 1997-08-05 | 2007-05-31 | Nventa Biopharma Corp | Fusion protein comprising an HPV E7 protein and a stress protein wherein the E7 protein is joined directly to the amino terminus of the stress protein |
| GB9720585D0 (en) | 1997-09-26 | 1997-11-26 | Smithkline Beecham Biolog | Vaccine |
| IT1297090B1 (it) | 1997-12-01 | 1999-08-03 | Barbara Ensoli | Tat di hiv-1 o suoi derivati, da soli od in combinazione, a scopo vaccinale, profilattico e terapeutico, contro l'aids i tumori e le |
| FR2773156B1 (fr) | 1997-12-26 | 2000-03-31 | Biovacs Inc | Nouveaux immunogenes anti-retroviraux (toxoides), nouveaux procedes de preparation et application a la prevention et au traitement du sida |
| FR2781158B1 (fr) | 1998-07-15 | 2002-12-13 | Vacs Internat | Nouvelles proteines modifiees immunogenes non immunosuppressives, leur procede de preparation et leurs applications |
| US6497880B1 (en) | 1998-12-08 | 2002-12-24 | Stressgen Biotechnologies Corporation | Heat shock genes and proteins from Neisseria meningitidis, Candida glabrata and Aspergillus fumigatus |
| AU4198200A (en) | 1999-04-05 | 2000-10-23 | Alicia Algeciras-Schminich | Anti-apoptotic fusion polypeptide |
| FR2792206B1 (fr) * | 1999-04-13 | 2006-08-04 | Centre Nat Rech Scient | Vaccin anti-vih-1 comprenant tout ou partie de la proteine tat de vih-1 |
| AU4082300A (en) | 1999-06-21 | 2001-01-09 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Hiv tat peptides and multiple peptide conjugate system |
| AU5821000A (en) | 1999-06-29 | 2001-01-31 | Smithkline Beecham Biologicals (Sa) | Vaccine |
| JP2003504074A (ja) | 1999-07-08 | 2003-02-04 | ストレスゲン バイオテクノロジーズ コーポレイション | インビトロでのTh1様応答の誘導 |
| ATE465754T1 (de) | 1999-08-12 | 2010-05-15 | Inist Inc | Nicht-immunsuppresives hiv tat-protein |
| US6593292B1 (en) | 1999-08-24 | 2003-07-15 | Cellgate, Inc. | Compositions and methods for enhancing drug delivery across and into epithelial tissues |
| AT408721B (de) | 1999-10-01 | 2002-02-25 | Cistem Biotechnologies Gmbh | Pharmazeutische zusammensetzung enthaltend ein antigen |
| FR2802426B1 (fr) | 1999-12-15 | 2004-04-02 | Neovacs | Utilisation de proteines immunogenes immunosuppressives et/ou angiogeniques rendues inactives, pour la production d'iga secretoires |
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| US20030198941A1 (en) | 2000-04-12 | 2003-10-23 | Watkins David I. | Method for making an HIV vaccine |
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| EP2329846B1 (en) | 2000-09-08 | 2014-11-12 | University Of Maryland, Baltimore | Genetically engineered co-expression DNA vaccines, construction methods and uses thereof |
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| KR100465589B1 (ko) * | 2001-04-20 | 2005-01-13 | 허만욱 | 비만 억제 폴리펩타이드 |
| EP1279404A1 (en) | 2001-07-26 | 2003-01-29 | Istituto Superiore di Sanità | Use of HIV-1 tat, fragments or derivatives thereof, to target or to activate antigen-presenting cells, to deliver cargo molecules for vaccination or to treat other diseases |
| AUPR842501A0 (en) * | 2001-10-23 | 2001-11-15 | Epipop Pty Ltd | A method for identification and development of therapeutic agents |
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| EP3006043B1 (en) | 2002-04-04 | 2019-05-29 | Zoetis Belgium S.A. | Immunostimulatory g,u-containing oligoribonucleotides |
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| US20050203041A1 (en) | 2003-09-23 | 2005-09-15 | Mourich Dan V. | Antisense compound and method for selectively killing activated T cells |
| GB2407500A (en) * | 2003-11-03 | 2005-05-04 | Ist Superiore Sanita | Use of microparticles for antigen delivery |
| US7927580B2 (en) | 2004-03-16 | 2011-04-19 | Nanirx, Inc. | Tat-based immunomodulatory compositions and methods of their discovery and use |
| FR2868319B1 (fr) * | 2004-04-01 | 2006-07-07 | Commissariat Energie Atomique | Antigene tat dimerique et ses applications pour la vaccination anti-vih |
| FR2868318B1 (fr) | 2004-04-01 | 2012-11-16 | Commissariat Energie Atomique | Antigene tat stabilise et ses applications pour la vaccination anti-vih |
| EP2411043B1 (en) | 2009-03-23 | 2013-07-31 | PIN Pharma, Inc. | Treatment of cancer with immunostimulatory hiv tat derivative polypeptides |
-
2010
- 2010-03-23 EP EP10712217.8A patent/EP2411043B1/en not_active Not-in-force
- 2010-03-23 AU AU2010230073A patent/AU2010230073B2/en not_active Ceased
- 2010-03-23 WO PCT/US2010/028347 patent/WO2010111292A1/en not_active Ceased
- 2010-03-23 BR BRPI1009215-3A patent/BRPI1009215B1/pt not_active IP Right Cessation
- 2010-03-23 CN CN201080013578.0A patent/CN102405057B/zh not_active Expired - Fee Related
- 2010-03-23 CA CA2755897A patent/CA2755897C/en not_active Expired - Fee Related
- 2010-03-23 NZ NZ595060A patent/NZ595060A/xx not_active IP Right Cessation
- 2010-03-23 JP JP2012502171A patent/JP5692933B2/ja not_active Expired - Fee Related
- 2010-03-23 US US12/730,043 patent/US8530431B2/en not_active Expired - Fee Related
- 2010-03-23 DK DK10712217.8T patent/DK2411043T3/da active
- 2010-03-23 ES ES10712217T patent/ES2432863T3/es active Active
-
2011
- 2011-09-22 IL IL215316A patent/IL215316A/en active IP Right Grant
-
2013
- 2013-08-19 US US13/969,917 patent/US9206239B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN102405057A (zh) | 2012-04-04 |
| US8530431B2 (en) | 2013-09-10 |
| IL215316A (en) | 2015-06-30 |
| DK2411043T3 (da) | 2013-10-21 |
| JP2012521986A (ja) | 2012-09-20 |
| ES2432863T3 (es) | 2013-12-05 |
| IL215316A0 (en) | 2011-12-29 |
| AU2010230073A1 (en) | 2011-09-29 |
| US20110009336A1 (en) | 2011-01-13 |
| CN102405057B (zh) | 2016-05-25 |
| NZ595060A (en) | 2013-05-31 |
| CA2755897A1 (en) | 2010-09-30 |
| WO2010111292A1 (en) | 2010-09-30 |
| CA2755897C (en) | 2020-01-28 |
| US20130331335A1 (en) | 2013-12-12 |
| EP2411043B1 (en) | 2013-07-31 |
| AU2010230073B2 (en) | 2016-05-26 |
| US9206239B2 (en) | 2015-12-08 |
| BRPI1009215B1 (pt) | 2019-10-29 |
| EP2411043A1 (en) | 2012-02-01 |
| JP5692933B2 (ja) | 2015-04-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
|
| B06T | Formal requirements before examination [chapter 6.20 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 23/03/2010, OBSERVADAS AS CONDICOES LEGAIS. (CO) 20 (VINTE) ANOS CONTADOS A PARTIR DE 23/03/2010, OBSERVADAS AS CONDICOES LEGAIS |
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| B21F | Lapse acc. art. 78, item iv - on non-payment of the annual fees in time |
Free format text: REFERENTE A 12A ANUIDADE. |
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| B24J | Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12) |
Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2663 DE 18-01-2022 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |