BRPI1009497A2 - Derivados de n-[(6-aza-biciclo[3.2.1] oct-5-il)-aril- metil]-heterobenzamida, o respectivo preparo e a respectiva aplicação em terapêutica - Google Patents

Derivados de n-[(6-aza-biciclo[3.2.1] oct-5-il)-aril- metil]-heterobenzamida, o respectivo preparo e a respectiva aplicação em terapêutica

Info

Publication number: BRPI1009497A2
Authority: BR; Brazil
Prior art keywords: alkyl; groups; alkoxy; cycloalkyl; halo
Prior art date: 2009-03-16

Application number

BRPI1009497-0A

Other languages

English (en)

Inventor

Estenne-Bouhtou Geneviève

Medaisko Florence

Original Assignee

Sanofi

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2009-03-16

Filing date

2010-03-15

Publication date

2018-03-13

2010-03-15 Application filed by Sanofi filed Critical Sanofi

2018-03-13 Publication of BRPI1009497A2 publication Critical patent/BRPI1009497A2/pt

Links

239000003814 drug Substances 0.000 title 1
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 6
125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 3
125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 3
125000005843 halogen group Chemical group 0.000 abstract 3
125000006700 (C1-C6) alkylthio group Chemical group 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
125000001424 substituent group Chemical group 0.000 abstract 2
239000002253 acid Substances 0.000 abstract 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
-1 halo-(C1-C6)alkoxy Chemical group 0.000 abstract 1
125000001072 heteroaryl group Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
230000001225 therapeutic effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Neurology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Addiction (AREA)
Hospice & Palliative Care (AREA)
Anesthesiology (AREA)
Gynecology & Obstetrics (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Indole Compounds (AREA)

BRPI1009497-0A 2009-03-16 2010-03-15 Derivados de n-[(6-aza-biciclo[3.2.1] oct-5-il)-aril- metil]-heterobenzamida, o respectivo preparo e a respectiva aplicação em terapêutica BRPI1009497A2 (pt)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
FR0901220A FR2943059A1 (fr)	2009-03-16	2009-03-16	Derives de n-°6-aza-bicyclo°3.2.1!oct-5-yl)-aryl-methyl!- heterobenzamide,leur preparation et leur application en therapeutique
FR09/01220		2009-03-16
PCT/FR2010/050448 WO2010106270A1 (fr)	2009-03-16	2010-03-15	Derives de n-[(6-aza-bicyclo[3.2.1]oct-5-yl)-aryl-methyl]-heterobenzamide, leur preparation et leur application en therapeutique

Publications (1)

Publication Number	Publication Date
BRPI1009497A2 true BRPI1009497A2 (pt)	2018-03-13

Family

ID=40720092

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI1009497-0A BRPI1009497A2 (pt)	2009-03-16	2010-03-15	Derivados de n-[(6-aza-biciclo[3.2.1] oct-5-il)-aril- metil]-heterobenzamida, o respectivo preparo e a respectiva aplicação em terapêutica

Country Status (17)

Country	Link
US (1)	US20120029027A1 (pt)
EP (1)	EP2408778A1 (pt)
JP (1)	JP2012520346A (pt)
KR (1)	KR20120013325A (pt)
CN (1)	CN102356084A (pt)
AR (1)	AR075838A1 (pt)
AU (1)	AU2010224721A1 (pt)
BR (1)	BRPI1009497A2 (pt)
CA (1)	CA2755528A1 (pt)
FR (1)	FR2943059A1 (pt)
IL (1)	IL215103A0 (pt)
MX (1)	MX2011009746A (pt)
RU (1)	RU2011141760A (pt)
SG (1)	SG174432A1 (pt)
TW (1)	TW201100431A (pt)
UY (1)	UY32496A (pt)
WO (1)	WO2010106270A1 (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP2545964A1 (en)	2011-07-13	2013-01-16	Phenex Pharmaceuticals AG	Novel FXR (NR1H4) binding and activity modulating compounds
CA3252823A1 (en)	2016-06-13	2025-02-25	Gilead Sciences, Inc.	Substituted tert-butyl-3-(2-chloro-phenyl)-3-hydroxyazetidine-1-carboxylate compounds
BR112018075734A2 (pt)	2016-06-13	2019-04-02	Gilead Sciences, Inc.	composto, composição farmacêutica, método para tratar um paciente com uma doença ou condição mediada pelo menos em parte por fxr, e, uso de um composto.
CN110461328A (zh)	2017-03-28	2019-11-15	吉利德科学公司	治疗肝疾病的治疗组合
EP4360632B1 (en)	2019-01-15	2025-10-29	Gilead Sciences, Inc.	Fxr (nr1h4) modulating compounds
US11524005B2 (en)	2019-02-19	2022-12-13	Gilead Sciences, Inc.	Solid forms of FXR agonists

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2861076B1 (fr) *	2003-10-17	2006-01-06	Sanofi Synthelabo	Derives de n-heterocyclymethylbenzamide, leur preparation et leur application en therapeutique
TW200911808A (en) *	2007-07-23	2009-03-16	Astrazeneca Ab	Novel compounds

2009
- 2009-03-16 FR FR0901220A patent/FR2943059A1/fr active Pending
2010
- 2010-03-15 EP EP10715933A patent/EP2408778A1/fr not_active Withdrawn
- 2010-03-15 CN CN2010800121523A patent/CN102356084A/zh active Pending
- 2010-03-15 JP JP2012500293A patent/JP2012520346A/ja not_active Withdrawn
- 2010-03-15 SG SG2011066842A patent/SG174432A1/en unknown
- 2010-03-15 WO PCT/FR2010/050448 patent/WO2010106270A1/fr not_active Ceased
- 2010-03-15 AR ARP100100801A patent/AR075838A1/es unknown
- 2010-03-15 MX MX2011009746A patent/MX2011009746A/es not_active Application Discontinuation
- 2010-03-15 TW TW099107513A patent/TW201100431A/zh unknown
- 2010-03-15 KR KR1020117024140A patent/KR20120013325A/ko not_active Withdrawn
- 2010-03-15 RU RU2011141760/04A patent/RU2011141760A/ru unknown
- 2010-03-15 BR BRPI1009497-0A patent/BRPI1009497A2/pt not_active IP Right Cessation
- 2010-03-15 AU AU2010224721A patent/AU2010224721A1/en not_active Abandoned
- 2010-03-15 CA CA2755528A patent/CA2755528A1/fr not_active Abandoned
- 2010-03-15 US US13/256,834 patent/US20120029027A1/en not_active Abandoned
- 2010-03-16 UY UY0001032496A patent/UY32496A/es not_active Application Discontinuation
2011
- 2011-09-12 IL IL215103A patent/IL215103A0/en unknown

Also Published As

Publication number	Publication date
RU2011141760A (ru)	2013-04-27
US20120029027A1 (en)	2012-02-02
KR20120013325A (ko)	2012-02-14
TW201100431A (en)	2011-01-01
JP2012520346A (ja)	2012-09-06
IL215103A0 (en)	2011-12-29
AU2010224721A1 (en)	2011-10-06
AR075838A1 (es)	2011-04-27
UY32496A (es)	2010-10-29
CN102356084A (zh)	2012-02-15
MX2011009746A (es)	2011-09-29
EP2408778A1 (fr)	2012-01-25
SG174432A1 (en)	2011-10-28
CA2755528A1 (fr)	2010-09-23
FR2943059A1 (fr)	2010-09-17
WO2010106270A1 (fr)	2010-09-23

Legal Events

Date	Code	Title	Description
2018-03-20	B08F	Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]	Free format text: REFERENTE AS 4A, 5A, 6A, 7A E 8A ANUIDADES.
2018-07-10	B08K	Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

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