BRPI1009497A2 - Derivados de n-[(6-aza-biciclo[3.2.1] oct-5-il)-aril- metil]-heterobenzamida, o respectivo preparo e a respectiva aplicação em terapêutica - Google Patents

Derivados de n-[(6-aza-biciclo[3.2.1] oct-5-il)-aril- metil]-heterobenzamida, o respectivo preparo e a respectiva aplicação em terapêutica

Info

Publication number: BRPI1009497A2
Authority: BR; Brazil
Prior art keywords: alkyl; groups; alkoxy; cycloalkyl; halo
Prior art date: 2009-03-16

Application number

BRPI1009497-0A

Other languages

English (en)

Inventor

Estenne-Bouhtou Geneviève

Medaisko Florence

Original Assignee

Sanofi

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2009-03-16

Filing date

2010-03-15

Publication date

2018-03-13

2010-03-15 Application filed by Sanofi filed Critical Sanofi

2018-03-13 Publication of BRPI1009497A2 publication Critical patent/BRPI1009497A2/pt

Links

239000003814 drug Substances 0.000 title 1
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 6
125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 3
125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 3
125000005843 halogen group Chemical group 0.000 abstract 3
125000006700 (C1-C6) alkylthio group Chemical group 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
125000001424 substituent group Chemical group 0.000 abstract 2
239000002253 acid Substances 0.000 abstract 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
-1 halo-(C1-C6)alkoxy Chemical group 0.000 abstract 1
125000001072 heteroaryl group Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
230000001225 therapeutic effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biomedical Technology (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Addiction (AREA)
Hospice & Palliative Care (AREA)
Anesthesiology (AREA)
Gynecology & Obstetrics (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Indole Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

BRPI1009497-0A 2009-03-16 2010-03-15 Derivados de n-[(6-aza-biciclo[3.2.1] oct-5-il)-aril- metil]-heterobenzamida, o respectivo preparo e a respectiva aplicação em terapêutica BRPI1009497A2 (pt)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
FR0901220A FR2943059A1 (fr)	2009-03-16	2009-03-16	Derives de n-°6-aza-bicyclo°3.2.1!oct-5-yl)-aryl-methyl!- heterobenzamide,leur preparation et leur application en therapeutique
FR09/01220		2009-03-16
PCT/FR2010/050448 WO2010106270A1 (fr)	2009-03-16	2010-03-15	Derives de n-[(6-aza-bicyclo[3.2.1]oct-5-yl)-aryl-methyl]-heterobenzamide, leur preparation et leur application en therapeutique

Publications (1)

Publication Number	Publication Date
BRPI1009497A2 true BRPI1009497A2 (pt)	2018-03-13

Family

ID=40720092

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI1009497-0A BRPI1009497A2 (pt)	2009-03-16	2010-03-15	Derivados de n-[(6-aza-biciclo[3.2.1] oct-5-il)-aril- metil]-heterobenzamida, o respectivo preparo e a respectiva aplicação em terapêutica

Country Status (17)

Country	Link
US (1)	US20120029027A1 (pt)
EP (1)	EP2408778A1 (pt)
JP (1)	JP2012520346A (pt)
KR (1)	KR20120013325A (pt)
CN (1)	CN102356084A (pt)
AR (1)	AR075838A1 (pt)
AU (1)	AU2010224721A1 (pt)
BR (1)	BRPI1009497A2 (pt)
CA (1)	CA2755528A1 (pt)
FR (1)	FR2943059A1 (pt)
IL (1)	IL215103A0 (pt)
MX (1)	MX2011009746A (pt)
RU (1)	RU2011141760A (pt)
SG (1)	SG174432A1 (pt)
TW (1)	TW201100431A (pt)
UY (1)	UY32496A (pt)
WO (1)	WO2010106270A1 (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP2545964A1 (en)	2011-07-13	2013-01-16	Phenex Pharmaceuticals AG	Novel FXR (NR1H4) binding and activity modulating compounds
CA2968836C (en)	2016-06-13	2025-09-02	Gilead Sciences, Inc.	FXR MODULATING COMPOUNDS (NR1H4)
NZ748641A (en)	2016-06-13	2020-04-24	Gilead Sciences Inc	Fxr (nr1h4) modulating compounds
SI4122464T1 (sl)	2017-03-28	2024-07-31	Gilead Sciences, Inc.	Terapevtske kombinacije za zdravljenje bolezni jeter
PT3911647T (pt)	2019-01-15	2024-03-04	Gilead Sciences Inc	Composto de isoxazole como agonista de fxr e composições farmacêuticas que o contenham
JP2022519906A (ja)	2019-02-19	2022-03-25	ギリアードサイエンシーズ，インコーポレイテッド	Ｆｘｒアゴニストの固体形態

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2861076B1 (fr) *	2003-10-17	2006-01-06	Sanofi Synthelabo	Derives de n-heterocyclymethylbenzamide, leur preparation et leur application en therapeutique
WO2009013535A1 (en) *	2007-07-23	2009-01-29	Astrazeneca Ab	2-azabicyclo(2.2.2)octane derivatives as modulators of the glycine transporter i receptor

2009
- 2009-03-16 FR FR0901220A patent/FR2943059A1/fr active Pending
2010
- 2010-03-15 CN CN2010800121523A patent/CN102356084A/zh active Pending
- 2010-03-15 JP JP2012500293A patent/JP2012520346A/ja not_active Withdrawn
- 2010-03-15 CA CA2755528A patent/CA2755528A1/fr not_active Abandoned
- 2010-03-15 KR KR1020117024140A patent/KR20120013325A/ko not_active Withdrawn
- 2010-03-15 RU RU2011141760/04A patent/RU2011141760A/ru unknown
- 2010-03-15 US US13/256,834 patent/US20120029027A1/en not_active Abandoned
- 2010-03-15 AU AU2010224721A patent/AU2010224721A1/en not_active Abandoned
- 2010-03-15 BR BRPI1009497-0A patent/BRPI1009497A2/pt not_active IP Right Cessation
- 2010-03-15 SG SG2011066842A patent/SG174432A1/en unknown
- 2010-03-15 WO PCT/FR2010/050448 patent/WO2010106270A1/fr not_active Ceased
- 2010-03-15 EP EP10715933A patent/EP2408778A1/fr not_active Withdrawn
- 2010-03-15 MX MX2011009746A patent/MX2011009746A/es not_active Application Discontinuation
- 2010-03-15 TW TW099107513A patent/TW201100431A/zh unknown
- 2010-03-15 AR ARP100100801A patent/AR075838A1/es unknown
- 2010-03-16 UY UY0001032496A patent/UY32496A/es not_active Application Discontinuation
2011
- 2011-09-12 IL IL215103A patent/IL215103A0/en unknown

Also Published As

Publication number	Publication date
UY32496A (es)	2010-10-29
RU2011141760A (ru)	2013-04-27
EP2408778A1 (fr)	2012-01-25
JP2012520346A (ja)	2012-09-06
CN102356084A (zh)	2012-02-15
WO2010106270A1 (fr)	2010-09-23
MX2011009746A (es)	2011-09-29
SG174432A1 (en)	2011-10-28
FR2943059A1 (fr)	2010-09-17
CA2755528A1 (fr)	2010-09-23
AR075838A1 (es)	2011-04-27
AU2010224721A1 (en)	2011-10-06
KR20120013325A (ko)	2012-02-14
US20120029027A1 (en)	2012-02-02
TW201100431A (en)	2011-01-01
IL215103A0 (en)	2011-12-29

Similar Documents

Publication	Publication Date	Title
MY168201A (en)	2018-10-15	Agricultural And Horticultural Fungicidal Composition
MY177250A (en)	2020-09-10	Novel nicotinamide derivative or salt thereof
NZ601489A (en)	2014-01-31	Cyclic amine compound and acaricide
MX2009002802A (es)	2009-04-01	Derivados de 2-aril-6-fenil-imidazo[1,2-a]piridinas, su preparacion y su aplicacion en terapeutica.
MY153393A (en)	2015-02-13	Amino nicotinic and isonicotinic acid derivatives as dhodh as inhibitors
WO2008108378A3 (en)	2008-12-04	Bicyclic oxomorpholine derivative
MX2009005616A (es)	2009-06-08	Derivados de pirido-pirazina utiles como compuestos herbicidas.
MX2014000359A (es)	2014-05-01	Metodos plaguicidas que utilizan compuestos de 3 - piridin tiazol sustituido y derivados para combatir las plagas de animales ii.
WO2009118473A3 (fr)	2009-11-19	Composés dérivés d'azétidines, leur préparation et leur application en thérapeutique
MX2010005109A (es)	2010-05-27	Compuestos herbicidas.
BRPI1009497A2 (pt)	2018-03-13	Derivados de n-[(6-aza-biciclo[3.2.1] oct-5-il)-aril- metil]-heterobenzamida, o respectivo preparo e a respectiva aplicação em terapêutica
WO2008003854A3 (fr)	2008-03-06	Derives de 2-benzoyl-imidazopyridines, leur preparation et leur application en therapeutique
JO3098B1 (ar)	2017-03-15	مركبات داي فينيل- بيرازول بيريدين وطريقة تحضيرها واستخدامها كمعدلات المستقبل النووي not
MX2014003419A (es)	2014-04-10	Composicion de control de fitoenfermedades y su uso.
WO2008006625A3 (en)	2008-04-17	Derivatives of urea and related diamines, methods for their manufacture, and uses therefor
PL2197860T3 (pl)	2011-09-30	Nowe związki jako antagonisty receptora adenozynowego A1
MY165634A (en)	2018-04-18	Pyrazole compounds having therapeutic effect on multiple myeloma
PH12012502030A1 (en)	2013-01-21	Plant disease control composition and its use
EA201400078A1 (ru)	2014-09-30	Микробиоцидные гетероциклы
MX2010007350A (es)	2010-08-18	Derivados de 2-heteroaroil-imidazol[1,2-a]piridina, su preparacion y aplicacion terapeutica.
WO2008110699A3 (fr)	2009-01-15	Dérivés d'azabicycloalkane, leur préparation et leur application en thérapeutique
MX2010007348A (es)	2010-08-18	Derivados de n-fenil-imidazo[1,2-a]piridin-2-carboxamidas, su preparacion y su aplicacion terapeutica.
NO20050391L (no)	2005-07-27	Nye fluorinerte benzotiadiazinforbindelser, fremgangsmate for deres fremstilling og farmasoytiske sammensetninger inneholdende dem
NZ593344A (en)	2013-08-30	Derivatives of morphine-6-glucuronide, preparation method thereof and use of same in therapeutics
WO2010106269A3 (fr)	2010-12-02	Derives de n-[(2-aza-bicyclo[2.1.1]hex-1-yl)-aryl-methyl]-heterobenzamide, leur preparation et leur application en therapeutique

Legal Events

Date	Code	Title	Description
2018-03-20	B08F	Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]	Free format text: REFERENTE AS 4A, 5A, 6A, 7A E 8A ANUIDADES.
2018-07-10	B08K	Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]