BRPI1009521A2 - pró-drogas. - Google Patents
pró-drogas.Info
- Publication number
- BRPI1009521A2 BRPI1009521A2 BRPI1009521A BRPI1009521A BRPI1009521A2 BR PI1009521 A2 BRPI1009521 A2 BR PI1009521A2 BR PI1009521 A BRPI1009521 A BR PI1009521A BR PI1009521 A BRPI1009521 A BR PI1009521A BR PI1009521 A2 BRPI1009521 A2 BR PI1009521A2
- Authority
- BR
- Brazil
- Prior art keywords
- pro
- drugs
- Prior art date
Links
- 229940002612 prodrug Drugs 0.000 title 1
- 239000000651 prodrug Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- C07K5/1013—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/0606—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing heteroatoms not provided for by C07K5/06086 - C07K5/06139, e.g. Ser, Met, Cys, Thr
- C07K5/06069—Ser-amino acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09003410 | 2009-03-09 | ||
| PCT/EP2010/001461 WO2010102788A1 (en) | 2009-03-09 | 2010-03-09 | Prodrugs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI1009521A2 true BRPI1009521A2 (pt) | 2016-03-15 |
Family
ID=42224218
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI1009521A BRPI1009521A2 (pt) | 2009-03-09 | 2010-03-09 | pró-drogas. |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US8642555B2 (pt) |
| EP (1) | EP2405944B1 (pt) |
| JP (1) | JP5734209B2 (pt) |
| KR (1) | KR101472316B1 (pt) |
| CN (1) | CN102413842B (pt) |
| AU (1) | AU2010223565B2 (pt) |
| BR (1) | BRPI1009521A2 (pt) |
| CA (1) | CA2754846C (pt) |
| WO (1) | WO2010102788A1 (pt) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8828678B2 (en) | 2010-11-16 | 2014-09-09 | Enzo Life Sciences, Inc. | Self-immolative probes for enzyme activity detection |
| WO2016080626A2 (en) | 2014-11-20 | 2016-05-26 | Pharosgen | Prodrugs activated by caspase |
| WO2025167999A1 (zh) | 2024-02-07 | 2025-08-14 | 珠海贝海生物技术有限公司 | 紫杉烷类偶联药物及其制备方法和用途 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5208020A (en) * | 1989-10-25 | 1993-05-04 | Immunogen Inc. | Cytotoxic agents comprising maytansinoids and their therapeutic use |
| US5998362A (en) * | 1996-09-12 | 1999-12-07 | Merck & Co., Inc. | Conjugates useful in the treatment of prostate cancer |
| HRP970566A2 (en) * | 1996-10-30 | 1998-08-31 | Jones Deborah Defeo | Conjugates useful in the treatment of prostate canser |
| CN1239204C (zh) * | 1996-10-30 | 2006-02-01 | 麦克公司 | 用于治疗前列腺癌的偶联物 |
| US5948750A (en) * | 1996-10-30 | 1999-09-07 | Merck & Co., Inc. | Conjugates useful in the treatment of prostate cancer |
| ATE256473T1 (de) | 1997-07-10 | 2004-01-15 | Merck & Co Inc | Konjugate welche bei der behandlung von prostatakrebs nützlich sind |
| US20030133927A1 (en) | 2001-10-10 | 2003-07-17 | Defeo-Jones Deborah | Conjugates useful in the treatment of prostate cancer |
| DE10310082A1 (de) | 2003-03-07 | 2004-09-16 | Ktb Tumorforschungsgesellschaft Mbh | Protein-bindende Doxorubicin-Peptid-Derivate |
| DE102005009084A1 (de) * | 2005-02-28 | 2006-08-31 | Ktb Tumorforschungsgesellschaft Mbh | Proteinbindende Anthrazyklin-Peptid-Derivate und diese enthaltende Arzneimittel |
| AU2008214801B2 (en) * | 2007-02-16 | 2014-02-27 | Ktb Tumorforschungsgesellschaft Mbh | Dual acting prodrugs |
| EP1977765A1 (en) * | 2007-04-03 | 2008-10-08 | Diatos | Peptide prodrugs |
-
2010
- 2010-03-09 CA CA2754846A patent/CA2754846C/en not_active Expired - Fee Related
- 2010-03-09 AU AU2010223565A patent/AU2010223565B2/en not_active Ceased
- 2010-03-09 CN CN201080018619.5A patent/CN102413842B/zh not_active Expired - Fee Related
- 2010-03-09 WO PCT/EP2010/001461 patent/WO2010102788A1/en not_active Ceased
- 2010-03-09 JP JP2011553344A patent/JP5734209B2/ja not_active Expired - Fee Related
- 2010-03-09 US US13/255,812 patent/US8642555B2/en not_active Expired - Fee Related
- 2010-03-09 EP EP10711007.4A patent/EP2405944B1/en not_active Not-in-force
- 2010-03-09 KR KR1020117023578A patent/KR101472316B1/ko not_active Expired - Fee Related
- 2010-03-09 BR BRPI1009521A patent/BRPI1009521A2/pt not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| KR101472316B1 (ko) | 2014-12-12 |
| CA2754846C (en) | 2015-05-12 |
| AU2010223565B2 (en) | 2016-06-23 |
| CN102413842A (zh) | 2012-04-11 |
| US20120094892A1 (en) | 2012-04-19 |
| EP2405944A1 (en) | 2012-01-18 |
| JP2012519720A (ja) | 2012-08-30 |
| AU2010223565A1 (en) | 2011-09-29 |
| JP5734209B2 (ja) | 2015-06-17 |
| EP2405944B1 (en) | 2016-01-27 |
| KR20120016050A (ko) | 2012-02-22 |
| US8642555B2 (en) | 2014-02-04 |
| WO2010102788A1 (en) | 2010-09-16 |
| CA2754846A1 (en) | 2010-09-16 |
| CN102413842B (zh) | 2014-06-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B15K | Others concerning applications: alteration of classification |
Ipc: C07K 5/103 (2006.01), A61K 47/65 (2017.01), C07K 5 |
|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL |