BRPI1010655A2 - novos agentes antienvelhecimento e métodos para identificá-los - Google Patents

novos agentes antienvelhecimento e métodos para identificá-los

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Publication number
BRPI1010655A2
BRPI1010655A2 BRPI1010655A BRPI1010655A BRPI1010655A2 BR PI1010655 A2 BRPI1010655 A2 BR PI1010655A2 BR PI1010655 A BRPI1010655 A BR PI1010655A BR PI1010655 A BRPI1010655 A BR PI1010655A BR PI1010655 A2 BRPI1010655 A2 BR PI1010655A2
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BR
Brazil
Prior art keywords
identify
methods
aging agents
new anti
anti aging
Prior art date
Application number
BRPI1010655A
Other languages
English (en)
Inventor
Qi Haiyan
Original Assignee
Qi Haiyan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Qi Haiyan filed Critical Qi Haiyan
Publication of BRPI1010655A2 publication Critical patent/BRPI1010655A2/pt

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    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
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Families Citing this family (116)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI1010655A2 (pt) 2009-04-10 2019-09-03 Qi Haiyan novos agentes antienvelhecimento e métodos para identificá-los
KR101372037B1 (ko) * 2010-04-06 2014-03-10 (주)아모레퍼시픽 근육 타입 변화를 촉진하는 조성물
US11844720B2 (en) 2011-02-04 2023-12-19 Seed Health, Inc. Method and system to reduce the likelihood of dental caries and halitosis
US11998479B2 (en) 2011-02-04 2024-06-04 Seed Health, Inc. Method and system for addressing adverse effects on the oral microbiome and restoring gingival health caused by sodium lauryl sulphate exposure
US10940169B2 (en) 2015-11-30 2021-03-09 Joseph E. Kovarik Method for reducing the likelihood of developing cancer in an individual human being
US11951140B2 (en) 2011-02-04 2024-04-09 Seed Health, Inc. Modulation of an individual's gut microbiome to address osteoporosis and bone disease
US11951139B2 (en) 2015-11-30 2024-04-09 Seed Health, Inc. Method and system for reducing the likelihood of osteoporosis
US12279989B2 (en) 2011-02-04 2025-04-22 Seed Health, Inc. Method and system for increasing beneficial bacteria and decreasing pathogenic bacteria in the oral cavity
US12257272B2 (en) 2015-12-24 2025-03-25 Seed Health, Inc. Method and system for reducing the likelihood of developing depression in an individual
US12533312B2 (en) 2011-02-04 2026-01-27 Seed Health, Inc. Method and system for preventing sore throat in humans
WO2012110953A1 (en) * 2011-02-16 2012-08-23 Novartis Ag Combinations of therapeutic agents for use in the treatment of neurodegenerative diseases
WO2012177927A1 (en) 2011-06-21 2012-12-27 Mayo Foundation For Medical Education And Research Transgenic animals capable of being induced to delete senescent cells
US8574852B2 (en) * 2011-07-01 2013-11-05 National Yang Ming University Method for evaluating cell aging by expression level of cofilin
KR101900478B1 (ko) * 2011-08-04 2018-09-20 한올바이오파마주식회사 암의 재발 또는 전이의 억제용 약제학적 조성물
RU2014128010A (ru) 2011-12-13 2016-02-10 Бак Инститьют Фо Рисерч Он Эйджин Способы улучшения средств консервативной терапии
CA2771621A1 (en) * 2011-12-15 2013-06-15 Sabine Mai Methods for diagnosing alzheimer's disease
US10272068B2 (en) 2012-01-17 2019-04-30 Tyme, Inc. Pharmaceutical compositions and methods
US20130183263A1 (en) 2012-01-17 2013-07-18 Steven Hoffman Pharmaceutical compositions and methods
US10646552B2 (en) 2012-01-17 2020-05-12 Tyme, Inc. Pharmaceutical compositions and methods
US8481498B1 (en) 2012-01-17 2013-07-09 Steven Hoffman Pharmaceutical compositions and methods
WO2013158664A2 (en) 2012-04-17 2013-10-24 Kythera Biopharmaceuticals, Inc. Use of engineered viruses to specifically kill senescent cells
EP2844266B1 (en) 2012-04-30 2024-09-11 Sonomaceuticals, LLC Therapeutic use of chardonnay seed products
WO2013177599A1 (en) * 2012-05-22 2013-11-28 Lunar Pharmaceuticals (Pty) Ltd Nutricosmetic composition
US20140010801A1 (en) * 2012-06-08 2014-01-09 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Compositions and Methods for Restoring or Rejuvenating Stem/Progenitor Cell Function
US9593363B2 (en) 2012-06-18 2017-03-14 The Procter & Gamble Company Methods and models for assessing anti-aging benefits of agents
KR102163091B1 (ko) * 2012-06-27 2020-10-08 아마젠티스 에스에이 우롤리틴 또는 이의 전구체를 투여에 의한 자가포식 향상 또는 장수 증가
US9901081B2 (en) 2012-08-23 2018-02-27 Buck Institute For Research On Aging Transgenic mouse for determining the role of senescent cells in cancer
US9901080B2 (en) 2012-08-23 2018-02-27 Buck Institute For Research On Aging Transgenic mouse having a transgene that converts a prodrug into a cytotoxic compound in senescent cells
CN102871991B (zh) * 2012-10-24 2014-06-18 中国医学科学院放射医学研究所 二甲双胍在对放化疗损伤起保护作用的药物中的应用
US10279018B2 (en) 2012-12-03 2019-05-07 Unity Biotechnology, Inc. Immunogenic compositions for inducing an immune response for elimination of senescent cells
KR101425303B1 (ko) * 2013-01-11 2014-07-31 공주대학교 산학협력단 이소플라본을 포함하는 관절염 예방 및 치료용 약학적 조성물
WO2014115167A2 (en) * 2013-01-23 2014-07-31 Sphaera Pharma Pvt. Ltd. Novel compounds of 11beta-hydroxy-steroids for use in mitochondria biogenesis and diseases associated with mitochondrial dysfunction or depletion
AU2014209141B2 (en) 2013-01-24 2018-05-10 Palvella Therapeutics, Inc. Compositions for transdermal delivery of mTOR inhibitors
FR3002453B1 (fr) * 2013-02-28 2015-08-07 Univ Bordeaux Segalen Nouvelles combinaisons comprenant un extrait polyphenolique de marc de raisin avec un antihypertenseur et leurs utilisations
EP2986158A1 (en) 2013-03-15 2016-02-24 Abbott Laboratories Methods of maintaining and improving muscle function
KR101497797B1 (ko) * 2013-03-19 2015-03-04 이화여자대학교 산학협력단 열충격단백질(Heat shock protein) 및 LRPPRC 단백질 신호전달을 이용한 파킨슨병 치료제 스크리닝 방법
US9943497B2 (en) * 2013-05-15 2018-04-17 Gachon University Of Industry-Academic Cooperation Foundation Pharmaceutical composition for preventing or treating pulmonary fibrosis
CA2856419C (en) 2013-09-20 2018-06-26 Telo Genomics Holdings Corp. Methods for evaluating alzheimer's disease and disease severity
EP3738592B1 (en) 2013-10-08 2022-01-26 AI Therapeutics, Inc. Rapamycin for the treatment of lymphangioleiomyomatosis
US10813901B2 (en) 2013-10-22 2020-10-27 Yamo Pharmaceuticals Llc Compositions and methods for treating autism
US10751313B2 (en) 2013-10-22 2020-08-25 Yamo Pharmaceuticals Llc Compositions and methods for treating autism
US9585841B2 (en) 2013-10-22 2017-03-07 Tyme, Inc. Tyrosine derivatives and compositions comprising them
US9326962B2 (en) 2013-10-22 2016-05-03 Steven Hoffman Compositions and methods for treating intestinal hyperpermeability
US9763903B2 (en) 2013-10-22 2017-09-19 Steven Hoffman Compositions and methods for treating intestinal hyperpermeability
US11839632B2 (en) 2013-12-20 2023-12-12 Seed Health, Inc. Topical application of CRISPR-modified bacteria to treat acne vulgaris
US11969445B2 (en) 2013-12-20 2024-04-30 Seed Health, Inc. Probiotic composition and method for controlling excess weight, obesity, NAFLD and NASH
US11213552B2 (en) 2015-11-30 2022-01-04 Joseph E. Kovarik Method for treating an individual suffering from a chronic infectious disease and cancer
US11980643B2 (en) 2013-12-20 2024-05-14 Seed Health, Inc. Method and system to modify an individual's gut-brain axis to provide neurocognitive protection
US11672835B2 (en) 2013-12-20 2023-06-13 Seed Health, Inc. Method for treating individuals having cancer and who are receiving cancer immunotherapy
US11826388B2 (en) 2013-12-20 2023-11-28 Seed Health, Inc. Topical application of Lactobacillus crispatus to ameliorate barrier damage and inflammation
US11998574B2 (en) 2013-12-20 2024-06-04 Seed Health, Inc. Method and system for modulating an individual's skin microbiome
US11642382B2 (en) 2013-12-20 2023-05-09 Seed Health, Inc. Method for treating an individual suffering from bladder cancer
US11833177B2 (en) 2013-12-20 2023-12-05 Seed Health, Inc. Probiotic to enhance an individual's skin microbiome
US12329783B2 (en) 2013-12-20 2025-06-17 Seed Health, Inc. Method and system to improve the health of a person's skin microbiome
US12005085B2 (en) 2013-12-20 2024-06-11 Seed Health, Inc. Probiotic method and composition for maintaining a healthy vaginal microbiome
US12246043B2 (en) 2013-12-20 2025-03-11 Seed Health, Inc. Topical application to treat acne vulgaris
US11026982B2 (en) 2015-11-30 2021-06-08 Joseph E. Kovarik Method for reducing the likelihood of developing bladder or colorectal cancer in an individual human being
US11529379B2 (en) 2013-12-20 2022-12-20 Seed Health, Inc. Method and system for reducing the likelihood of developing colorectal cancer in an individual human being
WO2015095968A1 (en) * 2013-12-23 2015-07-02 University Of Prince Edward Island Lipoic acid-resveratrol conjugates and uses thereof
US10143703B2 (en) 2014-01-02 2018-12-04 Massachusetts Eye And Ear Infirmary Treating ocular neovascularization
WO2015116735A1 (en) 2014-01-28 2015-08-06 Mayo Foundation For Medical Education And Research Methods and combinations for killing senescent cells and for treating senescence-associated diseases and disorders
US20190269675A1 (en) 2014-01-28 2019-09-05 Buck Institute for Research and Aging Treatment of parkinson's disease and other conditions caused or mediated by senescent astrocytes using small molecule senolytic agents
IL286427B2 (en) 2014-01-28 2024-08-01 Mayo Found Medical Education & Res Inhibitors bcl-2 anti-apoptotic protein family members for treatment of non cancer pulmonary disease or an opthalmic disease
EP3125875B1 (en) 2014-04-04 2023-06-07 AI Therapeutics, Inc. An inhalable rapamycin formulation for treating age-related conditions
AU2015249923B2 (en) 2014-04-21 2020-09-17 Sonomaceuticals, Llc Therapeutic use of grape seed products
GB201407805D0 (en) * 2014-05-02 2014-06-18 Dukosi Ltd Battery condition determination
CA2953387C (en) * 2014-06-30 2023-11-28 The Regents Of The University Of California Ketobutyrate compounds and compositions for treating age-related symptoms and diseases
EP3795578A3 (en) 2014-07-23 2021-05-26 Sphaera Pharma Pvt. Ltd. Hydroxysteroid compounds, their intermediates, process of preparation, composition and uses thereof
US20170290763A1 (en) * 2014-09-30 2017-10-12 Taiwan Mitochondrion Applied Technology Co., Ltd. Composition with exogenous mitochondria as active ingredients and use thereof and cell repairing method therefor
RU2732908C2 (ru) 2014-10-07 2020-09-24 ЭйАй ТЕРАПЬЮТИКС, ИНК. Ингаляционная лекарственная форма рапамицина для лечения легочной гипертензии
KR101676609B1 (ko) * 2014-10-07 2016-11-17 차의과학대학교 산학협력단 Rheb 유전자를 이용한 연골세포의 노화 및 탈분화 억제 방법
KR20160049435A (ko) 2014-10-27 2016-05-09 삼성전자주식회사 Atm 저해제를 포함하는 세포의 노화를 감소시키기 위한 조성물 및 그의 용도
WO2016066608A1 (en) * 2014-10-28 2016-05-06 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for treatment of pulmonary cell senescence and peripheral aging
EP3212194A4 (en) * 2014-10-29 2018-06-20 University Of Maryland Methods of treating age-related symptoms in mammals and compositions therefor
US20170304175A1 (en) * 2014-11-28 2017-10-26 Amorepacific Corporation Composition for inducing facilitation of cell rejuvenation comprising genistein or epigallocatechin gallate
WO2016117431A1 (ja) 2015-01-19 2016-07-28 学校法人慶應義塾 内耳性難聴治療薬
JP6524465B2 (ja) 2015-04-28 2019-06-05 タイコエレクトロニクスジャパン合同会社 コネクタ
AU2016263176A1 (en) 2015-05-20 2017-12-07 Novartis Ag Pharmaceutical combination of everolimus with dactolisib
CA3037469C (en) * 2015-09-24 2024-04-16 Drexel University Treatment of dermal disorders comprising a mtorc1 inhibitor
WO2017066712A2 (en) * 2015-10-16 2017-04-20 The Children's Medical Center Corporation Modulators of telomere disease
WO2017066796A2 (en) * 2015-10-16 2017-04-20 The Children's Medical Center Corporation Modulators of telomere disease
CN105441481B (zh) * 2015-12-29 2019-01-15 中国科学院生物物理研究所 一种sirtuin6基因缺失人类间充质干细胞的制备方法
ITUB20160068A1 (it) * 2016-01-28 2017-07-28 Paolo Ferrazza Composizione utile nella prevenzione o trattamento degli stati di malassorbimento secondari a chirurgia bariatrica in soggetti obesi.
WO2017129772A1 (en) * 2016-01-29 2017-08-03 Xellia Phamaceuticals Aps Stable pharmaceutical compositions of temsirolimus
JP2019505592A (ja) * 2016-02-15 2019-02-28 ユニバーシティ オブ サザン カリフォルニア 糖尿病及び他の疾患を治療するための胚様再生を刺激するための薬剤の組み合わせ及び方法
CN106109737A (zh) * 2016-06-29 2016-11-16 中科和素(天津)医药科技有限公司 一种抗氧化的营养制剂及其制备方法
KR20190089005A (ko) 2016-11-23 2019-07-29 노파르티스 아게 에베롤리무스, 닥톨리십 또는 둘 다를 사용하여 면역 반응을 증진시키는 방법
WO2018129007A1 (en) * 2017-01-03 2018-07-12 Bioatla Llc Protein therapeutics for treatment of senescent cells
CN110520097B (zh) 2017-01-06 2023-10-27 帕尔维拉治疗股份有限公司 Mtor抑制剂的无水组合物及其使用方法
JP6967261B2 (ja) * 2017-03-01 2021-11-17 国立大学法人九州大学 メタボリックシンドロームの予防又は改善用食品組成物及び医薬組成物
EP3600308A1 (en) * 2017-03-30 2020-02-05 INSERM - Institut National de la Santé et de la Recherche Médicale Methods for the treatment of mitochondrial genetic diseases
JP2018172346A (ja) * 2017-03-31 2018-11-08 株式会社東洋新薬 妊娠サポート用組成物
SG10202107237SA (en) * 2017-04-25 2021-08-30 Buck Inst Res Aging Formulations for extending lifespan and healthspan
EP3665184A4 (en) * 2017-08-09 2022-03-23 Intervene Immune, Inc. PHARMACEUTICAL PRODUCTS AND DOSAGE MEANS ALLOWING THE REVERSAL OF HUMAN AGING
RU2744299C1 (ru) * 2017-12-15 2021-03-05 Цукаса НАГАО Продукты лечебного питания и косметические средства для увеличения количества апоптотических клеток и уменьшения количества некротических клеток и способ получения компонента из прорастающих виноградных косточек для увеличения количества апоптотических клеток и уменьшения количества некротических клеток
WO2019126816A1 (en) * 2017-12-22 2019-06-27 The Johns Hopkins University Regulation of mutant tert by braf v600e/map kinase pathway through fos/gabp in human cancer
KR102878727B1 (ko) * 2018-01-23 2025-10-31 더 제너럴 하스피탈 코포레이션 미토콘드리아 기능 개선을 위한 조성물 및 방법
CN108295068A (zh) * 2018-01-25 2018-07-20 沈阳药科大学 小檗碱的医药用途
WO2019157516A1 (en) 2018-02-12 2019-08-15 resTORbio, Inc. Combination therapies
EP3817743A4 (en) 2018-07-02 2022-07-06 Palvella Therapeutics, Inc. ANHYDROUS COMPOSITIONS OF MTOR INHIBITORS AND METHODS OF USE
EP3823626A4 (en) 2018-07-19 2022-03-23 Yamo Pharmaceuticals LLC Compositions and methods for treating autism
KR102833111B1 (ko) 2018-09-25 2025-07-10 폰세 드 리온 헬스 데지그네이티드 액티비티 컴퍼니 칼슘 알파-케토글루타레이트의 제조 방법
KR102405350B1 (ko) * 2018-10-25 2022-06-07 한국과학기술원 Pdk1 저해제를 포함하는 역노화 유도용 조성물
KR20200046680A (ko) * 2018-10-25 2020-05-07 한국과학기술원 Pdk1 저해제를 포함하는 역노화 유도용 조성물
KR102132921B1 (ko) * 2018-12-13 2020-07-13 영남대학교 산학협력단 조타로리무스를 유효성분으로 함유하는 세포노화 관련 질환 예방 또는 치료용 조성물
CN110161226A (zh) * 2019-02-27 2019-08-23 杭州晟康细胞生物科技有限公司 一种检测衰老细胞用的抗体、试剂盒及检测方法
CN110101697A (zh) * 2019-05-28 2019-08-09 北京大学 小檗碱在制备抑制细胞周期蛋白依赖性激酶抑制因子p16表达的药物中的应用
JP2021038147A (ja) * 2019-08-30 2021-03-11 国立大学法人 鹿児島大学 ミトコンドリア生合成促進剤
CA3158905A1 (en) * 2019-12-09 2021-06-17 Wisconsin Alumni Research Foundation Chemical cocktail for inducing senescence in human neurons to promote disease modeling and drug discovery
CN111286500B (zh) * 2020-03-23 2022-08-23 华东理工大学 一种等离子体作用结合氧限制生产辅酶q10的方法
AU2021365292B2 (en) * 2020-10-21 2025-04-03 Nanjing Nutrabuilding Bio-Tech Co., Ltd. Methods for improving exercise performance and endurance thereof
CN112553288B (zh) * 2020-12-09 2022-06-07 汤臣倍健股份有限公司 一种筛选具有抗衰老潜力天然产物的方法
CN113215066B (zh) * 2021-06-29 2021-09-24 中国农业科学院农产品加工研究所 一种砖红链霉菌a001及其应用
CN114504598B (zh) * 2022-02-23 2023-08-22 前沿外泌体(珠海横琴)生物医药研发有限公司 脐带干细胞在制备抗衰老的药物中的应用
JP2025533322A (ja) * 2022-11-24 2025-10-03 長風薬業股▲ふん▼有限公司 (-)-エピガロカテキンガレート化合物の使用
CN115998881A (zh) * 2023-02-08 2023-04-25 暨南大学附属第一医院(广州华侨医院) 自噬调节剂在制备治疗脑梗死后脑细胞衰老的药物中的应用

Family Cites Families (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US525960A (en) * 1894-09-11 montgomery
ZA737247B (en) 1972-09-29 1975-04-30 Ayerst Mckenna & Harrison Rapamycin and process of preparation
US3993749A (en) 1974-04-12 1976-11-23 Ayerst Mckenna And Harrison Ltd. Rapamycin and process of preparation
US5206018A (en) 1978-11-03 1993-04-27 Ayerst, Mckenna & Harrison, Inc. Use of rapamycin in treatment of tumors
US4885171A (en) 1978-11-03 1989-12-05 American Home Products Corporation Use of rapamycin in treatment of certain tumors
US4401653A (en) 1981-03-09 1983-08-30 Ayerst, Mckenna & Harrison Inc. Combination of rapamycin and picibanil for the treatment of tumors
US4650803A (en) 1985-12-06 1987-03-17 University Of Kansas Prodrugs of rapamycin
US5355245A (en) * 1988-02-12 1994-10-11 Donnelly Corporation Ultraviolet protected electrochemichromic rearview mirror
US5080899A (en) 1991-02-22 1992-01-14 American Home Products Corporation Method of treating pulmonary inflammation
US5078999A (en) 1991-02-22 1992-01-07 American Home Products Corporation Method of treating systemic lupus erythematosus
US5321009A (en) 1991-04-03 1994-06-14 American Home Products Corporation Method of treating diabetes
ES2084940T3 (es) 1991-06-18 1996-05-16 American Home Prod Uso de la rapamicina para el tratamiento de la leucemia/linfoma de las celulas t adultas.
ZA924953B (en) 1991-07-25 1993-04-28 Univ Louisville Res Found Method of treating ocular inflammation
US5286730A (en) 1991-09-17 1994-02-15 American Home Products Corporation Method of treating immunoinflammatory disease
US5286731A (en) 1991-09-17 1994-02-15 American Home Products Corporation Method of treating immunoinflammatory bowel disease
US5151413A (en) 1991-11-06 1992-09-29 American Home Products Corporation Rapamycin acetals as immunosuppressant and antifungal agents
US5516781A (en) 1992-01-09 1996-05-14 American Home Products Corporation Method of treating restenosis with rapamycin
US5288711A (en) 1992-04-28 1994-02-22 American Home Products Corporation Method of treating hyperproliferative vascular disease
US5489508A (en) 1992-05-13 1996-02-06 University Of Texas System Board Of Regents Therapy and diagnosis of conditions related to telomere length and/or telomerase activity
DE4322826A1 (de) * 1993-07-08 1995-01-12 Galenik Labor Freiburg Gmbh Pharmazeutisches Präparat
US5561138A (en) 1994-12-13 1996-10-01 American Home Products Corporation Method of treating anemia
US5496832A (en) 1995-03-09 1996-03-05 American Home Products Corporation Method of treating cardiac inflammatory disease
TW427904B (en) * 1995-12-07 2001-04-01 American Home Prod Neuroprotective agents
US5688245A (en) * 1996-05-02 1997-11-18 Runge; Thomas M. Cannula system for a biventricular cardiac support system or a cardiopulmonary bypass system
CA2279651A1 (en) 1996-09-05 1998-03-12 Massachusetts Institute Of Technology Compositions and methods for treatment of neurological disorders and neurodegenerative diseases
US6273913B1 (en) 1997-04-18 2001-08-14 Cordis Corporation Modified stent useful for delivery of drugs along stent strut
US6890546B2 (en) * 1998-09-24 2005-05-10 Abbott Laboratories Medical devices containing rapamycin analogs
US6670355B2 (en) * 2000-06-16 2003-12-30 Wyeth Method of treating cardiovascular disease
EP1280932A1 (en) * 2000-10-03 2003-02-05 Fred Hutchinson Cancer Research Center Interfering with telomere maintenance in treatment of diseases
US7192612B2 (en) 2001-02-22 2007-03-20 Purdue Research Foundation Compositions and methods based on synergies between capsicum extracts and tea catechins for prevention and treatment of cancer
TWI296196B (en) 2001-04-06 2008-05-01 Wyeth Corp Antineoplastic combinations
US20040142048A1 (en) 2002-02-22 2004-07-22 Morre Dorothy M. Compositions based on proanthocyanadin-catechin synergies for prevention and treatment of cancer
AU2003247483A1 (en) 2002-05-30 2003-12-31 The Children's Hospital Of Philadelphia Methods for treatment of acute lymphocytic leukemia
WO2004000045A2 (en) 2002-06-21 2003-12-31 Canacure Corporation Liquid compositions comprising non-digestible oligosaccharides and green tea catechins, method and uses thereof
WO2004004644A2 (en) * 2002-07-05 2004-01-15 Beth Israel Deaconess Medical Center Combination of mtor inhibitor and a tyrosine kinase inhibitor for the treatment of neoplasms
US20050070567A1 (en) 2002-08-12 2005-03-31 The Regents Of The University Of Michigan Diagnosis and treatment of diseases arising from defects in the tuberous sclerosis pathway
US20060078533A1 (en) * 2004-10-12 2006-04-13 Omoigui Osemwota S Method of prevention and treatment of aging and age-related disorders including atherosclerosis, peripheral vascular disease, coronary artery disease, osteoporosis, arthritis, type 2 diabetes, dementia, alzheimer's disease and cancer
PT1539157E (pt) 2002-09-18 2013-10-04 Univ Pennsylvania Rapamicina para utilização na inibição ou prevenção de neovascularização coroidal
UA83484C2 (uk) 2003-03-05 2008-07-25 Уайт Спосіб лікування раку грудей комбінацією похідного рапаміцину і інгібітора ароматази - летрозолу, фармацевтична композиція
US20050013880A1 (en) 2003-03-06 2005-01-20 Magnuson Bernadene Ann Anthocyanin-rich compositions and methods for inhibiting cancer cell growth
WO2004094409A1 (en) 2003-03-27 2004-11-04 Lankenau Institute For Medical Research Novel ido inhibitors and methods of use
US20070155771A1 (en) 2003-04-11 2007-07-05 David Rubinsztein Methods and means for treating protein conformational disorders
PT1646634E (pt) 2003-07-08 2009-02-16 Novartis Ag Utilização de rapamicina e derivados de rapamicina para o tratamento de perda óssea
US7083802B2 (en) 2003-07-31 2006-08-01 Advanced Ocular Systems Limited Treatment of ocular disease
US20080194019A1 (en) * 2003-09-09 2008-08-14 Beth Israel Deaconess Medical Center, Inc. Tumor Suppressor Lkb1 Kinase Directly Activates Amp-Activated Kinase
US7901874B2 (en) 2003-09-11 2011-03-08 Hubit Genomix, Inc. Methods for identifying agents for preventing or treating proliferative diseases, and for inhibiting extracellular matrix or α1 type IV collagen
US20060035907A1 (en) 2004-02-23 2006-02-16 Christensen James G Methods of treating abnormal cell growth using c-MET and m-TOR inhibitors
US7241461B2 (en) 2004-03-23 2007-07-10 Lifeline Nutraceuticals Corporation Compositions for alleviating inflammation and oxidative stress in a mammal
US7846940B2 (en) * 2004-03-31 2010-12-07 Cordis Corporation Solution formulations of sirolimus and its analogs for CAD treatment
US8003122B2 (en) * 2004-03-31 2011-08-23 Cordis Corporation Device for local and/or regional delivery employing liquid formulations of therapeutic agents
US20070059336A1 (en) 2004-04-30 2007-03-15 Allergan, Inc. Anti-angiogenic sustained release intraocular implants and related methods
BRPI0518079A (pt) * 2004-10-28 2008-11-04 Wyeth Corp usos de um inibidor de mtor, de uma rapamicina, e de 42-éster de rapamicina com ácido 3-hidróxi-2- (hidroximetil) -2-metilpropiÈnico, composição farmacêutica, e, embalagem farmacêutica
WO2006068932A2 (en) 2004-12-20 2006-06-29 Wyeth Rapamycin analogues and the uses thereof in the treatment of neurological, proliferative, and inflammatory disorders
WO2006084233A2 (en) * 2005-02-04 2006-08-10 Cytrx Corporation Modulation of endogenous aicar levels for the treatment of diabetes and obesity
WO2006086744A1 (en) 2005-02-09 2006-08-17 Macusight, Inc. Formulations for ocular treatment
EP2532389A3 (en) * 2005-02-16 2013-02-20 Md Bioalpha Co., Ltd. Pharmaceutical composition for the treatment or prevention of diseases involving obesity, diabetes, metabolic syndrome, neuro-degenerative diseases and mitochondria dysfunction diseases
JP2006249015A (ja) * 2005-03-11 2006-09-21 Mochida Pharmaceut Co Ltd 細胞老化抑制剤
US20060247265A1 (en) 2005-04-28 2006-11-02 Clackson Timothy P Therapies for treating disorders of the eye
US8093401B2 (en) 2005-08-04 2012-01-10 Sirtris Pharmaceuticals, Inc. Sirtuin modulating compounds
US20070104721A1 (en) 2005-11-04 2007-05-10 Wyeth Antineoplastic combinations with mTOR inhibitor,herceptin, and/or hki-272
BRPI0618643A2 (pt) 2005-11-09 2011-09-06 Combinatorx Inc composição compreendendo um par de fármacos, composição compreendendo um corticosteróide e um imunossupressor dependente de imunofilina não-esteróide, kits e uso
ES2563288T3 (es) * 2006-03-23 2016-03-14 Santen Pharmaceutical Co., Ltd Rapamicina en dosis bajas para el tratamiento de enfermedades relacionadas con la permeabilidad vascular
WO2007124331A2 (en) * 2006-04-19 2007-11-01 Virginia Commonwealth University Cardioprotective and other uses of mammalian target of rapamycin (m-tor) inhibitors
US20090029904A1 (en) * 2006-07-21 2009-01-29 Sean Oldham Compositions and methods for treatment of insulin-resistance diseases
RU2010104916A (ru) * 2006-08-16 2011-08-20 Михаил В. Благосклонный (US) Способ профилактики и лечения возрастных заболеваний
PT2481409T (pt) * 2007-03-07 2018-10-18 Abraxis Bioscience Llc Nanopartícula que compreende rapamicina e albumina como agente anticancerígeno
WO2008137148A2 (en) * 2007-05-03 2008-11-13 Abraxis Bioscience, Llc Methods and compositions for treating pulmonary hypertension
CN101333503B (zh) * 2007-06-27 2013-02-06 中国科学院上海生命科学研究院 分离衰老细胞的方法和模型
BRPI1010655A2 (pt) 2009-04-10 2019-09-03 Qi Haiyan novos agentes antienvelhecimento e métodos para identificá-los

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