BRPI1010722A2 - micropartículas de dicetopiperazina com teores de isômero definidos. - Google Patents

micropartículas de dicetopiperazina com teores de isômero definidos.

Info

Publication number: BRPI1010722A2
Authority: BR; Brazil
Prior art keywords: diketopiperazine microparticles; isomer contents; defined isomer; contents; diketopiperazine
Prior art date: 2009-06-12

Application number

BRPI1010722A

Other languages

English (en)

Inventor

Karla Somerville

Kelly S Kraft

Original Assignee

Mannkind Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2009-06-12

Filing date

2010-06-11

Publication date

2016-03-15

2010-06-11 Application filed by Mannkind Corp filed Critical Mannkind Corp

2016-03-15 Publication of BRPI1010722A2 publication Critical patent/BRPI1010722A2/pt

2019-12-10 Publication of BRPI1010722B1 publication Critical patent/BRPI1010722B1/pt

Links

239000011859 microparticle Substances 0.000 title 1
BXRNXXXXHLBUKK-UHFFFAOYSA-N piperazine-2,5-dione Chemical compound O=C1CNC(=O)CN1 BXRNXXXXHLBUKK-UHFFFAOYSA-N 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Zoology (AREA)
Organic Chemistry (AREA)
Obesity (AREA)
Hematology (AREA)
General Chemical & Material Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Immunology (AREA)
Chemical Kinetics & Catalysis (AREA)
Gastroenterology & Hepatology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pulmonology (AREA)
Otolaryngology (AREA)
Child & Adolescent Psychology (AREA)
Emergency Medicine (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)

BRPI1010722 2009-06-12 2010-06-11 micropartículas de dicetopiperazina com teores de isômero definidos, pó seco, uso de uma formulação de pó seco compreendendo micropartículas de dicetopiperazina, método de preparar micropartículas e método para sintetizar uma dicetopiperazina BRPI1010722B1 (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US18677909P	2009-06-12	2009-06-12
PCT/US2010/038287 WO2010144785A2 (en)	2009-06-12	2010-06-11	Diketopiperazine microparticles with defined isomer contents

Publications (2)

Publication Number	Publication Date
BRPI1010722A2 true BRPI1010722A2 (pt)	2016-03-15
BRPI1010722B1 BRPI1010722B1 (pt)	2019-12-10

Family

ID=43306942

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI1010722 BRPI1010722B1 (pt)	2009-06-12	2010-06-11	micropartículas de dicetopiperazina com teores de isômero definidos, pó seco, uso de uma formulação de pó seco compreendendo micropartículas de dicetopiperazina, método de preparar micropartículas e método para sintetizar uma dicetopiperazina

Country Status (17)

Country	Link
US (1)	US8227409B2 (pt)
EP (2)	EP3556356B1 (pt)
JP (2)	JP5859432B2 (pt)
KR (1)	KR101782174B1 (pt)
CN (1)	CN102458371B (pt)
AR (1)	AR077087A1 (pt)
AU (1)	AU2010259939B2 (pt)
BR (1)	BRPI1010722B1 (pt)
CA (1)	CA2765156C (pt)
ES (2)	ES2751107T3 (pt)
IL (1)	IL216910A (pt)
MX (1)	MX2011013313A (pt)
MY (1)	MY172858A (pt)
RU (1)	RU2490026C1 (pt)
SG (4)	SG195546A1 (pt)
TW (1)	TWI513692B (pt)
WO (1)	WO2010144785A2 (pt)

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US9006175B2 (en)	1999-06-29	2015-04-14	Mannkind Corporation	Potentiation of glucose elimination
WO2003080149A2 (en)	2002-03-20	2003-10-02	Mannkind Corporation	Inhalation apparatus
US20070027063A1 (en) *	2004-01-12	2007-02-01	Mannkind Corporation	Method of preserving the function of insulin-producing cells
PL1786784T3 (pl)	2004-08-20	2011-04-29	Mannkind Corp	Kataliza syntezy diketopiperazyn
KR101644250B1 (ko)	2004-08-23	2016-07-29	맨카인드 코포레이션	약물 전달용 디케토피페라진염, 디케토모르포린염 또는 디케토디옥산염
CN104324362B (zh)	2005-09-14	2018-04-24	曼金德公司	以提高活性试剂对结晶微粒表面的亲和力为基础的药物配制方法
IN2015DN00888A (pt)	2006-02-22	2015-07-10	Mannkind Corp
ES2302448B1 (es) *	2006-10-20	2009-05-08	Vodafone España, S.A.	Sistema y metodo de difusion de informacion de area en entornos locales de tamaño reducido dentro de un sistema celular de comunicaciones moviles.
ES2929343T3 (es)	2008-06-13	2022-11-28	Mannkind Corp	Inhalador de polvo seco accionado por aspiración para la administración de fármacos
US8485180B2 (en)	2008-06-13	2013-07-16	Mannkind Corporation	Dry powder drug delivery system
KR101628410B1 (ko)	2008-06-20	2016-06-08	맨카인드 코포레이션	흡입 활동에 관한 실시간 프로파일링을 위한 대화형 장치 및 방법
TWI614024B (zh)	2008-08-11	2018-02-11	曼凱公司	超快起作用胰島素之用途
US8314106B2 (en)	2008-12-29	2012-11-20	Mannkind Corporation	Substituted diketopiperazine analogs for use as drug delivery agents
DK2405963T3 (da)	2009-03-11	2013-12-16	Mannkind Corp	Apparat, system og fremgangsmåde til at måle modstand i en inhalator
CN104721825B (zh)	2009-06-12	2019-04-12	曼金德公司	具有确定比表面积的二酮哌嗪颗粒
WO2011056889A1 (en)	2009-11-03	2011-05-12	Mannkind Corporation	An apparatus and method for simulating inhalation efforts
IL223742A (en)	2010-06-21	2016-06-30	Mannkind Corp	A dry powder inhaler and preparation for it
CN103108650A (zh)	2010-08-25	2013-05-15	Atyr医药公司	与酪氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现
AU2012236150B2 (en)	2011-04-01	2016-03-31	Mannkind Corporation	Blister package for pharmaceutical cartridges
PL3446714T3 (pl)	2011-06-02	2021-11-22	University Of Louisville Research Foundation, Inc.	Nanocząstki sprzężone z cząsteczką skierowaną przeciwko nukleolinie
WO2012174472A1 (en) *	2011-06-17	2012-12-20	Mannkind Corporation	High capacity diketopiperazine microparticles
BR112014009686A2 (pt)	2011-10-24	2018-08-07	Mannkind Corp	composição analgésica inalável, pó seco e método para tratar dor
CN104619369B (zh)	2012-07-12	2018-01-30	曼金德公司	干粉药物输送系统和方法
US10159644B2 (en)	2012-10-26	2018-12-25	Mannkind Corporation	Inhalable vaccine compositions and methods
AU2014228415B2 (en) *	2013-03-15	2018-08-09	Mannkind Corporation	Microcrystalline diketopiperazine compositions and methods
MX375448B (es)	2013-07-18	2025-03-06	Mannkind Corp	Composiciones farmacéuticas en polvo seco estables al calor y métodos.
US11446127B2 (en)	2013-08-05	2022-09-20	Mannkind Corporation	Insufflation apparatus and methods
US10307464B2 (en)	2014-03-28	2019-06-04	Mannkind Corporation	Use of ultrarapid acting insulin
US10561806B2 (en)	2014-10-02	2020-02-18	Mannkind Corporation	Mouthpiece cover for an inhaler
US9968125B2 (en) *	2015-01-09	2018-05-15	Philip Morris Products S.A.	Nicotine—diketopiperazine microparticle formulations and methods of making the same
PT108368B (pt) *	2015-03-31	2018-11-05	Hovione Farm S A	Produção contínua de partículas
CA3012679C (en) *	2016-01-29	2023-12-12	Mannkind Corporation	Dry powder inhaler
US20210299156A1 (en)	2020-03-28	2021-09-30	Qualigen Inc.	Methods of inhibiting or treating coronavirus infection, and methods for delivering an anti-nucleolin agent

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US5693338A (en) *	1994-09-29	1997-12-02	Emisphere Technologies, Inc.	Diketopiperazine-based delivery systems
US5352461A (en)	1992-03-11	1994-10-04	Pharmaceutical Discovery Corporation	Self assembling diketopiperazine drug delivery system
US5888477A (en) *	1993-01-29	1999-03-30	Aradigm Corporation	Use of monomeric insulin as a means for improving the bioavailability of inhaled insulin
US5506203C1 (en) *	1993-06-24	2001-02-06	Astra Ab	Systemic administration of a therapeutic preparation
US5547929A (en) *	1994-09-12	1996-08-20	Eli Lilly And Company	Insulin analog formulations
US6428771B1 (en)	1995-05-15	2002-08-06	Pharmaceutical Discovery Corporation	Method for drug delivery to the pulmonary system
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CN1423553A (zh)	1998-04-09	2003-06-11	阿克西瓦有限公司	用于肺部给药的颗粒赋形剂
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EP1734938B1 (en) *	2004-03-26	2012-06-20	Universita' Degli Studi Di Parma	Insulin highly respirable microparticles
PL1786784T3 (pl)	2004-08-20	2011-04-29	Mannkind Corp	Kataliza syntezy diketopiperazyn
KR101644250B1 (ko) *	2004-08-23	2016-07-29	맨카인드 코포레이션	약물 전달용 디케토피페라진염, 디케토모르포린염 또는 디케토디옥산염
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CN104324362B (zh)	2005-09-14	2018-04-24	曼金德公司	以提高活性试剂对结晶微粒表面的亲和力为基础的药物配制方法
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KR101438839B1 (ko)	2006-04-14	2014-10-02	맨카인드 코포레이션	글루카곤 유사 펩타이드 1 （ｇｌｐ-1） 약제학적 제제
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ES2929343T3 (es) *	2008-06-13	2022-11-28	Mannkind Corp	Inhalador de polvo seco accionado por aspiración para la administración de fármacos

2010
- 2010-06-11 EP EP19175215.3A patent/EP3556356B1/en active Active
- 2010-06-11 SG SG2013076096A patent/SG195546A1/en unknown
- 2010-06-11 BR BRPI1010722 patent/BRPI1010722B1/pt active IP Right Grant
- 2010-06-11 SG SG10201706995VA patent/SG10201706995VA/en unknown
- 2010-06-11 AU AU2010259939A patent/AU2010259939B2/en active Active
- 2010-06-11 MX MX2011013313A patent/MX2011013313A/es active IP Right Grant
- 2010-06-11 JP JP2012515175A patent/JP5859432B2/ja active Active
- 2010-06-11 RU RU2012100785/15A patent/RU2490026C1/ru active
- 2010-06-11 CN CN201080026117.7A patent/CN102458371B/zh active Active
- 2010-06-11 KR KR1020127000804A patent/KR101782174B1/ko active Active
- 2010-06-11 EP EP10724973.2A patent/EP2440186B1/en active Active
- 2010-06-11 TW TW099119045A patent/TWI513692B/zh active
- 2010-06-11 WO PCT/US2010/038287 patent/WO2010144785A2/en not_active Ceased
- 2010-06-11 US US12/813,839 patent/US8227409B2/en active Active
- 2010-06-11 SG SG2011091410A patent/SG176778A1/en unknown
- 2010-06-11 CA CA2765156A patent/CA2765156C/en active Active
- 2010-06-11 ES ES10724973T patent/ES2751107T3/es active Active
- 2010-06-11 SG SG10201403147SA patent/SG10201403147SA/en unknown
- 2010-06-11 MY MYPI2011006016A patent/MY172858A/en unknown
- 2010-06-11 ES ES19175215T patent/ES2880102T3/es active Active
- 2010-06-14 AR ARP100102093A patent/AR077087A1/es not_active Application Discontinuation
2011
- 2011-12-12 IL IL216910A patent/IL216910A/en active IP Right Grant
2015
- 2015-09-07 JP JP2015176164A patent/JP6101326B2/ja active Active

Also Published As

Publication number	Publication date
TWI513692B (zh)	2015-12-21
JP2012530062A (ja)	2012-11-29
IL216910A (en)	2016-05-31
SG10201706995VA (en)	2017-09-28
AR077087A1 (es)	2011-08-03
IL216910A0 (en)	2012-02-29
TW201113259A (en)	2011-04-16
MX2011013313A (es)	2012-01-25
JP6101326B2 (ja)	2017-03-22
ES2880102T3 (es)	2021-11-23
KR20120044971A (ko)	2012-05-08
ES2751107T3 (es)	2020-03-30
SG195546A1 (en)	2013-12-30
US8227409B2 (en)	2012-07-24
SG176778A1 (en)	2012-01-30
AU2010259939A1 (en)	2011-12-15
MY172858A (en)	2019-12-12
RU2012100785A (ru)	2013-07-20
BRPI1010722B1 (pt)	2019-12-10
SG10201403147SA (en)	2014-10-30
EP3556356A1 (en)	2019-10-23
CA2765156A1 (en)	2010-12-16
CN102458371B (zh)	2015-08-05
JP2016028068A (ja)	2016-02-25
EP2440186A2 (en)	2012-04-18
AU2010259939B2 (en)	2012-07-05
RU2490026C1 (ru)	2013-08-20
CA2765156C (en)	2018-04-10
EP2440186B1 (en)	2019-08-07
EP3556356B1 (en)	2021-05-05
CN102458371A (zh)	2012-05-16
WO2010144785A2 (en)	2010-12-16
JP5859432B2 (ja)	2016-02-10
WO2010144785A3 (en)	2011-03-03
US20100317574A1 (en)	2010-12-16
KR101782174B1 (ko)	2017-09-26

Legal Events

Date	Code	Title	Description
2017-10-10	B07D	Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
2018-04-10	B06F	Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
2018-05-15	B07E	Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
2018-12-26	B06T	Formal requirements before examination [chapter 6.20 patent gazette]
2019-08-06	B06A	Patent application procedure suspended [chapter 6.1 patent gazette]
2019-11-19	B09A	Decision: intention to grant [chapter 9.1 patent gazette]
2019-12-10	B16A	Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]	Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 11/06/2010, OBSERVADAS AS CONDICOES LEGAIS. (CO) 20 (VINTE) ANOS CONTADOS A PARTIR DE 11/06/2010, OBSERVADAS AS CONDICOES LEGAIS

Publication	Publication Date	Title
BRPI1010722A2 (pt)	2016-03-15	micropartículas de dicetopiperazina com teores de isômero definidos.
BRPI1013154A2 (pt)	2016-04-05	micropartículas de dicetopiperazina com áreas de superfície específicas definidas.
IT1403054B1 (it)	2013-09-27	Bottiglia.
BRPI0823297A2 (pt)	2015-06-23	Garrafa
TH91873B (th)	2008-10-20	ขวด
CL2008001738S1 (es)	2008-10-24	Envase.
CL2008001739S1 (es)	2008-10-24	Envase.
TH92008B (th)	2008-10-31	ขวดนม
ES1067722Y (es)	2008-09-16	Unidor de botellas
UA18028S (uk)	2008-12-25	Кришка до пляшки
CN301175543S (zh)	2010-04-21	瓶子
CN301260963S (zh)	2010-06-16	瓶子
UA17359S (uk)	2008-09-25	Пляшка
UA17647S (uk)	2008-10-27	Пляшка
TH106422B (th)	2011-03-15	ขวด
TH95711B (th)	2009-05-29	ขวด
TH97631B (th)	2009-08-13	ขวด
UA16009S (uk)	2008-02-25	Пляшка
UA16835S (uk)	2008-06-10	Пляшка
UA16896S (uk)	2008-06-25	Пляшка
UA17104S (uk)	2008-08-11	Пляшка
UA17321S (uk)	2008-09-10	Пляшка
TH101875B (th)	2010-06-25	ขวด
UA17375S (uk)	2008-09-25	Пляшка
UA17376S (uk)	2008-09-25	Пляшка