BRPI1010759A2 - processo para produção de proteína - Google Patents
processo para produção de proteínaInfo
- Publication number
- BRPI1010759A2 BRPI1010759A2 BRPI1010759A BRPI1010759A BRPI1010759A2 BR PI1010759 A2 BRPI1010759 A2 BR PI1010759A2 BR PI1010759 A BRPI1010759 A BR PI1010759A BR PI1010759 A BRPI1010759 A BR PI1010759A BR PI1010759 A2 BRPI1010759 A2 BR PI1010759A2
- Authority
- BR
- Brazil
- Prior art keywords
- protein production
- protein
- production
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—RNA viruses
- C07K16/108—Orthomyxoviridae (F), e.g. influenza virus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0681—Cells of the genital tract; Non-germinal cells from gonads
- C12N5/0682—Cells of the female genital tract, e.g. endometrium; Non-germinal cells from ovaries, e.g. ovarian follicle cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
- C12N2015/8518—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic expressing industrially exogenous proteins, e.g. for pharmaceutical use, human insulin, blood factors, immunoglobulins, pseudoparticles
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C12N2510/02—Cells for production
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/10—Plasmid DNA
- C12N2800/106—Plasmid DNA for vertebrates
- C12N2800/107—Plasmid DNA for vertebrates for mammalian
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/90—Vectors containing a transposable element
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Virology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Reproductive Health (AREA)
- Cell Biology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Communicable Diseases (AREA)
- Pulmonology (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18613809P | 2009-06-11 | 2009-06-11 | |
| JP2009-140626 | 2009-06-11 | ||
| US61/186,138 | 2009-06-11 | ||
| JP2009140626 | 2009-06-11 | ||
| PCT/JP2010/059881 WO2010143698A1 (ja) | 2009-06-11 | 2010-06-10 | タンパク質の生産方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BRPI1010759A2 true BRPI1010759A2 (pt) | 2016-08-09 |
| BRPI1010759B1 BRPI1010759B1 (pt) | 2019-07-16 |
Family
ID=43308953
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI1010759-2A BRPI1010759B1 (pt) | 2009-06-11 | 2010-06-10 | Método para produzir uma proteína de interesse ou para obter uma suspensão de células de mamíferos capaz de produzir uma proteína de interesse, bem como vetor de expressão de proteína |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US9034649B2 (pt) |
| EP (1) | EP2441831B9 (pt) |
| JP (2) | JP6039181B2 (pt) |
| KR (1) | KR101812348B1 (pt) |
| CN (2) | CN102803484A (pt) |
| AU (1) | AU2010259533B2 (pt) |
| BR (1) | BRPI1010759B1 (pt) |
| CA (1) | CA2765242C (pt) |
| DK (1) | DK2441831T3 (pt) |
| ES (1) | ES2697535T3 (pt) |
| RU (1) | RU2563514C2 (pt) |
| SG (1) | SG177247A1 (pt) |
| TW (2) | TW201546281A (pt) |
| WO (1) | WO2010143698A1 (pt) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8598328B2 (en) * | 2006-12-13 | 2013-12-03 | National University Corporation Nagoya University | Tol1 factor transposase and DNA introduction system using the same |
| CN102803484A (zh) * | 2009-06-11 | 2012-11-28 | 大学共同利用机关法人情报·系统研究机构 | 生产蛋白质的方法 |
| WO2012081628A1 (ja) * | 2010-12-15 | 2012-06-21 | 大学共同利用機関法人情報・システム研究機構 | タンパク質の生産方法 |
| CN103339255A (zh) * | 2010-12-15 | 2013-10-02 | 协和发酵麒麟株式会社 | 蛋白质的生产方法 |
| WO2012176779A1 (ja) | 2011-06-20 | 2012-12-27 | 協和発酵キリン株式会社 | 抗ｅｒｂＢ３抗体 |
| WO2014054804A1 (ja) | 2012-10-05 | 2014-04-10 | 協和発酵キリン株式会社 | ヘテロダイマータンパク質組成物 |
| EP2997134B1 (en) * | 2013-05-14 | 2020-06-24 | Board of Regents, The University of Texas System | Human application of engineered chimeric antigen receptor (car) t-cells |
| CA3047313A1 (en) | 2016-12-16 | 2018-06-21 | B-Mogen Biotechnologies, Inc. | Enhanced hat family transposon-mediated gene transfer and associated compositions, systems, and methods |
| US11278570B2 (en) | 2016-12-16 | 2022-03-22 | B-Mogen Biotechnologies, Inc. | Enhanced hAT family transposon-mediated gene transfer and associated compositions, systems, and methods |
| EP3653713A4 (en) | 2017-07-13 | 2021-03-31 | Kyowa Kirin Co., Ltd. | ANTIBODY ANTIBODY AND PROCESS FOR STABILIZING BRIL FUSION PROTEIN INVOLVING THE ANTIBODY |
| US11912775B2 (en) | 2017-07-18 | 2024-02-27 | Kyowa Kirin Co., Ltd. | Anti-human CCR1 monoclonal antibody |
| AU2018363922B2 (en) | 2017-11-08 | 2025-06-12 | Kyowa Kirin Co., Ltd. | Bispecific antibody which binds to CD40 and EpCAM |
| WO2019246486A2 (en) | 2018-06-21 | 2019-12-26 | B-Mogen Biotechnologies, Inc. | ENHANCED hAT FAMILY TRANSPOSON-MEDIATED GENE TRANSFER AND ASSOCIATED COMPOSITIONS, SYSTEMS, AND METHODS |
| CN112424358B (zh) | 2018-06-26 | 2025-07-01 | 协和麒麟株式会社 | 与细胞粘附分子3结合的抗体 |
| CA3104997A1 (en) | 2018-06-26 | 2020-01-02 | Kyowa Kirin Co., Ltd. | Antibody binding to chondroitin sulfate proteoglycan 5 |
| WO2020067541A1 (ja) | 2018-09-28 | 2020-04-02 | 協和キリン株式会社 | 抗体組成物 |
| HUE068630T2 (hu) | 2018-12-10 | 2025-01-28 | Amgen Inc | Mutáns PiggyBac transzpozáz |
| KR102991359B1 (ko) | 2018-12-28 | 2026-07-16 | 쿄와 기린 가부시키가이샤 | TfR에 결합하는 이중 특이적 항체 |
| US11060098B2 (en) * | 2019-04-08 | 2021-07-13 | Dna Twopointo Inc. | Integration of nucleic acid constructs into eukaryotic cells with a transposase from oryzias |
| WO2020210236A1 (en) | 2019-04-08 | 2020-10-15 | Dna Twopointo Inc. | Transposition of nucleic acids into eukaryotic genomes with a transposase from heliothis |
| IL287088B2 (en) * | 2019-04-08 | 2023-09-01 | Dna Twopointo Inc | Transposition of nucleic acid constructs into eukaryotic genomes with amylase transposases |
| CN110093361B (zh) * | 2019-04-17 | 2023-05-09 | 拜澳泰克(沈阳)生物医学集团有限公司 | 一种增强基因表达的增强子多肽及其应用 |
| CA3140385A1 (en) | 2019-05-15 | 2020-11-19 | Kyowa Kirin Co., Ltd. | Bispecific antibody binding to cd40 and fap |
| WO2020230901A1 (ja) | 2019-05-15 | 2020-11-19 | 協和キリン株式会社 | Ｃｄ４０とｇｐｃ３に結合するバイスペシフィック抗体 |
| CN114502739A (zh) | 2019-10-02 | 2022-05-13 | 国立大学法人九州大学 | 肝素样物质的制造方法、重组细胞及其制造方法 |
| TWI888487B (zh) | 2020-02-14 | 2025-07-01 | 日商協和麒麟股份有限公司 | 與ｃｄ３結合之雙特異性抗體 |
| TWI884247B (zh) | 2020-04-01 | 2025-05-21 | 日商協和麒麟股份有限公司 | 抗體組合物 |
| CN114113347B (zh) * | 2020-08-25 | 2025-06-20 | 越海百奥药业(绍兴)有限公司 | 核苷检测方法及其应用 |
| JP7551512B2 (ja) * | 2021-01-13 | 2024-09-17 | 株式会社東芝 | トランスポゼース活性測定用ベクターセット、キット、トランスポゼース活性測定方法及び細胞分離方法 |
| TW202317637A (zh) | 2021-08-26 | 2023-05-01 | 日商協和麒麟股份有限公司 | 與cd116及cd131結合之雙特異性抗體 |
| CN114045305B (zh) * | 2021-10-15 | 2023-03-24 | 深圳市深研生物科技有限公司 | 多转座子系统 |
| CA3252263A1 (en) | 2022-02-09 | 2025-07-07 | National Institutes Of Biomedical Innovation, Health And Nutrition | ANTIBODY OR FRAGMENT OF IT BINDING TO FCRL1 |
| CN119677855A (zh) | 2022-08-10 | 2025-03-21 | 协和麒麟株式会社 | 抗fgf23抗体或该抗体片段 |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1990005787A1 (en) * | 1988-11-23 | 1990-05-31 | The Regents Of The University Of California | Position-specific insertion vectors and method of using same |
| ES2121794T3 (es) * | 1990-10-25 | 1998-12-16 | Clague Pitman Hodgson | Procedimiento de transferencia de genes por medio de retrotransposones. |
| JPH10299A (ja) | 1996-06-18 | 1998-01-06 | Matsushita Electric Ind Co Ltd | 誘導加熱式アイロン装置 |
| US6528624B1 (en) | 1998-04-02 | 2003-03-04 | Genentech, Inc. | Polypeptide variants |
| US6737056B1 (en) | 1999-01-15 | 2004-05-18 | Genentech, Inc. | Polypeptide variants with altered effector function |
| EP2275540B1 (en) | 1999-04-09 | 2016-03-23 | Kyowa Hakko Kirin Co., Ltd. | Method for controlling the activity of immunologically functional molecule |
| AU4806100A (en) * | 1999-04-28 | 2000-11-10 | Board Of Trustees Of The Leland Stanford Junior University | P element derived vector and methods for its use |
| GB9924721D0 (en) | 1999-10-19 | 1999-12-22 | Craig Roger | Protein production system |
| EP1293564A4 (en) * | 2000-06-08 | 2005-08-17 | Mitsubishi Pharma Corp | EXPRESSION VECTOR FOR SCREENING CELLS HIGH EXPRESSION OF RECOMBINANT PROTEINS, TRANSFORMING HIGH EXPRESSION OF A RECOMBINANT PROTEIN AND USE THEREOF |
| JP2004524805A (ja) * | 2000-07-03 | 2004-08-19 | ギャラ デザイン インコーポレイテッド | 複数の組み込みベクターを含む宿主細胞 |
| US6946292B2 (en) | 2000-10-06 | 2005-09-20 | Kyowa Hakko Kogyo Co., Ltd. | Cells producing antibody compositions with increased antibody dependent cytotoxic activity |
| CN103333860B (zh) | 2000-10-06 | 2015-07-08 | 协和发酵麒麟株式会社 | 产生抗体组合物的细胞 |
| JP4817514B2 (ja) | 2001-03-09 | 2011-11-16 | 協和発酵キリン株式会社 | 新規動物細胞用ベクターおよびその使用 |
| JP4364474B2 (ja) | 2002-02-15 | 2009-11-18 | 大学共同利用機関法人情報・システム研究機構 | 哺乳動物において機能的なトランスポゾン |
| US7317091B2 (en) | 2002-03-01 | 2008-01-08 | Xencor, Inc. | Optimized Fc variants |
| US20040029229A1 (en) * | 2002-05-20 | 2004-02-12 | Reeves Philip J. | High level protein expression system |
| JP3793812B2 (ja) * | 2002-08-12 | 2006-07-05 | 独立行政法人産業技術総合研究所 | 低温での組み換えタンパク質の発現に適した新規発現ベクター |
| JPWO2005035586A1 (ja) | 2003-10-08 | 2007-11-22 | 協和醗酵工業株式会社 | 融合蛋白質組成物 |
| WO2006055931A2 (en) | 2004-11-18 | 2006-05-26 | Stratatech Corporation | Vectors for stable gene expression |
| EP1819732A2 (en) | 2004-12-06 | 2007-08-22 | Kirin Beer Kabushiki Kaisha | Human monoclonal antibodies to influenza m2 protein and methods of making and using same |
| JP4927730B2 (ja) * | 2005-07-05 | 2012-05-09 | 一般財団法人化学及血清療法研究所 | 改変トランスポゾンベクター及びその利用方法 |
| US7923538B2 (en) | 2005-07-22 | 2011-04-12 | Kyowa Hakko Kirin Co., Ltd | Recombinant antibody composition |
| WO2007082164A2 (en) | 2006-01-05 | 2007-07-19 | The Johns Hopkins University | Methods for identifying functional noncoding sequences |
| CN101104851A (zh) * | 2006-07-14 | 2008-01-16 | 金宁一 | 抗病毒蛋白cv-n的制备 |
| US8598328B2 (en) | 2006-12-13 | 2013-12-03 | National University Corporation Nagoya University | Tol1 factor transposase and DNA introduction system using the same |
| WO2008100424A2 (en) | 2007-02-09 | 2008-08-21 | University Of Hawaii | Animals and cells with genomic target sites for transposase-mediated transgenesis |
| PT2592148T (pt) * | 2007-10-12 | 2018-11-12 | Hoffmann La Roche | Expressão proteica de múltiplos ácidos nucleicos |
| EP2067402A1 (en) | 2007-12-07 | 2009-06-10 | Max Delbrück Centrum für Molekulare Medizin (MDC) Berlin-Buch; | Transponson-mediated mutagenesis in spermatogonial stem cells |
| US20100311116A1 (en) | 2009-06-04 | 2010-12-09 | Excellgene Sa | Fast generation of high expression stable cell lines expressing recombinant proteins under minimal and short-term selective pressure |
| CN102803484A (zh) * | 2009-06-11 | 2012-11-28 | 大学共同利用机关法人情报·系统研究机构 | 生产蛋白质的方法 |
-
2010
- 2010-06-10 CN CN2010800260085A patent/CN102803484A/zh active Pending
- 2010-06-10 CA CA2765242A patent/CA2765242C/en active Active
- 2010-06-10 CN CN201710099004.3A patent/CN106978441A/zh active Pending
- 2010-06-10 AU AU2010259533A patent/AU2010259533B2/en active Active
- 2010-06-10 EP EP10786229.4A patent/EP2441831B9/en active Active
- 2010-06-10 ES ES10786229T patent/ES2697535T3/es active Active
- 2010-06-10 JP JP2011518577A patent/JP6039181B2/ja active Active
- 2010-06-10 DK DK10786229.4T patent/DK2441831T3/en active
- 2010-06-10 BR BRPI1010759-2A patent/BRPI1010759B1/pt active IP Right Grant
- 2010-06-10 KR KR1020117029471A patent/KR101812348B1/ko active Active
- 2010-06-10 SG SG2011090925A patent/SG177247A1/en unknown
- 2010-06-10 RU RU2012100250/10A patent/RU2563514C2/ru active
- 2010-06-10 WO PCT/JP2010/059881 patent/WO2010143698A1/ja not_active Ceased
- 2010-06-11 TW TW104129432A patent/TW201546281A/zh unknown
- 2010-06-11 US US12/813,920 patent/US9034649B2/en active Active
- 2010-06-11 TW TW099119233A patent/TWI542686B/zh active
-
2015
- 2015-04-17 US US14/689,782 patent/US9725750B2/en active Active
- 2015-07-21 JP JP2015144268A patent/JP6152402B2/ja active Active
-
2017
- 2017-06-30 US US15/639,571 patent/US10358671B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| TW201546281A (zh) | 2015-12-16 |
| JP2015226541A (ja) | 2015-12-17 |
| US20110045532A1 (en) | 2011-02-24 |
| US20170306378A1 (en) | 2017-10-26 |
| KR101812348B1 (ko) | 2017-12-26 |
| JP6039181B2 (ja) | 2016-12-07 |
| RU2012100250A (ru) | 2013-07-20 |
| CN102803484A (zh) | 2012-11-28 |
| KR20120064057A (ko) | 2012-06-18 |
| EP2441831A4 (en) | 2014-01-08 |
| EP2441831B9 (en) | 2019-03-06 |
| US9725750B2 (en) | 2017-08-08 |
| AU2010259533A1 (en) | 2012-01-19 |
| JPWO2010143698A1 (ja) | 2012-11-29 |
| US20150218610A1 (en) | 2015-08-06 |
| US10358671B2 (en) | 2019-07-23 |
| SG177247A1 (en) | 2012-02-28 |
| ES2697535T3 (es) | 2019-01-24 |
| CN106978441A (zh) | 2017-07-25 |
| BRPI1010759B1 (pt) | 2019-07-16 |
| WO2010143698A1 (ja) | 2010-12-16 |
| RU2563514C2 (ru) | 2015-09-20 |
| US9034649B2 (en) | 2015-05-19 |
| EP2441831A1 (en) | 2012-04-18 |
| AU2010259533B2 (en) | 2015-03-12 |
| TWI542686B (zh) | 2016-07-21 |
| DK2441831T3 (en) | 2018-12-03 |
| TW201103978A (en) | 2011-02-01 |
| EP2441831B1 (en) | 2018-08-22 |
| JP6152402B2 (ja) | 2017-06-21 |
| ES2697535T9 (es) | 2019-03-29 |
| CA2765242C (en) | 2019-08-27 |
| CA2765242A1 (en) | 2010-12-16 |
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