BRPI1010759A2 - processo para produção de proteína - Google Patents
processo para produção de proteínaInfo
- Publication number
- BRPI1010759A2 BRPI1010759A2 BRPI1010759A BRPI1010759A BRPI1010759A2 BR PI1010759 A2 BRPI1010759 A2 BR PI1010759A2 BR PI1010759 A BRPI1010759 A BR PI1010759A BR PI1010759 A BRPI1010759 A BR PI1010759A BR PI1010759 A2 BRPI1010759 A2 BR PI1010759A2
- Authority
- BR
- Brazil
- Prior art keywords
- protein production
- protein
- production
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—RNA viruses
- C07K16/108—Orthomyxoviridae (F), e.g. influenza virus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0681—Cells of the genital tract; Non-germinal cells from gonads
- C12N5/0682—Cells of the female genital tract, e.g. endometrium; Non-germinal cells from ovaries, e.g. ovarian follicle cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
- C12N2015/8518—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic expressing industrially exogenous proteins, e.g. for pharmaceutical use, human insulin, blood factors, immunoglobulins, pseudoparticles
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C12N2510/02—Cells for production
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/10—Plasmid DNA
- C12N2800/106—Plasmid DNA for vertebrates
- C12N2800/107—Plasmid DNA for vertebrates for mammalian
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/90—Vectors containing a transposable element
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Virology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Reproductive Health (AREA)
- Cell Biology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Communicable Diseases (AREA)
- Pulmonology (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18613809P | 2009-06-11 | 2009-06-11 | |
| JP2009-140626 | 2009-06-11 | ||
| JP2009140626 | 2009-06-11 | ||
| US61/186,138 | 2009-06-11 | ||
| PCT/JP2010/059881 WO2010143698A1 (ja) | 2009-06-11 | 2010-06-10 | タンパク質の生産方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BRPI1010759A2 true BRPI1010759A2 (pt) | 2016-08-09 |
| BRPI1010759B1 BRPI1010759B1 (pt) | 2019-07-16 |
Family
ID=43308953
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI1010759-2A BRPI1010759B1 (pt) | 2009-06-11 | 2010-06-10 | Método para produzir uma proteína de interesse ou para obter uma suspensão de células de mamíferos capaz de produzir uma proteína de interesse, bem como vetor de expressão de proteína |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US9034649B2 (pt) |
| EP (1) | EP2441831B9 (pt) |
| JP (2) | JP6039181B2 (pt) |
| KR (1) | KR101812348B1 (pt) |
| CN (2) | CN106978441A (pt) |
| AU (1) | AU2010259533B2 (pt) |
| BR (1) | BRPI1010759B1 (pt) |
| CA (1) | CA2765242C (pt) |
| DK (1) | DK2441831T3 (pt) |
| ES (1) | ES2697535T3 (pt) |
| RU (1) | RU2563514C2 (pt) |
| SG (1) | SG177247A1 (pt) |
| TW (2) | TW201546281A (pt) |
| WO (1) | WO2010143698A1 (pt) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8598328B2 (en) * | 2006-12-13 | 2013-12-03 | National University Corporation Nagoya University | Tol1 factor transposase and DNA introduction system using the same |
| EP2441831B9 (en) * | 2009-06-11 | 2019-03-06 | Inter-University Research Institute Corporation Research Organization of Information and Systems | Process for production of protein |
| PT2653540T (pt) * | 2010-12-15 | 2018-02-27 | Kyowa Hakko Kirin Co Ltd | Processo de produção de proteínas |
| ES2656079T3 (es) * | 2010-12-15 | 2018-02-23 | Kyowa Hakko Kirin Co., Ltd. | Procedimiento para producir proteínas |
| KR20140033152A (ko) | 2011-06-20 | 2014-03-17 | 교와 핫꼬 기린 가부시키가이샤 | 항erbB3 항체 |
| EP2905290B1 (en) | 2012-10-05 | 2019-12-04 | Kyowa Kirin Co., Ltd. | Heterodimeric protein composition |
| EP3974520A1 (en) | 2013-05-14 | 2022-03-30 | Board of Regents, The University of Texas System | Human application of engineered chimeric antigen receptor (car) t-cells |
| KR102523318B1 (ko) | 2016-12-16 | 2023-04-18 | 비-모젠 바이오테크놀로지스, 인크. | 증진된 ｈＡＴ 패밀리 트랜스포존 매개 유전자 전달 및 연관된 조성물, 시스템, 및 방법 |
| US11278570B2 (en) | 2016-12-16 | 2022-03-22 | B-Mogen Biotechnologies, Inc. | Enhanced hAT family transposon-mediated gene transfer and associated compositions, systems, and methods |
| CN110914430B (zh) | 2017-07-13 | 2023-11-21 | 协和麒麟株式会社 | 抗bril抗体以及使用了该抗体的bril融合蛋白质的稳定化方法 |
| CA3070342A1 (en) | 2017-07-18 | 2019-01-24 | Kyowa Kirin Co., Ltd. | Anti-human ccr1 monoclonal antibody |
| KR102782136B1 (ko) | 2017-11-08 | 2025-03-18 | 쿄와 기린 가부시키가이샤 | CD40과 EpCAM에 결합하는 이중특이적 항체 |
| JP2021527427A (ja) | 2018-06-21 | 2021-10-14 | ビー−モーゲン・バイオテクノロジーズ，インコーポレーテッド | 強化されたｈＡＴファミリーのトランスポゾンが介在する遺伝子導入ならびに関連する組成物、システム、及び方法 |
| CN112424358B (zh) | 2018-06-26 | 2025-07-01 | 协和麒麟株式会社 | 与细胞粘附分子3结合的抗体 |
| JP7397444B2 (ja) | 2018-06-26 | 2023-12-13 | 協和キリン株式会社 | コンドロイチン硫酸プロテオグリカン－５に結合する抗体 |
| TW202028467A (zh) | 2018-09-28 | 2020-08-01 | 日商協和麒麟股份有限公司 | 抗體組合物 |
| WO2020123327A1 (en) | 2018-12-10 | 2020-06-18 | Amgen Inc. | Mutated piggybac transposase |
| WO2020138487A1 (ja) | 2018-12-28 | 2020-07-02 | 協和キリン株式会社 | ＴｆＲに結合するバイスペシフィック抗体 |
| BR112021020143A2 (pt) * | 2019-04-08 | 2021-12-14 | Dna Twopointo Inc | Integração de construções de ácidos nucleicos com células eucarióticas com uma transposase de oryzias |
| WO2020210236A1 (en) | 2019-04-08 | 2020-10-15 | Dna Twopointo Inc. | Transposition of nucleic acids into eukaryotic genomes with a transposase from heliothis |
| CN118620926A (zh) * | 2019-04-08 | 2024-09-10 | Dna2.0股份有限公司 | 使用来自螟蛾属的转座酶将核酸构建体转座入真核基因组 |
| CN110093361B (zh) * | 2019-04-17 | 2023-05-09 | 拜澳泰克(沈阳)生物医学集团有限公司 | 一种增强基因表达的增强子多肽及其应用 |
| US12466891B2 (en) | 2019-05-15 | 2025-11-11 | Kyowa Kirin Co., Ltd. | Bispecific antibody binding to CD40 and GPC3 |
| JPWO2020230899A1 (pt) | 2019-05-15 | 2020-11-19 | ||
| WO2021066167A1 (ja) | 2019-10-02 | 2021-04-08 | 国立大学法人九州大学 | ヘパリン様物質の製造方法、組換え細胞及びその製造方法 |
| TWI888487B (zh) | 2020-02-14 | 2025-07-01 | 日商協和麒麟股份有限公司 | 與ｃｄ３結合之雙特異性抗體 |
| TWI884247B (zh) | 2020-04-01 | 2025-05-21 | 日商協和麒麟股份有限公司 | 抗體組合物 |
| CN114113347B (zh) * | 2020-08-25 | 2025-06-20 | 越海百奥药业(绍兴)有限公司 | 核苷检测方法及其应用 |
| JP7551512B2 (ja) * | 2021-01-13 | 2024-09-17 | 株式会社東芝 | トランスポゼース活性測定用ベクターセット、キット、トランスポゼース活性測定方法及び細胞分離方法 |
| TW202317637A (zh) | 2021-08-26 | 2023-05-01 | 日商協和麒麟股份有限公司 | 與cd116及cd131結合之雙特異性抗體 |
| CN114045305B (zh) * | 2021-10-15 | 2023-03-24 | 深圳市深研生物科技有限公司 | 多转座子系统 |
| CA3252263A1 (en) | 2022-02-09 | 2025-07-07 | National Institutes Of Biomedical Innovation, Health And Nutrition | ANTIBODY OR FRAGMENT OF IT BINDING TO FCRL1 |
| EP4570910A1 (en) | 2022-08-10 | 2025-06-18 | Kyowa Kirin Co., Ltd. | Anti-fgf23 antibody, and fragment of said antibody |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH04504950A (ja) * | 1988-11-23 | 1992-09-03 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 位置特異的挿入ベクターおよびこれを用いた方法 |
| ATE169061T1 (de) * | 1990-10-25 | 1998-08-15 | Clague Pitman Hodgson | Methode des gentransfers mittels retrotransposons |
| JPH10299A (ja) | 1996-06-18 | 1998-01-06 | Matsushita Electric Ind Co Ltd | 誘導加熱式アイロン装置 |
| US6528624B1 (en) | 1998-04-02 | 2003-03-04 | Genentech, Inc. | Polypeptide variants |
| US6737056B1 (en) | 1999-01-15 | 2004-05-18 | Genentech, Inc. | Polypeptide variants with altered effector function |
| PT1176195E (pt) | 1999-04-09 | 2013-07-18 | Kyowa Hakko Kirin Co Ltd | Processo para controlar a actividade de uma molécula funcional sob o ponto de vista imunológico |
| EP1171588A4 (en) | 1999-04-28 | 2002-06-26 | Univ Leland Stanford Junior | VECTOR FROM THE P ELEMENT AND METHOD FOR APPLYING IT |
| GB9924721D0 (en) | 1999-10-19 | 1999-12-22 | Craig Roger | Protein production system |
| EP1293564A4 (en) * | 2000-06-08 | 2005-08-17 | Mitsubishi Pharma Corp | EXPRESSION VECTOR FOR SCREENING CELLS HIGH EXPRESSION OF RECOMBINANT PROTEINS, TRANSFORMING HIGH EXPRESSION OF A RECOMBINANT PROTEIN AND USE THEREOF |
| EP1299556A2 (en) * | 2000-07-03 | 2003-04-09 | Gala Design, Inc. | Host cells containing multiple integrating vectors |
| DK2314686T4 (da) | 2000-10-06 | 2023-08-21 | Kyowa Kirin Co Ltd | Celler, der danner antistofsammensætninger |
| US6946292B2 (en) | 2000-10-06 | 2005-09-20 | Kyowa Hakko Kogyo Co., Ltd. | Cells producing antibody compositions with increased antibody dependent cytotoxic activity |
| JP4817514B2 (ja) * | 2001-03-09 | 2011-11-16 | 協和発酵キリン株式会社 | 新規動物細胞用ベクターおよびその使用 |
| JP4364474B2 (ja) | 2002-02-15 | 2009-11-18 | 大学共同利用機関法人情報・システム研究機構 | 哺乳動物において機能的なトランスポゾン |
| US7317091B2 (en) | 2002-03-01 | 2008-01-08 | Xencor, Inc. | Optimized Fc variants |
| US20040029229A1 (en) * | 2002-05-20 | 2004-02-12 | Reeves Philip J. | High level protein expression system |
| JP3793812B2 (ja) * | 2002-08-12 | 2006-07-05 | 独立行政法人産業技術総合研究所 | 低温での組み換えタンパク質の発現に適した新規発現ベクター |
| AU2004279742A1 (en) | 2003-10-08 | 2005-04-21 | Kyowa Hakko Kirin Co., Ltd. | Fused protein composition |
| US20060141627A1 (en) | 2004-11-18 | 2006-06-29 | Stratatech Corporation | Vectors for stable gene expression |
| EP1819732A2 (en) | 2004-12-06 | 2007-08-22 | Kirin Beer Kabushiki Kaisha | Human monoclonal antibodies to influenza m2 protein and methods of making and using same |
| WO2007004642A1 (ja) * | 2005-07-05 | 2007-01-11 | Juridical Foundation The Chemo-Sero-Therapeutic Research Institute | 改変トランスポゾンベクター及びその利用方法 |
| US7923538B2 (en) | 2005-07-22 | 2011-04-12 | Kyowa Hakko Kirin Co., Ltd | Recombinant antibody composition |
| US20090298065A1 (en) | 2006-01-05 | 2009-12-03 | The John Hopkins University | Methods for Identifying Functional Noncoding Sequences |
| CN101104851A (zh) * | 2006-07-14 | 2008-01-16 | 金宁一 | 抗病毒蛋白cv-n的制备 |
| US8598328B2 (en) | 2006-12-13 | 2013-12-03 | National University Corporation Nagoya University | Tol1 factor transposase and DNA introduction system using the same |
| WO2008100424A2 (en) | 2007-02-09 | 2008-08-21 | University Of Hawaii | Animals and cells with genomic target sites for transposase-mediated transgenesis |
| ES2695999T3 (es) * | 2007-10-12 | 2019-01-11 | Hoffmann La Roche | Expresión de proteínas a partir de múltiples ácidos nucleicos |
| EP2067402A1 (en) | 2007-12-07 | 2009-06-10 | Max Delbrück Centrum für Molekulare Medizin (MDC) Berlin-Buch; | Transponson-mediated mutagenesis in spermatogonial stem cells |
| US20100311116A1 (en) | 2009-06-04 | 2010-12-09 | Excellgene Sa | Fast generation of high expression stable cell lines expressing recombinant proteins under minimal and short-term selective pressure |
| EP2441831B9 (en) * | 2009-06-11 | 2019-03-06 | Inter-University Research Institute Corporation Research Organization of Information and Systems | Process for production of protein |
-
2010
- 2010-06-10 EP EP10786229.4A patent/EP2441831B9/en active Active
- 2010-06-10 ES ES10786229T patent/ES2697535T3/es active Active
- 2010-06-10 CA CA2765242A patent/CA2765242C/en active Active
- 2010-06-10 JP JP2011518577A patent/JP6039181B2/ja active Active
- 2010-06-10 DK DK10786229.4T patent/DK2441831T3/en active
- 2010-06-10 CN CN201710099004.3A patent/CN106978441A/zh active Pending
- 2010-06-10 SG SG2011090925A patent/SG177247A1/en unknown
- 2010-06-10 WO PCT/JP2010/059881 patent/WO2010143698A1/ja not_active Ceased
- 2010-06-10 CN CN2010800260085A patent/CN102803484A/zh active Pending
- 2010-06-10 RU RU2012100250/10A patent/RU2563514C2/ru active
- 2010-06-10 AU AU2010259533A patent/AU2010259533B2/en active Active
- 2010-06-10 BR BRPI1010759-2A patent/BRPI1010759B1/pt active IP Right Grant
- 2010-06-10 KR KR1020117029471A patent/KR101812348B1/ko active Active
- 2010-06-11 TW TW104129432A patent/TW201546281A/zh unknown
- 2010-06-11 TW TW099119233A patent/TWI542686B/zh active
- 2010-06-11 US US12/813,920 patent/US9034649B2/en active Active
-
2015
- 2015-04-17 US US14/689,782 patent/US9725750B2/en active Active
- 2015-07-21 JP JP2015144268A patent/JP6152402B2/ja active Active
-
2017
- 2017-06-30 US US15/639,571 patent/US10358671B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| DK2441831T3 (en) | 2018-12-03 |
| US20110045532A1 (en) | 2011-02-24 |
| TW201546281A (zh) | 2015-12-16 |
| CA2765242A1 (en) | 2010-12-16 |
| RU2563514C2 (ru) | 2015-09-20 |
| JPWO2010143698A1 (ja) | 2012-11-29 |
| US20170306378A1 (en) | 2017-10-26 |
| US9725750B2 (en) | 2017-08-08 |
| TWI542686B (zh) | 2016-07-21 |
| US10358671B2 (en) | 2019-07-23 |
| BRPI1010759B1 (pt) | 2019-07-16 |
| EP2441831A1 (en) | 2012-04-18 |
| ES2697535T9 (es) | 2019-03-29 |
| RU2012100250A (ru) | 2013-07-20 |
| AU2010259533A1 (en) | 2012-01-19 |
| CN102803484A (zh) | 2012-11-28 |
| EP2441831B9 (en) | 2019-03-06 |
| KR101812348B1 (ko) | 2017-12-26 |
| US9034649B2 (en) | 2015-05-19 |
| CA2765242C (en) | 2019-08-27 |
| KR20120064057A (ko) | 2012-06-18 |
| JP6039181B2 (ja) | 2016-12-07 |
| CN106978441A (zh) | 2017-07-25 |
| AU2010259533B2 (en) | 2015-03-12 |
| JP2015226541A (ja) | 2015-12-17 |
| ES2697535T3 (es) | 2019-01-24 |
| EP2441831A4 (en) | 2014-01-08 |
| EP2441831B1 (en) | 2018-08-22 |
| JP6152402B2 (ja) | 2017-06-21 |
| TW201103978A (en) | 2011-02-01 |
| US20150218610A1 (en) | 2015-08-06 |
| SG177247A1 (en) | 2012-02-28 |
| WO2010143698A1 (ja) | 2010-12-16 |
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