BRPI1010920B1 - processo para a produção biológica de álcoois graxos - Google Patents

processo para a produção biológica de álcoois graxos Download PDF

Info

Publication number
BRPI1010920B1
BRPI1010920B1 BRPI1010920A BRPI1010920A BRPI1010920B1 BR PI1010920 B1 BRPI1010920 B1 BR PI1010920B1 BR PI1010920 A BRPI1010920 A BR PI1010920A BR PI1010920 A BRPI1010920 A BR PI1010920A BR PI1010920 B1 BRPI1010920 B1 BR PI1010920B1
Authority
BR
Brazil
Prior art keywords
fatty alcohols
production
organic production
long chain
fatty
Prior art date
Application number
BRPI1010920A
Other languages
English (en)
Inventor
Behrouzian Behnaz
Clark Louis
Mcdaniel Robert
Zhang Xiyun
Original Assignee
Codexis Inc
Shell Int Research
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Codexis Inc, Shell Int Research filed Critical Codexis Inc
Publication of BRPI1010920A2 publication Critical patent/BRPI1010920A2/pt
Publication of BRPI1010920B1 publication Critical patent/BRPI1010920B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1288—Transferases for other substituted phosphate groups (2.7.8)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

processo para a produção biológica de álcoois graxos a presente invenção trata de processos para a produção de alcoóis graxos de cadeia longa por células hospedeiras recombinantes que expressam um ou mais enzimas ácido carboxílico redutase heteróloga eficientes na conversão de ácidos graxos e seus derivados em alcoóis graxos de cadeia longa.
BRPI1010920A 2009-05-22 2010-05-21 processo para a produção biológica de álcoois graxos BRPI1010920B1 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US18053409P 2009-05-22 2009-05-22
PCT/US2010/035737 WO2010135624A2 (en) 2009-05-22 2010-05-21 Engineered biosynthesis of fatty alcohols

Publications (2)

Publication Number Publication Date
BRPI1010920A2 BRPI1010920A2 (pt) 2017-07-11
BRPI1010920B1 true BRPI1010920B1 (pt) 2020-04-28

Family

ID=43124998

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI1010920A BRPI1010920B1 (pt) 2009-05-22 2010-05-21 processo para a produção biológica de álcoois graxos

Country Status (4)

Country Link
US (1) US20100298612A1 (pt)
EP (1) EP2432890B1 (pt)
BR (1) BRPI1010920B1 (pt)
WO (1) WO2010135624A2 (pt)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110151526A1 (en) 2009-12-22 2011-06-23 Charles Winston Saunders Branched-Chain Fatty Acids And Biological Production Thereof
US20110166370A1 (en) 2010-01-12 2011-07-07 Charles Winston Saunders Scattered Branched-Chain Fatty Acids And Biological Production Thereof
US8372610B2 (en) * 2010-09-15 2013-02-12 Ls9, Inc. Production of odd chain fatty acid derivatives in recombinant microbial cells
US20130035513A1 (en) * 2011-01-26 2013-02-07 Ls9, Inc. Methods and compositions for enhanced production of fatty aldehydes and fatty alcohols
EP3702363A1 (en) * 2011-04-01 2020-09-02 Genomatica, Inc. Fadr overexpressing bacterial cells for improved production of fatty acids and derivatives thereof
EP2720997A1 (en) 2011-06-17 2014-04-23 Invista Technologies S.à.r.l. Use of hydrolases to increase monomer content in waste stream
WO2012177943A1 (en) 2011-06-22 2012-12-27 Genomatica, Inc. Microorganisms for producing 1,4-butanediol and methods related thereto
EP2726627A2 (en) * 2011-06-30 2014-05-07 Invista Technologies S.à.r.l. Bioconversion process for producing nylon-7, nylon-7,7 and polyesters
DE102011110945A1 (de) 2011-08-15 2013-02-21 Evonik Degussa Gmbh Biotechnologisches Syntheseverfahren von organischen Verbindungen mit alkIL-Genprodukt
DE102011110946A1 (de) 2011-08-15 2016-01-21 Evonik Degussa Gmbh Biotechnologisches Syntheseverfahren von omegafunktionalisierten Carbonsäuren und Carbonsäure-Estern aus einfachen Kohlenstoffquellen
EP2753701B1 (en) 2011-09-27 2018-05-02 ExxonMobil Research and Engineering Company Acyl-acp wax ester synthases
US9102960B2 (en) 2011-12-16 2015-08-11 Invista North America S.á.r.l. Methods of producing 6-carbon chemicals via CoA-dependent carbon chain elongation associated with carbon storage
US9102958B2 (en) 2011-12-16 2015-08-11 Invista North America S.á.r.l. Methods of producing 6-carbon chemicals via CoA-dependent carbon chain elongation associated with carbon storage
ES2795842T3 (es) 2012-02-24 2020-11-24 Exxonmobil Res & Eng Co Producción mejorada de ácidos grasos y derivados de ácidos grasos por microorganismos recombinantes
US9096834B2 (en) 2012-02-24 2015-08-04 Exxonmobil Research And Engineering Company Recombinant microorganisms comprising thioesterase and lysophosphatidic acid acyltransferase genes for fatty acid production
US8962299B2 (en) 2012-02-29 2015-02-24 Exxonmobil Research And Engineering Company Four-gene pathway for wax ester synthesis
CN104704113B (zh) * 2012-04-02 2018-01-23 Reg生命科学有限责任公司 Car酶及脂肪醇的改良生产
US9181568B2 (en) 2012-04-23 2015-11-10 Exxonmobil Research And Engineering Company Cell systems and methods for improving fatty acid synthesis by expression of dehydrogenases
KR20210118216A (ko) 2012-10-15 2021-09-29 게노마티카 인코포레이티드 특정 길이의 지방 알콜 및 관련 화합물의 생산을 위한 미생물 및 방법
DK2917358T3 (da) 2012-11-09 2019-09-30 Calysta Inc Sammensætninger og fremgangsmåder til biologisk fremstilling af fedtsyrederivater
US9790525B2 (en) 2012-12-14 2017-10-17 Invista North America S.A.R.L. Methods of producing 7-carbon chemicals via CoA-dependent carbon chain elongation associated with carbon storage
EP2746397A1 (de) * 2012-12-21 2014-06-25 Evonik Industries AG Herstellung von Omega-Aminofettsäuren
EP2746400A1 (de) * 2012-12-21 2014-06-25 Evonik Industries AG Herstellung von Aminen und Diaminen aus einer Carbonsäure oder Dicarbonsäure oder eines Monoesters davon
CN105073214A (zh) 2012-12-31 2015-11-18 英威达技术有限责任公司 通过甲酯保护的碳链延伸生产6碳化学物的方法
EP2938736A2 (en) 2012-12-31 2015-11-04 Invista Technologies S.A R.L. Methods of producing 7-carbon chemicals via c1 carbon chain elongation associated with coenzyme b synthesis
WO2014105797A2 (en) 2012-12-31 2014-07-03 Invista North America S.A.R.L. Methods of producing 7-carbon chemicals via pyruvate and succinate semialdehyde aldol condensation
WO2014105793A1 (en) 2012-12-31 2014-07-03 Invista North America S.A.R.L. Methods of producing 7-carbon chemicals from long chain fatty acids via oxidative cleavage
EP2938734A2 (en) 2012-12-31 2015-11-04 Invista Technologies S.A R.L. Methods of producing 7-carbon chemicals via aromatic compounds
EP2938731A2 (en) 2012-12-31 2015-11-04 Invista Technologies S.A R.L. Methods of producing 7-carbon chemicals via carbon chain elongation associated with cyclohexane carboxylate synthesis
CN105408487A (zh) 2012-12-31 2016-03-16 英威达技术有限责任公司 通过甲酯保护的碳链延伸生产7碳化学物的方法
KR101746040B1 (ko) 2013-01-16 2017-06-13 알이지 라이프 사이언시스, 엘엘씨 개선된 특성들을 갖는 아실-ａｃｐ 레덕타아제
US9850512B2 (en) 2013-03-15 2017-12-26 The Research Foundation For The State University Of New York Hydrolysis of cellulosic fines in primary clarified sludge of paper mills and the addition of a surfactant to increase the yield
US10119145B2 (en) 2013-03-15 2018-11-06 Consejo Nacional De Investigaciones Cientificas Y Tecnicas (Conicet) Engineered organisms for production of novel lipids
JP6486372B2 (ja) 2013-09-13 2019-03-20 アールイージー ライフ サイエンシズ リミテッド ライアビリティ カンパニー 改善されたアセチル−ＣｏＡカルボキシラーゼ変種
US20160376600A1 (en) 2013-11-25 2016-12-29 Genomatica, Inc. Methods for enhancing microbial production of specific length fatty alcohols in the presence of methanol
US9951363B2 (en) 2014-03-14 2018-04-24 The Research Foundation for the State University of New York College of Environmental Science and Forestry Enzymatic hydrolysis of old corrugated cardboard (OCC) fines from recycled linerboard mill waste rejects
US9957535B2 (en) 2014-06-16 2018-05-01 Invista North America S.A.R.L. Methods, reagents and cells for biosynthesizing compounds
US9988654B2 (en) 2014-06-16 2018-06-05 Invista North America S.A.R.L. Methods, reagents and cells for biosynthesizing compounds
CN106795535A (zh) 2014-06-16 2017-05-31 英威达技术有限责任公司 用于生物合成化合物的方法，试剂和细胞
US20170152531A1 (en) 2014-06-16 2017-06-01 North America S.A.R.L. Process for producing glutarate and glutaric acid methyl ester
KR20170029625A (ko) * 2014-07-18 2017-03-15 알이지 라이프 사이언시스, 엘엘씨 지방 디올의 미생물 생산
US11352601B2 (en) 2017-07-27 2022-06-07 University Of Florida Research Foundation, Incorporated Cyanobacterial hosts and methods for producing chemicals
US20240229086A1 (en) * 2021-03-29 2024-07-11 Genomatica, Inc. Production Of Non-Native Monounsaturated Fatty Acids In Bacteria
CN116162559A (zh) * 2022-12-14 2023-05-26 南京师范大学 一种利用重组解脂耶氏酵母合成对羟基苯甲醇的方法
KR20250098104A (ko) * 2023-12-21 2025-07-01 대상 주식회사 1,4-부탄디올 생산능이 향상된 변이 미생물 및 이를 이용한 1,4-부탄디올의 생산 방법

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN163393B (pt) 1983-10-06 1988-09-17 Pfizer
US5071764A (en) 1983-10-06 1991-12-10 Pfizer Inc. Process for integrative transformation of yarrowia lipolytica
US4889741A (en) 1987-04-13 1989-12-26 Cornell Research Foundation, Inc. Processed egg product
WO1995033836A1 (en) 1994-06-03 1995-12-14 Novo Nordisk Biotech, Inc. Phosphonyldipeptides useful in the treatment of cardiovascular diseases
ATE294871T1 (de) 1994-06-30 2005-05-15 Novozymes Biotech Inc Nicht-toxisches, nicht-toxigenes, nicht- pathogenes fusarium expressionssystem und darin zu verwendende promotoren und terminatoren
AU727348B2 (en) * 1995-10-13 2000-12-14 President And Fellows Of Harvard College Phosphopantetheinyl transferases and uses thereof
US5795759A (en) * 1997-03-10 1998-08-18 The University Of Iowa Research Foundation Carboxylic acid reductase, and methods of using same
US7074559B2 (en) * 2002-03-06 2006-07-11 Refents of the University of Minnesota Mycobacterial diagnostics
US7056714B2 (en) * 2003-03-11 2006-06-06 University Of Iowa Research Foundation, Inc. Carboxylic acid reductase polypeptide, nucleotide sequence encoding same and methods of use
EP1654354A1 (en) 2003-08-11 2006-05-10 Codexis, Inc. Improved ketoreductase polypeptides and related polynucleotides
WO2007142784A1 (en) * 2006-05-31 2007-12-13 Archer-Daniels-Midland Company Enzymatic method of making aldehydes from fatty acids
US7879585B2 (en) 2006-10-02 2011-02-01 Codexis, Inc. Ketoreductase enzymes and uses thereof
CN101627116B (zh) 2007-02-08 2013-07-10 科德克希思公司 酮还原酶及其用途
JP2012504963A (ja) * 2008-10-07 2012-03-01 エルエス９・インコーポレイテッド 脂肪アルデヒドを生産するための方法および組成物
KR101700296B1 (ko) 2008-10-28 2017-01-26 알이지 라이프 사이언시스, 엘엘씨 지방족 알코올들을 생산하기 위한 방법들과 조성물들

Also Published As

Publication number Publication date
EP2432890A4 (en) 2012-11-21
WO2010135624A3 (en) 2011-01-13
EP2432890B1 (en) 2015-09-02
US20100298612A1 (en) 2010-11-25
WO2010135624A2 (en) 2010-11-25
BRPI1010920A2 (pt) 2017-07-11
EP2432890A2 (en) 2012-03-28

Similar Documents

Publication Publication Date Title
BRPI1010920B1 (pt) processo para a produção biológica de álcoois graxos
AR115692A2 (es) Método para la producción de promotores constitutivos de plantas, constructos y células transgénicas
BR112012021933A2 (pt) método para processamento de soluções de peroxigênio.
BR112013031422A2 (pt) métodos para converter material lignocelulósico em produtos úteis
BR112014014652A2 (pt) microrganismos modificados e métodos de fazer butadieno usando os mesmos
BR112012000486A2 (pt) método e sistema para processar uma biomassa para produzir biocombustíveis e outros produtos.
BR112013018857A2 (pt) processo para a produção dos ésteres de álcool dos ácidos graxos e composição do processo de fermentação do álcool
CR20110241A (es) Método para inducir pluripotencia en células
BR112012022006A2 (pt) um processo para a síntese enzimática de alquil ésteres de ácido graxo
BR112012015727A2 (pt) diferenciacao de celulas-tronco embrionarias humanas
AR079821A1 (es) Cepas y metodo para la produccion de metionina
CO7170148A2 (es) Enzimas car novedosas y producción mejorada de alcoholes grasos
CL2011003281A1 (es) Composición y procedimientos para desinfectar, destruir o inhibir un microorganismo patógeno que consiste en aplicar la composición que comprende sulfato de 2-etilexilo o una sal del mismo, un ácido alquil-bencenosulfónico, naoh o koh, y un portador; procedimientos que emplean dicha composición para limpiar superficies.
BR112016029033A2 (pt) processo para a produção de ésteres de éter glicólico com baixo teor de voc
BR112015025767A2 (pt) composição e método para decompor polietileno
BR112014014151A2 (pt) células fúngicas e processos de fermentação
BR112014001371A2 (pt) fermentação de glicerol para ácidos orgânicos
BR112013010169A8 (pt) uso de monascus na produção de ácido orgânico.
BR112014003600A2 (pt) Polipeptídeo transportador de sacarose variante, bactéria e processo para produção de glicerol, 1,3-propanodiol e/ou ácido 3- hidroxipropiônico
BRPI1013673A2 (pt) Microorganismo que produz l-amiácido e método para a produção de l-aminoácido usando o mesmo
AR100382A1 (es) Método para producir nailon
BR112014004290A2 (pt) processos enzimáticos de transesterificação/esterificação empregando lipases imobilizadas em resinas hidrofóbicas na presença de soluções aquosas
BRPI0922484A2 (pt) Cultura de célula de planta para produção de produtos naturais com contaminação de glucosinolato reduzida
BRPI1009227A2 (pt) Microorganismos que produz l-aminoácido e método para a produção de l-aminoácido com o uso do mesmo.
BR112012009461A2 (pt) processo hidrotermico (htp) de crescimento de algas em uma corrente de esgoto htp

Legal Events

Date Code Title Description
B25A Requested transfer of rights approved

Owner name: SHELL INTERNATIONALE RESEARCH MAATSCHAPPIJ B.V. (N

Owner name: SHELL INTERNATIONALE RESEARCH MAATSCHAPPIJ B.V. (NL)

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06T Formal requirements before examination [chapter 6.20 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 21/05/2010, OBSERVADAS AS CONDICOES LEGAIS.