BRPI1011195A2 - Biblioteca de polipeptpideos sintéticos e métodos para geração de variantes diversificadas de polipeptídeo - Google Patents
Biblioteca de polipeptpideos sintéticos e métodos para geração de variantes diversificadas de polipeptídeoInfo
- Publication number
- BRPI1011195A2 BRPI1011195A2 BRPI1011195A BRPI1011195A BRPI1011195A2 BR PI1011195 A2 BRPI1011195 A2 BR PI1011195A2 BR PI1011195 A BRPI1011195 A BR PI1011195A BR PI1011195 A BRPI1011195 A BR PI1011195A BR PI1011195 A2 BRPI1011195 A2 BR PI1011195A2
- Authority
- BR
- Brazil
- Prior art keywords
- polypeptipids
- library
- synthetic
- methods
- polypeptide variants
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/005—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/66—General methods for inserting a gene into a vector to form a recombinant vector using cleavage and ligation; Use of non-functional linkers or adaptors, e.g. linkers containing the sequence for a restriction endonuclease
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
- C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
- C40B40/08—Libraries containing RNA or DNA which encodes proteins, e.g. gene libraries
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
- C40B50/06—Biochemical methods, e.g. using enzymes or whole viable microorganisms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Virology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Crystallography & Structural Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17985009P | 2009-05-20 | 2009-05-20 | |
| US61/179.850 | 2009-05-20 | ||
| US28733609P | 2009-12-17 | 2009-12-17 | |
| US61/287.336 | 2009-12-17 | ||
| US31479410P | 2010-03-17 | 2010-03-17 | |
| US61/314.794 | 2010-03-17 | ||
| PCT/US2010/035619 WO2010135558A1 (en) | 2009-05-20 | 2010-05-20 | Systhetic polypeptide libraries and methods for generating naturally diversified polypeptide variants |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BRPI1011195A2 true BRPI1011195A2 (pt) | 2018-12-11 |
| BRPI1011195B1 BRPI1011195B1 (pt) | 2020-10-13 |
Family
ID=42561627
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI1011195-6A BRPI1011195B1 (pt) | 2009-05-20 | 2010-05-20 | métodos para produzir uma coleção de ácidos nucleicos |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US8921281B2 (pt) |
| EP (1) | EP2432878B2 (pt) |
| JP (1) | JP5797642B2 (pt) |
| CN (1) | CN102459591B (pt) |
| AU (1) | AU2010249470B2 (pt) |
| BR (1) | BRPI1011195B1 (pt) |
| CA (1) | CA2762837C (pt) |
| ES (1) | ES2545792T5 (pt) |
| MX (1) | MX2011012299A (pt) |
| RU (1) | RU2562163C2 (pt) |
| WO (1) | WO2010135558A1 (pt) |
Families Citing this family (36)
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| US9834615B2 (en) | 2010-08-16 | 2017-12-05 | Novimmune Sa | Methods for the generation of multispecific and multivalent antibodies |
| ES2682254T3 (es) | 2011-08-18 | 2018-09-19 | Affinity Biosciences Pty Ltd | Polipéptidos solubles |
| CA2853011C (en) | 2011-10-19 | 2022-09-06 | Novimmune S.A. | Methods of purifying antibodies |
| CA2879834A1 (en) * | 2012-08-31 | 2014-03-06 | arGEN-X BV | Highly diverse combinatorial antibody libraries |
| EP2925782B1 (en) | 2012-12-03 | 2020-01-22 | NovImmune SA | Anti-cd47 antibodies and methods of use thereof |
| US9487773B2 (en) * | 2013-03-01 | 2016-11-08 | Technophage, Investigacao E Desenvolvimento Em Biotecnologia, Sa | Cell-based methods for coupling protein interactions and binding molecule selection |
| EP3126384B1 (en) * | 2014-04-01 | 2020-12-02 | Adimab, LLC | Multispecific antibody analogs comprising a common light chain, and methods of their preparation and use |
| GB201420852D0 (en) | 2014-11-24 | 2015-01-07 | Genevillage Kft | Method |
| CN114249831A (zh) | 2015-03-13 | 2022-03-29 | 诺夫免疫股份有限公司 | 纯化双特异性抗体的方法 |
| EP3288973B1 (en) * | 2015-04-30 | 2021-10-20 | AbCheck s.r.o. | Method for mass humanization of rabbit antibodies |
| EP3277810B8 (en) * | 2016-01-08 | 2020-07-15 | Maxion Therapeutics Limited | Binding members with altered diversity scaffold domains |
| AU2017353936A1 (en) | 2016-11-04 | 2019-05-02 | Novimmune Sa | Anti-CD19 antibodies and methods of use thereof |
| EP3630167A1 (en) | 2017-05-26 | 2020-04-08 | NovImmune SA | Anti-cd47 x anti-mesothelin antibodies and methods of use thereof |
| GB201711208D0 (en) | 2017-07-12 | 2017-08-23 | Iontas Ltd | Ion channel inhibitors |
| CN112334484A (zh) | 2018-03-14 | 2021-02-05 | 诺维莫尼公司 | 抗-CD3ε抗体及其应用方法 |
| CA3094318A1 (en) | 2018-03-30 | 2019-10-03 | Merus N.V. | Multivalent antibody |
| KR102115300B1 (ko) * | 2018-06-01 | 2020-05-26 | 재단법인 목암생명과학연구소 | 항체 라이브러리 및 이를 이용한 항체 스크리닝 방법 |
| WO2020114614A1 (en) | 2018-12-07 | 2020-06-11 | Baxalta GmbH | Proteinaceous molecules binding factor ixa and factor x |
| TW202039583A (zh) | 2018-12-07 | 2020-11-01 | 瑞士商巴克斯歐塔有限公司 | 結合因子IXa及因子X的蛋白分子 |
| WO2020115283A1 (en) | 2018-12-07 | 2020-06-11 | Baxalta GmbH | Bispecific antibodies binding factor ixa and factor x |
| WO2020114615A1 (en) | 2018-12-07 | 2020-06-11 | Baxalta GmbH | Bispecific antibodies binding factor ixa and factor x |
| AR117741A1 (es) | 2018-12-31 | 2021-08-25 | Merus Nv | Dominios de unión mixtos |
| US20230348902A1 (en) * | 2020-08-10 | 2023-11-02 | Integral Molecular, Inc. | Methods and compositions for making antibody libraries and antibodies isolated from the same |
| CN114539422B (zh) * | 2020-11-25 | 2024-03-29 | 安升（上海）医药科技有限公司 | 核酸多聚化介导的多价蛋白药物和疫苗的构建方法及应用 |
| JP2024511137A (ja) | 2021-03-22 | 2024-03-12 | ノビミューン エスアー | Ｃｄ４７およびｐｄ－ｌ１を標的とする二重特異性抗体ならびにその使用方法 |
| CA3212599A1 (en) | 2021-03-22 | 2022-09-29 | Novimmune S.A. | Bispecific antibodies targeting cd47 and pd-l1 and methods of use thereof |
| JP2025509702A (ja) | 2022-03-14 | 2025-04-11 | ラムキャップ バイオ ガンマ エージー | ＧＰＣ３陽性悪性細胞を標的殺傷するための二重特異性ＧＰＣ３ｘＣＤ２８抗体およびＧＰＣ３ｘＣＤ３抗体ならびにそれらの組み合わせ |
| CN119562970A (zh) | 2022-03-18 | 2025-03-04 | 进化免疫治疗公司 | 双特异性抗体融合分子及其使用方法 |
| CN114775065B (zh) * | 2022-04-22 | 2026-01-06 | 武汉华美生物工程有限公司 | 一种半合成纳米抗体库构建方法和纳米抗体库 |
| WO2024084052A1 (en) | 2022-10-21 | 2024-04-25 | Novimmune Sa | Pd-l1xcd28 bispecific antibodies for immune checkpoint-dependent t cell activation |
| WO2024173607A2 (en) | 2023-02-14 | 2024-08-22 | Evolveimmune Therapeutics, Inc. | Combination of bispecific antibodies and chimeric antigen receptor t cells for treatment |
| WO2025059037A1 (en) | 2023-09-11 | 2025-03-20 | Evolveimmune Therapeutics, Inc. | Bispecific antibody fusion molecules targeting b7-h4 and cd3 and methods of use thereof |
| WO2025064885A1 (en) | 2023-09-20 | 2025-03-27 | Evolveimmune Therapeutics, Inc. | Multispecific antibodies that bind cd3 and cd2 and methods of use thereof |
| AU2024346729A1 (en) | 2023-09-20 | 2026-03-19 | Evolveimmune Therapeutics, Inc. | Bispecific antibody fusion molecules targeting cd180 and cd3 and methods of use thereof |
| WO2025114357A1 (en) | 2023-11-28 | 2025-06-05 | Novimmune Sa | Method of treating disease using anti-cd47 x anti-mesothelin antibodies as a sole agent and in combination with anti-pd-1 antibodies |
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| US20040038304A1 (en) | 2002-03-28 | 2004-02-26 | Gala Design, Inc. | Antibody libraries |
| US7135310B2 (en) * | 2002-04-24 | 2006-11-14 | The Regents Of The University Of California | Method to amplify variable sequences without imposing primer sequences |
| WO2004073319A2 (en) * | 2003-02-14 | 2004-08-26 | Anosys, Inc. | Methods and compounds for raising antibodies and for screening antibody repertoires |
| US7981843B2 (en) * | 2004-01-20 | 2011-07-19 | Kalobios Pharmaceuticals, Inc. | Antibody specificity transfer using minimal essential binding determinants |
| DK3540062T3 (da) * | 2004-11-16 | 2021-06-28 | Humanigen Inc | Immunoglobulin-variabel region kassetteudskiftning |
| ES2384006T3 (es) * | 2007-03-15 | 2012-06-28 | Inserm | Métodos para producir anticuerpos scFv activos y bibliotecas para los mismos |
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2010
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- 2010-05-20 JP JP2012512040A patent/JP5797642B2/ja active Active
- 2010-05-20 AU AU2010249470A patent/AU2010249470B2/en active Active
- 2010-05-20 ES ES10731846T patent/ES2545792T5/es active Active
- 2010-05-20 US US12/784,190 patent/US8921281B2/en active Active
- 2010-05-20 RU RU2011151974/10A patent/RU2562163C2/ru active
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2014
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| Publication number | Publication date |
|---|---|
| JP5797642B2 (ja) | 2015-10-21 |
| ES2545792T3 (es) | 2015-09-15 |
| AU2010249470A1 (en) | 2011-12-15 |
| EP2432878B2 (en) | 2018-05-16 |
| US20150119294A1 (en) | 2015-04-30 |
| WO2010135558A1 (en) | 2010-11-25 |
| BRPI1011195B1 (pt) | 2020-10-13 |
| CN102459591A (zh) | 2012-05-16 |
| AU2010249470B2 (en) | 2015-06-25 |
| RU2011151974A (ru) | 2013-06-27 |
| CA2762837A1 (en) | 2011-11-25 |
| EP2432878A1 (en) | 2012-03-28 |
| US8921281B2 (en) | 2014-12-30 |
| US20110065610A1 (en) | 2011-03-17 |
| CA2762837C (en) | 2021-08-03 |
| JP2012527246A (ja) | 2012-11-08 |
| RU2562163C2 (ru) | 2015-09-10 |
| MX2011012299A (es) | 2012-03-29 |
| ES2545792T5 (es) | 2018-09-14 |
| CN102459591B (zh) | 2015-05-13 |
| EP2432878B1 (en) | 2015-05-20 |
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