BRPI1011683A2 - derivado isoquinolina substituída - Google Patents
derivado isoquinolina substituídaInfo
- Publication number
- BRPI1011683A2 BRPI1011683A2 BRPI1011683A BRPI1011683A BRPI1011683A2 BR PI1011683 A2 BRPI1011683 A2 BR PI1011683A2 BR PI1011683 A BRPI1011683 A BR PI1011683A BR PI1011683 A BRPI1011683 A BR PI1011683A BR PI1011683 A2 BRPI1011683 A2 BR PI1011683A2
- Authority
- BR
- Brazil
- Prior art keywords
- isoquinoline derivative
- substituted isoquinoline
- substituted
- derivative
- isoquinoline
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Ophthalmology & Optometry (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychiatry (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2009146040 | 2009-06-19 | ||
| JP2009-146040 | 2009-06-19 | ||
| PCT/JP2010/004101 WO2010146881A1 (ja) | 2009-06-19 | 2010-06-18 | 置換されたイソキノリン誘導体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BRPI1011683A2 true BRPI1011683A2 (pt) | 2016-03-22 |
| BRPI1011683B1 BRPI1011683B1 (pt) | 2020-10-20 |
| BRPI1011683B8 BRPI1011683B8 (pt) | 2021-05-25 |
Family
ID=43356211
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI1011683A BRPI1011683B8 (pt) | 2009-06-19 | 2010-06-18 | derivados de isoquinolina substituída, suas composições farmacêuticas e seus usos |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US8951997B2 (pt) |
| EP (1) | EP2444395B1 (pt) |
| JP (1) | JP4915010B2 (pt) |
| KR (1) | KR101732907B1 (pt) |
| CN (1) | CN102448941B (pt) |
| AU (1) | AU2010261206B2 (pt) |
| BR (1) | BRPI1011683B8 (pt) |
| CA (1) | CA2764124C (pt) |
| CY (1) | CY1117157T1 (pt) |
| DK (1) | DK2444395T3 (pt) |
| EA (1) | EA019523B1 (pt) |
| ES (1) | ES2560603T3 (pt) |
| HR (1) | HRP20160096T1 (pt) |
| HU (1) | HUE028684T2 (pt) |
| MX (1) | MX2011013857A (pt) |
| NZ (1) | NZ596615A (pt) |
| PL (1) | PL2444395T3 (pt) |
| TW (1) | TWI527798B (pt) |
| WO (1) | WO2010146881A1 (pt) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8455513B2 (en) | 2007-01-10 | 2013-06-04 | Aerie Pharmaceuticals, Inc. | 6-aminoisoquinoline compounds |
| US8450344B2 (en) | 2008-07-25 | 2013-05-28 | Aerie Pharmaceuticals, Inc. | Beta- and gamma-amino-isoquinoline amide compounds and substituted benzamide compounds |
| EP3828172A1 (en) | 2009-05-01 | 2021-06-02 | Aerie Pharmaceuticals, Inc. | Dual mechanism inhibitors for the treatment of disease |
| US8883792B2 (en) | 2010-12-22 | 2014-11-11 | D. Western Therapeutics Institute, Inc. | Substituted isoquinoline derivative |
| JP2013035802A (ja) * | 2011-08-10 | 2013-02-21 | D Western Therapeutics Institute Inc | 緑内障又は高眼圧症の予防又は治療剤 |
| ES2852377T3 (es) | 2013-03-15 | 2021-09-13 | Aerie Pharmaceuticals Inc | Sales dimesilato de 4-(3-amino-1-(isoquinolin-6-ilamino)-1-oxopropan-2-il)bencilo, sus combinaciones con prostaglandinas y el uso de las mismas en el tratamiento de trastornos oculares |
| JP5557408B1 (ja) * | 2013-04-24 | 2014-07-23 | 国立大学法人九州大学 | 眼底疾患治療剤 |
| CN105085478B (zh) * | 2014-04-28 | 2019-04-12 | 南京明德新药研发股份有限公司 | 异喹啉磺胺衍生物及其药物组合物和制药用途 |
| CN105906609A (zh) * | 2016-05-19 | 2016-08-31 | 武昌理工学院 | 一种1，4-二氮杂环庚烷衍生物的制备方法 |
| KR102568079B1 (ko) | 2016-08-31 | 2023-08-17 | 에어리 파마슈티컬즈, 인코포레이티드 | 안과용 조성물 |
| BR112019003557A2 (pt) | 2016-08-31 | 2019-05-21 | Jiangsu Hengrui Medicine Co., Ltd. | derivados de oxopicolinamida, método de preparação dos mesmos e uso farmacêutico dos mesmos |
| US9840468B1 (en) | 2016-12-30 | 2017-12-12 | Aerie Pharmaceuticals, Inc. | Methods for the preparation of 6-aminoisoquinoline |
| AU2018243687C1 (en) | 2017-03-31 | 2020-12-24 | Alcon Inc. | Aryl cyclopropyl-amino-isoquinolinyl amide compounds |
| CN109134433B (zh) * | 2017-06-16 | 2021-05-25 | 成都先导药物开发股份有限公司 | 一种抑制rock的化合物及其应用 |
| CN108929270B (zh) * | 2018-08-15 | 2021-06-08 | 上海罕道医药科技有限公司 | 一种药物中间体双取代含氮杂环的胺类化合物的合成 |
| CA3112391A1 (en) | 2018-09-14 | 2020-03-19 | Aerie Pharmaceuticals, Inc. | Aryl cyclopropyl-amino-isoquinolinyl amide compounds |
| KR102811620B1 (ko) * | 2018-11-01 | 2025-05-22 | 가부시키가이샤 디. 웨스턴 세라퓨틱스 겡큐쇼 | 1,4-디아조칸 화합물 또는 이의 염 |
| JP7792670B2 (ja) * | 2018-12-18 | 2025-12-26 | 株式会社デ・ウエスタン・セラピテクス研究所 | イソキノリンスルホニルクロリド酸付加塩及びその製造方法 |
| AU2021331624A1 (en) * | 2020-08-31 | 2023-05-04 | Visus Therapeutics, Inc. | Compounds and formulations for treating ophthalmic diseases |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4456757A (en) | 1981-03-20 | 1984-06-26 | Asahi Kasei Kogyo Kabushiki Kaisha | Isoquinolinesulfonyl derivatives and process for the preparation thereof |
| JPS5993054A (ja) | 1982-11-18 | 1984-05-29 | Asahi Chem Ind Co Ltd | イソキノリンスルホン酸アミド誘導体 |
| US4678783B1 (en) | 1983-11-04 | 1995-04-04 | Asahi Chemical Ind | Substituted isoquinolinesulfonyl compounds |
| JPH0667926B2 (ja) | 1985-11-12 | 1994-08-31 | 旭化成工業株式会社 | 環状のイソキノリンスルホンアミド誘導体 |
| JPH0215067A (ja) | 1988-07-04 | 1990-01-18 | Hokuriku Seiyaku Co Ltd | イソキノリンスルホンアミド誘導体 |
| US5216150A (en) | 1988-12-26 | 1993-06-01 | Hiroyoshi Hidaka | Derivatives of isoquinoline (and naphthalene) sulfonamides |
| US5245034A (en) | 1988-12-26 | 1993-09-14 | Kiroyoshi Hidaka | Compound having vessel smooth muscle relaxation activity |
| JPH069402A (ja) | 1991-05-15 | 1994-01-18 | Hiroyoshi Hidaka | 抗潰瘍剤 |
| ES2205166T3 (es) | 1996-02-02 | 2004-05-01 | D. Western Therapeutics Institute | Derivados de isoquinolina y medicamento. |
| EP1395257A1 (en) * | 2001-06-12 | 2004-03-10 | Elan Pharmaceuticals, Inc. | Macrocycles useful in the treatment of alzheimer's disease |
| CA2556589A1 (en) * | 2004-02-24 | 2005-09-01 | Bioaxone Therapeutique Inc. | 4-substituted piperidine derivatives |
| US20050272723A1 (en) | 2004-04-27 | 2005-12-08 | The Regents Of The University Of Michigan | Methods and compositions for treating diseases and conditions associated with mitochondrial function |
| US7517991B2 (en) | 2004-10-12 | 2009-04-14 | Bristol-Myers Squibb Company | N-sulfonylpiperidine cannabinoid receptor 1 antagonists |
| WO2006115247A1 (ja) | 2005-04-25 | 2006-11-02 | D. Western Therapeutics Institute, Inc. | 高選択的Ｒｈｏキナーゼ阻害剤 |
| WO2006115244A1 (ja) | 2005-04-25 | 2006-11-02 | D. Western Therapeutics Institute, Inc. | ４－ブロモイソキノリン誘導体及びこれを含有する医薬 |
| CA2621181C (en) | 2005-08-30 | 2011-04-19 | Asahi Kasei Pharma Corporation | 5-isoquinolinesulfonamide compounds |
| US20080064681A1 (en) | 2006-09-11 | 2008-03-13 | Hiroyoshi Hidaka | Therapeutic agent for treating glaucoma |
| PT2125744E (pt) | 2006-12-27 | 2011-07-01 | Sanofi Aventis | Derivados de isoquinolona e isoquinolinona substituídos com cicloalquilamina |
| MX2009005964A (es) | 2006-12-27 | 2009-06-15 | Sanofi Aventis | Derivados de isoquinolina sustituidos con cicloalquilamina. |
| AU2008220104B2 (en) | 2007-02-28 | 2012-09-27 | Asahi Kasei Pharma Corporation | Sulfonamide derivative |
-
2010
- 2010-06-18 BR BRPI1011683A patent/BRPI1011683B8/pt active IP Right Grant
- 2010-06-18 PL PL10789260T patent/PL2444395T3/pl unknown
- 2010-06-18 HU HUE10789260A patent/HUE028684T2/en unknown
- 2010-06-18 CN CN201080023516.8A patent/CN102448941B/zh active Active
- 2010-06-18 WO PCT/JP2010/004101 patent/WO2010146881A1/ja not_active Ceased
- 2010-06-18 US US13/265,246 patent/US8951997B2/en active Active
- 2010-06-18 AU AU2010261206A patent/AU2010261206B2/en active Active
- 2010-06-18 KR KR1020117028931A patent/KR101732907B1/ko active Active
- 2010-06-18 MX MX2011013857A patent/MX2011013857A/es active IP Right Grant
- 2010-06-18 JP JP2011519583A patent/JP4915010B2/ja active Active
- 2010-06-18 HR HRP20160096TT patent/HRP20160096T1/hr unknown
- 2010-06-18 EA EA201171328A patent/EA019523B1/ru unknown
- 2010-06-18 ES ES10789260.6T patent/ES2560603T3/es active Active
- 2010-06-18 TW TW099120004A patent/TWI527798B/zh active
- 2010-06-18 CA CA2764124A patent/CA2764124C/en active Active
- 2010-06-18 NZ NZ596615A patent/NZ596615A/xx unknown
- 2010-06-18 EP EP10789260.6A patent/EP2444395B1/en active Active
- 2010-06-18 DK DK10789260.6T patent/DK2444395T3/en active
-
2016
- 2016-01-21 CY CY20161100066T patent/CY1117157T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL2444395T3 (pl) | 2016-06-30 |
| CN102448941B (zh) | 2016-04-06 |
| AU2010261206A1 (en) | 2011-12-15 |
| TW201100385A (en) | 2011-01-01 |
| KR101732907B1 (ko) | 2017-05-08 |
| EP2444395A4 (en) | 2012-11-28 |
| JP4915010B2 (ja) | 2012-04-11 |
| HUE028684T2 (en) | 2016-12-28 |
| HRP20160096T1 (hr) | 2016-02-26 |
| DK2444395T3 (en) | 2016-03-14 |
| CA2764124A1 (en) | 2010-12-23 |
| WO2010146881A1 (ja) | 2010-12-23 |
| BRPI1011683B1 (pt) | 2020-10-20 |
| EA201171328A1 (ru) | 2012-05-30 |
| EA019523B1 (ru) | 2014-04-30 |
| JPWO2010146881A1 (ja) | 2012-12-06 |
| CN102448941A (zh) | 2012-05-09 |
| EP2444395A1 (en) | 2012-04-25 |
| AU2010261206B2 (en) | 2015-10-08 |
| US8951997B2 (en) | 2015-02-10 |
| EP2444395B1 (en) | 2016-01-06 |
| US20120035159A1 (en) | 2012-02-09 |
| NZ596615A (en) | 2013-07-26 |
| KR20120069609A (ko) | 2012-06-28 |
| TWI527798B (zh) | 2016-04-01 |
| BRPI1011683B8 (pt) | 2021-05-25 |
| CY1117157T1 (el) | 2017-04-05 |
| ES2560603T3 (es) | 2016-02-22 |
| CA2764124C (en) | 2016-12-13 |
| MX2011013857A (es) | 2012-01-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07E | Notice of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
| B06T | Formal requirements before examination [chapter 6.20 patent gazette] | ||
| B06A | Notification to applicant to reply to the report for non-patentability or inadequacy of the application [chapter 6.1 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 20/10/2020, OBSERVADAS AS CONDICOES LEGAIS. |
|
| B16C | Correction of notification of the grant |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 18/06/2010 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF |