BRPI1011725A2 - método e sistema para direcionar uma resposta biológica localizada em um implante - Google Patents

método e sistema para direcionar uma resposta biológica localizada em um implante

Info

Publication number
BRPI1011725A2
BRPI1011725A2 BRPI1011725A BRPI1011725A BRPI1011725A2 BR PI1011725 A2 BRPI1011725 A2 BR PI1011725A2 BR PI1011725 A BRPI1011725 A BR PI1011725A BR PI1011725 A BRPI1011725 A BR PI1011725A BR PI1011725 A2 BRPI1011725 A2 BR PI1011725A2
Authority
BR
Brazil
Prior art keywords
implant
directing
biological response
localized biological
localized
Prior art date
Application number
BRPI1011725A
Other languages
English (en)
Inventor
Wisniewski Natalie
A Mcmillan William
Original Assignee
Profusa Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Profusa Inc filed Critical Profusa Inc
Publication of BRPI1011725A2 publication Critical patent/BRPI1011725A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0613—Apparatus adapted for a specific treatment
    • A61N5/062—Photodynamic therapy, i.e. excitation of an agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14503—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/1459—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters invasive, e.g. introduced into the body by a catheter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M35/00—Devices for applying media, e.g. remedies, on the human body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
    • A61M5/14276—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body specially adapted for implantation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0023—Drug applicators using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0061—Methods for using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/50—General characteristics of the apparatus with microprocessors or computers
    • A61M2205/52—General characteristics of the apparatus with microprocessors or computers with memories providing a history of measured variating parameters of apparatus or patient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
    • A61M2205/587—Lighting arrangements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2230/00—Measuring parameters of the user
    • A61M2230/005—Parameter used as control input for the apparatus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2230/00—Measuring parameters of the user
    • A61M2230/20—Blood composition characteristics
    • A61M2230/201—Glucose concentration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/0626—Monitoring, verifying, controlling systems and methods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/0635—Radiation therapy using light characterised by the body area to be irradiated
    • A61N2005/0643—Applicators, probes irradiating specific body areas in close proximity
    • A61N2005/0645—Applicators worn by the patient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/065—Light sources therefor
    • A61N2005/0651—Diodes
    • A61N2005/0652—Arrays of diodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/0658—Radiation therapy using light characterised by the wavelength of light used
    • A61N2005/0661—Radiation therapy using light characterised by the wavelength of light used ultraviolet
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/067—Radiation therapy using light using laser light

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pathology (AREA)
  • Medical Informatics (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Optics & Photonics (AREA)
  • Dermatology (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Vascular Medicine (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Electrotherapy Devices (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)
BRPI1011725A 2009-06-01 2010-05-28 método e sistema para direcionar uma resposta biológica localizada em um implante BRPI1011725A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US18299509P 2009-06-01 2009-06-01
US12/789,048 US9517023B2 (en) 2009-06-01 2010-05-27 Method and system for directing a localized biological response to an implant
PCT/US2010/036698 WO2010141377A2 (en) 2009-06-01 2010-05-28 Method and system for directing a localized biological response to an implant

Publications (1)

Publication Number Publication Date
BRPI1011725A2 true BRPI1011725A2 (pt) 2017-03-21

Family

ID=43220477

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI1011725A BRPI1011725A2 (pt) 2009-06-01 2010-05-28 método e sistema para direcionar uma resposta biológica localizada em um implante

Country Status (8)

Country Link
US (2) US9517023B2 (pt)
EP (1) EP2437846B1 (pt)
JP (2) JP2012528686A (pt)
CN (1) CN102458560B (pt)
AU (1) AU2010256930B2 (pt)
BR (1) BRPI1011725A2 (pt)
CA (1) CA2763687C (pt)
WO (1) WO2010141377A2 (pt)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9517023B2 (en) 2009-06-01 2016-12-13 Profusa, Inc. Method and system for directing a localized biological response to an implant
US8834423B2 (en) 2009-10-23 2014-09-16 University of Pittsburgh—of the Commonwealth System of Higher Education Dissolvable microneedle arrays for transdermal delivery to human skin
US10852069B2 (en) 2010-05-04 2020-12-01 Fractal Heatsink Technologies, LLC System and method for maintaining efficiency of a fractal heat sink
US10010272B2 (en) 2010-05-27 2018-07-03 Profusa, Inc. Tissue-integrating electronic apparatus
US10463287B2 (en) 2010-10-06 2019-11-05 Profusa, Inc. Tissue-integrating sensors
EP4112112A1 (en) 2012-05-01 2023-01-04 University of Pittsburgh - Of the Commonwealth System of Higher Education Tip-loaded microneedle arrays for transdermal insertion
EP3763292A1 (en) * 2013-03-14 2021-01-13 Profusa, Inc. Method and device for correcting optical signals
EP3797798B1 (en) 2013-03-14 2022-09-28 Profusa, Inc. Oxygen sensors
AU2014232969A1 (en) * 2013-03-15 2015-10-15 Prometheon Pharma, Llc Devices, systems, and methods for transdermal delivery of compounds
US10219729B2 (en) 2013-06-06 2019-03-05 Profusa, Inc. Apparatus and methods for detecting optical signals from implanted sensors
WO2016014987A2 (en) 2014-07-24 2016-01-28 Thomas Jefferson University Long-term implantable monitoring system & methods of use
WO2016149673A1 (en) 2015-03-18 2016-09-22 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Bioactive components conjugated to substrates of microneedle arrays
CA2990873A1 (en) * 2015-06-25 2016-12-29 Profusa, Inc. Transcutaneous reader for use with implantable analyte sensors
US9838576B2 (en) 2015-08-31 2017-12-05 Panasonic Corporation Endoscope
US11684763B2 (en) 2015-10-16 2023-06-27 University of Pittsburgh—of the Commonwealth System of Higher Education Multi-component bio-active drug delivery and controlled release to the skin by microneedle array devices
US11744889B2 (en) 2016-01-05 2023-09-05 University of Pittsburgh—of the Commonwealth System of Higher Education Skin microenvironment targeted delivery for promoting immune and other responses
JP7090067B2 (ja) * 2016-07-18 2022-06-23 シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレイテッド ウェアラブルセンサの生物付着防止、ならびにそれに関連した使用方法および較正
CN106618591A (zh) * 2016-11-03 2017-05-10 深圳市元征软件开发有限公司 一种检测血糖的方法及植入设备
CN115505280A (zh) 2016-12-21 2022-12-23 普罗菲尤萨股份有限公司 可聚合的近红外染料
WO2018119400A1 (en) 2016-12-22 2018-06-28 Profusa, Inc. System and single-channel luminescent sensor for and method of determining analyte value
WO2018169975A1 (en) * 2017-03-13 2018-09-20 Profusa, Inc. Inserter and method of inserting an implant under the skin
US10413658B2 (en) 2017-03-31 2019-09-17 Capillary Biomedical, Inc. Helical insertion infusion device
WO2019006400A1 (en) 2017-06-29 2019-01-03 Profusa, Inc. FABRIC INTEGRATION SENSORS FOR DETECTION OF MULTIPLE ANALYTES
US11534503B2 (en) 2017-12-28 2022-12-27 Profusa, Inc. Oxidase-based sensors and methods of using
WO2019157018A1 (en) * 2018-02-06 2019-08-15 Mencanin Steve Apparatus for and method of treating viral infections
EP3545897A1 (en) * 2018-03-29 2019-10-02 Koninklijke Philips N.V. An implantable device
WO2019231505A1 (en) * 2018-06-02 2019-12-05 Mencanin Steve Apparatus for and method of treating viral infections
JP7561037B2 (ja) 2018-06-27 2024-10-03 プロフサ，インコーポレイテッド 近赤外線グルコースセンサー
US12357751B2 (en) 2018-11-08 2025-07-15 Tandem Diabetes Care, Inc. Linear insertion device with rotational drive
US12678067B1 (en) 2019-03-20 2026-07-14 Biological Art Group, Inc. Telemetry implants
JP2022532215A (ja) 2019-05-16 2022-07-13 ユニバーシティ オブ ピッツバーグ － オブ ザ コモンウェルス システム オブ ハイヤー エデュケイション 皮膚および非皮膚薬物送達のためのアンダーカット特徴を有するマイクロニードルアレイ
WO2021034784A1 (en) 2019-08-16 2021-02-25 Poltorak Technologies, LLC Device and method for medical diagnostics
US12616845B2 (en) * 2020-05-29 2026-05-05 Know Bio, Llc Devices and related methods for light-based modulation of foreign body responses in living tissue
EP4204066A4 (en) 2020-08-28 2024-11-13 Tandem Diabetes Care, Inc. INSULIN INFUSION SET
CN113289237A (zh) * 2021-05-19 2021-08-24 中山大学 基于离子导入驱动的触控微针阵列诊疗一体化可穿戴设备

Family Cites Families (148)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4703756A (en) 1986-05-06 1987-11-03 The Regents Of The University Of California Complete glucose monitoring system with an implantable, telemetered sensor module
US5342789A (en) 1989-12-14 1994-08-30 Sensor Technologies, Inc. Method and device for detecting and quantifying glucose in body fluids
US6040194A (en) 1989-12-14 2000-03-21 Sensor Technologies, Inc. Methods and device for detecting and quantifying substances in body fluids
US5284140A (en) * 1992-02-11 1994-02-08 Eli Lilly And Company Acrylic copolymer membranes for biosensors
US5882494A (en) * 1995-03-27 1999-03-16 Minimed, Inc. Polyurethane/polyurea compositions containing silicone for biosensor membranes
US6002954A (en) 1995-11-22 1999-12-14 The Regents Of The University Of California Detection of biological molecules using boronate-based chemical amplification and optical sensors
US6766183B2 (en) 1995-11-22 2004-07-20 Medtronic Minimed, Inc. Long wave fluorophore sensor compounds and other fluorescent sensor compounds in polymers
US5711861A (en) * 1995-11-22 1998-01-27 Ward; W. Kenneth Device for monitoring changes in analyte concentration
WO1997019188A1 (en) 1995-11-22 1997-05-29 Minimed, Inc. Detection of biological molecules using chemical amplification and optical sensors
AUPN814496A0 (en) * 1996-02-19 1996-03-14 Monash University Dermal penetration enhancer
GB9616896D0 (en) 1996-08-12 1996-09-25 British Tech Group Pharmaceutical compositions
WO1998022820A1 (en) 1996-11-21 1998-05-28 Lawrence Livermore National Laboratory Detection of biological molecules using boronate-based chemical amplification and optical sensors
US6043437A (en) * 1996-12-20 2000-03-28 Alfred E. Mann Foundation Alumina insulation for coating implantable components and other microminiature devices
US8527026B2 (en) 1997-03-04 2013-09-03 Dexcom, Inc. Device and method for determining analyte levels
US6001067A (en) 1997-03-04 1999-12-14 Shults; Mark C. Device and method for determining analyte levels
US7192450B2 (en) * 2003-05-21 2007-03-20 Dexcom, Inc. Porous membranes for use with implantable devices
US6741877B1 (en) * 1997-03-04 2004-05-25 Dexcom, Inc. Device and method for determining analyte levels
US5895658A (en) * 1997-09-17 1999-04-20 Fossel; Eric T. Topical delivery of L-arginine to cause tissue warming
US6175752B1 (en) 1998-04-30 2001-01-16 Therasense, Inc. Analyte monitoring device and methods of use
US8346337B2 (en) 1998-04-30 2013-01-01 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8465425B2 (en) 1998-04-30 2013-06-18 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
GB9814506D0 (en) 1998-07-03 1998-09-02 Stanley Christopher J Optical sensor for insitu measurement of analytes
ATE468068T1 (de) 1998-07-04 2010-06-15 Whitland Res Ltd Unblutige messung von analyten aus blut
US6013122A (en) 1998-08-18 2000-01-11 Option Technologies, Inc. Tattoo inks
WO2000010622A1 (en) * 1998-08-20 2000-03-02 Cook Incorporated Coated implantable medical device
EP2325622B1 (en) 1998-08-26 2014-03-12 Sensors for Medicine and Science, Inc. Optical-based sensing device
US6602678B2 (en) 1998-09-04 2003-08-05 Powderject Research Limited Non- or minimally invasive monitoring methods
DE69924749T2 (de) * 1998-11-20 2006-04-27 The University Of Connecticut, Farmington Generisch integrierte implantierbare Potentiostatfernmeßanordnung für elektrochemische Fühler
US20030099682A1 (en) * 1998-11-20 2003-05-29 Francis Moussy Apparatus and method for control of tissue/implant interactions
US6783937B1 (en) * 1999-02-25 2004-08-31 Pall Corporation Negatively charged membrane
US8346363B2 (en) 1999-03-05 2013-01-01 Metacure Limited Blood glucose level control
US6475750B1 (en) * 1999-05-11 2002-11-05 M-Biotech, Inc. Glucose biosensor
US6682938B1 (en) * 1999-09-15 2004-01-27 The Regents Of The University Of California Glucose sensing molecules having selected fluorescent properties
US20050119737A1 (en) 2000-01-12 2005-06-02 Bene Eric A. Ocular implant and methods for making and using same
US20020043651A1 (en) 2000-04-04 2002-04-18 Darrow Christopher B. Fluorescent lifetime assays for non-invasive quantification of analytes such as glucose
US6565960B2 (en) 2000-06-01 2003-05-20 Shriners Hospital Of Children Polymer composite compositions
US20020048577A1 (en) * 2000-08-01 2002-04-25 University Of Washington Methods and devices to modulate the wound response
CA2415338C (en) 2000-08-04 2012-10-23 Sensors For Medicine And Science, Inc. Detection of analytes in aqueous environments
GB0025147D0 (en) * 2000-10-13 2000-11-29 Torsana Diabetes Diagnostics A Optical sensor for in situ measurement of analytes
US6642015B2 (en) * 2000-12-29 2003-11-04 Minimed Inc. Hydrophilic polymeric material for coating biosensors
US8069254B2 (en) * 2001-02-28 2011-11-29 Sharp Laboratories Of America, Inc. Communication period management in a communication system
US6694158B2 (en) 2001-04-11 2004-02-17 Motorola, Inc. System using a portable detection device for detection of an analyte through body tissue
US20040152963A1 (en) 2001-04-27 2004-08-05 March Wayne Front Apparatus for measuring blood glucose concentrations
FI20010898A0 (fi) 2001-04-30 2001-04-30 Ylae Herttuala Seppo Ekstrasellulaarinen superoksididismutaasi (EC-SOD) geeniterapia restenoosoin ehkäisemiseksi
WO2002087696A1 (en) * 2001-04-30 2002-11-07 Medtronic,Inc. Transcutaneous monitor and method of use, using therapeutic output from an implanted medical device
US6844028B2 (en) * 2001-06-26 2005-01-18 Accelr8 Technology Corporation Functional surface coating
GB0116853D0 (en) 2001-07-10 2001-09-05 Torsana Diabetes Diagnostics A Optical sensor containing particles for in SITU measurement of analytes
US6702857B2 (en) * 2001-07-27 2004-03-09 Dexcom, Inc. Membrane for use with implantable devices
US7096053B2 (en) 2001-10-02 2006-08-22 Alfred E. Mann Institute For Biomedical Engineering At The University Of Southern California Internal biochemical sensing device
US7202947B2 (en) 2001-12-19 2007-04-10 Wisconsin Alumni Research Foundation Depth-resolved fluorescence instrument with angled excitation
US7613491B2 (en) 2002-05-22 2009-11-03 Dexcom, Inc. Silicone based membranes for use in implantable glucose sensors
GB0204640D0 (en) 2002-02-27 2002-04-10 Torsana Diabetes Diagnostics A Injection apparatus
US7153265B2 (en) * 2002-04-22 2006-12-26 Medtronic Minimed, Inc. Anti-inflammatory biosensor for reduced biofouling and enhanced sensor performance
US7813780B2 (en) * 2005-12-13 2010-10-12 Medtronic Minimed, Inc. Biosensors and methods for making and using them
US20030208166A1 (en) 2002-05-06 2003-11-06 Schwartz Anthony H. Implantable device with free-flowing exit and uses thereof
CN1655738A (zh) * 2002-05-20 2005-08-17 奥勃斯医学技术股份有限公司 可植入的药物洗脱医疗装置
US7226978B2 (en) 2002-05-22 2007-06-05 Dexcom, Inc. Techniques to improve polyurethane membranes for implantable glucose sensors
US7162289B2 (en) * 2002-09-27 2007-01-09 Medtronic Minimed, Inc. Method and apparatus for enhancing the integrity of an implantable sensor device
US20040106951A1 (en) * 2002-11-22 2004-06-03 Edman Carl Frederick Use of electric fields to minimize rejection of implanted devices and materials
US20040143221A1 (en) 2002-12-27 2004-07-22 Shadduck John H. Biomedical implant for sustained agent release
US7811231B2 (en) 2002-12-31 2010-10-12 Abbott Diabetes Care Inc. Continuous glucose monitoring system and methods of use
DE602004007771T2 (de) 2003-02-14 2007-12-06 Eyesense Ag Vorrichtung zur messung der konzentration eines analyten in einer augenflüssigkeit
US7772286B2 (en) 2003-02-28 2010-08-10 Eyesense Ag Polyvinyl alcohol copolymers comprising biomolecules
WO2005016396A1 (en) * 2003-08-13 2005-02-24 Poly-Med, Inc. Biocompatible controlled release coatings for medical devices and related methods
US6965791B1 (en) * 2003-03-26 2005-11-15 Sorenson Medical, Inc. Implantable biosensor system, apparatus and method
US6828572B2 (en) 2003-04-01 2004-12-07 Axcelis Technologies, Inc. Ion beam incident angle detector for ion implant systems
US7134999B2 (en) * 2003-04-04 2006-11-14 Dexcom, Inc. Optimized sensor geometry for an implantable glucose sensor
US20070010702A1 (en) 2003-04-08 2007-01-11 Xingwu Wang Medical device with low magnetic susceptibility
US7186789B2 (en) * 2003-06-11 2007-03-06 Advanced Cardiovascular Systems, Inc. Bioabsorbable, biobeneficial polyester polymers for use in drug eluting stent coatings
WO2005015184A1 (en) 2003-07-30 2005-02-17 Novartis Ag Reflection hologram sensor in contact lens
US20050027175A1 (en) * 2003-07-31 2005-02-03 Zhongping Yang Implantable biosensor
US7591801B2 (en) 2004-02-26 2009-09-22 Dexcom, Inc. Integrated delivery device for continuous glucose sensor
DE602004028020D1 (de) 2003-08-07 2010-08-19 Eyesense Ag Ophthalmischer sensor
EP1670385B1 (en) 2003-10-01 2013-01-23 University of Washington Novel porous biomaterials
ATE482650T1 (de) * 2003-11-03 2010-10-15 Microchips Inc Medizinprodukt zum messen von glucose
US20050158356A1 (en) * 2003-11-20 2005-07-21 Angiotech International Ag Implantable sensors and implantable pumps and anti-scarring agents
US7146203B2 (en) 2003-12-18 2006-12-05 Elliot Botvinick Implantable biosensor and methods of use thereof
US20060002969A1 (en) * 2004-01-27 2006-01-05 University Of Washington Methods for reducing the foreign body reaction
US7450980B2 (en) 2004-03-31 2008-11-11 Terumo Kabushiki Kaisha Intracorporeal substance measuring assembly
US20050245799A1 (en) * 2004-05-03 2005-11-03 Dexcom, Inc. Implantable analyte sensor
US8849416B2 (en) 2004-05-04 2014-09-30 University Of Rochester Implantable bio-electro-physiologic interface matrix
GB0411162D0 (en) 2004-05-19 2004-06-23 Precisense As Optical sensor for in vivo detection of analyte
US8690865B2 (en) * 2004-05-28 2014-04-08 Georgia Tech Research Corporation Methods and devices for thermal treatment
AU2004320509A1 (en) 2004-06-02 2005-12-22 Darrel Dean Drinan Use of electric fields to minimize rejection of implanted devices and materials
WO2005120334A1 (en) 2004-06-14 2005-12-22 Eyesense Ag Combined apparatus for measuring the blood glucose level from an ocular fluid
CA2578227A1 (en) * 2004-08-24 2006-11-30 University Of South Florida Epoxy enhanced polymer membrane to increase durability of biosensors
US7166680B2 (en) * 2004-10-06 2007-01-23 Advanced Cardiovascular Systems, Inc. Blends of poly(ester amide) polymers
US7248907B2 (en) 2004-10-23 2007-07-24 Hogan Josh N Correlation of concurrent non-invasively acquired signals
GB0426822D0 (en) 2004-12-07 2005-01-12 Precisense As Sensor for detection of glucose
JP2006296511A (ja) * 2005-04-15 2006-11-02 Transcutaneous Technologies Inc 外用剤、外用剤の塗布方法、イオントフォレーシス装置及び経皮パッチ
WO2006121522A2 (en) * 2005-05-10 2006-11-16 Angiotech International Ag Implantable sensors and pumps, anti-scarring agents, and therapeutic compositions
JP2008541881A (ja) 2005-05-27 2008-11-27 ジョンソン・アンド・ジョンソン・コンシューマー・カンパニーズ・インコーポレイテッド ウィルス性疾患用の孤立パッチ
US7704704B2 (en) * 2005-09-28 2010-04-27 The Texas A&M University System Implantable system for glucose monitoring using fluorescence quenching
US8160670B2 (en) * 2005-12-28 2012-04-17 Abbott Diabetes Care Inc. Analyte monitoring: stabilizer for subcutaneous glucose sensor with incorporated antiglycolytic agent
US8515518B2 (en) 2005-12-28 2013-08-20 Abbott Diabetes Care Inc. Analyte monitoring
US8114269B2 (en) 2005-12-30 2012-02-14 Medtronic Minimed, Inc. System and method for determining the point of hydration and proper time to apply potential to a glucose sensor
EP2004241B1 (en) 2006-03-28 2013-08-07 Glusense Ltd. Implantable sensor
US8126554B2 (en) 2006-05-17 2012-02-28 Cardiac Pacemakers, Inc. Implantable medical device with chemical sensor and related methods
CN101505723A (zh) * 2006-06-22 2009-08-12 南佛罗里达大学 胶原支架、具有其的医用植入物以及使用方法
ES2314793T3 (es) 2006-07-24 2009-03-16 Eyesense Ag Dispositivo para medir un analito en un fluido ocular.
US8326389B2 (en) 2006-12-07 2012-12-04 The Ohio State University Research Foundation System for in vivo biosensing based on the optical response of electronic polymers
US20080139903A1 (en) * 2006-12-08 2008-06-12 Isense Corporation Method and apparatus for insertion of a sensor using an introducer
DE102007003341B4 (de) 2007-01-17 2018-01-04 Eyesense Ag Okularsensor und Messsystem zum Nachweis eines Analyten in einer Augenflüssigkeit
US8088097B2 (en) 2007-11-21 2012-01-03 Glumetrics, Inc. Use of an equilibrium intravascular sensor to achieve tight glycemic control
EP2162057A1 (en) 2007-05-10 2010-03-17 Glumetrics, Inc. Equilibrium non-consuming fluorescence sensor for real time intravascular glucose measurement
DE102007024642A1 (de) 2007-05-24 2008-11-27 Eyesense Ag Hydrogel-Implantat für Sensorik von Metaboliten am Auge
GB0715590D0 (en) 2007-08-09 2007-09-19 Glysure Ltd Sensing apparatus
GB0800278D0 (en) 2008-01-08 2008-02-13 Glysure Ltd Surface functionalisation
GB0803492D0 (en) 2008-02-26 2008-04-02 Glysure Ltd Fibre optic sensor
US8080821B2 (en) 2008-03-18 2011-12-20 The University Of Connecticut Thyristor radiation detector array and applications thereof
WO2009129186A2 (en) 2008-04-17 2009-10-22 Glumetrics, Inc. Sensor for percutaneous intravascular deployment without an indwelling cannula
US8986208B2 (en) 2008-09-30 2015-03-24 Abbott Diabetes Care Inc. Analyte sensor sensitivity attenuation mitigation
ES2530450T3 (es) 2008-10-02 2015-03-03 Eyesense Ag Elemento sensor implantable
ATE507768T1 (de) 2008-10-02 2011-05-15 Eyesense Ag Implantationsvorrichtung für metabolitsensoren
US20100160749A1 (en) 2008-12-24 2010-06-24 Glusense Ltd. Implantable optical glucose sensing
EP2424426B1 (en) 2009-04-29 2020-01-08 Abbott Diabetes Care, Inc. Method and system for providing data communication in continuous glucose monitoring and management system
ES2571135T3 (es) 2009-05-18 2016-05-24 Lightship Medical Ltd Método de calibración de sensor de glucosa
US9517023B2 (en) 2009-06-01 2016-12-13 Profusa, Inc. Method and system for directing a localized biological response to an implant
US20110028806A1 (en) 2009-07-29 2011-02-03 Sean Merritt Reflectance calibration of fluorescence-based glucose measurements
EP2314608A1 (de) 2009-10-26 2011-04-27 EyeSense AG Stabilisierung von Biosensoren für in vivo Anwendungen
EP2537034B1 (en) 2010-02-16 2019-01-02 Lightship Medical Limited Barrier layer for glucose sensor
CA2790198A1 (en) 2010-02-19 2011-08-25 Lightship Medical Limited Subcutaneous glucose sensor
JP2013519894A (ja) 2010-02-19 2013-05-30 ライトシップ メディカル リミテッド 光ファイバーセンサ用の指示システム
US20130072768A1 (en) 2010-02-19 2013-03-21 Barry Colin Crane Intravascular glucose sensor
WO2011101627A2 (en) 2010-02-19 2011-08-25 Glysure Ltd Fluorescence measurement
US8579879B2 (en) 2010-02-19 2013-11-12 Medtronic Minimed, Inc. Closed-loop glucose control startup
EP2974673B1 (en) 2010-03-17 2017-03-22 The Board of Trustees of the University of Illionis Implantable biomedical devices on bioresorbable substrates
KR101813300B1 (ko) 2010-04-08 2017-12-28 힐리오닉스 코포레이션 미세다공성 표면 층을 가지는 이식형 의료 장치 및 이에 대한 이물 반응을 감소시키는 방법
US10010272B2 (en) 2010-05-27 2018-07-03 Profusa, Inc. Tissue-integrating electronic apparatus
US10463287B2 (en) 2010-10-06 2019-11-05 Profusa, Inc. Tissue-integrating sensors
US8543354B2 (en) 2010-06-23 2013-09-24 Medtronic Minimed, Inc. Glucose sensor signal stability analysis
US9167138B2 (en) 2010-12-06 2015-10-20 Apple Inc. Pattern projection and imaging using lens arrays
AU2011344290B2 (en) 2010-12-17 2016-02-25 Eyesense Ag Competitive biosensor having elevated sensitivity
ES2593458T3 (es) 2010-12-17 2016-12-09 Eyesense Ag Uso de hidrogeles para biosensores con sensibilidad elevada
US20120245445A1 (en) 2011-03-21 2012-09-27 Michael Darryl Black Glucose Monitoring System
US9008744B2 (en) 2011-05-06 2015-04-14 Medtronic Minimed, Inc. Method and apparatus for continuous analyte monitoring
US9037205B2 (en) 2011-06-30 2015-05-19 Glusense, Ltd Implantable optical glucose sensing
WO2013025801A2 (en) 2011-08-15 2013-02-21 University Of Connecticut Control of biofouling in implantable biosensors
US20130060106A1 (en) 2011-09-06 2013-03-07 Medtronic Minimed, Inc. Optical sensing systems and methods
US20130158413A1 (en) 2011-12-15 2013-06-20 Nellcor Puritan Bennett Llc Optical measurement of physiological blood parameters
US8891088B2 (en) 2012-01-20 2014-11-18 The Curators Of The University Of Missouri Total internal reflection photoacoustic spectroscopy
DE102012201892A1 (de) 2012-02-09 2013-08-14 Robert Bosch Gmbh Bestimmung des Blutzuckerspiegels eines Patienten unter Verwendung eines implantierbaren Sensors und eines elektrischen Funktionspflasters
US9693714B2 (en) 2012-02-10 2017-07-04 Senseonics, Incorporated Digital ASIC sensor platform
US8869588B2 (en) 2012-02-21 2014-10-28 Symbol Technologies, Inc. Ultrasonic positioning system with reverberation and flight time compensation
WO2013132400A1 (en) 2012-03-08 2013-09-12 Koninklijke Philips N.V. Apparatus for determining a property of a tissue
EP3763292A1 (en) 2013-03-14 2021-01-13 Profusa, Inc. Method and device for correcting optical signals
US10219729B2 (en) 2013-06-06 2019-03-05 Profusa, Inc. Apparatus and methods for detecting optical signals from implanted sensors
CA2990873A1 (en) 2015-06-25 2016-12-29 Profusa, Inc. Transcutaneous reader for use with implantable analyte sensors

Also Published As

Publication number Publication date
WO2010141377A3 (en) 2011-04-07
US10583308B2 (en) 2020-03-10
EP2437846A2 (en) 2012-04-11
JP2015171550A (ja) 2015-10-01
WO2010141377A2 (en) 2010-12-09
JP6073959B2 (ja) 2017-02-01
US20100303772A1 (en) 2010-12-02
CA2763687A1 (en) 2010-12-09
AU2010256930B2 (en) 2015-09-17
JP2012528686A (ja) 2012-11-15
AU2010256930A1 (en) 2011-12-22
EP2437846A4 (en) 2015-09-23
CN102458560A (zh) 2012-05-16
CN102458560B (zh) 2014-06-25
CA2763687C (en) 2023-05-23
EP2437846B1 (en) 2021-06-23
US9517023B2 (en) 2016-12-13
US20170087376A1 (en) 2017-03-30

Similar Documents

Publication Publication Date Title
BRPI1012599A2 (pt) sistema e método para a colocação de uma prótese endoluminal em um local cirúrgico
BRPI0911078A2 (pt) sistema e método para a projetar e formar um implante cirúrgico
BRPI0814077A2 (pt) Controlador e sistema e método para medir consumo de energia.
BRPI0921659A2 (pt) metodo e sistema para formar uma protese dentaria
BR112012012231A2 (pt) método e sistema
BRPI1015164A2 (pt) método e sistema para gerar automaticamente conteúdo específico de localização para uma entidade particular, e, método e sistema para fornecer conteúdo específico de localização para uma entidade particular tendo uma pluralidade de localizações físicas
BRPI0912794A2 (pt) sistema e método para controlar uma plantadeira
BRPI1006398A2 (pt) método e sistema
BR112012002301A2 (pt) método e sistema
BRPI1010203A2 (pt) sistema e método
BR112012006947A2 (pt) método e sistema para a fabricação de uma peça dental em camadas
BRPI0823032A2 (pt) Método e sistema para gerenciar potência em um sistema de elevador
BRPI0923566A2 (pt) método e sistema para detecção de uma expressão vocal relevante
BRPI1006265A8 (pt) unidade de flutuação, sistema e método para a operação de uma unidade de flutuação
BRPI1006434A2 (pt) encosto para um sistema de ressuscitação cardiopulmonar automatizado e sistema de ressuscitação cardiopulmonar automatizado
BRPI0907548A2 (pt) Sistema e método de rastreamento da zona dental para uma escova de dentes
BRPI0915864A2 (pt) método e sistema para controle de giroscópio e gnss combinados
BR112013015870A2 (pt) método para o tratamento de biomassa e sistema
BRPI0909748A2 (pt) sistema e método de simulação
BRPI0817450A2 (pt) Sistema e método para determinar a força descendente apropriada para uma unidade de fila de plantar
BRPI1008076A2 (pt) sistema, método e aparelho para implementar implantes dentários
BRPI1006885A2 (pt) sistema de completação utilizável com um poço, e método utilizável com um poço
BRPI0813757A2 (pt) Sistema de implante, e, método
BR112012005778A2 (pt) método e sistema para simulação em uma subestação
BR112012003127A2 (pt) sistema e método para equilíbrio de corrente

Legal Events

Date Code Title Description
B25G Requested change of headquarter approved

Owner name: PROFUSA, INC. (US)

B25H Request for change of headquarter rejected

Owner name: PROFUSA, INC. (US)

Free format text: INDEFERIDO O PEDIDO DE ALTERACAO DE SEDE CONTIDO NA PETICAO 20120063760 DE 10/07/2012,POR JA TER SIDO ATENDIDO NA RPI2496 DE 06/11/2018.

B25G Requested change of headquarter approved

Owner name: PROFUSA, INC. (US)

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06T Formal requirements before examination [chapter 6.20 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B12B Appeal against refusal [chapter 12.2 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 12A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2673 DE 29-03-2022 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.