BRPI1012113A2 - identificação de micro-rnas envolvidos na remodelação pós-infarto do miocárdio e insuficiência cardíada - Google Patents

identificação de micro-rnas envolvidos na remodelação pós-infarto do miocárdio e insuficiência cardíada

Info

Publication number
BRPI1012113A2
BRPI1012113A2 BRPI1012113A BRPI1012113A BRPI1012113A2 BR PI1012113 A2 BRPI1012113 A2 BR PI1012113A2 BR PI1012113 A BRPI1012113 A BR PI1012113A BR PI1012113 A BRPI1012113 A BR PI1012113A BR PI1012113 A2 BRPI1012113 A2 BR PI1012113A2
Authority
BR
Brazil
Prior art keywords
micro
post
identification
heart failure
myocardial infarction
Prior art date
Application number
BRPI1012113A
Other languages
English (en)
Inventor
Eric N Olson
Eva Van Rooij
Original Assignee
Univ Texas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Texas filed Critical Univ Texas
Publication of BRPI1012113A2 publication Critical patent/BRPI1012113A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
BRPI1012113A 2009-05-20 2010-05-20 identificação de micro-rnas envolvidos na remodelação pós-infarto do miocárdio e insuficiência cardíada BRPI1012113A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17977509P 2009-05-20 2009-05-20
PCT/US2010/035642 WO2010135570A1 (en) 2009-05-20 2010-05-20 Identification of micro-rnas involved in post-myocardial infarction remodeling and heart failure

Publications (1)

Publication Number Publication Date
BRPI1012113A2 true BRPI1012113A2 (pt) 2016-03-29

Family

ID=43126512

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI1012113A BRPI1012113A2 (pt) 2009-05-20 2010-05-20 identificação de micro-rnas envolvidos na remodelação pós-infarto do miocárdio e insuficiência cardíada

Country Status (12)

Country Link
US (1) US9072765B2 (pt)
EP (1) EP2437750A4 (pt)
JP (1) JP2012527478A (pt)
KR (1) KR20120047214A (pt)
CN (1) CN102481310A (pt)
AU (1) AU2010249482A1 (pt)
BR (1) BRPI1012113A2 (pt)
CA (1) CA2763156A1 (pt)
MX (1) MX2011012418A (pt)
NZ (1) NZ596971A (pt)
RU (1) RU2011151991A (pt)
WO (1) WO2010135570A1 (pt)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITRM20030376A1 (it) 2003-07-31 2005-02-01 Univ Roma Procedimento per l'isolamento e l'espansione di cellule staminali cardiache da biopsia.
US11660317B2 (en) 2004-11-08 2023-05-30 The Johns Hopkins University Compositions comprising cardiosphere-derived cells for use in cell therapy
US7696309B2 (en) * 2006-10-23 2010-04-13 The Brigham And Women's Hospital, Inc. Protease resistant mutants of stromal cell derived factor-1 in the repair of tissue damage
US8415096B2 (en) 2007-05-23 2013-04-09 University Of South Florida Micro-RNAs modulating immunity and inflammation
ES2531964T3 (es) * 2009-08-06 2015-03-23 Universiteit Maastricht Medios y métodos para contrarrestar, demorar y/o prevenir cambios adversos del metabolismo energético en enfermedades del corazón
US9308277B2 (en) 2010-02-25 2016-04-12 Mesoblast International Sàrl Protease-resistant mutants of stromal cell derived factor-1 in the repair of tissue damage
CA2792411A1 (en) * 2010-03-12 2011-09-15 Daiichi Sankyo Company, Limited Method for proliferating cardiomyocytes using micro-rna
EP2561091B1 (en) * 2010-04-20 2014-08-06 Comprehensive Biomarker Center GmbH Complex mirna sets as novel biomarkers for an acute coronary syndrome
US9249392B2 (en) 2010-04-30 2016-02-02 Cedars-Sinai Medical Center Methods and compositions for maintaining genomic stability in cultured stem cells
US9845457B2 (en) 2010-04-30 2017-12-19 Cedars-Sinai Medical Center Maintenance of genomic stability in cultured stem cells
US8815826B2 (en) 2010-07-23 2014-08-26 Regulus Therapeutics, Inc. Targeting microRNAs for the treatment of fibrosis
CN102453757B (zh) * 2010-10-22 2014-02-12 中国科学院动物研究所 一种微小rna及其反义核酸在诊断、预防、治疗和/或预后评估心肌缺血性损伤中的用途
US8871731B2 (en) * 2011-03-16 2014-10-28 Migagen Therapeutics, Inc. Micro-RNA for the regulation of cardiac apoptosis and contractile function
US20120289420A1 (en) * 2011-03-18 2012-11-15 University Of South Florida Microrna biomarkers for airway diseases
TWI421084B (zh) 2011-04-01 2014-01-01 Univ Kaohsiung Medical 微小ＲＮＡ ｌｅｔ－７ｇ的新用途
WO2012170495A1 (en) 2011-06-07 2012-12-13 Provasculon, Inc. Methods for repairing tissue damage using protease-resistant mutants of stromal cell derived factor-1
EP2584040A1 (en) 2011-10-17 2013-04-24 Pharmahungary 2000 Kft. Compounds for treatment of ischemic injury
US20140288156A1 (en) * 2011-10-27 2014-09-25 Inserm (Institut National De La Sante Et De La Recherche Medicale) Methods for the treatment and diagnosis of atherosclerosis
CN102416184A (zh) * 2011-12-08 2012-04-18 哈尔滨医科大学 microRNA-1的反义锁核苷酸序列在制备预防或治疗心肌梗死后心衰药物中的应用
ITRM20110685A1 (it) 2011-12-23 2013-06-24 Internat Ct For Genetic En Gineering And Microrna per la rigenerazione cardiaca attraverso l induzione della proliferazione dei miociti cardiaci
CN102580117B (zh) * 2012-01-17 2013-08-28 杨德业 miRNA-122抑制剂在制备治疗先天性心脏病的药物中的应用
WO2013184527A1 (en) 2012-06-05 2013-12-12 Capricor, Inc. Optimized methods for generation of cardiac stem cells from cardiac tissue and their use in cardiac therapy
EP3563859B1 (en) 2012-08-13 2021-10-13 Cedars-Sinai Medical Center Cardiosphere-derived exosomes for tissue regeneration
WO2014028762A1 (en) 2012-08-15 2014-02-20 University Of Virginia Patent Foundation Compositions and methods for treating peripheral arterial disease
CN102980920A (zh) * 2012-11-14 2013-03-20 华东师范大学 同时检测miRNAs与蛋白标记物的硅纳米线芯片及其检测方法和应用
ES2606636T3 (es) * 2013-01-24 2017-03-24 Pierre Fabre Médicament S.A.S. Composición que comprende un antagomir encapsulado
US20160076026A1 (en) * 2013-03-15 2016-03-17 The Hospital For Sick Children Diagnostic and therapeutic methods relating to microrna-144
CN103290011B (zh) * 2013-05-16 2015-09-16 南京市妇幼保健院 与胎儿先天性心脏病相关的母体血清/血浆miRNA标志物mir-29c及其应用
CN103293318B (zh) * 2013-05-22 2014-10-29 吉林大学 利用地高辛标记EDC交联桥连法检测miRNAs方法
WO2015074010A2 (en) 2013-11-18 2015-05-21 Beth Israel Deaconess Medical Center, Inc. Compositions and methods for cardiac regeneration
CN104667295A (zh) * 2013-11-30 2015-06-03 复旦大学 miR-30家族抑制剂在制备防治急性心肌梗死药物中的用途
WO2016054591A1 (en) 2014-10-03 2016-04-07 Cedars-Sinai Medical Center Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of muscular dystrophy
AU2016209386A1 (en) 2015-01-20 2017-08-03 MiRagen Therapeutics, Inc. miR-92 inhibitors and uses thereof
EP3261718B1 (en) * 2015-02-24 2020-03-25 The Administrators of The Tulane Educational Fund Methods of detecting, diagnosing, and treating atherosclerotic plaque rupture
EP3294910B1 (en) * 2015-05-08 2021-03-17 Agency For Science, Technology And Research Method for diagnosis and prognosis of chronic heart failure
EP3138914A1 (en) * 2015-09-01 2017-03-08 Universiteit Maastricht Micrornas for the treatment of heart diseases
US10119139B2 (en) 2015-09-14 2018-11-06 Vanderbilt University Treatment for conditions associated with fibrosis and collagen deposition
EP3402543B1 (en) 2016-01-11 2021-09-08 Cedars-Sinai Medical Center Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of heart failure with preserved ejection fraction
CN105695612A (zh) * 2016-04-19 2016-06-22 中南大学 microRNA-126-5p在心肌损伤中的表达检测方法
WO2017210652A1 (en) 2016-06-03 2017-12-07 Cedars-Sinai Medical Center Cdc-derived exosomes for treatment of ventricular tachyarrythmias
CN109715218A (zh) * 2016-07-18 2019-05-03 嘉安生物治疗有限责任公司 用于治疗心脏疾病的组合物和方法
WO2018041726A1 (en) * 2016-08-27 2018-03-08 Academisch Medisch Centrum Biomarkers for determining the presence of an unstable atherosclerotic plaque
WO2018057542A1 (en) 2016-09-20 2018-03-29 Cedars-Sinai Medical Center Cardiosphere-derived cells and their extracellular vesicles to retard or reverse aging and age-related disorders
US11246883B2 (en) * 2016-09-30 2022-02-15 Academia Sinica Microrna let-7 and transforming growth factor beta receptor III axis as target for cardiac injuries
EP3601565A4 (en) * 2017-03-25 2021-01-06 Miragen Therapeutics, Inc. MIR-92 INHIBITORS IN THE TREATMENT OF HEART FAILURE
US11759482B2 (en) 2017-04-19 2023-09-19 Cedars-Sinai Medical Center Methods and compositions for treating skeletal muscular dystrophy
CN107312836A (zh) * 2017-06-22 2017-11-03 深圳大学 小分子RNAmiRNA‑146a‑5p在相关疾病风险诊断中的应用
CN111093769A (zh) * 2017-08-01 2020-05-01 英联邦高等教育系统天普大学 来源于皮质骨干细胞的外来体可以增强心脏损伤后的心脏功能
CN107460241B (zh) * 2017-08-09 2020-05-19 深圳承启生物科技有限公司 外泌体小分子rna在急性心肌梗死风险评估中的应用
US11225660B2 (en) 2017-10-12 2022-01-18 Emory University Methods and compositions for managing vascular conditions using miR-483 mimics and HIF1alpha pathway inhibitors
ES2711003A1 (es) * 2017-10-25 2019-04-29 Univ Cadiz Marcadores para la miocardiopatía dilatada
CN107858419A (zh) * 2017-11-10 2018-03-30 青岛大学 miRNA的应用、应用其的产品及检测方法
WO2019126068A1 (en) 2017-12-20 2019-06-27 Cedars-Sinai Medical Center Engineered extracellular vesicles for enhanced tissue delivery
CN108004316A (zh) * 2018-01-09 2018-05-08 青岛大学 用于预测急性心肌梗死风险的试剂盒
EP3749344A4 (en) 2018-02-05 2022-01-26 Cedars-Sinai Medical Center METHODS OF THERAPEUTIC USE OF EXOSOMES AND Y-RNAS
CN110055322A (zh) * 2019-05-12 2019-07-26 青岛大学 用于急性心肌梗死诊断的循环miRNA标志物及其应用
CN110354275B (zh) * 2019-07-22 2022-06-14 上海交通大学医学院附属第九人民医院 MSN/miRNA水凝胶在制备治疗心肌梗死药物中的应用
CN111850047B (zh) * 2020-07-28 2022-08-12 枣庄学院 一种miR-16与miR-30c联合表达载体及其构建方法与应用
US20230287427A1 (en) * 2020-07-29 2023-09-14 The General Hospital Corporation Inhibition of lncExACT1 to Treat Heart Disease
KR20220082579A (ko) 2020-12-10 2022-06-17 연세대학교 산학협력단 심방세동 진단용 마이크로rna 바이오마커 및 이의 용도
DE202022100355U1 (de) 2022-01-22 2022-03-08 Fahad Ahmed Al Abbasi Ein System für die pharmakologische Anwendung von Metformin bei kardialem Remodelling
CN115181797B (zh) * 2022-04-19 2023-08-18 唐颢 MicroRNA在扩张型心肌病治疗中的应用
CN116850201A (zh) * 2023-06-29 2023-10-10 南昌市高新区人民医院(南昌大学第一附属医院高新医院) miR-221-3p的应用
AU2024331551A1 (en) * 2023-08-28 2026-03-12 MI:RNA Ltd. Assessment and differential diagnosis of cardiovascular disease in companion animals using a microrna assay

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2005333165B2 (en) * 2004-11-12 2012-07-19 Asuragen, Inc. Methods and compositions involving miRNA and miRNA inhibitor molecules
EP2094869B1 (de) * 2006-10-09 2012-07-25 Julius-Maximilians-Universität Würzburg Microrna (mirna) zur diagnose und therapie von herzerkrankungen
KR101706259B1 (ko) * 2007-07-31 2017-02-14 보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템 섬유증을 조절하는 마이크로-ｒｎａ 집단 및 이의 용도
MX2010005166A (es) * 2007-11-09 2010-10-07 Univ Texas Micro arn de la familia mir-15 que modulan la sobrevivencia de cardiomiocitos y reparacion cardiaca.

Also Published As

Publication number Publication date
AU2010249482A1 (en) 2012-01-12
EP2437750A1 (en) 2012-04-11
MX2011012418A (es) 2012-07-20
KR20120047214A (ko) 2012-05-11
US20120165392A1 (en) 2012-06-28
WO2010135570A1 (en) 2010-11-25
US9072765B2 (en) 2015-07-07
EP2437750A4 (en) 2014-11-05
CA2763156A1 (en) 2010-11-25
JP2012527478A (ja) 2012-11-08
CN102481310A (zh) 2012-05-30
NZ596971A (en) 2013-12-20
RU2011151991A (ru) 2013-06-27

Similar Documents

Publication Publication Date Title
BRPI1012113A2 (pt) identificação de micro-rnas envolvidos na remodelação pós-infarto do miocárdio e insuficiência cardíada
SMT201600075B (it) Composto di diamminocarbossammide eterociclica
EP2387686A4 (en) ENHANCED BIOMATERIAL FREEZING
PL3056224T3 (pl) Sposób sterylizacji
EP2485698A4 (en) WHEELCHAIR SUSPENSION
EP2488987A4 (en) SAFE STORAGE OF TIME LIMITED SECRETS
EP2456858A4 (en) DIFFERENTIATION OF HUMAN EMBRYONIC STEM CELLS
BR112012001480A2 (pt) Diferenciação de células-tronco embriônicas humanas
EP2485589A4 (en) HETEROARYL-BTK INHIBITORS
PT3509341T (pt) Adaptação de parâmetros de transferência
EP2641343A4 (en) CONFIGURATION OF A BUILDING
EP2488630A4 (en) INDUCTION OF PLURIPOTENTER CELLS
EP3578664C0 (en) COLLAGEN IV NEO-EPITOPE FIBROSIS ASSAY
EP2442711A4 (en) DETERMINATION OF HEMODYNAMIC PERFORMANCE
BR112012005146A2 (pt) fotobiorreator
EP2456440A4 (en) Quinolinone PDE2 INHIBITORS
DK2617392T3 (da) Protese med overflader med forskellige teksturer
BR112012005371A2 (pt) desmontagem de componentes interligados
PL2493466T3 (pl) Nowe przeciwguzowe zastosowanie kabazytakselu
DOP2011000397A (es) Nuevos derivados de fenilimidazol como inhibidores de la enzima pde10a
EP2409696A4 (en) AGENT PROMOTING ENERGY CONSUMPTION
BR112012007260A2 (pt) garrafa de água
EP2519636A4 (en) PREPARATION OF A HEMAGGLUTININE NEURAMINIDASE PROTEIN IN MICROALGEN
DK2453858T3 (da) Fremgangsmåde
BRPI1009018A2 (pt) fotobiorreator

Legal Events

Date Code Title Description
B08F Application fees: application dismissed [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 5A E 6A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2385 DE 20-09-2016 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.