BRPI1012789A2 - "materiais sólidos de {ácido[(2s,5r,8s,11s)-5-benzil-11 -(3-guanidino-propil)-8-isopropil-7-metil-3,6,9,12,15- pentaoxo-1,4,7,10,13-penta-aza-ciclopentadec-2-il]- acético} e métodos para obter os mesmos" - Google Patents

"materiais sólidos de {ácido[(2s,5r,8s,11s)-5-benzil-11 -(3-guanidino-propil)-8-isopropil-7-metil-3,6,9,12,15- pentaoxo-1,4,7,10,13-penta-aza-ciclopentadec-2-il]- acético} e métodos para obter os mesmos"

Info

Publication number
BRPI1012789A2
BRPI1012789A2 BRPI1012789A BRPI1012789A BRPI1012789A2 BR PI1012789 A2 BRPI1012789 A2 BR PI1012789A2 BR PI1012789 A BRPI1012789 A BR PI1012789A BR PI1012789 A BRPI1012789 A BR PI1012789A BR PI1012789 A2 BRPI1012789 A2 BR PI1012789A2
Authority
BR
Brazil
Prior art keywords
ciclopentadec
isopropil
propil
pentaoxo
aza
Prior art date
Application number
BRPI1012789A
Other languages
English (en)
Inventor
Jonczyk Alfred
Saal Christoph
Kuehn Clemens
Scholz Gerald
Untenecker Harald
Seemann Kerstin
Lange Michael
Petersen Soenke
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of BRPI1012789A2 publication Critical patent/BRPI1012789A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Oncology (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Peptides Or Proteins (AREA)
BRPI1012789A 2009-05-20 2010-05-20 "materiais sólidos de {ácido[(2s,5r,8s,11s)-5-benzil-11 -(3-guanidino-propil)-8-isopropil-7-metil-3,6,9,12,15- pentaoxo-1,4,7,10,13-penta-aza-ciclopentadec-2-il]- acético} e métodos para obter os mesmos" BRPI1012789A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09006790 2009-05-20
PCT/EP2010/003100 WO2010133367A2 (en) 2009-05-20 2010-05-20 Novel solid materials of {[2s, 5r,8s,11s)-5-benzyl-11-(3-guanidino-propyl)-8-isopropyl-7-methyl-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaaza-cyclopentadec-2-yl]-acetic acid} and methods for obtaining them

Publications (1)

Publication Number Publication Date
BRPI1012789A2 true BRPI1012789A2 (pt) 2018-01-16

Family

ID=41338466

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI1012789A BRPI1012789A2 (pt) 2009-05-20 2010-05-20 "materiais sólidos de {ácido[(2s,5r,8s,11s)-5-benzil-11 -(3-guanidino-propil)-8-isopropil-7-metil-3,6,9,12,15- pentaoxo-1,4,7,10,13-penta-aza-ciclopentadec-2-il]- acético} e métodos para obter os mesmos"

Country Status (13)

Country Link
US (2) US8586545B2 (pt)
EP (2) EP3085704A1 (pt)
JP (1) JP5878864B2 (pt)
KR (1) KR20120060947A (pt)
CN (1) CN102428098B (pt)
AU (1) AU2010251385B2 (pt)
BR (1) BRPI1012789A2 (pt)
CA (1) CA2762652C (pt)
EA (1) EA022831B1 (pt)
ES (1) ES2578026T3 (pt)
MX (1) MX2011012231A (pt)
WO (1) WO2010133367A2 (pt)
ZA (1) ZA201109327B (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20110086757A (ko) * 2008-11-20 2011-07-29 메르크 파텐트 게엠베하 암을 치료하기 위해 인테그린 리간드를 사용하는 신규한 치료요법 및 약제
PE20121359A1 (es) * 2009-12-10 2012-10-15 Merck Patent Gmbh Composicion farmaceutica que comprende oligopeptidos
EP2717854B1 (en) * 2011-06-09 2019-01-16 Merck Patent GmbH Treatment of cancers and metastases with suspensions of cilengitide in carrier
CN119264211A (zh) 2018-08-27 2025-01-07 瑞泽恩制药公司 拉曼光谱在下游纯化中的应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19534177A1 (de) * 1995-09-15 1997-03-20 Merck Patent Gmbh Cyclische Adhäsionsinhibitoren
WO1998057648A1 (en) * 1997-06-16 1998-12-23 Vertex Pharmaceuticals Incorporated Methods of increasing the bioavailability of stable crystal polymorphs of a compound
UA71608C2 (en) * 1999-03-11 2004-12-15 Merck Patent Gmbh A method for producing the cyclic pentapeptide
PE20121359A1 (es) * 2009-12-10 2012-10-15 Merck Patent Gmbh Composicion farmaceutica que comprende oligopeptidos

Also Published As

Publication number Publication date
CA2762652C (en) 2018-10-02
JP2012527417A (ja) 2012-11-08
WO2010133367A3 (en) 2011-10-27
HK1169832A1 (en) 2013-02-08
EA022831B1 (ru) 2016-03-31
US8586545B2 (en) 2013-11-19
EP3085704A1 (en) 2016-10-26
CA2762652A1 (en) 2010-11-25
EP2432801B1 (en) 2016-03-23
EP2432801A2 (en) 2012-03-28
EA201101638A1 (ru) 2012-06-29
AU2010251385A1 (en) 2012-01-19
ZA201109327B (en) 2012-08-29
US20120065142A1 (en) 2012-03-15
US20140088022A1 (en) 2014-03-27
JP5878864B2 (ja) 2016-03-08
WO2010133367A2 (en) 2010-11-25
CN102428098B (zh) 2014-11-05
AU2010251385A8 (en) 2012-02-16
MX2011012231A (es) 2011-12-08
AU2010251385B2 (en) 2016-04-14
ES2578026T3 (es) 2016-07-20
KR20120060947A (ko) 2012-06-12
US8765684B2 (en) 2014-07-01
CN102428098A (zh) 2012-04-25

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 8A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]