BRPI1012980A2 - dispositivo e métodos para analisar a capacidade de resposta celular e a resposta de células neoplásticas a drogas - Google Patents

dispositivo e métodos para analisar a capacidade de resposta celular e a resposta de células neoplásticas a drogas

Info

Publication number
BRPI1012980A2
BRPI1012980A2 BRPI1012980A BRPI1012980A BRPI1012980A2 BR PI1012980 A2 BRPI1012980 A2 BR PI1012980A2 BR PI1012980 A BRPI1012980 A BR PI1012980A BR PI1012980 A BRPI1012980 A BR PI1012980A BR PI1012980 A2 BRPI1012980 A2 BR PI1012980A2
Authority
BR
Brazil
Prior art keywords
drugs
methods
cell response
neoplastic cell
cellular responsiveness
Prior art date
Application number
BRPI1012980A
Other languages
English (en)
Inventor
Alberto Orfao
Andrew Bosanquet
Consuelo Tudela
Coyt Jackson
Daniel Primo
Juan Ballesteros
Julian Gorrochategui
Lilia Suarez
Luis Ignacio Caveda
Maria Matoses
Pilar Hernandez
Sandra Sapia
Santiago Lago
Teresa Bennett
Original Assignee
Vivia Biotech Sl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42342776&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI1012980(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Vivia Biotech Sl filed Critical Vivia Biotech Sl
Publication of BRPI1012980A2 publication Critical patent/BRPI1012980A2/pt

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5011Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57505Immunoassay; Biospecific binding assay; Materials therefor for cancer of the blood, e.g. leukaemia
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57557Immunoassay; Biospecific binding assay; Materials therefor for cancer of other specific parts of the body, e.g. brain
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/52Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Toxicology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
BRPI1012980A 2009-05-19 2010-05-19 dispositivo e métodos para analisar a capacidade de resposta celular e a resposta de células neoplásticas a drogas BRPI1012980A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17968509P 2009-05-19 2009-05-19
PCT/US2010/035474 WO2010135468A1 (en) 2009-05-19 2010-05-19 Methods for providing personalized medicine tests ex vivo for hematological neoplasms

Publications (1)

Publication Number Publication Date
BRPI1012980A2 true BRPI1012980A2 (pt) 2016-03-29

Family

ID=42342776

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI1012980A BRPI1012980A2 (pt) 2009-05-19 2010-05-19 dispositivo e métodos para analisar a capacidade de resposta celular e a resposta de células neoplásticas a drogas

Country Status (17)

Country Link
US (2) US20100298255A1 (pt)
EP (1) EP2433124B1 (pt)
JP (1) JP5851984B2 (pt)
CN (1) CN102460165B (pt)
AR (1) AR076590A1 (pt)
AU (1) AU2010249593B2 (pt)
BR (1) BRPI1012980A2 (pt)
CA (1) CA2762783C (pt)
CL (1) CL2011002905A1 (pt)
DK (1) DK2433124T3 (pt)
ES (1) ES2628219T3 (pt)
IL (1) IL216419A (pt)
MX (1) MX2011012267A (pt)
RU (1) RU2636614C2 (pt)
SG (2) SG176571A1 (pt)
TW (1) TWI546537B (pt)
WO (1) WO2010135468A1 (pt)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130226469A1 (en) * 2008-04-01 2013-08-29 Purdue Research Foundation Gate-free flow cytometry data analysis
US8491927B2 (en) * 2009-12-02 2013-07-23 Nimble Epitech, Llc Pharmaceutical composition containing a hypomethylating agent and a histone deacetylase inhibitor
US10571475B2 (en) 2010-12-03 2020-02-25 Cellply S.R.L. Rapid screening of monoclonal antibodies
TWI503545B (zh) * 2010-12-24 2015-10-11 Methods of Screening Probiotics for Individual Differences
US8679767B2 (en) * 2011-05-12 2014-03-25 Genentech, Inc. Multiple reaction monitoring LC-MS/MS method to detect therapeutic antibodies in animal samples using framework signature peptides
SI2776032T1 (sl) 2011-11-09 2018-12-31 Bristol-Myers Squibb Company Zdravljenje hematoloških malignih obolenj z anti-CXCR4 protitelesom
KR101327533B1 (ko) * 2012-12-11 2013-11-08 사회복지법인 삼성생명공익재단 환자 맞춤형 항암제 선별용 시스템
EP3027763B1 (en) * 2013-07-29 2018-05-30 The Regents of The University of California Real-time feedback system control technology platform with dynamically changing stimulations
EP2959904A1 (en) * 2014-06-27 2015-12-30 Institut De Recerca Contra La Leucemia Josep Carreras Methods for treating, diagnosing and prognosing a haematological malignancy
CN104606207A (zh) * 2015-02-09 2015-05-13 南京格耀生物科技有限公司 磺胺甲恶唑在制备抑制肿瘤细胞转移和扩散的药物中的应用
CN104958312A (zh) * 2015-05-14 2015-10-07 四川大学华西医院 一种治疗急性淋巴细胞白血病的联合用药物
SG11201803461RA (en) * 2015-11-04 2018-05-30 Vivia Biotech Sl An ex vivo method for testing cellular responsiveness of primary cell populations to a drug or combination of drugs
HK1258724A1 (zh) 2015-11-11 2019-11-15 Celator Pharmaceuticals, Inc. 选择白血病对象的治疗方案的分析和方法
SG11201808909WA (en) 2016-04-13 2018-11-29 Vivia Biotech Sl Ex vivo bite-activated t cells
CN106093394B (zh) * 2016-06-07 2017-12-26 中国人民解放军第二军医大学 Flt3蛋白在制备肝癌对索拉菲尼疗效评估试剂盒中的应用
EP3258240B1 (en) 2016-06-14 2023-06-07 Cellply S.R.L. Screening kit and methods
WO2019077062A1 (en) 2017-10-18 2019-04-25 Vivia Biotech, S.L. C-CELLS ACTIVATED BY BIT
JP7478094B2 (ja) 2017-10-31 2024-05-02 エクセンシア ゲゼルシャフト ミット ベシュレンクテル ハフツング 試験化合物の選択性を決定する方法
US11116692B2 (en) 2018-06-07 2021-09-14 Gecko Alliance Group Inc. Method, system, computer program product and device for facilitating centralized control and monitoring over a network of a set of remote bathing unit systems
WO2020043716A1 (en) * 2018-08-27 2020-03-05 Katholieke Universiteit Leuven Pharmacological targeting of de novo serine/glycine synthesis
EP3853859A1 (en) * 2018-10-11 2021-07-28 Vivia Biotech, S.L. A method for determining the efficacy of treatment with a combination of drugs in a subject diagnosed with a disease and a method for classifying the utility of drug combinations in treatment of said subject
US20220011296A1 (en) * 2018-11-14 2022-01-13 Dana-Farber Cancer Institute, Inc. Determining treatment response in single cells
EP3887395A4 (en) * 2018-11-30 2022-07-27 Intima Bioscience, Inc. METHODS FOR IDENTIFICATION OF IMMUNOMODULATORY GENES
US12560590B2 (en) 2019-01-23 2026-02-24 Massachusetts Institute Of Technology Rapid analysis of live cells
WO2021138391A1 (en) 2019-12-30 2021-07-08 Tyra Biosciences, Inc. Indazole compounds
CN113975659B (zh) 2020-07-27 2024-07-30 佳能医疗系统株式会社 放射线治疗辅助系统及方法
CN112569342A (zh) * 2020-12-21 2021-03-30 中南大学 卡泊芬净和/或其可药用盐在制备抗肿瘤药物中的应用及抗肿瘤药物
CN117043597A (zh) * 2021-03-10 2023-11-10 敦提大学 细胞分析
CN115531391B (zh) * 2022-11-03 2023-07-18 浙江大学 一种治疗白血病的药物及应用
CN116808176B (zh) * 2023-08-30 2023-12-05 上海彗天锦泽生物医学科技有限公司 一种基于免疫检查点阻断的抗肿瘤药物组合物及其应用
WO2025172529A1 (en) 2024-02-16 2025-08-21 Medizinische Universität Wien New methods for assessing cell-specific drug response
WO2026093568A1 (en) * 2024-11-04 2026-05-07 Vivia Biotech, S.L. A method to determine simultaneously anti-cancer activity and hematotoxicity of an antibody-drug conjugate

Family Cites Families (115)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989006162A1 (en) * 1988-01-04 1989-07-13 Oncotech Incorporated Methods and apparatus assessing tumor resistance
US5366885A (en) * 1992-06-09 1994-11-22 Barranco Iii Sam C Method and kit for testing tumors for drug sensitivity
US5474909A (en) * 1992-08-07 1995-12-12 Anticancer, Inc. Noncolorimetric histoculture method for predicting drug response of tumors
AU2265695A (en) * 1995-01-17 1996-08-07 Pfizer Inc. The use of sertraline to treat cancer patients
US6825174B2 (en) * 1995-06-07 2004-11-30 East Carolina University Composition, formulations & method for prevention & treatment of diseases and conditions associated with bronchoconstriction, allergy(ies) & inflammation
US5736129A (en) * 1995-11-17 1998-04-07 Medenica; Rajko D. Flow cytometric pharmacosensitivity assay and method of cancer treatment
US6576636B2 (en) * 1996-05-22 2003-06-10 Protarga, Inc. Method of treating a liver disorder with fatty acid-antiviral agent conjugates
US5795909A (en) * 1996-05-22 1998-08-18 Neuromedica, Inc. DHA-pharmaceutical agent conjugates of taxanes
ES2248847T3 (es) * 1996-05-24 2006-03-16 Angiotech Pharmaceuticals, Inc. Composiciones y metodos para tratar o prevenir enfermedades de las vias de conduccion del cuerpo.
US8828432B2 (en) * 1996-10-28 2014-09-09 General Mills, Inc. Embedding and encapsulation of sensitive components into a matrix to obtain discrete controlled release particles
US20030049618A1 (en) * 1997-03-07 2003-03-13 Ruben Steven M. 186 human secreted proteins
US7026447B2 (en) * 1997-10-09 2006-04-11 Human Genome Sciences, Inc. 53 human secreted proteins
US20030059471A1 (en) * 1997-12-15 2003-03-27 Compton Bruce Jon Oral delivery formulation
US6207717B1 (en) * 1999-01-12 2001-03-27 Dow Corning Corporation Entrapment of vitamins with an elastomeric silicone polyether
US6890904B1 (en) * 1999-05-25 2005-05-10 Point Therapeutics, Inc. Anti-tumor agents
US6911306B1 (en) * 1999-10-18 2005-06-28 Emory University TMS1 compositions and methods of use
WO2001032677A1 (en) * 1999-11-04 2001-05-10 Human Genome Sciences, Inc. Uteroglobin-like polynucleotides, polypeptides, and antibodies
US6448030B1 (en) * 2000-02-18 2002-09-10 University Of Nevada-Las Vegas Method for predicting the efficacy of anti-cancer drugs
US7723303B2 (en) * 2000-08-24 2010-05-25 The Regents Of The University Of California Peptides and peptide mimetics to treat pathologies characterized by an inflammatory response
CA2427858A1 (en) * 2000-11-03 2002-05-10 University Of Vermont And State Agricultural College Compositions for inhibiting grb7
AU2002239771A1 (en) * 2000-11-13 2002-06-18 Vanderbilt University Methods of predicting chemotherapy response
IL139975A0 (en) * 2000-11-29 2002-02-10 Univ Ramot Anti proliferative drugs
US20050013853A1 (en) * 2000-11-29 2005-01-20 Irit Gil-Ad Anti-proliferative drugs
DE10064997A1 (de) * 2000-12-23 2002-06-27 Merck Patent Gmbh Benzoylpyridazine
KR20030070150A (ko) * 2001-01-31 2003-08-27 화이자 프로덕츠 인크. Pde4 이소자임 억제제로서 유용한 에테르 유도체
EP1364949A4 (en) * 2001-02-02 2005-11-23 Takeda Pharmaceutical JNK INHIBITOR
US20070054393A1 (en) * 2001-02-14 2007-03-08 Markus Kehlenbeck Dispensing device
JP4634694B2 (ja) * 2001-03-23 2011-02-16 ルイトポルド・ファーマシューティカルズ・インコーポレーテッド 脂肪アルコール薬物複合体
AU2002256359A1 (en) * 2001-04-24 2002-11-05 Epigenesis Pharmaceuticals, Inc. Antisense and anti-inflammatory based compositions to treat respiratory disorders
US20040072824A1 (en) * 2001-06-01 2004-04-15 Adam Telerman Methods and compositions for the treatment of cancer
US7355042B2 (en) * 2001-10-16 2008-04-08 Hypnion, Inc. Treatment of CNS disorders using CNS target modulators
WO2003039462A2 (en) * 2001-11-02 2003-05-15 Tanox, Inc. B-cell lymphoma specific antigen for use in diagnosis and treatment of b-cell malignancies
AU2003212822A1 (en) * 2002-01-22 2003-09-02 Trustees Of The University Of Pennsylvania Methods for determining drug responsiveness
GB0202337D0 (en) * 2002-02-01 2002-03-20 Univ Birmingham Cancer treatment
GB0203276D0 (en) * 2002-02-12 2002-03-27 Novartis Ag Organic compounds
DE10214388A1 (de) * 2002-03-30 2003-10-16 Cognis Deutschland Gmbh Verfahren zur Herstellung fester Mittel
AU2003273281A1 (en) * 2002-05-31 2003-12-19 The Forsyth Institute Methods for increasing bone density
AU2003248921A1 (en) * 2002-07-09 2004-01-23 Point Therapeutics, Inc. Boroproline compound combination therapy
CN1389462A (zh) * 2002-07-12 2003-01-08 复旦大学 大叶蒟素及其同系物,和在制备药物组合物中的应用
US20060009378A1 (en) * 2002-11-14 2006-01-12 Itshak Golan Novel galectin sequences and compositions and methods utilizing same for treating or diagnosing arthritis and other chronic inflammatory diseases
US20040101477A1 (en) * 2002-11-27 2004-05-27 Xanthus Life Sciences, Inc. Individualization of therapy with anesthetics
JP4789208B2 (ja) * 2003-04-09 2011-10-12 バイオデリバリー サイエンシーズ インターナショナル インコーポレイティッド タンパク質発現に向けられた渦巻型組成物
EP1624858B1 (en) * 2003-04-09 2018-06-06 Rutgers, the State University of New Jersey Novel encochleation methods
US7329638B2 (en) * 2003-04-30 2008-02-12 The Regents Of The University Of Michigan Drug delivery compositions
US20050136043A1 (en) * 2003-08-07 2005-06-23 Ludwig Institute For Cancer Research TGFbeta signaling inhibitors
SE0302232D0 (sv) * 2003-08-18 2003-08-18 Astrazeneca Ab Novel Compounds
US9149440B2 (en) * 2003-09-02 2015-10-06 University Of South Florida Nanoparticles for drug-delivery
JP4767857B2 (ja) * 2003-09-30 2011-09-07 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ベンゾイミダゾール化合物
US20050143378A1 (en) * 2003-12-29 2005-06-30 Yun Anthony J. Treatment of conditions through pharmacological modulation of the autonomic nervous system
US9173847B2 (en) * 2003-10-10 2015-11-03 Veloxis Pharmaceuticals A/S Tablet comprising a fibrate
JP2007511528A (ja) * 2003-11-13 2007-05-10 ボード・オブ・リージエンツ,ザ・ユニバーシテイ・オブ・テキサス・システム 心肥大および心不全の処置としてのtrpチャネル阻害方法
US7211275B2 (en) * 2004-01-16 2007-05-01 Massachusetts Institute Of Technology Composite materials for controlled release of water soluble products
EP1718291A1 (en) * 2004-02-19 2006-11-08 Novartis AG Use of cholinesterase inhibitors for treating vascular depression
CA2821167C (en) * 2004-05-03 2016-06-28 Merrimack Pharmaceuticals, Inc. Drug delivery liposomes containing anionic polyols or anionic sugars
WO2006088491A2 (en) * 2004-06-29 2006-08-24 Massachusetts Institute Of Technology Methods and compositions related to the modulation of intercellular junctions
US20060009506A1 (en) * 2004-07-09 2006-01-12 Odyssey Thera, Inc. Drugs for the treatment of neoplastic disorders
WO2006010567A1 (de) * 2004-07-23 2006-02-02 Curacyte Discovery Gmbh INHIBITOREN DER PHOSPHODIESTERASE 4 UND TNFα-FREISETZUNG
US7566548B2 (en) * 2004-08-13 2009-07-28 University Of Massachusetts Methods for identifying therapeutic agents and for treating disease
US20060039975A1 (en) * 2004-08-20 2006-02-23 Zalman Vilkov Paroxetine formulations
EP1627610A1 (en) * 2004-08-21 2006-02-22 TLT Medical Ltd Drug delivery throug application in nails
US7393662B2 (en) * 2004-09-03 2008-07-01 Centocor, Inc. Human EPO mimetic hinge core mimetibodies, compositions, methods and uses
US7326171B2 (en) * 2004-09-10 2008-02-05 Otologics, Llc Adjustable bone bracket
US20060058966A1 (en) * 2004-09-15 2006-03-16 Bruckner Howard W Methods and systems for guiding selection of chemotherapeutic agents
US20060062734A1 (en) * 2004-09-20 2006-03-23 Melker Richard J Methods and systems for preventing diversion of prescription drugs
CA2580694A1 (en) * 2004-09-23 2006-03-30 Alexander Michalow Methods for regulating neurotransmitter systems by inducing counteradaptations
CA2581816A1 (en) * 2004-09-27 2006-04-06 Sigmoid Biotechnologies Limited Microcapsules comprising a methylxanthine and a corticosteroid
CN101044249B (zh) * 2004-10-20 2012-09-05 日立化成工业株式会社 通过定量mRNA定制给药的方法
EP1809607B1 (en) * 2004-11-02 2008-12-17 Pfizer, Inc. Sulfonyl benzimidazole derivatives
WO2006053252A2 (en) * 2004-11-12 2006-05-18 Northwestern University Methods of treating hematological malignancies with nucleoside analog drugs
US20080096872A1 (en) * 2004-12-22 2008-04-24 Friedman Robert S Composition for Treatment of Pain Specification
AU2006210641A1 (en) * 2005-02-01 2006-08-10 Icagen, Inc. Imines as ion channel modulators
CN101201349B (zh) * 2005-03-17 2011-10-12 希森美康株式会社 试料分析装置和试料分析方法以及血液分析装置
US7601355B2 (en) * 2005-06-01 2009-10-13 Northwestern University Compositions and methods for altering immune function
US7655421B2 (en) * 2005-06-17 2010-02-02 Ciencia, Inc. Cytometer on a chip
EP2452694B1 (en) * 2005-06-30 2018-11-14 Janssen Biotech, Inc. Anti-IL-23 antibodies, compositions, methods and uses
JP2009501792A (ja) * 2005-07-21 2009-01-22 アストラゼネカ・アクチエボラーグ ケモカイン受容体のモジュレーターとしてのn−ベンジル−モルホリン誘導体
WO2007015926A2 (en) * 2005-07-25 2007-02-08 Oregon Health And Science University Multiparameter flow cytometric cytometric cytotoxicity systems, methods, compositions and kits for evaluating the susceptibility of cancer
TW200745106A (en) * 2005-10-03 2007-12-16 Astrazeneca Ab Chemical compounds
BRPI0520530A2 (pt) * 2005-10-05 2009-09-29 Astrazeneca Uk Ltd método para predizer ou monitorar a resposta de um paciente a uma droga receptora do erbb
US20080318252A1 (en) * 2007-04-23 2008-12-25 Scott Kachlany Rapid assay to test anti-cancer drugs under physiological conditions
EP1957467A2 (en) * 2005-12-02 2008-08-20 Pfizer Limited Spirocyclic derivatives
DK1973527T3 (da) * 2005-12-15 2010-02-01 Acusphere Inc Fremgangsmåder til fremstilling af partikelbaserede farmaceutiske formulationer til parenteral indgivelse
JP2009528382A (ja) * 2006-03-01 2009-08-06 トリストラータ・インコーポレイテッド タール応答性皮膚疾患の局所治療のための組成物及び方法
JP2009536918A (ja) * 2006-03-06 2009-10-22 ファイザー株式会社 スルホニルベンゾイミダゾール誘導体
EP1996551A2 (en) * 2006-03-07 2008-12-03 AstraZeneca AB Piperidine derivatives, their process for preparation, their use as therapeutic agents and pharmaceutical compositions containing them.
US20090029958A1 (en) * 2006-03-08 2009-01-29 Lilian Alcaraz Phenethanolamine derivatives as beta2 adrenoreceptor agonists
TW200808763A (en) * 2006-05-08 2008-02-16 Astrazeneca Ab Novel compounds I
US20100009352A1 (en) * 2006-05-24 2010-01-14 Gough Albert H Method for Modeling a Disease
TW200815469A (en) * 2006-06-23 2008-04-01 Astrazeneca Ab Compounds
US7767666B2 (en) * 2006-06-29 2010-08-03 Janssen Pharmaceutica Nv Butyl and butynyl benzyl amine compounds
WO2008021088A2 (en) * 2006-08-08 2008-02-21 The Regents Of The University Of Californina Salicylanilides enhance oral delivery of therapeutic peptides
US20080066739A1 (en) * 2006-09-20 2008-03-20 Lemahieu Edward Methods and systems of delivering medication via inhalation
LT2420498T (lt) * 2006-09-26 2017-10-25 Celgene Corporation 5-pakeistieji chinazolinono dariniai, kaip priešvėžiniai agentai
US8841300B2 (en) * 2006-10-02 2014-09-23 Jerry M. Held Treatment for Parkinson's disease—combination high dose serotonergic synaptic reuptake inhibitor with phosphodiesterase inhibitor
US7981893B2 (en) * 2006-10-19 2011-07-19 Signal Pharmaceuticals, Llc Heteroaryl compounds, compositions thereof, and methods of treatment therewith
US7661326B2 (en) * 2006-10-26 2010-02-16 Beckman Coulter, Inc. Apparatus for aspirating and dispensing liquids in an automated analyzer
TW200825084A (en) * 2006-11-14 2008-06-16 Astrazeneca Ab New compounds 521
GB0625322D0 (en) * 2006-12-19 2007-01-24 Pharmakodex Ltd Pharmaceutical compositions
WO2008098019A2 (en) * 2007-02-05 2008-08-14 Carbylan Biosurgery, Inc. Polymer formulations for delivery of bioactive agents
GB0704000D0 (en) * 2007-03-01 2007-04-11 Astrazeneca Ab Salts 670
US7846953B2 (en) * 2007-03-07 2010-12-07 Janssen Pharmaceutica, Nv Substituted phenoxy thiazolidinediones as estrogen related receptor-α modulators
GB0707127D0 (en) * 2007-04-13 2007-05-23 Zysis Ltd Pharmaceutical compositions
US20090004281A1 (en) * 2007-06-26 2009-01-01 Biovail Laboratories International S.R.L. Multiparticulate osmotic delivery system
US7943658B2 (en) * 2007-07-23 2011-05-17 Bristol-Myers Squibb Company Indole indane amide compounds useful as CB2 agonists and method
SI2200588T1 (sl) * 2007-09-25 2019-08-30 Solubest Ltd. Sestavki, ki obsegajo lipofilne aktivne spojine, in postopek za njihovo pripravo
US8354417B2 (en) * 2007-09-26 2013-01-15 Celgene Corporation Solid forms comprising 3-(2,5-dimethyl-4-oxo-4H-quinazolin-3-yl)-piperidine-2,6-dione, compositions comprising the same, and methods of using the same
WO2009051238A1 (ja) * 2007-10-18 2009-04-23 Riken ヒト白血病幹細胞および白血病非幹細胞が増幅されたマウスおよびその製造方法
US20090124675A1 (en) * 2007-10-19 2009-05-14 Burnham Institute For Medical Research Inhibitors of anti-apoptotic proteins
AU2008311827A1 (en) * 2007-10-19 2009-04-23 Burnham Institute For Medical Research Naphthalene-based inhibitors of anti-apoptotic proteins
US20110009496A1 (en) * 2008-01-08 2011-01-13 Sirtris Pharmaceuticas, Inc. Resveratrol formulations
CN102105448B (zh) * 2008-05-27 2013-11-13 阿斯利康(瑞典)有限公司 苯氧基吡啶基酰胺衍生物和它们在治疗由pde4介导的病症中的用途
EP2304436A1 (en) * 2008-07-10 2011-04-06 Nodality, Inc. Methods for diagnosis, prognosis and treatment
TWI453207B (zh) * 2008-09-08 2014-09-21 Signal Pharm Llc 胺基三唑并吡啶,其組合物及使用其之治療方法
US20100099109A1 (en) * 2008-10-17 2010-04-22 Nodality, Inc., A Delaware Corporation Methods for Analyzing Drug Response
KR101046883B1 (ko) * 2008-11-19 2011-07-06 재단법인 아산사회복지재단 항암제 치료약제에 대한 감수성을 일괄적으로 결정하는 방법

Also Published As

Publication number Publication date
RU2011148289A (ru) 2013-06-27
RU2636614C2 (ru) 2017-11-24
EP2433124A1 (en) 2012-03-28
WO2010135468A1 (en) 2010-11-25
US20170205395A1 (en) 2017-07-20
AR076590A1 (es) 2011-06-22
TW201043955A (en) 2010-12-16
SG176571A1 (en) 2012-01-30
AU2010249593B2 (en) 2016-03-17
SG10201402346UA (en) 2014-10-30
CL2011002905A1 (es) 2012-07-13
CA2762783C (en) 2018-06-26
AU2010249593A1 (en) 2012-01-12
JP2012527627A (ja) 2012-11-08
IL216419A (en) 2016-05-31
TWI546537B (zh) 2016-08-21
CN102460165A (zh) 2012-05-16
EP2433124B1 (en) 2017-03-01
CN102460165B (zh) 2016-08-17
IL216419A0 (en) 2012-02-29
MX2011012267A (es) 2012-04-11
CA2762783A1 (en) 2010-11-25
US20100298255A1 (en) 2010-11-25
DK2433124T3 (en) 2017-06-19
ES2628219T3 (es) 2017-08-02
JP5851984B2 (ja) 2016-02-03

Similar Documents

Publication Publication Date Title
BRPI0921726A2 (pt) método e dispositivo para ativar células tronco
IL254144A0 (en) Methods for reprogramming cells and uses thereof
BRPI0912680A2 (pt) sistema e métodos para medição e análise do consumo de energia de eventos dentro de um dispositivo portátil
BRPI0911758A2 (pt) anticorpos para receptor de produtos finais de glicação avançada (rage) e utilizações dos mesmos
BRPI1015026A2 (pt) método e aparelho para facilitar os procedimentos de medição em operação de multiportadora.
BRPI0818011A2 (pt) Método e dispositivo para associar objetos
BR112012011910A2 (pt) dispositivo e método
BRPI1015922A2 (pt) sistemas e métodos para testar analitos
DK2688629T3 (da) Urinopsamlingsenhed og fremgangsmåde til fremstilling deraf
BRPI1106096A2 (pt) dispositivo de monitoramento de material analítico e métodos.
BRPI0909657A2 (pt) dispositivo espaçador intersomático expansível
BR112012005568A2 (pt) aparelho e métodos para medir processos biológicos
BRPI0918294A2 (pt) dispositivo e método para produzir explosões
BRPI0821617A2 (pt) Dispositivos e métodos para reatores de fluxo contínuo alveolados
BRPI0924215A2 (pt) método e sistema para execução de medição
BRPI0812236A2 (pt) Método e dispositivo para a detecção de água em uma estruturas celular
BRPI0820007A2 (pt) Dispositivo e método para conectar tiras
BRPI1013533A2 (pt) aparelho e método para suportar múltiplos serviços
BRPI0907150A8 (pt) dispositivo e método para microelastografia
EP2510352A4 (en) APPARATUS FOR COLLECTING AND SAMPLE ANALYSIS
BR112012000477A2 (pt) módulo de tensão de furo de sondagem e métodos para uso
EP2432073A4 (en) ANTENNA ASSESSMENT APPARATUS AND ANTENNA ASSESSMENT METHOD
FI20075686A0 (fi) Konfigurointimenetelmä ja -laite
BRPI1007890A2 (pt) dispositivo e método para perfurar material
BR112013012248A2 (pt) dispositivo e método para imunotestes

Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements