BRPI1013012A2 - identificação de pequenas moléculas reconhecidas por anticorpos em indivíduos com doenças neurodegenerativas - Google Patents

identificação de pequenas moléculas reconhecidas por anticorpos em indivíduos com doenças neurodegenerativas

Info

Publication number
BRPI1013012A2
BRPI1013012A2 BRPI1013012A BRPI1013012A BRPI1013012A2 BR PI1013012 A2 BRPI1013012 A2 BR PI1013012A2 BR PI1013012 A BRPI1013012 A BR PI1013012A BR PI1013012 A BRPI1013012 A BR PI1013012A BR PI1013012 A2 BRPI1013012 A2 BR PI1013012A2
Authority
BR
Brazil
Prior art keywords
individuals
identification
neurodegenerative diseases
small antibody
molecules
Prior art date
Application number
BRPI1013012A
Other languages
English (en)
Inventor
Dwight German
Johnnie Wilson
Reddy Moola
Rosemary Wilson
Steven Connell
Thomas Kodadek
Original Assignee
Opko Health Inc
Univ Texas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42269525&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI1013012(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Opko Health Inc, Univ Texas filed Critical Opko Health Inc
Publication of BRPI1013012A2 publication Critical patent/BRPI1013012A2/pt

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896Neurological disorders, e.g. Alzheimer's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/564Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6845Methods of identifying protein-protein interactions in protein mixtures
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/28Neurological disorders
    • G01N2800/2814Dementia; Cognitive disorders
    • G01N2800/2821Alzheimer
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/28Neurological disorders
    • G01N2800/2835Movement disorders, e.g. Parkinson, Huntington, Tourette

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Rehabilitation Therapy (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)
BRPI1013012A 2009-06-02 2010-06-01 identificação de pequenas moléculas reconhecidas por anticorpos em indivíduos com doenças neurodegenerativas BRPI1013012A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US18326009P 2009-06-02 2009-06-02
US31865510P 2010-03-29 2010-03-29
PCT/US2010/036827 WO2010141421A1 (en) 2009-06-02 2010-06-01 Identification of small molecules recognized by antibodies in subjects with neurodegenerative diseases

Publications (1)

Publication Number Publication Date
BRPI1013012A2 true BRPI1013012A2 (pt) 2016-10-18

Family

ID=42269525

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI1013012A BRPI1013012A2 (pt) 2009-06-02 2010-06-01 identificação de pequenas moléculas reconhecidas por anticorpos em indivíduos com doenças neurodegenerativas

Country Status (15)

Country Link
US (1) US9551721B2 (pt)
EP (1) EP2438444A1 (pt)
JP (1) JP5828837B2 (pt)
KR (1) KR20120122869A (pt)
CN (1) CN102439451B (pt)
AU (1) AU2010256880B2 (pt)
BR (1) BRPI1013012A2 (pt)
CA (1) CA2764153C (pt)
CL (1) CL2011002973A1 (pt)
CO (1) CO6450654A2 (pt)
IL (1) IL216689A (pt)
MX (1) MX2011012933A (pt)
RU (1) RU2566064C2 (pt)
TW (1) TWI569014B (pt)
WO (1) WO2010141421A1 (pt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014504594A (ja) 2011-01-10 2014-02-24 オプコ ファーマシューティカルズ、エルエルシー 自己免疫疾患における抗原代用物
MX2013011000A (es) * 2011-03-24 2014-03-27 Opko Pharmaceuticals Llc Descubrimiento de biomarcador en fluido biologico complejo usando genotecas basadas en microesferao particula y kits de diagnostico y terapeuticos.
WO2012154484A1 (en) * 2011-05-06 2012-11-15 Elwha Llc Compositions and methods for antibody and ligand identification
US11360098B2 (en) * 2015-09-28 2022-06-14 Quest Diagnostics Investments Llc Amyloid beta detection by mass spectrometry
MX391259B (es) 2015-10-14 2025-03-21 X Therma Inc Composiciones y métodos para reducir la formación de cristales de hielo.
EP3426673B1 (en) * 2016-03-09 2021-05-05 Mike-Ann, LLC Peptoid affinity ligands
EP3433262A4 (en) * 2016-03-25 2019-11-20 Muralidhar Reddy Moola COMBINATORY SYNTHESIS AND DEVELOPMENT OF BIOMARKERS
CN106866794B (zh) * 2017-02-15 2020-09-08 国家纳米科学中心 一种类肽及其制备方法和应用
CN108484905A (zh) * 2018-04-16 2018-09-04 青岛科技大学 一种侧链含羧基具有ucst行为的聚类肽及其制备方法
WO2019211878A1 (en) * 2018-05-04 2019-11-07 Council Of Scientific And Industrial Research, An Indian Registered Body Incorporated Under The Registration Of Societies Act (Act Xxi Of 1860) Peptoid of formula i, pharmaceutical compositions and method for preparation thereof
CN108586579B (zh) * 2018-05-11 2021-11-30 京东方科技集团股份有限公司 一种类肽及其衍生物、盐、制备方法和用途

Family Cites Families (80)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL154598B (nl) 1970-11-10 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking.
US3817837A (en) 1971-05-14 1974-06-18 Syva Corp Enzyme amplification assay
US3939350A (en) 1974-04-29 1976-02-17 Board Of Trustees Of The Leland Stanford Junior University Fluorescent immunoassay employing total reflection for activation
US3996345A (en) 1974-08-12 1976-12-07 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US4277437A (en) 1978-04-05 1981-07-07 Syva Company Kit for carrying out chemically induced fluorescence immunoassay
US4275149A (en) 1978-11-24 1981-06-23 Syva Company Macromolecular environment control in specific receptor assays
US4366241A (en) 1980-08-07 1982-12-28 Syva Company Concentrating zone method in heterogeneous immunoassays
US5011771A (en) * 1984-04-12 1991-04-30 The General Hospital Corporation Multiepitopic immunometric assay
US4789628A (en) * 1986-06-16 1988-12-06 Vxr, Inc. Devices for carrying out ligand/anti-ligand assays, methods of using such devices and diagnostic reagents and kits incorporating such devices
CA1304682C (en) 1986-11-19 1992-07-07 Nobuo Monji Membrane affinity concentration immunoassay
US5149626A (en) * 1987-05-14 1992-09-22 Mclean Hospital Corporation Multiple antigen immunoassay
ES2080047T3 (es) 1987-11-24 1996-02-01 Abbott Lab Peptidos hiv y metodos para la deteccion de hiv.
DE4040669A1 (de) 1990-12-19 1992-06-25 Behringwerke Ag Verwendung von peptidpaaren mit extrem hoher spezifischer affinitaet zueinander im bereich der in vitro diagnostik
DK51092D0 (da) 1991-05-24 1992-04-15 Ole Buchardt Oligonucleotid-analoge betegnet pna, monomere synthoner og fremgangsmaade til fremstilling deraf samt anvendelser deraf
CA2115333A1 (en) * 1993-02-16 1994-08-17 Shigeo Hozumi Polyfunctional vinyl ether compounds and photoresist resin composition containing the same
US5705614A (en) * 1993-04-09 1998-01-06 Chiron Corporation Methods of producing antigen forks
EP1347493A3 (en) * 1993-05-28 2005-11-23 Baylor College Of Medicine Method and apparatus for desorption and ionization of analytes
ZA95605B (en) * 1994-04-28 1995-12-20 Qualcomm Inc Method and apparatus for automatic gain control and dc offset cancellation in quadrature receiver
AUPO591797A0 (en) * 1997-03-27 1997-04-24 Commonwealth Scientific And Industrial Research Organisation High avidity polyvalent and polyspecific reagents
ES2303338T3 (es) * 1995-06-07 2008-08-01 Glaxo Group Limited Peptidos y compuestos que se unen a un receptor de trombopoyetina.
JPH1025299A (ja) 1996-07-12 1998-01-27 Nec Corp 整列ペプチド、及びそれを用いたタンパク質の結合・相互作用部位検出方法
US20020022227A1 (en) * 1996-10-17 2002-02-21 Short Jay M. Morphatides: novel shape and structure libraries
US20020006620A1 (en) * 1996-10-17 2002-01-17 Invitrogen Corporation Morphatides: novel shape and structure libraries
AU5729898A (en) * 1996-12-18 1998-07-15 Emory University Polycationic oligomers
WO1998046796A1 (en) * 1997-04-11 1998-10-22 The Regents Of The University Of California A method of screening nucleotide sequences to identify disruptors or effectors of biological processes or pathways
NZ516848A (en) * 1997-06-20 2004-03-26 Ciphergen Biosystems Inc Retentate chromatography apparatus with applications in biology and medicine
US6344330B1 (en) * 1998-03-27 2002-02-05 The Regents Of The University Of California Pharmacophore recombination for the identification of small molecule drug lead compounds
AU3463699A (en) 1998-04-03 1999-10-25 Phylos, Inc. Addressable protein arrays
US6406632B1 (en) * 1998-04-03 2002-06-18 Symyx Technologies, Inc. Rapid characterization of polymers
WO1999067640A1 (en) * 1998-06-22 1999-12-29 The Regents Of The University Of California Triggered optical biosensor
US6406921B1 (en) * 1998-07-14 2002-06-18 Zyomyx, Incorporated Protein arrays for high-throughput screening
US6780582B1 (en) * 1998-07-14 2004-08-24 Zyomyx, Inc. Arrays of protein-capture agents and methods of use thereof
US6197599B1 (en) * 1998-07-30 2001-03-06 Guorong Chin Method to detect proteins
US6306643B1 (en) * 1998-08-24 2001-10-23 Affymetrix, Inc. Methods of using an array of pooled probes in genetic analysis
KR100728405B1 (ko) * 1998-11-06 2007-06-13 더 유니버시티 오브 취리히 Nogo 유전자의 뉴클레오티드와 단백질 서열 및 이들에기초한 방법
AU4025300A (en) 1999-03-24 2000-10-09 Packard Bioscience Company Continuous porous matrix arrays
US6465183B2 (en) * 1999-07-01 2002-10-15 Agilent Technologies, Inc. Multidentate arrays
WO2001027624A2 (en) * 1999-10-08 2001-04-19 Superarray, Inc. Compositions and methods for detecting protein modification and enzymatic activity
EP1155327A1 (en) 1999-11-02 2001-11-21 Chiron Corporation Biological sample component purification and differential display
AU2001233276A1 (en) 2000-02-03 2001-08-14 Immunomatrix Inc. Method and apparatus for signal transduction pathway profiling
WO2001060837A2 (en) 2000-02-16 2001-08-23 Northwestern University Polypeptoid pulmonary surfactants
ATE335202T1 (de) 2000-03-16 2006-08-15 Biacore Ab Verfahren zur erfassung von analyten, die aus oberflächengebundenen liganden eluiert werden
WO2001070685A2 (en) * 2000-03-22 2001-09-27 Solulink, Incorporated Hydrazine-based and carbonyl-based bifunctional crosslinking reagents
CA2408291C (en) * 2000-05-04 2014-07-15 Yale University High density protein arrays for screening of protein activity
EP1314032A2 (en) 2000-05-12 2003-05-28 David P. Dumas Compositions and methods for epitope mapping
US20020108130A1 (en) * 2000-05-25 2002-08-08 Asher Nathan Extracellular drug-oligonucleotides chimeric molecules
ATE360207T1 (de) * 2000-06-05 2007-05-15 Novartis Vaccines & Diagnostic Mikroarrays für durchführen von proteomanalyse
US7148058B2 (en) 2000-06-05 2006-12-12 Chiron Corporation Protein microarrays on mirrored surfaces for performing proteomic analyses
US7153682B2 (en) 2000-06-05 2006-12-26 Chiron Corporation Microarrays on mirrored substrates for performing proteomic analyses
US20020013334A1 (en) 2000-06-15 2002-01-31 Robl Jeffrey A. HMG-CoA reductase inhibitors and method
PT1292710E (pt) 2000-06-23 2007-12-04 Domantis Ltd Método de rastreio de matriz
ES2266224T3 (es) * 2000-08-15 2007-03-01 Discerna Limited Series de proteinas funcionales.
AU2001285252A1 (en) 2000-08-25 2002-03-13 Gendaq, Ltd. Analysis of binding interactions
GB0022978D0 (en) * 2000-09-19 2000-11-01 Oxford Glycosciences Uk Ltd Detection of peptides
EP1197755A1 (en) 2000-10-11 2002-04-17 Pepscan Systems B.V. Identification of protein binding sites
CA2432639A1 (en) * 2000-11-16 2002-05-23 Cemines, Llc Profiling tumor specific markers for the diagnosis and treatment of neoplastic disease
US20020137104A1 (en) 2000-11-27 2002-09-26 Antonio Cosma High throughput determination of antigen expression
AU2002230788A1 (en) * 2000-12-11 2002-06-24 Hk Pharmaceuticals, Inc. Multiplexed protein expression and activity assay
ATE538380T1 (de) * 2001-01-23 2012-01-15 Harvard College Nukleinsäure-programmierbare protein-arrays
JP2004531700A (ja) 2001-02-05 2004-10-14 グラフィニティー、ファーマスーティカルス アーゲー 低親和性スクリーニング法
US20020137106A1 (en) * 2001-03-09 2002-09-26 Ciphergen Biosystems, Inc. Detection of biological pathway components
AU2002302410A1 (en) 2001-03-10 2002-09-24 Affina Immuntechnik Gmbh Method for identifying immune reactive epitopes on proteins
JP4594588B2 (ja) * 2001-04-10 2010-12-08 ザ ボード オブ トラスティーズ オブ ザ リランド スタンフォード ジュニア ユニヴァーシティ 抗体特異的プロファイルの治療的および診断的使用方法
US6777239B2 (en) * 2001-04-17 2004-08-17 Xenoport, Inc. Epitope-captured antibody display
JP2004536290A (ja) * 2001-04-19 2004-12-02 ゲゼルシャフト フュア バイオテクノロギッシェ フォーシュンク エム ベー ハー(ゲー ベー エフ) 安定した、再生可能な抗体アレイの作製方法
US6989276B2 (en) * 2001-05-10 2006-01-24 Battelle Energy Alliance, Llc Rapid classification of biological components
WO2003019192A1 (en) * 2001-08-27 2003-03-06 The Trustees Of Boston University Apparatus, composition and method for proteome profiling
US20050202421A1 (en) 2001-10-31 2005-09-15 Raphael Hirsch Method for diagnosis and treatment of rheumatoid arthritis
EP1319954A1 (en) 2001-12-12 2003-06-18 Centre National de Genotypage Methods for protein analysis using protein capture arrays
US7504364B2 (en) * 2002-03-01 2009-03-17 Receptors Llc Methods of making arrays and artificial receptors
EP1565744A4 (en) 2002-03-07 2007-06-20 Zephyr Proteomix Ltd MICROARRAY'S CELLULOSE BINDING CHIMERIC PROTEINS AND METHOD OF USE THEREOF
US7736909B2 (en) * 2003-01-09 2010-06-15 Board Of Regents, The University Of Texas System Methods and compositions comprising capture agents
WO2005007677A2 (en) 2003-07-10 2005-01-27 The Institute For Systems Biology Affinity capture of peptides by microarray and related methods
GB2404734A (en) 2003-08-05 2005-02-09 Secr Defence A method of screening a sample for abnormally glycosylated and/or expressed proteins
US7504365B2 (en) * 2004-09-03 2009-03-17 Receptors Llc Combinatorial artificial receptors including tether building blocks
EP1688137A1 (en) 2005-01-28 2006-08-09 Schwarz Pharma Ag SPM 927 for add-on therapy of schizophrenia
US20070003954A1 (en) 2005-05-12 2007-01-04 The Board Of Regents Of The University Of Texas System Protein and antibody profiling using small molecule microarrays
DK1931695T3 (da) 2005-09-09 2013-07-01 Novartis Ag Prionspecifikke peptoidreagenser
JP2010507099A (ja) 2006-10-16 2010-03-04 ザ アリゾナ ボード オブ リージェンツ ア ボディ コーポレイト オブ ザ ステイト オブ アリゾナ アクティング フォー アンド オン ビハーフ オブ アリゾナ ステイト ユニバーシティー 合成抗体
MX2011012680A (es) 2009-05-29 2012-03-06 Univ Texas Ligandos peptoides para aislamiento y tratamiento de celulas-t autoinmune.

Also Published As

Publication number Publication date
IL216689A (en) 2016-09-29
TW201109662A (en) 2011-03-16
HK1169709A1 (en) 2013-02-01
JP2012529053A (ja) 2012-11-15
WO2010141421A1 (en) 2010-12-09
EP2438444A1 (en) 2012-04-11
RU2566064C2 (ru) 2015-10-20
TWI569014B (zh) 2017-02-01
US9551721B2 (en) 2017-01-24
CO6450654A2 (es) 2012-05-31
CA2764153A1 (en) 2010-12-09
CN102439451B (zh) 2014-12-03
AU2010256880B2 (en) 2015-01-22
CN102439451A (zh) 2012-05-02
US20100303805A1 (en) 2010-12-02
CL2011002973A1 (es) 2012-03-23
IL216689A0 (en) 2012-02-29
CA2764153C (en) 2021-07-27
AU2010256880A1 (en) 2011-11-03
MX2011012933A (es) 2012-03-07
KR20120122869A (ko) 2012-11-07
JP5828837B2 (ja) 2015-12-09

Similar Documents

Publication Publication Date Title
BRPI1013012A2 (pt) identificação de pequenas moléculas reconhecidas por anticorpos em indivíduos com doenças neurodegenerativas
BRPI1015379A2 (pt) sistemas de cálculo biométrico e métodos
BRPI0914623A2 (pt) identificação de consulta e associação
BR112012003867A2 (pt) sistema de visão e exibição integrado
BR112012016918A2 (pt) detecção do risco de pré-eclâmpsia
EP2766482A4 (en) MICRO-RNAS IN NEURODEGENERATIVE DISEASES
HRP20160737T1 (hr) Anti-her3-protutijela i njihove uporabe
BR112012009704A2 (pt) dispositivo de iluminação com funcionalidade de despertar e / ou dormir
EP2313000A4 (en) INTRAOPERATIVE FLUORESCENCE SPECTROSCOPY AND APPLICATIONS THEREOF
PT3279313T (pt) Estirpes de shigella com hipervesiculação
EP2256672A4 (en) TRANSPONDER AND BOOK FORM
BR112012000025A2 (pt) polipeptídos e processo de tratamento.
BRPI0910116A2 (pt) desvio transparente e mecanismos associados
BRPI1012854A2 (pt) processo de curtimento e composição de curtimento
HRP20170234T1 (hr) Molekule antitijela koje imaju specifično vezanje za ljudski il-13
DK2260994T3 (da) Formsystem samt anvendelse deraf
EP2519636A4 (en) PREPARATION OF A HEMAGGLUTININE NEURAMINIDASE PROTEIN IN MICROALGEN
BRPI0915036A2 (pt) processo de produção de caspofungina e seus intermediários
BRPI0914151A2 (pt) distribuidor de medicamento e método
DK2443304T3 (da) Person- eller laststighjælp
BRPI0814685A2 (pt) variantes com splicing de cd44 em doenças neurodegenerativas
FI20090161A0 (fi) Uusi solu ja siihen pohjautuvia terapeuttisia ja diagnostisia menetelmiä
EP2488507A4 (en) NEW MEK INHIBITORS TO TREAT DIABETES
EP2368499A4 (en) TREATMENT INSTRUMENT
PT2519505E (pt) Derivados de 8-hidroxiquinolina-7-carboxamida terciários e suas utilizações

Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001

B07G Grant request does not fulfill article 229-c lpi (prior consent of anvisa) [chapter 7.7 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements
B350 Update of information on the portal [chapter 15.35 patent gazette]