BRPI1013546A2 - usos de um inibidor da timidilato sintase e de uma terapia anticâncer - Google Patents

usos de um inibidor da timidilato sintase e de uma terapia anticâncer

Info

Publication number
BRPI1013546A2
BRPI1013546A2 BRPI1013546-4A BRPI1013546A BRPI1013546A2 BR PI1013546 A2 BRPI1013546 A2 BR PI1013546A2 BR PI1013546 A BRPI1013546 A BR PI1013546A BR PI1013546 A2 BRPI1013546 A2 BR PI1013546A2
Authority
BR
Brazil
Prior art keywords
synthase inhibitor
thymidylate synthase
cancer
therapy
anticancer therapy
Prior art date
Application number
BRPI1013546-4A
Other languages
English (en)
Inventor
W. Dawson David
K. Kurdistani Siavash
B. Seligson David
Original Assignee
The Regente Of The University Of California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Regente Of The University Of California filed Critical The Regente Of The University Of California
Publication of BRPI1013546A2 publication Critical patent/BRPI1013546A2/pt

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
    • G01N33/57595—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites involving intracellular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

métodos de prever a resposta de um paciente com câncer à terapia com 5-fu ou outro inibidor da timidilato sintase, para identificar um paciente com câncer e para tratar um paciente tendo um câncer pancreático a presente invenção fornece métodos de diagnosticar e fornecer um prognóstico e terapia para o câncer incluindo, mas não limitado a, câncer pancreático e responsividade à terapia com o inibidor da timidilato sintase (por exemplo, 5-fu), pela identificação de cânceres com padrões de modificação de histona alterados selecionados do grupo que consiste de h3k4me2, h3k9me2, ou h3k18ac.
BRPI1013546-4A 2009-04-14 2010-04-14 usos de um inibidor da timidilato sintase e de uma terapia anticâncer BRPI1013546A2 (pt)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US16921209P 2009-04-14 2009-04-14
US16921609P 2009-04-14 2009-04-14
US61/169216 2009-04-14
US61/169212 2009-04-14
US22516209P 2009-07-13 2009-07-13
US61/225162 2009-07-13
PCT/US2010/031112 WO2010120942A2 (en) 2009-04-14 2010-04-14 Histone modification patterns for clinical diagnosis and prognosis of cancer

Publications (1)

Publication Number Publication Date
BRPI1013546A2 true BRPI1013546A2 (pt) 2019-04-09

Family

ID=42983132

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI1013546-4A BRPI1013546A2 (pt) 2009-04-14 2010-04-14 usos de um inibidor da timidilato sintase e de uma terapia anticâncer

Country Status (8)

Country Link
US (1) US20120094949A1 (pt)
EP (1) EP2419737A4 (pt)
JP (1) JP2012524278A (pt)
CN (1) CN102460173A (pt)
AU (1) AU2010236415A1 (pt)
BR (1) BRPI1013546A2 (pt)
CA (1) CA2758933A1 (pt)
WO (1) WO2010120942A2 (pt)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201115095D0 (en) 2011-09-01 2011-10-19 Singapore Volition Pte Ltd Method for detecting nucleosomes containing nucleotides
MX356986B (es) 2011-12-07 2018-06-22 Singapore Volition Pte Ltd Metodo para detectar aductos de nucleosomas.
GB201303575D0 (en) * 2013-02-28 2013-04-10 Singapore Volition Pte Ltd Method for detecting histone modifications in nucleosomes
GB201303576D0 (en) * 2013-02-28 2013-04-10 Singapore Volition Pte Ltd Method for predicting therapy efficacy using nucleosome structure biomarkers
JP6553085B2 (ja) * 2013-12-30 2019-07-31 エイジェンシー フォー サイエンス，テクノロジー アンド リサーチ 消化管癌においてバイオマーカーを測定する方法
JP2016044993A (ja) * 2014-08-20 2016-04-04 有限会社マイテック ヒストン化学修飾判定による癌診断方法
CN107209190B (zh) * 2014-10-29 2021-07-16 比利时意志有限责任公司 用于富集循环肿瘤dna的方法
US10639349B2 (en) 2015-04-06 2020-05-05 The Johns Hopkins University H3T3A mutant protein efficiently reduces H3T3P and causes increased cell death of rapidly dividing cells
US10441644B2 (en) 2015-05-05 2019-10-15 The Regents Of The University Of California H3.3 CTL peptides and uses thereof
EP3359508B1 (en) * 2015-10-06 2020-09-09 Ontario Institute for Cancer Research Targeting the histone pathway to detect and overcome anthracyclin resistance
GB201612815D0 (en) * 2016-07-25 2016-09-07 Belgian Volition Sa Novel combination test
CN109564225B (zh) * 2016-08-09 2022-05-13 B.R.A.H.M.S 有限公司 作为指示不良事件的标志物的组蛋白和/或proADM
CN108957004B (zh) * 2018-07-09 2021-10-19 东南大学 检测H3K9me2和H3K36me3表达量的试剂在制备胃癌预后评估试剂盒中的应用
CN110221072B (zh) * 2019-06-10 2022-08-02 东南大学 检测H3K9甲基化和E-cadherin表达量试剂在制备肝癌预后评估试剂盒的应用
CN112904006B (zh) * 2021-01-28 2022-12-27 中山大学 一种乳腺癌预后预测分子标志物及其应用
CN120712104A (zh) * 2022-10-14 2025-09-26 广东天科雅生物医药科技有限公司 针对神经胶质瘤的肽疫苗及其用途
EP4705997A1 (en) * 2023-05-05 2026-03-11 University of Utah Research Foundation Systems and methods for point-of-care assessment based on pathology image analysis

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR901228A (fr) 1943-01-16 1945-07-20 Deutsche Edelstahlwerke Ag Système d'aimant à entrefer annulaire
ATE489624T1 (de) * 2005-04-29 2010-12-15 Univ California Antikörper gegen histonmodifikationen für die klinische krebsdiagnose und -prognose
WO2007015947A2 (en) * 2005-07-29 2007-02-08 Bayer Healthcare Llc Methods and kits for the prediction of therapeutic success, recurrence free and overall survival in cancer therapies

Also Published As

Publication number Publication date
WO2010120942A2 (en) 2010-10-21
CN102460173A (zh) 2012-05-16
US20120094949A1 (en) 2012-04-19
JP2012524278A (ja) 2012-10-11
EP2419737A2 (en) 2012-02-22
AU2010236415A1 (en) 2011-12-01
WO2010120942A3 (en) 2011-02-24
EP2419737A4 (en) 2013-02-13
CA2758933A1 (en) 2010-10-21

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 6A, 7A, 8A E 9A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2519 DE 16-04-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.

B350 Update of information on the portal [chapter 15.35 patent gazette]