BRPI1013553A2 - derivados de nicotinamida, o respectivo preparo e a respectiva aplicação em terapêutica como anticancerígenos - Google Patents
derivados de nicotinamida, o respectivo preparo e a respectiva aplicação em terapêutica como anticancerígenosInfo
- Publication number
- BRPI1013553A2 BRPI1013553A2 BRPI1013553A BRPI1013553A BRPI1013553A2 BR PI1013553 A2 BRPI1013553 A2 BR PI1013553A2 BR PI1013553 A BRPI1013553 A BR PI1013553A BR PI1013553 A BRPI1013553 A BR PI1013553A BR PI1013553 A2 BRPI1013553 A2 BR PI1013553A2
- Authority
- BR
- Brazil
- Prior art keywords
- anticancer
- preparation
- therapeutic application
- nicotinamide derivatives
- nicotinamide
- Prior art date
Links
- 230000001093 anti-cancer Effects 0.000 title 1
- 150000005480 nicotinamides Chemical class 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0901365A FR2943669B1 (fr) | 2009-03-24 | 2009-03-24 | Derives de nicotinamide,leur preparation et leur application en therapeutique |
| PCT/FR2010/050511 WO2010109122A1 (fr) | 2009-03-24 | 2010-03-22 | Derives de nicotinamide, leur preparation et leur application en therapeutique comme anticancereux |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI1013553A2 true BRPI1013553A2 (pt) | 2016-04-12 |
Family
ID=40792887
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI1013553A BRPI1013553A2 (pt) | 2009-03-24 | 2010-03-22 | derivados de nicotinamida, o respectivo preparo e a respectiva aplicação em terapêutica como anticancerígenos |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US20120053170A1 (pt) |
| EP (1) | EP2411368A1 (pt) |
| JP (1) | JP2012521396A (pt) |
| KR (1) | KR20110133049A (pt) |
| CN (1) | CN102448939A (pt) |
| AR (1) | AR075920A1 (pt) |
| AU (1) | AU2010227402A1 (pt) |
| BR (1) | BRPI1013553A2 (pt) |
| CA (1) | CA2756099A1 (pt) |
| FR (1) | FR2943669B1 (pt) |
| IL (1) | IL215285A0 (pt) |
| MX (1) | MX2011010052A (pt) |
| RU (1) | RU2011142753A (pt) |
| SG (1) | SG174902A1 (pt) |
| TW (1) | TW201038554A (pt) |
| UY (1) | UY32517A (pt) |
| WO (1) | WO2010109122A1 (pt) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR082885A1 (es) | 2010-09-03 | 2013-01-16 | Genentech Inc | Compuestos y composiciones para la inhibicion de nampt |
| CN106986856A (zh) | 2010-09-03 | 2017-07-28 | 福马Tm有限责任公司 | 作为用于治疗疾病诸如癌症的nampt抑制剂的4‑{[(吡啶‑3‑基‑甲基)氨基羰基]氨基}苯‑砜衍生物 |
| JP5978293B2 (ja) | 2011-05-04 | 2016-08-24 | フォーマ ティーエム， エルエルシー． | Ｎａｍｐｔを阻害するための新規な化合物および組成物 |
| EP2739144A4 (en) * | 2011-06-20 | 2015-04-01 | Alzheimer S Inst Of America Inc | COMPOUNDS AND ITS THERAPEUTIC USE |
| EP2712862A1 (en) * | 2012-09-28 | 2014-04-02 | Splicos | New anti-invasive compounds |
| EP2925750A1 (en) | 2012-11-29 | 2015-10-07 | Karyopharm Therapeutics, Inc. | Substituted 2,3-dihydrobenzofuranyl compounds and uses thereof |
| JP6397010B2 (ja) | 2013-07-03 | 2018-09-26 | カリオファーム セラピューティクス，インコーポレイテッド | 置換されたベンゾフラニル及びベンゾオキサゾリル化合物並びにその使用 |
| WO2015042414A1 (en) | 2013-09-20 | 2015-03-26 | Karyopharm Therapeutics Inc. | Multicyclic compounds and methods of using same |
| US9931298B2 (en) * | 2015-05-26 | 2018-04-03 | Comfort Care For Animals Llc | Liposome loading |
| WO2017031323A1 (en) | 2015-08-18 | 2017-02-23 | Karyopharm Therapeutics Inc. | (s,e)-3-(6-aminopyridin-3-yl)-n-((5-(4-(3-fluoro-3-methylpyrrolidine-1-carbonyl)phenyl)-7-(4-fluorophenyl)benzofuran-2-yl)methyl)acrylamide for the treatment of cancer |
| US10858347B2 (en) | 2015-12-31 | 2020-12-08 | Karyopharm Therapeutics Inc. | Multicyclic compounds and uses thereof |
| CA3217380A1 (en) * | 2021-05-13 | 2022-11-17 | Yushma Bhurruth-Alcor | Nampt inhibitors and uses thereof |
| WO2023119230A1 (en) | 2021-12-22 | 2023-06-29 | L'oreal | Coagulation pathway and nicotinamide-adenine dinucleotide pathway modulating compositions and methods of their use |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0327734D0 (en) * | 2003-11-28 | 2003-12-31 | Novartis Ag | Organic compounds |
| RU2006122853A (ru) * | 2003-11-28 | 2008-01-10 | Новартис АГ (CH) | Производные диарилмочевины для лечения заболеваний, зависимых от протеинкиназы |
| WO2006028958A2 (en) * | 2004-09-02 | 2006-03-16 | Genentech, Inc. | Pyridyl inhibitors of hedgehog signalling |
| FR2921657A1 (fr) * | 2007-09-28 | 2009-04-03 | Sanofi Aventis Sa | Derives de nicotinamide, leur preparation et leur application en therapeutique |
-
2009
- 2009-03-24 FR FR0901365A patent/FR2943669B1/fr not_active Expired - Fee Related
-
2010
- 2010-03-22 AU AU2010227402A patent/AU2010227402A1/en not_active Abandoned
- 2010-03-22 BR BRPI1013553A patent/BRPI1013553A2/pt not_active IP Right Cessation
- 2010-03-22 CA CA2756099A patent/CA2756099A1/fr not_active Abandoned
- 2010-03-22 JP JP2012501349A patent/JP2012521396A/ja not_active Withdrawn
- 2010-03-22 SG SG2011068871A patent/SG174902A1/en unknown
- 2010-03-22 US US13/258,220 patent/US20120053170A1/en not_active Abandoned
- 2010-03-22 EP EP10716566A patent/EP2411368A1/fr not_active Withdrawn
- 2010-03-22 MX MX2011010052A patent/MX2011010052A/es not_active Application Discontinuation
- 2010-03-22 KR KR1020117024865A patent/KR20110133049A/ko not_active Withdrawn
- 2010-03-22 WO PCT/FR2010/050511 patent/WO2010109122A1/fr not_active Ceased
- 2010-03-22 RU RU2011142753/04A patent/RU2011142753A/ru unknown
- 2010-03-22 CN CN2010800227689A patent/CN102448939A/zh active Pending
- 2010-03-23 TW TW099108544A patent/TW201038554A/zh unknown
- 2010-03-23 AR ARP100100920A patent/AR075920A1/es unknown
- 2010-03-24 UY UY0001032517A patent/UY32517A/es not_active Application Discontinuation
-
2011
- 2011-09-21 IL IL215285A patent/IL215285A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP2411368A1 (fr) | 2012-02-01 |
| UY32517A (es) | 2010-10-29 |
| SG174902A1 (en) | 2011-11-28 |
| WO2010109122A1 (fr) | 2010-09-30 |
| MX2011010052A (es) | 2012-01-12 |
| AU2010227402A1 (en) | 2011-10-20 |
| FR2943669A1 (fr) | 2010-10-01 |
| US20120053170A1 (en) | 2012-03-01 |
| CA2756099A1 (fr) | 2010-09-30 |
| RU2011142753A (ru) | 2013-04-27 |
| KR20110133049A (ko) | 2011-12-09 |
| FR2943669B1 (fr) | 2011-05-06 |
| AR075920A1 (es) | 2011-05-04 |
| TW201038554A (en) | 2010-11-01 |
| IL215285A0 (en) | 2011-11-30 |
| CN102448939A (zh) | 2012-05-09 |
| JP2012521396A (ja) | 2012-09-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE AS 4A, 5A E 6A ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2385 DE 20-09-2016 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |