BRPI1013677A2 - método para detectar inflamação ou infecção, e, usos de um 13c-piruvato hiperpolarizado, e de um meio de formação de imagem. - Google Patents

método para detectar inflamação ou infecção, e, usos de um 13c-piruvato hiperpolarizado, e de um meio de formação de imagem.

Info

Publication number
BRPI1013677A2
BRPI1013677A2 BRPI1013677A BRPI1013677A BRPI1013677A2 BR PI1013677 A2 BRPI1013677 A2 BR PI1013677A2 BR PI1013677 A BRPI1013677 A BR PI1013677A BR PI1013677 A BRPI1013677 A BR PI1013677A BR PI1013677 A2 BRPI1013677 A2 BR PI1013677A2
Authority
BR
Brazil
Prior art keywords
hyperpolarized
pyruvate
infection
imaging medium
detecting inflammation
Prior art date
Application number
BRPI1013677A
Other languages
English (en)
Inventor
Daniel M Spielman
Dirk Mayer
John D Mackenzie
Yi-Fen Yen
Original Assignee
Ge Healthcare Ltd
Univ Leland Stanford Junior
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ge Healthcare Ltd, Univ Leland Stanford Junior filed Critical Ge Healthcare Ltd
Publication of BRPI1013677A2 publication Critical patent/BRPI1013677A2/pt

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
    • G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
    • G01R33/5601—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
    • A61B5/055—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/10—Musculoskeletal or connective tissue disorders
    • G01N2800/101—Diffuse connective tissue disease, e.g. Sjögren, Wegener's granulomatosis
    • G01N2800/102—Arthritis; Rheumatoid arthritis, i.e. inflammation of peripheral joints

Landscapes

  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Radiology & Medical Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Signal Processing (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • General Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
BRPI1013677A 2009-04-02 2010-03-25 método para detectar inflamação ou infecção, e, usos de um 13c-piruvato hiperpolarizado, e de um meio de formação de imagem. BRPI1013677A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09157152 2009-04-02
PCT/EP2010/053912 WO2010112397A1 (en) 2009-04-02 2010-03-25 Use of a magnetic resonance imaging medium comprising hyperpolarized 13c pyruvate for the detection of inflammation or infection

Publications (1)

Publication Number Publication Date
BRPI1013677A2 true BRPI1013677A2 (pt) 2016-04-26

Family

ID=42128552

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI1013677A BRPI1013677A2 (pt) 2009-04-02 2010-03-25 método para detectar inflamação ou infecção, e, usos de um 13c-piruvato hiperpolarizado, e de um meio de formação de imagem.

Country Status (11)

Country Link
US (1) US20120128593A1 (pt)
EP (1) EP2414854A1 (pt)
JP (1) JP5868311B2 (pt)
KR (1) KR101666239B1 (pt)
CN (1) CN102388317B (pt)
AU (1) AU2010230330B2 (pt)
BR (1) BRPI1013677A2 (pt)
CA (1) CA2757227A1 (pt)
MX (1) MX2011010294A (pt)
RU (1) RU2543704C2 (pt)
WO (1) WO2010112397A1 (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2010230330B2 (en) * 2009-04-02 2015-06-25 Ge Healthcare Limited Use of a magnetic resonance imaging medium comprising hyperpolarized 13C pyruvate for the detection of inflammation or infection
DE102014112924A1 (de) 2014-09-09 2016-03-10 Friedrich-Alexander-Universität Erlangen-Nürnberg Verfahren und System zur Detektion von Krankheitsbildern
DE102014112923A1 (de) 2014-09-09 2016-03-10 Friedrich-Alexander-Universität Erlangen-Nürnberg Verfahren und System zur Detektion von Krankheitsbildern
KR101939454B1 (ko) * 2017-03-21 2019-01-16 전남대학교산학협력단 생체 내 과분극화 c13 피루베이트 자기공명분광법을 이용하여 새로운 정량적 생체지표를 통한 비알코올성 지방간질환 진단 방법
WO2024254159A1 (en) * 2023-06-05 2024-12-12 The Regents Of The University Of California Compositions and method for diagnosing and treating alzheimer's disease

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EP0951650B1 (en) 1997-01-08 2003-12-10 Amersham Health AS Method of magnetic resonance imaging
CN1269015A (zh) 1997-06-19 2000-10-04 耐克麦德英梅金公司 使用体外极化磁共振成像剂的奥氏磁共振成像方法
KR100600670B1 (ko) 1997-11-12 2006-07-13 지이 헬스케어 에이에스 파라수소 표지된 작용물질 및 자기공명영상에서의 그의 용도
US6278893B1 (en) 1998-01-05 2001-08-21 Nycomed Imaging As Method of magnetic resonance imaging of a sample with ex vivo polarization of an MR imaging agent
US6232497B1 (en) 1998-12-23 2001-05-15 Skw Trostberg Aktiengesellschaft Method for producing alkali metal and alkaline earth metal pyruvates
NO20002644D0 (no) * 2000-05-23 2000-05-23 Nycomed Imaging As Kontrastmiddel
WO2001089584A2 (en) * 2000-05-23 2001-11-29 Amersham Health As Contrast agents
GB0014463D0 (en) 2000-06-14 2000-08-09 Nycomed Amersham Plc NMR Method
NO20004561D0 (no) 2000-09-13 2000-09-13 Nycomed Imaging As Metode for magnetisk resonansavbildning
BR0115124B1 (pt) 2000-11-03 2012-12-25 dispositivo para fundir uma amostra hiperpolarizada sàlida, mÉtodo para produzir uma amostra hiperpolarizada fundida, e, uso de um dispositivo ou mÉtodo.
JP4061192B2 (ja) 2000-11-03 2008-03-12 ジーイー・ヘルスケア・アクスイェ・セルスカプ 分極ｎｍｒ試料用のデバイス及び方法
WO2002102418A2 (en) * 2001-06-15 2002-12-27 Uv-Solutions, Llc. Method and apparatus for sterilizing or disinfecting a region on a patient
NZ552898A (en) 2004-07-30 2011-02-25 Ge Healthcare As Method of producing a composition, composition and its use
WO2006011810A2 (en) * 2004-07-30 2006-02-02 Ge Healthcare As Mr imaging method for the discrimination between healthy and tumour tissue
KR20070067113A (ko) 2004-10-01 2007-06-27 지이 헬스케어 에이에스 피루브산의 제조 방법
WO2006054903A2 (en) 2004-11-19 2006-05-26 Ge Healthcare As Method of cardiac imaging with the use of hyperpolarized 13 c-pyruvate
WO2007044867A2 (en) * 2005-10-11 2007-04-19 Huntington Medical Research Institutes Imaging agents and methods of use thereof
JP5475995B2 (ja) 2005-12-01 2014-04-16 ジーイー・ヘルスケア・アクスイェ・セルスカプ 動的核分極（ｄｎｐ）法
PL1962912T3 (pl) 2005-12-16 2013-03-29 Ge Healthcare As Sposób wytwarzania hiperpolaryzowanych karboksylanów amin organicznych
US20100233096A1 (en) 2006-03-29 2010-09-16 Lerche Mathilde H Method to produce hyperpolarised carboxylates and sulphonates
EP2051739A2 (en) * 2006-08-18 2009-04-29 GE Healthcare AS Imaging medium comprising lactate and hyperpolarised 13c-pyruvate
CN101506679B (zh) * 2006-08-18 2013-03-06 通用电气医疗集团股份有限公司 细胞死亡的13c-mr成像或波谱分析
CN101970014A (zh) * 2007-07-26 2011-02-09 通用电气医疗集团英国有限公司 包含超极化的13c-乳酸盐的成像介质及其用途
US20090060841A1 (en) * 2007-08-27 2009-03-05 Yi-Fen Yen Apparatus and method for combined use of variable flip angles and centric phase encoding in hyperpolarized 13c imaging
US20110038802A1 (en) * 2008-05-02 2011-02-17 Zhong-Min Hu Method of determining alanine transaminase (alt) activity by 13c-mr detection using hyperpolarised 13c-pyruvate
AU2010230330B2 (en) * 2009-04-02 2015-06-25 Ge Healthcare Limited Use of a magnetic resonance imaging medium comprising hyperpolarized 13C pyruvate for the detection of inflammation or infection

Also Published As

Publication number Publication date
MX2011010294A (es) 2012-01-27
JP5868311B2 (ja) 2016-02-24
EP2414854A1 (en) 2012-02-08
CA2757227A1 (en) 2010-10-07
KR101666239B1 (ko) 2016-10-13
RU2543704C2 (ru) 2015-03-10
JP2012522549A (ja) 2012-09-27
CN102388317A (zh) 2012-03-21
AU2010230330B2 (en) 2015-06-25
AU2010230330A1 (en) 2011-10-13
CN102388317B (zh) 2015-11-25
RU2011139218A (ru) 2013-05-10
WO2010112397A1 (en) 2010-10-07
US20120128593A1 (en) 2012-05-24
KR20120016047A (ko) 2012-02-22

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Legal Events

Date Code Title Description
B06T Formal requirements before examination [chapter 6.20 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B11E Dismissal acc. art. 34 of ipl - requirements for examination incomplete
B11T Dismissal: dismissal of application maintained