BRPI1013677A2 - método para detectar inflamação ou infecção, e, usos de um 13c-piruvato hiperpolarizado, e de um meio de formação de imagem. - Google Patents

método para detectar inflamação ou infecção, e, usos de um 13c-piruvato hiperpolarizado, e de um meio de formação de imagem.

Info

Publication number
BRPI1013677A2
BRPI1013677A2 BRPI1013677A BRPI1013677A BRPI1013677A2 BR PI1013677 A2 BRPI1013677 A2 BR PI1013677A2 BR PI1013677 A BRPI1013677 A BR PI1013677A BR PI1013677 A BRPI1013677 A BR PI1013677A BR PI1013677 A2 BRPI1013677 A2 BR PI1013677A2
Authority
BR
Brazil
Prior art keywords
hyperpolarized
pyruvate
infection
imaging medium
detecting inflammation
Prior art date
Application number
BRPI1013677A
Other languages
English (en)
Inventor
Daniel M Spielman
Dirk Mayer
John D Mackenzie
Yi-Fen Yen
Original Assignee
Ge Healthcare Ltd
Univ Leland Stanford Junior
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ge Healthcare Ltd, Univ Leland Stanford Junior filed Critical Ge Healthcare Ltd
Publication of BRPI1013677A2 publication Critical patent/BRPI1013677A2/pt

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
    • G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
    • G01R33/5601—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
    • A61B5/055—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/10—Musculoskeletal or connective tissue disorders
    • G01N2800/101—Diffuse connective tissue disease, e.g. Sjögren, Wegener's granulomatosis
    • G01N2800/102—Arthritis; Rheumatoid arthritis, i.e. inflammation of peripheral joints

Landscapes

  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Radiology & Medical Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Signal Processing (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • General Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
BRPI1013677A 2009-04-02 2010-03-25 método para detectar inflamação ou infecção, e, usos de um 13c-piruvato hiperpolarizado, e de um meio de formação de imagem. BRPI1013677A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09157152 2009-04-02
PCT/EP2010/053912 WO2010112397A1 (en) 2009-04-02 2010-03-25 Use of a magnetic resonance imaging medium comprising hyperpolarized 13c pyruvate for the detection of inflammation or infection

Publications (1)

Publication Number Publication Date
BRPI1013677A2 true BRPI1013677A2 (pt) 2016-04-26

Family

ID=42128552

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI1013677A BRPI1013677A2 (pt) 2009-04-02 2010-03-25 método para detectar inflamação ou infecção, e, usos de um 13c-piruvato hiperpolarizado, e de um meio de formação de imagem.

Country Status (11)

Country Link
US (1) US20120128593A1 (pt)
EP (1) EP2414854A1 (pt)
JP (1) JP5868311B2 (pt)
KR (1) KR101666239B1 (pt)
CN (1) CN102388317B (pt)
AU (1) AU2010230330B2 (pt)
BR (1) BRPI1013677A2 (pt)
CA (1) CA2757227A1 (pt)
MX (1) MX2011010294A (pt)
RU (1) RU2543704C2 (pt)
WO (1) WO2010112397A1 (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI1013677A2 (pt) * 2009-04-02 2016-04-26 Ge Healthcare Ltd método para detectar inflamação ou infecção, e, usos de um 13c-piruvato hiperpolarizado, e de um meio de formação de imagem.
DE102014112923A1 (de) 2014-09-09 2016-03-10 Friedrich-Alexander-Universität Erlangen-Nürnberg Verfahren und System zur Detektion von Krankheitsbildern
DE102014112924A1 (de) 2014-09-09 2016-03-10 Friedrich-Alexander-Universität Erlangen-Nürnberg Verfahren und System zur Detektion von Krankheitsbildern
KR101939454B1 (ko) * 2017-03-21 2019-01-16 전남대학교산학협력단 생체 내 과분극화 c13 피루베이트 자기공명분광법을 이용하여 새로운 정량적 생체지표를 통한 비알코올성 지방간질환 진단 방법
WO2024254159A1 (en) * 2023-06-05 2024-12-12 The Regents Of The University Of California Compositions and method for diagnosing and treating alzheimer's disease

Family Cites Families (26)

* Cited by examiner, † Cited by third party
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WO1998030918A1 (en) 1997-01-08 1998-07-16 Nycomed Imaging As Method of magnetic resonance imaging
JP2002508687A (ja) 1997-06-19 2002-03-19 ナイコムド イメージング エーエス 磁気共鳴（ｍｒ）イメージング剤の生体外分極を含むオーバーハウザー磁気共鳴画像（ｏｒｍｉ）法
JP2001522819A (ja) 1997-11-12 2001-11-20 ナイコムド イメージング エーエス パラ水素で標識された作用剤およびその磁気共鳴イメージングにおける使用
US6278893B1 (en) 1998-01-05 2001-08-21 Nycomed Imaging As Method of magnetic resonance imaging of a sample with ex vivo polarization of an MR imaging agent
US6232497B1 (en) 1998-12-23 2001-05-15 Skw Trostberg Aktiengesellschaft Method for producing alkali metal and alkaline earth metal pyruvates
WO2001089584A2 (en) 2000-05-23 2001-11-29 Amersham Health As Contrast agents
NO20002644D0 (no) * 2000-05-23 2000-05-23 Nycomed Imaging As Kontrastmiddel
GB0014463D0 (en) 2000-06-14 2000-08-09 Nycomed Amersham Plc NMR Method
NO20004561D0 (no) 2000-09-13 2000-09-13 Nycomed Imaging As Metode for magnetisk resonansavbildning
CA2427726C (en) 2000-11-03 2012-01-24 Amersham Health As Methods and devices for polarised nmr samples
WO2002037132A1 (en) 2000-11-03 2002-05-10 Amersham Health As Methods and devices for dissolving hyperpolarised solid material for nmr analyses
EP2295112A1 (en) * 2001-06-15 2011-03-16 UV-Solutions, LLC Apparatus for sterilizing or disinfecting a region through a bandage
AU2005267668B2 (en) 2004-07-30 2011-10-20 Ge Healthcare As Method of producing a composition, composition and its use
CA2576202A1 (en) * 2004-07-30 2006-02-02 Ge Healthcare As Mr imaging method for the discrimination between healthy and tumour tissue
US20090118540A1 (en) 2004-10-01 2009-05-07 Ge Healthcare As Method For Producing Pyruvic Acid
PL1824523T3 (pl) * 2004-11-19 2013-12-31 Ge Healthcare As Sposób obrazowania serca przy zastosowaniu hiperspolaryzowanego 13C-pirogronianu
ES2654520T3 (es) * 2005-10-11 2018-02-14 Huntington Medical Research Institutes Agentes de formación de imágenes y métodos de uso de los mismos
EP1954321B1 (en) 2005-12-01 2011-11-23 Ge Healthcare As Method of dynamic nuclear polarisation (dnp) using a trityl radical and a paramagnetic metal ion
US9272056B2 (en) 2005-12-16 2016-03-01 Ge Healthcare As Method to produce hyperpolarised carboxylates
EP1998813A2 (en) 2006-03-29 2008-12-10 GE Healthcare AS Method to produce hyperpolarised carboxylates and sulphonates in the presence of inorganic cations
EP2051739A2 (en) * 2006-08-18 2009-04-29 GE Healthcare AS Imaging medium comprising lactate and hyperpolarised 13c-pyruvate
ES2381380T3 (es) * 2006-08-18 2012-05-25 Ge Healthcare As Formación de imagenes de 13C-RM o de espectroscopia de muerte celular
WO2009013350A2 (en) * 2007-07-26 2009-01-29 Ge Healthcare Uk Limited Imaging medium comprising hyperpolarised 13 c-lactate and use thereof
US20090060841A1 (en) * 2007-08-27 2009-03-05 Yi-Fen Yen Apparatus and method for combined use of variable flip angles and centric phase encoding in hyperpolarized 13c imaging
WO2009133169A1 (en) * 2008-05-02 2009-11-05 General Electric Company Method of determining alanine transaminase (alt) activity by 13c-mr detection using hyperpolarised 13c-pyruvate
BRPI1013677A2 (pt) * 2009-04-02 2016-04-26 Ge Healthcare Ltd método para detectar inflamação ou infecção, e, usos de um 13c-piruvato hiperpolarizado, e de um meio de formação de imagem.

Also Published As

Publication number Publication date
CN102388317B (zh) 2015-11-25
CN102388317A (zh) 2012-03-21
KR20120016047A (ko) 2012-02-22
RU2011139218A (ru) 2013-05-10
CA2757227A1 (en) 2010-10-07
WO2010112397A1 (en) 2010-10-07
AU2010230330B2 (en) 2015-06-25
JP2012522549A (ja) 2012-09-27
US20120128593A1 (en) 2012-05-24
AU2010230330A1 (en) 2011-10-13
EP2414854A1 (en) 2012-02-08
KR101666239B1 (ko) 2016-10-13
RU2543704C2 (ru) 2015-03-10
JP5868311B2 (ja) 2016-02-24
MX2011010294A (es) 2012-01-27

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Legal Events

Date Code Title Description
B06T Formal requirements before examination [chapter 6.20 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B11E Dismissal acc. art. 34 of ipl - requirements for examination incomplete
B11T Dismissal: dismissal of application maintained