BRPI1013677A2 - método para detectar inflamação ou infecção, e, usos de um 13c-piruvato hiperpolarizado, e de um meio de formação de imagem. - Google Patents

método para detectar inflamação ou infecção, e, usos de um 13c-piruvato hiperpolarizado, e de um meio de formação de imagem.

Info

Publication number
BRPI1013677A2
BRPI1013677A2 BRPI1013677A BRPI1013677A BRPI1013677A2 BR PI1013677 A2 BRPI1013677 A2 BR PI1013677A2 BR PI1013677 A BRPI1013677 A BR PI1013677A BR PI1013677 A BRPI1013677 A BR PI1013677A BR PI1013677 A2 BRPI1013677 A2 BR PI1013677A2
Authority
BR
Brazil
Prior art keywords
hyperpolarized
pyruvate
infection
imaging medium
detecting inflammation
Prior art date
Application number
BRPI1013677A
Other languages
English (en)
Inventor
Daniel M Spielman
Dirk Mayer
John D Mackenzie
Yi-Fen Yen
Original Assignee
Ge Healthcare Ltd
Univ Leland Stanford Junior
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ge Healthcare Ltd, Univ Leland Stanford Junior filed Critical Ge Healthcare Ltd
Publication of BRPI1013677A2 publication Critical patent/BRPI1013677A2/pt

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
    • G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
    • G01R33/5601—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
    • A61B5/055—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/10—Musculoskeletal or connective tissue disorders
    • G01N2800/101—Diffuse connective tissue disease, e.g. Sjögren, Wegener's granulomatosis
    • G01N2800/102—Arthritis; Rheumatoid arthritis, i.e. inflammation of peripheral joints

Landscapes

  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Radiology & Medical Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Signal Processing (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • General Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
BRPI1013677A 2009-04-02 2010-03-25 método para detectar inflamação ou infecção, e, usos de um 13c-piruvato hiperpolarizado, e de um meio de formação de imagem. BRPI1013677A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09157152 2009-04-02
PCT/EP2010/053912 WO2010112397A1 (en) 2009-04-02 2010-03-25 Use of a magnetic resonance imaging medium comprising hyperpolarized 13c pyruvate for the detection of inflammation or infection

Publications (1)

Publication Number Publication Date
BRPI1013677A2 true BRPI1013677A2 (pt) 2016-04-26

Family

ID=42128552

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI1013677A BRPI1013677A2 (pt) 2009-04-02 2010-03-25 método para detectar inflamação ou infecção, e, usos de um 13c-piruvato hiperpolarizado, e de um meio de formação de imagem.

Country Status (11)

Country Link
US (1) US20120128593A1 (pt)
EP (1) EP2414854A1 (pt)
JP (1) JP5868311B2 (pt)
KR (1) KR101666239B1 (pt)
CN (1) CN102388317B (pt)
AU (1) AU2010230330B2 (pt)
BR (1) BRPI1013677A2 (pt)
CA (1) CA2757227A1 (pt)
MX (1) MX2011010294A (pt)
RU (1) RU2543704C2 (pt)
WO (1) WO2010112397A1 (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5868311B2 (ja) * 2009-04-02 2016-02-24 ジーイー・ヘルスケア・リミテッド 炎症又は感染の検出のための過分極１３ｃピルビン酸塩を含む磁気共鳴造影媒体の使用
DE102014112924A1 (de) 2014-09-09 2016-03-10 Friedrich-Alexander-Universität Erlangen-Nürnberg Verfahren und System zur Detektion von Krankheitsbildern
DE102014112923A1 (de) 2014-09-09 2016-03-10 Friedrich-Alexander-Universität Erlangen-Nürnberg Verfahren und System zur Detektion von Krankheitsbildern
KR101939454B1 (ko) * 2017-03-21 2019-01-16 전남대학교산학협력단 생체 내 과분극화 c13 피루베이트 자기공명분광법을 이용하여 새로운 정량적 생체지표를 통한 비알코올성 지방간질환 진단 방법
WO2024254159A1 (en) * 2023-06-05 2024-12-12 The Regents Of The University Of California Compositions and method for diagnosing and treating alzheimer's disease

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69820415T2 (de) 1997-01-08 2004-09-16 Amersham Health As Verfahren zur bilderzeugung mit magnetischer resonanz
AU8119298A (en) 1997-06-19 1999-01-04 Nycomed Imaging As Overhauser magnetic resonance imaging (ormi) method comprising ex vivo polarization of a magnetic resonance (mr) imaging agent
EP1047455B1 (en) 1997-11-12 2008-08-20 GE Healthcare AS Para-hydrogen labelled agents and their use in non-proton magnetic resonance imaging
US6278893B1 (en) 1998-01-05 2001-08-21 Nycomed Imaging As Method of magnetic resonance imaging of a sample with ex vivo polarization of an MR imaging agent
US6232497B1 (en) 1998-12-23 2001-05-15 Skw Trostberg Aktiengesellschaft Method for producing alkali metal and alkaline earth metal pyruvates
NO20002644D0 (no) * 2000-05-23 2000-05-23 Nycomed Imaging As Kontrastmiddel
WO2001089584A2 (en) 2000-05-23 2001-11-29 Amersham Health As Contrast agents
GB0014463D0 (en) 2000-06-14 2000-08-09 Nycomed Amersham Plc NMR Method
NO20004561D0 (no) 2000-09-13 2000-09-13 Nycomed Imaging As Metode for magnetisk resonansavbildning
CA2427726C (en) 2000-11-03 2012-01-24 Amersham Health As Methods and devices for polarised nmr samples
DK1330659T3 (da) 2000-11-03 2006-12-18 Amersham Health As Fremgangsmåde og indretning til oplösning af hyperpolariseret, fast materiale til NMR-analyser
US6730113B2 (en) * 2001-06-15 2004-05-04 Uv-Solutions Llc Method and apparatus for sterilizing or disinfecting a region through a bandage
CN101031811A (zh) * 2004-07-30 2007-09-05 通用电气医疗集团股份有限公司 肿瘤成像方法
WO2006011809A1 (en) 2004-07-30 2006-02-02 Ge Healthcare As Method of producing a composition, composition and its use
KR20070067113A (ko) 2004-10-01 2007-06-27 지이 헬스케어 에이에스 피루브산의 제조 방법
KR101249634B1 (ko) * 2004-11-19 2013-04-01 지이 헬스케어 에이에스 과분극화 13ｃ-피루베이트를 사용한 심장 영상화 방법
EP1933884B1 (en) * 2005-10-11 2017-09-06 Huntington Medical Research Institutes Imaging agents and methods of use thereof
JP5475995B2 (ja) 2005-12-01 2014-04-16 ジーイー・ヘルスケア・アクスイェ・セルスカプ 動的核分極（ｄｎｐ）法
EP1962912B1 (en) 2005-12-16 2012-09-26 Ge Healthcare As Method to produce hyperpolarised carboxylates of organic amines
JP2009531422A (ja) 2006-03-29 2009-09-03 ジーイー・ヘルスケア・アクスイェ・セルスカプ 過分極カルボン酸塩及びスルホン酸塩の製造方法
PL2052273T3 (pl) * 2006-08-18 2012-08-31 Ge Healthcare As Obrazowanie lub spektroskopia metodą rezonansu magnetycznego 13C śmierci komórkowej
CN101505802A (zh) * 2006-08-18 2009-08-12 通用电气医疗集团股份有限公司 含有乳酸盐类和超极化的13c-丙酮酸盐的成像介质
CN101970014A (zh) * 2007-07-26 2011-02-09 通用电气医疗集团英国有限公司 包含超极化的13c-乳酸盐的成像介质及其用途
US20090060841A1 (en) * 2007-08-27 2009-03-05 Yi-Fen Yen Apparatus and method for combined use of variable flip angles and centric phase encoding in hyperpolarized 13c imaging
DK2268321T3 (da) * 2008-05-02 2013-12-02 Gen Electric Fremgangsmåde til bestemmelse af alanintransaminase (alt)-aktivitet ved 13c-mr-detektion under anvendelse af hyperpolariseret 13c-pyruvat
JP5868311B2 (ja) * 2009-04-02 2016-02-24 ジーイー・ヘルスケア・リミテッド 炎症又は感染の検出のための過分極１３ｃピルビン酸塩を含む磁気共鳴造影媒体の使用

Also Published As

Publication number Publication date
US20120128593A1 (en) 2012-05-24
JP5868311B2 (ja) 2016-02-24
JP2012522549A (ja) 2012-09-27
RU2543704C2 (ru) 2015-03-10
MX2011010294A (es) 2012-01-27
CN102388317A (zh) 2012-03-21
KR101666239B1 (ko) 2016-10-13
AU2010230330B2 (en) 2015-06-25
CN102388317B (zh) 2015-11-25
WO2010112397A1 (en) 2010-10-07
AU2010230330A1 (en) 2011-10-13
EP2414854A1 (en) 2012-02-08
CA2757227A1 (en) 2010-10-07
RU2011139218A (ru) 2013-05-10
KR20120016047A (ko) 2012-02-22

Similar Documents

Publication Publication Date Title
BRPI0917250A2 (pt) sistema para detecção de tecido em um paciente, sistema para detectar característica de tecido em um paciente
BRPI1016158A2 (pt) "sistema e método para monitorar um desempenho atlético, e, sistema e método de monitoramento do desempenho atlético."
BRPI1009004A2 (pt) método para integrar diagnóstico e tratamento para tecidos internos, e, sistema para integrar diagnóstico e tratamento para tecidos internos
BR112012024268A2 (pt) dispositivo médico, método médico para liberar um dispositivo médico, método e sistema para permanentemente intensificar a função de bombeamento ventricular esquerdo e meio de leitura
BRPI0914511A2 (pt) sistema de imageamento, e, método
BRPI0907279A2 (pt) sistema de monitoramento fetal e método para o monitoramento fetal.
BRPI1006885A2 (pt) sistema de completação utilizável com um poço, e método utilizável com um poço
BRPI0925314A2 (pt) Sistema e método para preparar uma quantidade predeterminada de bebida, cápsula, e, uso de uma cápsula.
BRPI1016218A2 (pt) sistema, e, método
BRPI1014894A2 (pt) método, e sistema
BR112012011083A2 (pt) sistema para comunicar dados do paciente, metodo para comunicar dados do paciente e unidade de comunicação
BRPI1013625A2 (pt) sistema, e método para determinar saúde de equipamento
BRPI0810760A2 (pt) Dispositivo, sistema e método para detecção de um analito, e, detector de fluorescência.
BRPI0925331A2 (pt) "sistema e método para preparar uma quantidade predeterminada de bebida, cápsula, e, uso de uma cápsula."
BRPI0823030A2 (pt) Sistema de elevador, e, método para fazer um sistema de elevador.
BR112013009450A2 (pt) módulo de impressão, método e sistema de impressão
BRPI1009079A2 (pt) método para formação de imagem médica nuclear e sistema de formação de imagem médica nuclear
BR112012014414A2 (pt) "método, sistema e meio legível por máquina codificado com instruções, para adaptar um fluxo de trabalho médico"
BRPI1009591A2 (pt) monitor de paciente, método de monitoramento de paciente e meio de armazenamento
BRPI0822726A2 (pt) Aparelho para aquisição de dados, sistema de aquisição de dados e métodos de aquisição de dados
BRPI0908763A2 (pt) Dispositivo, método para a obtenção de uma referência de freqüência e sistema.
BRPI1007070A2 (pt) sistema de dispositivo implantável.
BRPI1014150A2 (pt) método e sistema de diagnose de aparelho.
BR112012001212A2 (pt) aparelho, metodo e meio de armazenamento
BR112012009933A2 (pt) métoddo para operação de token, meio de armazenamento e token de segarança

Legal Events

Date Code Title Description
B06T Formal requirements before examination [chapter 6.20 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B11E Dismissal acc. art. 34 of ipl - requirements for examination incomplete
B11T Dismissal: dismissal of application maintained