BRPI1013690B8 - processo para a preparação de um comprimido - Google Patents

processo para a preparação de um comprimido

Info

Publication number
BRPI1013690B8
BRPI1013690B8 BRPI1013690A BRPI1013690A BRPI1013690B8 BR PI1013690 B8 BRPI1013690 B8 BR PI1013690B8 BR PI1013690 A BRPI1013690 A BR PI1013690A BR PI1013690 A BRPI1013690 A BR PI1013690A BR PI1013690 B8 BRPI1013690 B8 BR PI1013690B8
Authority
BR
Brazil
Prior art keywords
tablet
cavity
formulation
medical substance
preparing
Prior art date
Application number
BRPI1013690A
Other languages
English (en)
Inventor
Almer Middelbeek Hans
Johannes Adriana Maria Verheezen Jacobus
A C Smit Jozefus
Original Assignee
Intervet Int Bv
Merck Sharp & Dohme
Msd Oss Bv
N V Organon
Organon Biosciences Nederland B V
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Intervet Int Bv, Merck Sharp & Dohme, Msd Oss Bv, N V Organon, Organon Biosciences Nederland B V filed Critical Intervet Int Bv
Publication of BRPI1013690A2 publication Critical patent/BRPI1013690A2/pt
Publication of BRPI1013690B1 publication Critical patent/BRPI1013690B1/pt
Publication of BRPI1013690B8 publication Critical patent/BRPI1013690B8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/10—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of compressed tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J7/00—Devices for administering medicines orally, e.g. spoons; Pill counting devices; Arrangements for time indication or reminder for taking medicine
    • A61J7/0007—Pill breaking or crushing devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

processo para a preparação de um comprimido, comprimido, e, embalagem. a presente invenção diz respeito a um processo para a preparação de um comprimido que desintegra oralmente para administração a um sujeito humano, o comprimido contendo uma substância médica para tratar uma desordem do sujeito humano, compreendendo as etapas de fornecer uma formulação fluida compreendendo a substância médica, fornecendo um elemento sólido tendo formado nele pelo menos uma cavidade, resfriar o elemento sólido a uma temperatura abaixo de uma temperatura de congelamento da formulação, preenchendo a cavidade com a formulação fluida, solidificar a formulação ao mesmo tempo presente na cavidade extraindo calor da formulação por meio de uma parede da cavidade por condução, para formar uma pastilha sólida compreendendo a substância médica sem ativamente modelar toda a superfície da pastilha, retirando a pastilha da cavidade, e secar a pastilha em um vácuo para obter o comprimido. a invenção também diz respeito ao comprimido em si e uma embalagem compreendendo um comprimido como este.
BRPI1013690A 2009-04-29 2010-04-28 processo para a preparação de um comprimido BRPI1013690B8 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US17363409P 2009-04-29 2009-04-29
EP09159050.5 2009-04-29
EP09159050 2009-04-29
US61/173,634 2009-04-29
PCT/EP2010/055682 WO2010125087A1 (en) 2009-04-29 2010-04-28 Process to form an orally disintegrating tablet for human use

Publications (3)

Publication Number Publication Date
BRPI1013690A2 BRPI1013690A2 (pt) 2016-04-26
BRPI1013690B1 BRPI1013690B1 (pt) 2020-02-11
BRPI1013690B8 true BRPI1013690B8 (pt) 2020-12-08

Family

ID=40908570

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI1013690A BRPI1013690B8 (pt) 2009-04-29 2010-04-28 processo para a preparação de um comprimido

Country Status (10)

Country Link
US (2) US9119794B2 (pt)
EP (1) EP2424496B1 (pt)
JP (1) JP5620977B2 (pt)
CN (1) CN102413815B (pt)
AR (1) AR076465A1 (pt)
BR (1) BRPI1013690B8 (pt)
ES (1) ES2663073T3 (pt)
RU (1) RU2554757C2 (pt)
TW (1) TWI471127B (pt)
WO (1) WO2010125087A1 (pt)

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US20140017318A1 (en) 2012-07-10 2014-01-16 Kevin O'Connell Method to produce a medicinal product comprising a biologically active protein and the resulting product
US9314519B2 (en) 2012-08-21 2016-04-19 Intervet Inc. Liquid stable virus vaccines
US9597291B2 (en) 2012-12-11 2017-03-21 Alfred E. Tiefenbacher (Gmbh & Co. Kg) Orally disintegrating tablet containing asenapine
US9393298B2 (en) 2013-03-15 2016-07-19 Intervet Inc. Liquid stable bovine virus vaccines
US9480739B2 (en) 2013-03-15 2016-11-01 Intervet Inc. Bovine virus vaccines that are liquid stable
AR097762A1 (es) 2013-09-27 2016-04-13 Intervet Int Bv Formulaciones secas de vacunas que son estables a temperatura ambiente
US10429129B2 (en) * 2013-10-16 2019-10-01 Merck Sharp & Dohme Corp. Method of microwave vacuum drying spherical-shaped pellets of biological materials
AR099470A1 (es) 2014-02-17 2016-07-27 Intervet Int Bv Vacunas de virus de aves de corral líquidas
TWI670085B (zh) 2014-02-19 2019-09-01 荷蘭商英特威國際公司 液體穩定之豬病毒疫苗
CZ306556B6 (cs) * 2015-06-23 2017-03-08 České Vysoké Učení Technické V Praze, Fakulta Strojní, Ústav Materiálového Inženýrství Indentační hlavice, instrumentovaný měřící systém a způsob stanovení mechanických vlastností materiálů indentační metodou
JP6855469B2 (ja) * 2015-10-16 2021-04-07 メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． 消化器標的療法のための処方物を調製するための工程
PL3338768T3 (pl) 2016-12-20 2020-05-18 Lts Lohmann Therapie-Systeme Ag Transdermalny system terapeutyczny zawierający asenapinę
ES3001152T3 (es) 2016-12-20 2025-03-04 Lts Lohmann Therapie Systeme Ag Sistema terapéutico transdérmico que contiene asenapina y polisiloxano o poliisobutileno
JP6823234B2 (ja) * 2016-12-22 2021-02-03 大森機械工業株式会社 包装シート製造装置
WO2019002204A1 (en) 2017-06-26 2019-01-03 Lts Lohmann Therapie-Systeme Ag TRANSDERMAL THERAPEUTIC SYSTEM CONTAINING ASENAPINE AND SILICONE-TYPE ACRYLIC HYBRID POLYMER
CN108906188A (zh) * 2018-06-04 2018-11-30 邓帅 一种重症监护室用药片粉碎冲剂装置
EP3810099A1 (en) 2018-06-20 2021-04-28 LTS Lohmann Therapie-Systeme AG Transdermal therapeutic system containing asenapine
AU2019291060B2 (en) 2018-06-20 2024-09-05 Lts Lohmann Therapie-Systeme Ag Transdermal therapeutic system containing asenapine
US20220080425A1 (en) 2018-12-31 2022-03-17 Gen-Probe Incorporated Tray for transfering solid reagents to a multi-well cartridge
KR102281776B1 (ko) * 2019-09-10 2021-07-27 주식회사 제네웰 동결건조용 몰드 및 이를 사용하는 수용성 고분자 구의 제조방법
US12601542B2 (en) 2019-12-16 2026-04-14 Northwestern University Lyophilized reagents
EP4243796A4 (en) 2020-11-16 2025-01-22 Orcosa Inc. IMPROVED USE OF CANNABINOIDS IN THE TREATMENT OF EPILEPSY
US11672761B2 (en) 2020-11-16 2023-06-13 Orcosa Inc. Rapidly infusing platform and compositions for therapeutic treatment in humans
CA3147803C (en) 2021-02-05 2025-12-23 Thomas Babineau Systems and methods for troche production
DE102023101970B4 (de) 2023-01-26 2025-06-12 Applyo Jena GmbH Kühlbarer Träger sowie Vorrichtung und Verfahren zur Herstellung gefrorener Probensphären
DE102023200788A1 (de) 2023-01-31 2024-08-01 Technische Universität Braunschweig - Körperschaft des öffentlichen Rechts Festes Lyophilisat und Verfahren zur Herstellung
EP4686504A1 (en) 2024-08-01 2026-02-04 Jena Biotech Invest GmbH Method for the manufacture of frozen pellets and a product in the form of frozen pellets

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JP3981569B2 (ja) * 2002-02-26 2007-09-26 天野実業株式会社 乾燥装置
PT1501534E (pt) 2002-05-07 2006-09-29 Ferring Bv Formulacoes farmaceuticas
FR2868520B1 (fr) 2004-04-06 2006-07-07 Millennium Energy Sa Installation de deshydratation par zeolithes
TWI398272B (zh) 2005-03-08 2013-06-11 Intervet Int Bv 化學定義的安定劑
WO2008059818A1 (en) * 2006-11-15 2008-05-22 Sintokogio, Ltd. Tabletting method and roll compression molding machine for the method

Also Published As

Publication number Publication date
TWI471127B (zh) 2015-02-01
JP2012525177A (ja) 2012-10-22
US9119794B2 (en) 2015-09-01
TW201103525A (en) 2011-02-01
JP5620977B2 (ja) 2014-11-05
CN102413815B (zh) 2013-10-23
CN102413815A (zh) 2012-04-11
BRPI1013690B1 (pt) 2020-02-11
BRPI1013690A2 (pt) 2016-04-26
ES2663073T3 (es) 2018-04-11
US20120049412A1 (en) 2012-03-01
US20120048764A1 (en) 2012-03-01
RU2011148342A (ru) 2013-06-10
AR076465A1 (es) 2011-06-15
WO2010125087A1 (en) 2010-11-04
EP2424496A1 (en) 2012-03-07
EP2424496B1 (en) 2018-02-21
RU2554757C2 (ru) 2015-06-27
US9095516B2 (en) 2015-08-04

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Legal Events

Date Code Title Description
B25A Requested transfer of rights approved

Owner name: INTERVET INTERNATIONAL B.V. (NL) , MSD OSS B.V. (N

B25A Requested transfer of rights approved

Owner name: MSD OSS B.V. (NL) , ORGANON BIOSCIENCES NEDERLAND

B25A Requested transfer of rights approved

Owner name: MSD OSS B.V. (NL) , MERCK SHARP AND DOHME B.V. (NL

B25K Entry of change of name and/or headquarter and transfer of application, patent and certificate of addition of invention: republication

Owner name: MERCK SHARP AND DOHME B.V. (NL) , INTERVET INTERNA

B07D Technical examination (opinion) related to article 229 of industrial property law
B06F Objections, documents and/or translations needed after an examination request according art. 34 industrial property law
B07E Notice of approval relating to section 229 industrial property law
B06T Formal requirements before examination
B09A Decision: intention to grant
B16A Patent or certificate of addition of invention granted

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 28/04/2010, OBSERVADAS AS CONDICOES LEGAIS.

B16C Correction of notification of the grant

Free format text: REF. RPI 2562 DE 11/02/2020 QUANTO AO ENDERECO