BRPI1014184A8 - compostos carboxamida e seus usos como inibidores de calpaína - Google Patents

compostos carboxamida e seus usos como inibidores de calpaína

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Publication number
BRPI1014184A8
BRPI1014184A8 BRPI1014184A BRPI1014184A BRPI1014184A8 BR PI1014184 A8 BRPI1014184 A8 BR PI1014184A8 BR PI1014184 A BRPI1014184 A BR PI1014184A BR PI1014184 A BRPI1014184 A BR PI1014184A BR PI1014184 A8 BRPI1014184 A8 BR PI1014184A8
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Brazil
Prior art keywords
compounds
carboxamide compounds
meanings mentioned
carboxamide
tautomers
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BRPI1014184A
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English (en)
Inventor
Mack Helmut
Kling Andreas
Jantos Katja
Moeller Achim
Hornberger Wilfried
W Hutchins Charles
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Abbott Gmbh & Co Kg
Abbott Lab
Abbvie Inc
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Family has litigation
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Application filed by Abbott Gmbh & Co Kg, Abbott Lab, Abbvie Inc filed Critical Abbott Gmbh & Co Kg
Publication of BRPI1014184A2 publication Critical patent/BRPI1014184A2/pt
Publication of BRPI1014184A8 publication Critical patent/BRPI1014184A8/pt

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Abstract

COMPOSTOS CARBOXAMIDA E SEUS USOS COMO INIBIDORES DE CALPAÍNA. A presente invenção refere-se aos novos compostos carboxamida e seus usos para a fabricação de um medicamento. Os compostos carboxamida são inibidores de calpaína (proteases de cisteína dependentes de cálcio). A invenção portanto ainda refere-se ao uso destes compostos carboxamida para o tratamento de um transtorno associado com uma atividade elevada de calpaína. Os compostos carboxamida são compostos de fórmula geral I. No qual R1, R2, R3a, R3b, R4, Q, Y, A e X têm os significados nas reivindicações e na descrição, os tautômeros e os sais farmaceuticamente apropriados dos mesmos. Em particular,os compostos têm a fórmula geral la e Ib. Na qual R1, r, R2b, R3a, R3b, R4, Y e X têm os significados mencionados nas reivindicações, incluindo os tautômeros e os sais farmaceuticamente apropriados dos mesmos. Destes compostos, são preferenciais aqueles onde Y é uma fração CH2-CH2, CH2-CH2-CH2, N(Ry#)-CH2, N(Ry#)-CH2-CH2 or CH=CH-CH=, cada uma opcionalmente contendo 1 ou 2 átomos de H substituídos com radicais Ry idênticos ou diferentes, onde Ry e Ry# têm os significados nas reivindicações.
BRPI1014184A 2009-05-07 2010-05-06 compostos carboxamida e seus usos como inibidores de calpaína BRPI1014184A8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US17613809P 2009-05-07 2009-05-07
US28975309P 2009-12-23 2009-12-23
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