BRPI1014821A2 - "inibidores de replicação de hiv" - Google Patents
"inibidores de replicação de hiv"Info
- Publication number
- BRPI1014821A2 BRPI1014821A2 BRPI1014821A BRPI1014821A BRPI1014821A2 BR PI1014821 A2 BRPI1014821 A2 BR PI1014821A2 BR PI1014821 A BRPI1014821 A BR PI1014821A BR PI1014821 A BRPI1014821 A BR PI1014821A BR PI1014821 A2 BRPI1014821 A2 BR PI1014821A2
- Authority
- BR
- Brazil
- Prior art keywords
- hiv replication
- replication inhibitors
- inhibitors
- hiv
- replication
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title 1
- 230000010076 replication Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
- C07D491/147—Ortho-condensed systems the condensed system containing one ring with oxygen as ring hetero atom and two rings with nitrogen as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- AIDS & HIV (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Tropical Medicine & Parasitology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16803209P | 2009-04-09 | 2009-04-09 | |
| US26368909P | 2009-11-23 | 2009-11-23 | |
| PCT/CA2010/000478 WO2010115264A1 (en) | 2009-04-09 | 2010-04-07 | Inhibitors of hiv replication |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI1014821A2 true BRPI1014821A2 (pt) | 2016-04-05 |
Family
ID=42934876
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI1014821A BRPI1014821A2 (pt) | 2009-04-09 | 2010-04-07 | "inibidores de replicação de hiv" |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US8349839B2 (pt) |
| EP (1) | EP2417140B1 (pt) |
| JP (1) | JP5643290B2 (pt) |
| KR (1) | KR20120034592A (pt) |
| CN (1) | CN102388051A (pt) |
| AR (1) | AR076252A1 (pt) |
| AU (1) | AU2010234241A1 (pt) |
| BR (1) | BRPI1014821A2 (pt) |
| CA (1) | CA2758149A1 (pt) |
| CL (1) | CL2011002258A1 (pt) |
| EA (1) | EA201101397A1 (pt) |
| IL (1) | IL214606A0 (pt) |
| MX (1) | MX2011010582A (pt) |
| TW (1) | TW201103940A (pt) |
| WO (1) | WO2010115264A1 (pt) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6144698B2 (ja) * | 2011-12-20 | 2017-06-07 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｈｉｖ複製の阻害剤としての縮合三環式化合物 |
| EP3233797B1 (en) * | 2015-01-18 | 2019-05-08 | SRI International Inc. | Map4k4 (hgk) inhibitors |
| WO2016126726A1 (en) | 2015-02-02 | 2016-08-11 | Forma Therapeutics, Inc. | Bicyclic [4,6,0] hydroxamic acids as hdac6 inhibitors |
| TW201629026A (zh) | 2015-02-02 | 2016-08-16 | 佛瑪治療公司 | 作為ｈｄａｃ抑制劑的３－烷基雙環［４，５，０］異羥肟酸 |
| US10555935B2 (en) | 2016-06-17 | 2020-02-11 | Forma Therapeutics, Inc. | 2-spiro-5- and 6-hydroxamic acid indanes as HDAC inhibitors |
| WO2019126731A1 (en) | 2017-12-22 | 2019-06-27 | Petra Pharma Corporation | Aminopyridine derivatives as phosphatidylinositol phosphate kinase inhibitors |
| WO2020028482A1 (en) * | 2018-07-31 | 2020-02-06 | The Trustees Of The University Of Pennsylvania | Small molecules that sensitize hiv-1 infected cells to antibody dependent cellular cytotoxicity |
| TW202112767A (zh) | 2019-06-17 | 2021-04-01 | 美商佩特拉製藥公司 | 作為磷脂酸肌醇磷酸激酶抑制劑之胺基吡啶衍生物 |
| CN111560022A (zh) * | 2020-05-13 | 2020-08-21 | 深圳职业技术学院 | 四氢苯并呋喃[3,2-d]嘧啶类衍生物及其制备方法及应用 |
| CN116332947A (zh) * | 2021-12-24 | 2023-06-27 | 上海海和药物研究开发股份有限公司 | 具有mat2a抑制活性的嘧啶-2(1h)-酮并二环类化合物及其用途 |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8016A (en) * | 1851-04-01 | Improvement in the manufacture of india-rubber | ||
| JPH06172365A (ja) * | 1992-12-11 | 1994-06-21 | Yamasa Shoyu Co Ltd | １０−チアイソアロキサジン誘導体およびその用途 |
| JPH06220059A (ja) * | 1993-01-28 | 1994-08-09 | Tanabe Seiyaku Co Ltd | 縮合ピリミジン誘導体及びその製法 |
| US6593337B1 (en) * | 1999-10-19 | 2003-07-15 | Bristol-Myers Squibb Pharma Company | Tricyclic compounds useful as HIV reverse transcriptase inhibitors |
| EP1209158A1 (en) | 2000-11-18 | 2002-05-29 | Aventis Pharma Deutschland GmbH | Substituted beta-carbolines |
| TWI270547B (en) * | 2000-06-16 | 2007-01-11 | Boehringer Ingelheim Ca Ltd | Non-nucleoside reverse transcriptase inhibitors |
| US7008958B2 (en) | 2002-05-21 | 2006-03-07 | Bristol-Myers Squibb Company | 2-substituted 5-oxazolyl indole compounds useful as IMPDH inhibitors and pharmaceutical compositions comprising same |
| US20030139427A1 (en) | 2002-08-23 | 2003-07-24 | Osi Pharmaceuticals Inc. | Bicyclic pyrimidinyl derivatives and methods of use thereof |
| EP1559720A1 (en) | 2002-11-08 | 2005-08-03 | Kaneka Corporation | Method of separating ergosterol |
| MXPA05005146A (es) | 2002-11-15 | 2005-07-22 | Tibotec Pharm Ltd | Indolpiridinio sustituido como compuestos antiinfecciosos. |
| US7642277B2 (en) | 2002-12-04 | 2010-01-05 | Boehringer Ingelheim International Gmbh | Non-nucleoside reverse transcriptase inhibitors |
| CN1812992A (zh) * | 2003-04-28 | 2006-08-02 | 泰博特克药品有限公司 | Hiv整合酶抑制剂 |
| US20060074124A1 (en) | 2003-09-12 | 2006-04-06 | Andrew Napper | Methods of treating a disorder |
| CN1870896A (zh) * | 2003-10-20 | 2006-11-29 | 默克公司 | 用作hiv整合酶抑制剂的羟基吡啶并吡咯并吡嗪二酮化合物 |
| CA2555132A1 (en) * | 2004-02-04 | 2005-08-25 | University Of Virginia Patent Foundation | Compounds that inhibit hiv particle formation |
| KR20070015608A (ko) | 2004-05-17 | 2007-02-05 | 티보텍 파마슈티칼즈 리미티드 | 1-헤테로사이클일-1,5-디히드로-피리도[3,2-ｂ]인돌-2-온 |
| MXPA06013312A (es) | 2004-05-17 | 2007-02-02 | Tibotec Pharm Ltd | 1-fenil-1,5-dihidro-pirido[3,2-b]indol-2-onas 5-sustituidas y analogos como antivirales. |
| TW200607502A (en) | 2004-05-17 | 2006-03-01 | Tibotec Pharm Ltd | 6, 7, 8, 9-substituted 1-phenyl-1, 5-dihydro-pyrido[3, 2-b]indol-2-ones |
| MXPA06013315A (es) * | 2004-05-17 | 2007-02-02 | Tibotec Pharm Ltd | 1,5-dihidro-pirido[3,2-b]indol-2-onas 4-sustituidas. |
| EA200602136A1 (ru) * | 2004-05-17 | 2007-04-27 | Тиботек Фармасьютикалз Лтд. | Комбинации замещенных 1-фенил-1,5-дигидропиридо[3,2-b] индол-2-онов и других ингибиторов вич |
| ATE455777T1 (de) * | 2004-07-23 | 2010-02-15 | Medicines Co Leipzig Gmbh | Substituierte pyridoä3',2':4,5üthienoä3,2- düpyrimidine und pyridoä3',2':4,5üfuroä3,2-dü- pyrimidine zur verwendung als inhibitoren der pda-4 und/oder tnf-alpha freisetzung |
| WO2006034583A1 (en) | 2004-09-30 | 2006-04-06 | Boehringer Ingelheim International Gmbh & Co Kg | Alkynyl based dervatives of benzophenone as non-nucleoside reverse transcriptase inhibitors |
| EP1802299A2 (en) | 2004-10-13 | 2007-07-04 | Merck & Co., Inc. | Ophthalmic compositions for treating ocular hypertension |
| PL1831227T3 (pl) | 2004-12-17 | 2013-10-31 | Glenmark Pharmaceuticals Sa | Nowe związki heterocykliczne użyteczne w leczeniu stanów zapalnych i dolegliwości alergicznych |
| US20060276440A1 (en) | 2005-01-03 | 2006-12-07 | An Wenqian F | Treatment of inflammatory disorders |
| US20070049591A1 (en) | 2005-08-25 | 2007-03-01 | Kalypsys, Inc. | Inhibitors of MAPK/Erk Kinase |
| JP2009525310A (ja) | 2006-02-03 | 2009-07-09 | テイボテク・フアーマシユーチカルズ・リミテツド | 突然変異したｈｉｖを処置する方法 |
| WO2008037783A1 (en) | 2006-09-29 | 2008-04-03 | Tibotec Pharmaceuticals Ltd. | Process for preparing 2-oxo-2,5-dihydro-1h-pyrido[3,2-b]indole-3-carbonitriles |
| DE102006062203A1 (de) * | 2006-12-22 | 2008-06-26 | Curacyte Discovery Gmbh | Substituierte 5H-Pyrimido[5,4-b]indole als Induktoren der Apoptose bei B-CLL Zellen |
| JP2010519186A (ja) | 2007-02-19 | 2010-06-03 | スミスクライン ビーチャム コーポレーション | 免疫調節物質としてのプリン誘導体 |
| WO2008119070A1 (en) | 2007-03-28 | 2008-10-02 | Trustees Of Boston University | Methods of treatment using sirt modulators and compositions containing sirt1 modulators |
| AU2008343932B2 (en) | 2007-12-19 | 2013-08-15 | Amgen Inc. | Fused pyridine, pyrimidine and triazine compounds as cell cycle inhibitors |
-
2010
- 2010-04-07 BR BRPI1014821A patent/BRPI1014821A2/pt not_active Application Discontinuation
- 2010-04-07 JP JP2012503835A patent/JP5643290B2/ja active Active
- 2010-04-07 CA CA2758149A patent/CA2758149A1/en not_active Abandoned
- 2010-04-07 MX MX2011010582A patent/MX2011010582A/es unknown
- 2010-04-07 KR KR1020117023696A patent/KR20120034592A/ko not_active Withdrawn
- 2010-04-07 EP EP10761139.4A patent/EP2417140B1/en active Active
- 2010-04-07 WO PCT/CA2010/000478 patent/WO2010115264A1/en not_active Ceased
- 2010-04-07 AU AU2010234241A patent/AU2010234241A1/en not_active Abandoned
- 2010-04-07 EA EA201101397A patent/EA201101397A1/ru unknown
- 2010-04-07 CN CN2010800156236A patent/CN102388051A/zh active Pending
- 2010-04-08 US US12/756,276 patent/US8349839B2/en active Active
- 2010-04-08 AR ARP100101202A patent/AR076252A1/es unknown
- 2010-04-08 TW TW099110936A patent/TW201103940A/zh unknown
-
2011
- 2011-08-11 IL IL214606A patent/IL214606A0/en unknown
- 2011-09-12 CL CL2011002258A patent/CL2011002258A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AR076252A1 (es) | 2011-05-26 |
| US20100261714A1 (en) | 2010-10-14 |
| EP2417140A4 (en) | 2013-02-20 |
| CA2758149A1 (en) | 2010-10-14 |
| JP2012523380A (ja) | 2012-10-04 |
| TW201103940A (en) | 2011-02-01 |
| MX2011010582A (es) | 2011-10-19 |
| CL2011002258A1 (es) | 2012-02-10 |
| WO2010115264A1 (en) | 2010-10-14 |
| EP2417140A1 (en) | 2012-02-15 |
| IL214606A0 (en) | 2011-09-27 |
| EP2417140B1 (en) | 2014-11-26 |
| AU2010234241A1 (en) | 2011-09-08 |
| US8349839B2 (en) | 2013-01-08 |
| KR20120034592A (ko) | 2012-04-12 |
| CN102388051A (zh) | 2012-03-21 |
| JP5643290B2 (ja) | 2014-12-17 |
| EA201101397A1 (ru) | 2012-05-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
| B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |