BRPI9915841B8 - processo de moagem para a produção de substâncias medicinais finamente moídas - Google Patents

processo de moagem para a produção de substâncias medicinais finamente moídas

Info

Publication number
BRPI9915841B8
BRPI9915841B8 BRPI9915841A BR9915841A BRPI9915841B8 BR PI9915841 B8 BRPI9915841 B8 BR PI9915841B8 BR PI9915841 A BRPI9915841 A BR PI9915841A BR 9915841 A BR9915841 A BR 9915841A BR PI9915841 B8 BRPI9915841 B8 BR PI9915841B8
Authority
BR
Brazil
Prior art keywords
production
finely ground
medicinal substances
milling process
grinding
Prior art date
Application number
BRPI9915841A
Other languages
English (en)
Other versions
BRPI9915841B1 (pt
BR9915841A (pt
Inventor
Authelin Jean-Rene
Hosek Patrick
Original Assignee
Aventis Pharma Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Ltd filed Critical Aventis Pharma Ltd
Publication of BR9915841A publication Critical patent/BR9915841A/pt
Publication of BRPI9915841B1 publication Critical patent/BRPI9915841B1/pt
Publication of BRPI9915841B8 publication Critical patent/BRPI9915841B8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B02—CRUSHING, PULVERISING, OR DISINTEGRATING; PREPARATORY TREATMENT OF GRAIN FOR MILLING
    • B02C—CRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL; MILLING GRAIN
    • B02C19/00—Other disintegrating devices or methods
    • B02C19/06—Jet mills
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B02—CRUSHING, PULVERISING, OR DISINTEGRATING; PREPARATORY TREATMENT OF GRAIN FOR MILLING
    • B02C—CRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL; MILLING GRAIN
    • B02C19/00—Other disintegrating devices or methods
    • B02C19/18—Use of auxiliary physical effects, e.g. ultrasonic waves or irradiation, for disintegrating
    • B02C19/186—Use of cold or heat for disintegrating

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Toxicology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Disintegrating Or Milling (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
  • Crushing And Grinding (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Finish Polishing, Edge Sharpening, And Grinding By Specific Grinding Devices (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Silicates, Zeolites, And Molecular Sieves (AREA)
  • Glass Compositions (AREA)
  • Iron Core Of Rotating Electric Machines (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Oxygen, Ozone, And Oxides In General (AREA)

Abstract

patente de invenção: <b>"processo de moagem para a produção de substâncias medicinais finamente moídas"<d>. a presente invenção refere-se a um método de moagem de materiais para formar um pó fino com um tamanho de partícula média abaixo de 10 micrômetros que é adequado para inalação e que substancialmente não tem conteúdo amorfo gerado durante a moagem. o método é particularmente adequado para moagem de materiais que são macios. o método compreende moer o material em um moinho de energia fluida em temperatura reduzida usando hélio, ou hélio misturado com um outro gás, como o fluido de moagem. temperaturas de -30°c ou menor são usadas.
BRPI9915841A 1998-12-01 1999-12-01 processo de moagem para a produção de substâncias medicinais finamente moídas BRPI9915841B8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9826286.8A GB9826286D0 (en) 1998-12-01 1998-12-01 Process
PCT/GB1999/004047 WO2000032313A1 (en) 1998-12-01 1999-12-01 Milling process for the production of finely milled medicinal substances

Publications (3)

Publication Number Publication Date
BR9915841A BR9915841A (pt) 2001-09-04
BRPI9915841B1 BRPI9915841B1 (pt) 2016-11-22
BRPI9915841B8 true BRPI9915841B8 (pt) 2021-05-25

Family

ID=10843362

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI9915841A BRPI9915841B8 (pt) 1998-12-01 1999-12-01 processo de moagem para a produção de substâncias medicinais finamente moídas

Country Status (24)

Country Link
US (2) US7041318B2 (pt)
EP (2) EP1338273B1 (pt)
JP (1) JP4592955B2 (pt)
KR (1) KR100658010B1 (pt)
CN (1) CN1096886C (pt)
AT (1) ATE234684T1 (pt)
AU (1) AU758212B2 (pt)
BR (1) BRPI9915841B8 (pt)
CA (1) CA2352779A1 (pt)
CZ (2) CZ296782B6 (pt)
DE (1) DE69906147T2 (pt)
DK (2) DK1146964T3 (pt)
ES (2) ES2634255T3 (pt)
GB (1) GB9826286D0 (pt)
HU (1) HU226221B1 (pt)
IL (1) IL143345A (pt)
MX (1) MXPA01005471A (pt)
NO (1) NO324231B1 (pt)
NZ (1) NZ512091A (pt)
PL (1) PL193799B1 (pt)
PT (1) PT1146964E (pt)
RU (1) RU2234375C2 (pt)
SI (1) SI1146964T1 (pt)
WO (1) WO2000032313A1 (pt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0409703D0 (en) 2004-04-30 2004-06-02 Vectura Ltd Pharmaceutical compositions
RU2376079C1 (ru) * 2008-06-11 2009-12-20 Государственное образовательное учреждение высшего профессионального образования "Московский государственный университет инженерной экологии" Способ получения порошков микронизированных частиц
RU2386536C1 (ru) * 2008-12-24 2010-04-20 Евгений Владимирович Основин Способ утилизации резинотехнических изделий и устройство для его осуществления
RU2423182C1 (ru) * 2009-11-24 2011-07-10 Учреждение Российской академии наук Физико-технический институт им. А.Ф. Иоффе РАН Способ измельчения кристаллического порошкового материала
JO3510B1 (ar) 2011-03-04 2020-07-05 Heptares Therapeutics Ltd استخدام جلايكوبيرولات لعلاج عدم انتظام دقات القلب
DE102011102614A1 (de) 2011-05-27 2012-11-29 Roland Nied Verfahren zum Betrieb einer Strahlmühle sowie Strahlmühle
WO2015071841A1 (en) 2013-11-12 2015-05-21 Druggability Technologies Holdings Limited Complexes of dabigatran and its derivatives, process for the preparation thereof and pharmaceutical compositions containing them
SG11201700536XA (en) 2014-09-09 2017-02-27 Vectura Ltd Formulation comprising glycopyrrolate, method and apparatus
RU2623608C1 (ru) * 2016-02-09 2017-06-28 Владимир Никитович Анциферов Способ размола порошка из пластичного материала
CN109097582B (zh) * 2018-08-17 2020-07-03 安阳工学院 一种机械工程粉状废弃物处理系统
WO2020071448A1 (ja) * 2018-10-02 2020-04-09 学校法人名城大学 吸入粉末剤、その評価方法及びその用途
CN113751171A (zh) * 2021-09-14 2021-12-07 威海德尚医中医药科技有限公司 一种中药超微细粉制剂的制备方法
CN115737610B (zh) * 2021-12-13 2024-02-27 苏州欧米尼医药有限公司 一种噻托溴铵吸入粉雾剂及其活性成分的气流粉碎方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3897010A (en) * 1971-07-02 1975-07-29 Linde Ag Method of and apparatus for the milling of granular materials
DE2133019A1 (de) * 1971-07-02 1973-01-18 Linde Ag Verfahren und vorrichtung zum kaltstrahlmahlen
GB1481304A (en) * 1974-09-05 1977-07-27 Boc International Ltd Powder forming
CA1103379A (en) * 1976-05-19 1981-06-16 Willy Manfroy Process for wet grinding non-organic or fossilized organic minerals
DK452378A (da) * 1977-10-12 1979-04-13 M Tucek Fremgangsmaade til behandling af skrot
GB8432063D0 (en) * 1984-12-19 1985-01-30 Riker Laboratories Inc Physically modified steroids
US4767612A (en) * 1987-01-23 1988-08-30 Rorer Pharmaceutical Corporation Triamcinolone acetonide for the treatment of allergic rhinitis
FR2628415A1 (fr) * 1988-03-09 1989-09-15 Rhone Poulenc Chimie Procede de fabrication de materiaux supraconducteurs et produits ainsi obtenus
ES2060040T5 (es) 1989-05-31 1999-09-16 Fisons Plc Dispositivo y formulacion de inhalacion de medicamento.
SE9302777D0 (sv) * 1993-08-27 1993-08-27 Astra Ab Process for conditioning substances
SE9101090D0 (sv) * 1991-04-11 1991-04-11 Astra Ab Process for conditioning of water-soluble substances
RU2044570C1 (ru) * 1993-07-12 1995-09-27 Научно-техническое и производственное общество с ограниченной ответственностью "Стеклокремнезит" Способ дробления силикатных стекол
US5747002A (en) * 1995-04-05 1998-05-05 Genentech, Inc. Preparation of sodium chloride aerosol formulations
SE9501384D0 (sv) * 1995-04-13 1995-04-13 Astra Ab Process for the preparation of respirable particles
US5682658A (en) 1996-03-04 1997-11-04 Utica Enterprises, Inc. Rotary index table assembly
ZA972050B (en) * 1996-03-08 1998-09-10 Du Pont Fluid energy mill
RU2111057C1 (ru) * 1996-08-29 1998-05-20 Василий Степанович Марков Способ утилизации отходов
SE9700135D0 (sv) * 1997-01-20 1997-01-20 Astra Ab New formulation

Also Published As

Publication number Publication date
DE69906147T2 (de) 2003-12-04
PL193799B1 (pl) 2007-03-30
NO20012653L (no) 2001-05-30
HK1037563A1 (en) 2002-02-15
KR100658010B1 (ko) 2006-12-15
BRPI9915841B1 (pt) 2016-11-22
IL143345A0 (en) 2002-04-21
ES2195668T3 (es) 2003-12-01
DK1338273T3 (en) 2017-09-18
NO324231B1 (no) 2007-09-10
CN1096886C (zh) 2002-12-25
SI1146964T1 (en) 2003-10-31
NZ512091A (en) 2003-03-28
CZ307438B6 (cs) 2018-08-22
HUP0201662A2 (en) 2002-09-28
JP4592955B2 (ja) 2010-12-08
EP1146964A1 (en) 2001-10-24
EP1338273A3 (en) 2003-11-05
AU1401200A (en) 2000-06-19
NO20012653D0 (no) 2001-05-30
US7041318B2 (en) 2006-05-09
MXPA01005471A (es) 2003-03-27
EP1146964B1 (en) 2003-03-19
JP2002531240A (ja) 2002-09-24
CA2352779A1 (en) 2000-06-08
GB9826286D0 (en) 1999-01-20
BR9915841A (pt) 2001-09-04
CZ296782B6 (cs) 2006-06-14
DK1146964T3 (da) 2003-06-02
US20060002864A1 (en) 2006-01-05
RU2234375C2 (ru) 2004-08-20
AU758212B2 (en) 2003-03-20
KR20010093130A (ko) 2001-10-27
EP1338273B1 (en) 2017-06-07
PT1146964E (pt) 2003-08-29
PL348613A1 (en) 2002-06-03
EP1338273A2 (en) 2003-08-27
CZ20011874A3 (cs) 2001-12-12
ES2634255T3 (es) 2017-09-27
IL143345A (en) 2005-11-20
CN1328489A (zh) 2001-12-26
DE69906147D1 (de) 2003-04-24
HU226221B1 (en) 2008-06-30
ATE234684T1 (de) 2003-04-15
WO2000032313A1 (en) 2000-06-08
US20020114766A1 (en) 2002-08-22

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B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
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B12B Appeal against refusal [chapter 12.2 patent gazette]
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