CA1021778A - Mode de preparation de derives du 1,4-benzodiazepin-2-one a activite optique - Google Patents

Mode de preparation de derives du 1,4-benzodiazepin-2-one a activite optique

Info

Publication number
CA1021778A
CA1021778A CA205,715A CA205715A CA1021778A CA 1021778 A CA1021778 A CA 1021778A CA 205715 A CA205715 A CA 205715A CA 1021778 A CA1021778 A CA 1021778A
Authority
CA
Canada
Prior art keywords
benzodiazepin
derivatives
preparation
optically active
optically
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA205,715A
Other languages
English (en)
Other versions
CA205715S (en
Inventor
Vitomir Sunjic
Franjo Kajfez
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Crc Di Ricerca Chimica Sa Cia
Original Assignee
Crc Di Ricerca Chimica Sa Cia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Crc Di Ricerca Chimica Sa Cia filed Critical Crc Di Ricerca Chimica Sa Cia
Application granted granted Critical
Publication of CA1021778A publication Critical patent/CA1021778A/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • C07D243/28—Preparation including building-up the benzodiazepine skeleton from compounds containing no hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
CA205,715A 1973-07-30 1974-07-26 Mode de preparation de derives du 1,4-benzodiazepin-2-one a activite optique Expired CA1021778A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH1105673A CH573928A5 (fr) 1973-07-30 1973-07-30

Publications (1)

Publication Number Publication Date
CA1021778A true CA1021778A (fr) 1977-11-29

Family

ID=4369623

Family Applications (1)

Application Number Title Priority Date Filing Date
CA205,715A Expired CA1021778A (fr) 1973-07-30 1974-07-26 Mode de preparation de derives du 1,4-benzodiazepin-2-one a activite optique

Country Status (21)

Country Link
US (1) US4010153A (fr)
JP (1) JPS5041886A (fr)
AR (1) AR202224A1 (fr)
AT (1) AT337192B (fr)
BE (1) BE818047A (fr)
CA (1) CA1021778A (fr)
CH (1) CH573928A5 (fr)
DE (1) DE2436744A1 (fr)
DK (1) DK138798B (fr)
ES (1) ES428675A1 (fr)
FI (1) FI227474A7 (fr)
FR (1) FR2239464B1 (fr)
GB (1) GB1481219A (fr)
HU (1) HU169180B (fr)
IE (1) IE39904B1 (fr)
IL (1) IL45289A (fr)
NL (1) NL7410256A (fr)
NO (1) NO137897C (fr)
SE (2) SE7409708L (fr)
SU (1) SU528872A3 (fr)
ZA (1) ZA744635B (fr)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4820834A (en) * 1984-06-26 1989-04-11 Merck & Co., Inc. Benzodiazepine analogs
CA1332410C (fr) * 1984-06-26 1994-10-11 Roger M. Freidinger Analogues de benzodiazepines
DK3324977T3 (da) 2015-07-22 2022-10-17 Enanta Pharm Inc Benzodiazepinderivater som rsv-inhibitorer
EP3402799B1 (fr) 2016-01-15 2022-05-04 Enanta Pharmaceuticals, Inc. Composés hétérocycliques utilisés comme inhibiteurs du vrs
CN110809472B (zh) 2017-02-16 2023-05-23 英安塔制药有限公司 用于制备苯二氮䓬衍生物的方法
WO2018226801A1 (fr) 2017-06-07 2018-12-13 Enanta Pharmaceuticals, Inc. Dérivés d'aryldiazépine utilisés en tant qu'inhibiteurs du vrs
US11091501B2 (en) 2017-06-30 2021-08-17 Enanta Pharmaceuticals, Inc. Heterocyclic compounds as RSV inhibitors
WO2019006291A1 (fr) 2017-06-30 2019-01-03 Enanta Pharmaceuticals, Inc. Composés hétérocycliques utilisés en tant qu'inhibiteurs du vrs
BR112020006334A2 (pt) 2017-09-29 2020-09-24 Enanta Pharmaceuticals, Inc. combinação de agentes farmacêuticos como inibidores de rsv
CA3080138A1 (fr) * 2017-11-13 2019-05-16 Enanta Pharmaceuticals, Inc. Procede pour la resolution de derives benzodiazepin-2-one et benzoazepin-2-one
US10647711B2 (en) 2017-11-13 2020-05-12 Enanta Pharmaceuticals, Inc. Azepin-2-one derivatives as RSV inhibitors
WO2019199908A1 (fr) 2018-04-11 2019-10-17 Enanta Pharmaceuticals, Inc. Composés hétérocycliques en tant qu'inhibiteurs de vrs
BR112021018335A2 (pt) 2019-03-18 2021-11-23 Enanta Pharm Inc Derivados de benzodiazepina como inibidores de rsv
WO2020210246A1 (fr) 2019-04-09 2020-10-15 Enanta Pharmaceuticals, Inc, Composés hétérocycliques utilisés comme inhibiteurs du vrs
US11505558B1 (en) 2019-10-04 2022-11-22 Enanta Pharmaceuticals, Inc. Antiviral heterocyclic compounds
UY39032A (es) 2020-01-24 2021-07-30 Enanta Pharm Inc Compuestos heterocíclicos como agentes antivirales
WO2022010882A1 (fr) 2020-07-07 2022-01-13 Enanta Pharmaceuticals, Inc, Dérivés de dihydroquinoxaline et de dihydropyridopyrazine utilisés comme inhibiteurs de rsv
US11945824B2 (en) 2020-10-19 2024-04-02 Enanta Pharmaceuticals, Inc. Heterocyclic compounds as anti-viral agents
US12612412B2 (en) 2021-02-26 2026-04-28 Enanta Pharmaceuticals, Inc. Antiviral heterocyclic compounds
AR129003A1 (es) 2022-04-07 2024-07-03 Enanta Pharm Inc Compuestos heterocíclicos antivirales
WO2023211997A1 (fr) 2022-04-27 2023-11-02 Enanta Pharmaceuticals, Inc. Composés antiviraux
USD1093203S1 (en) * 2023-10-24 2025-09-16 Lumos Scintillation, Inc. Multifaceted gemstone

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3371085A (en) * 1959-12-10 1968-02-27 Hoffmann La Roche 5-aryl-3h-1,4-benzodiazepin-2(1h)-ones
JPS4426302Y1 (fr) * 1966-04-22 1969-11-05

Also Published As

Publication number Publication date
IE39904B1 (en) 1979-01-31
DK138798C (fr) 1979-04-09
AR202224A1 (es) 1975-05-23
FR2239464A1 (fr) 1975-02-28
DE2436744A1 (de) 1975-02-27
NO137897B (no) 1978-02-06
NO137897C (no) 1978-05-16
IE39904L (en) 1975-01-30
ES428675A1 (es) 1976-09-01
BE818047A (fr) 1974-11-18
GB1481219A (en) 1977-07-27
US4010153A (en) 1977-03-01
SE7510823L (sv) 1975-09-26
ATA567674A (de) 1976-10-15
DK138798B (da) 1978-10-30
CH573928A5 (fr) 1976-03-31
HU169180B (fr) 1976-10-28
SE7409708L (fr) 1975-01-31
AT337192B (de) 1977-06-10
JPS5041886A (fr) 1975-04-16
SU528872A3 (ru) 1976-09-15
FI227474A7 (fr) 1975-01-31
IL45289A (en) 1979-12-30
IL45289A0 (en) 1974-10-22
ZA744635B (en) 1975-08-27
DK393274A (fr) 1975-04-01
NO742739L (fr) 1975-02-24
NL7410256A (nl) 1975-02-03
FR2239464B1 (fr) 1978-04-14

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