CA1038289A - Process and device for blood examination using substances labelled with radioactive nuclides - Google Patents

Process and device for blood examination using substances labelled with radioactive nuclides

Info

Publication number: CA1038289A
Authority: CA; Canada
Prior art keywords: liquid; hormone; vessel; adsorption; measuring
Prior art date: 1973-05-30
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

CA201,168A

Other languages

English (en)

French (fr)

Inventor

Rudolf Kern

Karl-Friedrich Muck

Stratos Paschalis

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Hoechst AG

Original Assignee

Hoechst AG

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1973-05-30

Filing date

1974-05-29

Publication date

1978-09-12

1973-05-30 Priority claimed from DE19732327576 external-priority patent/DE2327576C3/de

1974-05-29 Application filed by Hoechst AG filed Critical Hoechst AG

1978-09-12 Application granted granted Critical

1978-09-12 Publication of CA1038289A publication Critical patent/CA1038289A/en

Status Expired legal-status Critical Current

Links

238000000034 method Methods 0.000 title claims abstract description 38
239000000126 substance Substances 0.000 title claims description 9
230000002285 radioactive effect Effects 0.000 title claims description 4
238000004159 blood analysis Methods 0.000 title description 2
238000001179 sorption measurement Methods 0.000 claims abstract description 56
229940088597 hormone Drugs 0.000 claims abstract description 49
239000005556 hormone Substances 0.000 claims abstract description 49
239000007788 liquid Substances 0.000 claims abstract description 35
102000004169 proteins and genes Human genes 0.000 claims abstract description 19
108090000623 proteins and genes Proteins 0.000 claims abstract description 19
230000000694 effects Effects 0.000 claims abstract description 8
230000000274 adsorptive effect Effects 0.000 claims abstract description 5
150000002500 ions Chemical class 0.000 claims description 18
210000002966 serum Anatomy 0.000 claims description 16
XUIIKFGFIJCVMT-GFCCVEGCSA-N D-thyroxine Chemical compound IC1=CC(C[C@@H](N)C(O)=O)=CC(I)=C1OC1=CC(I)=C(O)C(I)=C1 XUIIKFGFIJCVMT-GFCCVEGCSA-N 0.000 claims description 15
-1 polyethylene Polymers 0.000 claims description 13
229940034208 thyroxine Drugs 0.000 claims description 12
XUIIKFGFIJCVMT-UHFFFAOYSA-N thyroxine-binding globulin Natural products IC1=CC(CC([NH3+])C([O-])=O)=CC(I)=C1OC1=CC(I)=C(O)C(I)=C1 XUIIKFGFIJCVMT-UHFFFAOYSA-N 0.000 claims description 12
239000004698 Polyethylene Substances 0.000 claims description 9
229920000573 polyethylene Polymers 0.000 claims description 9
210000004369 blood Anatomy 0.000 claims description 7
239000008280 blood Substances 0.000 claims description 7
AUYYCJSJGJYCDS-LBPRGKRZSA-N Thyrolar Chemical compound IC1=CC(C[C@H](N)C(O)=O)=CC(I)=C1OC1=CC=C(O)C(I)=C1 AUYYCJSJGJYCDS-LBPRGKRZSA-N 0.000 claims description 6
230000000295 complement effect Effects 0.000 claims description 4
238000002156 mixing Methods 0.000 claims description 4
125000003580 L-valyl group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(C([H])([H])[H])(C([H])([H])[H])[H] 0.000 claims description 3
102000036124 hormone binding proteins Human genes 0.000 claims description 3
108091011044 hormone binding proteins Proteins 0.000 claims description 3
239000002245 particle Substances 0.000 claims description 3
239000012815 thermoplastic material Substances 0.000 claims description 3
125000003277 amino group Chemical group 0.000 claims description 2
150000001450 anions Chemical class 0.000 claims description 2
150000001875 compounds Chemical class 0.000 claims description 2
210000003141 lower extremity Anatomy 0.000 claims description 2
210000001364 upper extremity Anatomy 0.000 claims description 2
239000000243 solution Substances 0.000 description 31
229920001429 chelating resin Polymers 0.000 description 6
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 5
102000023732 binding proteins Human genes 0.000 description 4
108091008324 binding proteins Proteins 0.000 description 4
239000000203 mixture Substances 0.000 description 4
210000001685 thyroid gland Anatomy 0.000 description 4
LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 3
239000002253 acid Substances 0.000 description 3
239000000872 buffer Substances 0.000 description 3
238000006243 chemical reaction Methods 0.000 description 3
239000003795 chemical substances by application Substances 0.000 description 3
238000004440 column chromatography Methods 0.000 description 3
239000008187 granular material Substances 0.000 description 3
238000011534 incubation Methods 0.000 description 3
238000004519 manufacturing process Methods 0.000 description 3
229920000728 polyester Polymers 0.000 description 3
238000003127 radioimmunoassay Methods 0.000 description 3
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical class OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 2
239000004743 Polypropylene Substances 0.000 description 2
PXIPVTKHYLBLMZ-UHFFFAOYSA-N Sodium azide Chemical compound [Na+].[N-]=[N+]=[N-] PXIPVTKHYLBLMZ-UHFFFAOYSA-N 0.000 description 2
239000012675 alcoholic extract Substances 0.000 description 2
239000007853 buffer solution Substances 0.000 description 2
125000004432 carbon atom Chemical group C* 0.000 description 2
230000002860 competitive effect Effects 0.000 description 2
JHIVVAPYMSGYDF-UHFFFAOYSA-N cyclohexanone Chemical compound O=C1CCCCC1 JHIVVAPYMSGYDF-UHFFFAOYSA-N 0.000 description 2
230000008030 elimination Effects 0.000 description 2
238000003379 elimination reaction Methods 0.000 description 2
238000000605 extraction Methods 0.000 description 2
230000002163 immunogen Effects 0.000 description 2
238000001746 injection moulding Methods 0.000 description 2
238000005259 measurement Methods 0.000 description 2
229920000642 polymer Polymers 0.000 description 2
229920001155 polypropylene Polymers 0.000 description 2
229920005989 resin Polymers 0.000 description 2
239000011347 resin Substances 0.000 description 2
239000012086 standard solution Substances 0.000 description 2
229940035722 triiodothyronine Drugs 0.000 description 2
LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 2
VSWSDTLXDWESGZ-AWEZNQCLSA-N (2s)-3-[4-(4-hydroxyphenoxy)phenyl]-2-(iodoamino)propanoic acid Chemical compound C1=CC(C[C@@H](C(=O)O)NI)=CC=C1OC1=CC=C(O)C=C1 VSWSDTLXDWESGZ-AWEZNQCLSA-N 0.000 description 1
BGJSXRVXTHVRSN-UHFFFAOYSA-N 1,3,5-trioxane Chemical compound C1OCOCO1 BGJSXRVXTHVRSN-UHFFFAOYSA-N 0.000 description 1
102000004506 Blood Proteins Human genes 0.000 description 1
108010017384 Blood Proteins Proteins 0.000 description 1
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
241000282414 Homo sapiens Species 0.000 description 1
229910019142 PO4 Inorganic materials 0.000 description 1
229930040373 Paraformaldehyde Natural products 0.000 description 1
239000004952 Polyamide Substances 0.000 description 1
239000004793 Polystyrene Substances 0.000 description 1
102000009488 Thyroxine-Binding Proteins Human genes 0.000 description 1
108010048889 Thyroxine-Binding Proteins Proteins 0.000 description 1
239000007983 Tris buffer Substances 0.000 description 1
150000007513 acids Chemical class 0.000 description 1
125000001931 aliphatic group Chemical group 0.000 description 1
238000004458 analytical method Methods 0.000 description 1
210000000601 blood cell Anatomy 0.000 description 1
150000001735 carboxylic acids Chemical class 0.000 description 1
150000001768 cations Chemical class 0.000 description 1
238000005345 coagulation Methods 0.000 description 1
230000015271 coagulation Effects 0.000 description 1
239000012141 concentrate Substances 0.000 description 1
238000011109 contamination Methods 0.000 description 1
238000007334 copolymerization reaction Methods 0.000 description 1
230000003297 denaturating effect Effects 0.000 description 1
150000004985 diamines Chemical class 0.000 description 1
150000001991 dicarboxylic acids Chemical class 0.000 description 1
150000002009 diols Chemical class 0.000 description 1
230000009977 dual effect Effects 0.000 description 1
125000004185 ester group Chemical group 0.000 description 1
210000003414 extremity Anatomy 0.000 description 1
238000001125 extrusion Methods 0.000 description 1
210000004907 gland Anatomy 0.000 description 1
239000011521 glass Substances 0.000 description 1
230000000977 initiatory effect Effects 0.000 description 1
238000005342 ion exchange Methods 0.000 description 1
239000007791 liquid phase Substances 0.000 description 1
239000000463 material Substances 0.000 description 1
238000002844 melting Methods 0.000 description 1
230000008018 melting Effects 0.000 description 1
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
239000010452 phosphate Substances 0.000 description 1
229920003023 plastic Polymers 0.000 description 1
239000004033 plastic Substances 0.000 description 1
229920001467 poly(styrenesulfonates) Polymers 0.000 description 1
229920002647 polyamide Polymers 0.000 description 1
229920000193 polymethacrylate Polymers 0.000 description 1
229920006324 polyoxymethylene Polymers 0.000 description 1
229920002223 polystyrene Polymers 0.000 description 1
229920002635 polyurethane Polymers 0.000 description 1
239000004814 polyurethane Substances 0.000 description 1
239000004800 polyvinyl chloride Substances 0.000 description 1
229920000915 polyvinyl chloride Polymers 0.000 description 1
239000000843 powder Substances 0.000 description 1
238000002360 preparation method Methods 0.000 description 1
238000000926 separation method Methods 0.000 description 1
239000006228 supernatant Substances 0.000 description 1
230000008961 swelling Effects 0.000 description 1
229920001169 thermoplastic Polymers 0.000 description 1
239000004416 thermosoftening plastic Substances 0.000 description 1
239000005495 thyroid hormone Substances 0.000 description 1
229940036555 thyroid hormone Drugs 0.000 description 1
230000009466 transformation Effects 0.000 description 1
238000005406 washing Methods 0.000 description 1

Classifications

- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
- G01N33/78—Thyroid gland hormones, e.g. T3, T4, TBH, TBG or their receptors

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Molecular Biology (AREA)
Engineering & Computer Science (AREA)
Endocrinology (AREA)
Biomedical Technology (AREA)
Chemical & Material Sciences (AREA)
Urology & Nephrology (AREA)
Hematology (AREA)
Immunology (AREA)
Microbiology (AREA)
Cell Biology (AREA)
Biotechnology (AREA)
Food Science & Technology (AREA)
Medicinal Chemistry (AREA)
Physics & Mathematics (AREA)
Analytical Chemistry (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
General Physics & Mathematics (AREA)
Pathology (AREA)
Investigating Or Analysing Biological Materials (AREA)
Devices For Use In Laboratory Experiments (AREA)

CA201,168A 1973-05-30 1974-05-29 Process and device for blood examination using substances labelled with radioactive nuclides Expired CA1038289A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19732327576 DE2327576C3 (de)		1973-05-30	Vorrichtung zur Bestimmung von Hormonen unter Verwendung radioaktiv markierter Verbindungen

Publications (1)

Publication Number	Publication Date
CA1038289A true CA1038289A (en)	1978-09-12

Family

ID=5882596

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA201,168A Expired CA1038289A (en)	1973-05-30	1974-05-29	Process and device for blood examination using substances labelled with radioactive nuclides

Country Status (13)

Country	Link
JP (1)	JPS5318576B2 (de)
AT (1)	AT350733B (de)
CA (1)	CA1038289A (de)
CH (1)	CH611425A5 (de)
DD (1)	DD118945A5 (de)
DK (1)	DK290674A (de)
ES (1)	ES426624A1 (de)
FI (1)	FI162974A7 (de)
HU (1)	HU171452B (de)
IL (1)	IL44910A (de)
IT (1)	IT1019628B (de)
SE (1)	SE7407209L (de)
ZA (1)	ZA743462B (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS55162682A (en) *	1979-06-05	1980-12-18	Tokai Daigaku	Video broadcast system using fm broadcast band
JPS55162681A (en) *	1979-06-05	1980-12-18	Tokai Daigaku	Video broadcast reception system using fm broadcast band

1974
- 1974-05-06 HU HU74HO00001673A patent/HU171452B/hu unknown
- 1974-05-24 ES ES426624A patent/ES426624A1/es not_active Expired
- 1974-05-27 CH CH718374A patent/CH611425A5/de not_active IP Right Cessation
- 1974-05-28 IT IT23293/74A patent/IT1019628B/it active
- 1974-05-28 FI FI1629/74A patent/FI162974A7/fi unknown
- 1974-05-28 DD DD178809A patent/DD118945A5/xx unknown
- 1974-05-29 AT AT445274A patent/AT350733B/de not_active IP Right Cessation
- 1974-05-29 IL IL44910A patent/IL44910A/en unknown
- 1974-05-29 CA CA201,168A patent/CA1038289A/en not_active Expired
- 1974-05-29 DK DK290674A patent/DK290674A/da not_active Application Discontinuation
- 1974-05-29 ZA ZA00743462A patent/ZA743462B/xx unknown
- 1974-05-30 JP JP6035374A patent/JPS5318576B2/ja not_active Expired
- 1974-05-30 SE SE7407209A patent/SE7407209L/xx unknown

Also Published As

Publication number	Publication date
JPS5318576B2 (de)	1978-06-15
AT350733B (de)	1979-06-11
FI162974A7 (de)	1974-12-01
DD118945A5 (de)	1976-03-20
CH611425A5 (en)	1979-05-31
IL44910A0 (en)	1974-07-31
JPS5040723A (de)	1975-04-14
DK290674A (de)	1975-01-27
ZA743462B (en)	1975-05-28
ES426624A1 (es)	1977-01-01
SE7407209L (de)	1974-12-02
ATA445274A (de)	1978-11-15
IL44910A (en)	1977-06-30
IT1019628B (it)	1977-11-30
HU171452B (hu)	1978-01-28

Publication	Publication Date	Title
US3938953A (en)	1976-02-17	Process and device for blood examination using substances labelled with radioactive nuclides
US3666854A (en)	1972-05-30	Test for thyroid hormone
Fairclough Jr et al.	1966	Peptide-protein interaction as studied by gel filtration
Benson Jr et al.	1967	Accelerated chromatographic analysis of amino acids in physiological fluids containing glutamine and asparagine
US3776698A (en)	1973-12-04	Test for thyroid hormone
US4410660A (en)	1983-10-18	Binding assay for the detection of mycobacteria
US4166104A (en)	1979-08-28	Specific binding assay method and test kit employing polystyrene as separating agent
US4849110A (en)	1989-07-18	Method and apparatus for liquid chromatography
US3659104A (en)	1972-04-25	Method of measuring serum thyroxine
US3961894A (en)	1976-06-08	Test for determination of triiodothyronine
CN101706469A (zh)	2010-05-12	一种三聚氰胺的检测方法及其装置
US3206602A (en)	1965-09-14	Apparatus for measuring the binding capacity of serum proteins
Gallorini et al.	1978	Simultaneous determination of arsenic, antimony, cadmium, chromium, copper, and selenium in environmental material by radiochemical neutron activation analysis
US3714344A (en)	1973-01-30	Method for determining thyroxine in blood serum and reagent therefor
CA1038289A (en)	1978-09-12	Process and device for blood examination using substances labelled with radioactive nuclides
US4489158A (en)	1984-12-18	Binding assay for the detection of mycobacteria
US4225784A (en)	1980-09-30	Covalently bound biological substances to plastic materials and use in radioassay
US4136159A (en)	1979-01-23	Radioassay of folates
US3592888A (en)	1971-07-13	Radioimmunoassay of angiotensin and renin activity
US3843775A (en)	1974-10-22	Radioimmunoassay of angiotensin and renin activity
US4348374A (en)	1982-09-07	Charcoal coated adsorbent device
Petersen et al.	1977	Measurement of free thyroid hormones in serum by dialysis and gas chromatography.
US3710117A (en)	1973-01-09	Vitro test system for assessing thyroid function
US4005187A (en)	1977-01-25	Diagnostic test method
Hansson et al.	1978	Quantitative Analysts of 5-Hydroxytryptamtne in Biological Material by High Perfornance Liquid Chromatography and Electrochmical Detection