CA1041012A - Methode pour diminuer l'incidence des effets secondaires d'ordre gastro-intestinal durant le traitement des affections inflammatoires a l'aide d'agents anti-inflammatoires et composes connexes - Google Patents

Methode pour diminuer l'incidence des effets secondaires d'ordre gastro-intestinal durant le traitement des affections inflammatoires a l'aide d'agents anti-inflammatoires et composes connexes

Info

Publication number: CA1041012A
Authority: CA; Canada
Prior art keywords: hydrogen; trans; double bond; choh; lower alkyl
Prior art date: 1973-07-10
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

CA204,494A

Other languages

English (en)

Other versions

CA204494S (en

Inventor

Wilbur Lippmann

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Wyeth LLC

Original Assignee

American Home Products Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1973-07-10

Filing date

1974-07-10

Publication date

1978-10-24

1973-07-10 Priority claimed from US378113A external-priority patent/US3927213A/en

1973-07-10 Priority claimed from US05/378,112 external-priority patent/US3937801A/en

1974-07-10 Application filed by American Home Products Corp filed Critical American Home Products Corp

1978-10-24 Application granted granted Critical

1978-10-24 Publication of CA1041012A publication Critical patent/CA1041012A/fr

Status Expired legal-status Critical Current

Links

230000000694 effects Effects 0.000 title claims abstract description 24
230000002496 gastric effect Effects 0.000 title claims abstract description 21
230000004968 inflammatory condition Effects 0.000 title claims abstract description 12
238000000034 method Methods 0.000 title abstract description 19
239000000203 mixture Substances 0.000 title description 43
238000011282 treatment Methods 0.000 title description 13
239000003814 drug Substances 0.000 title 1
229940079593 drug Drugs 0.000 title 1
229910052739 hydrogen Inorganic materials 0.000 claims abstract description 72
239000001257 hydrogen Substances 0.000 claims abstract description 72
150000003180 prostaglandins Chemical class 0.000 claims abstract description 49
125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract description 48
239000002260 anti-inflammatory agent Substances 0.000 claims abstract description 30
125000000217 alkyl group Chemical group 0.000 claims abstract description 27
230000002401 inhibitory effect Effects 0.000 claims abstract description 22
238000011287 therapeutic dose Methods 0.000 claims abstract description 17
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims abstract description 15
150000002431 hydrogen Chemical class 0.000 claims abstract description 13
239000008194 pharmaceutical composition Substances 0.000 claims abstract description 13
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims abstract description 11
125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract description 11
125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims abstract description 4
JERCJPRNXXOPNI-UHFFFAOYSA-N 7-[2-(3-hydroxy-3-methyloctyl)-5-oxocyclopentyl]heptanoic acid Chemical compound CCCCCC(C)(O)CCC1CCC(=O)C1CCCCCCC(O)=O JERCJPRNXXOPNI-UHFFFAOYSA-N 0.000 claims description 12
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235000013311 vegetables Nutrition 0.000 description 1

Landscapes

Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

CA204,494A 1973-07-10 1974-07-10 Methode pour diminuer l'incidence des effets secondaires d'ordre gastro-intestinal durant le traitement des affections inflammatoires a l'aide d'agents anti-inflammatoires et composes connexes Expired CA1041012A (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US378113A US3927213A (en)	1973-07-10	1973-07-10	Prostaglandin E{HD 2 {B and derivatives for reducing the side effects of anti-inflammatory agents
US05/378,112 US3937801A (en)	1973-07-10	1973-07-10	Reducing the incidence of gastrointestinal side effects during the treatment of inflammatory conditions with antiinflammatory drugs

Publications (1)

Publication Number	Publication Date
CA1041012A true CA1041012A (fr)	1978-10-24

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ID=27008075

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Application Number	Title	Priority Date	Filing Date
CA204,494A Expired CA1041012A (fr)	1973-07-10	1974-07-10	Methode pour diminuer l'incidence des effets secondaires d'ordre gastro-intestinal durant le traitement des affections inflammatoires a l'aide d'agents anti-inflammatoires et composes connexes

Country Status (1)

Country	Link
CA (1)	CA1041012A (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2009005172A1 (fr) *	2007-07-03	2009-01-08	Sucampo Ag	Combinaison pharmaceutique d'un ains et d'un composé de prostaglandine
EP2448573A4 (fr) *	2009-06-30	2012-11-28	Sucampo Ag	Médicament pour l'utilisation à long terme d'un ains

1974
- 1974-07-10 CA CA204,494A patent/CA1041012A/fr not_active Expired

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2009005172A1 (fr) *	2007-07-03	2009-01-08	Sucampo Ag	Combinaison pharmaceutique d'un ains et d'un composé de prostaglandine
AU2008271982B2 (en) *	2007-07-03	2014-04-24	Sucampo Ag	Pharmaceutical combination of NSAID and prostaglandin compound
EP2448573A4 (fr) *	2009-06-30	2012-11-28	Sucampo Ag	Médicament pour l'utilisation à long terme d'un ains

Publication	Publication Date	Title
US3937801A (en)	1976-02-10	Reducing the incidence of gastrointestinal side effects during the treatment of inflammatory conditions with antiinflammatory drugs
US4024179A (en)	1977-05-17	Substituted ω-pentanorprostaglandins
DE2902442A1 (de)	1979-08-30	9-deoxy-9a-methylen-isostere von pgi tief 2 , verfahren zu ihrer herstellung und sie enthaltende pharmazeutische und veterinaermedizinische mittel
US3962293A (en)	1976-06-08	13,14-Dihydro-16-fluoro prostaglandin F1
US3927213A (en)	1975-12-16	Prostaglandin E{HD 2 {B and derivatives for reducing the side effects of anti-inflammatory agents
US4052446A (en)	1977-10-04	11,16-substituted prostaglandins
US4169895A (en)	1979-10-02	Antisecretory 16,16-dimethyl-17-oxaprostaglandins
US4187381A (en)	1980-02-05	16-Substituted prostaglandins
US4004020A (en)	1977-01-18	Novel prostanoic acid derivatives and process for the preparation thereof
KR20010042286A (ko)	2001-05-25	의약으로 유용한 ｃ１１ 옥시밀 및 히드록실아미노프로스타글란딘
CA1041012A (fr)	1978-10-24	Methode pour diminuer l'incidence des effets secondaires d'ordre gastro-intestinal durant le traitement des affections inflammatoires a l'aide d'agents anti-inflammatoires et composes connexes
US3917668A (en)	1975-11-04	Prostanoic acid intermediates
GB1583263A (en)	1981-01-21	Nor-aryl-13,14-dehydro-prostaglandins and process for their preparation
US4190587A (en)	1980-02-26	4-(3-Oxo-4-trifluoromethyl-1-octenyl)-2-oxo-2H-cyclopenta[b]furans
US3959263A (en)	1976-05-25	Prostaglandin intermediate
US4163016A (en)	1979-07-31	16-Substituted prostaglandins
DE2610718A1 (de)	1976-10-14	Neue 16-phenoxy-prostaglandin-verbindungen
GB1598143A (en)	1981-09-16	6,9-epoxy-prostaglandin analogues
US4112225A (en)	1978-09-05	16-CF3 prostaglandins
US4410720A (en)	1983-10-18	16-Fluoro prostaglandins
US4055593A (en)	1977-10-25	Alkyl diethers of prostaglandins
FR2515642A1 (fr)	1983-05-06	Nouvelles (11r)-11-deoxy-11-alkyl-6-oxo-prostaglandines et compositions pharmaceutiques les contenant
US4306078A (en)	1981-12-15	16-Substituted prostaglandins
US4204074A (en)	1980-05-20	16-Substituted prostaglandins
DE2606051A1 (de)	1976-09-02	2,2-difluor-prostaglandin-e, -f tief alpha, -f tief beta, -a und -b-analoga und verfahren zu deren herstellung