CA1041013A - Appetite curbing preparation containing an alginate and a diphosphonic acid - Google Patents

Appetite curbing preparation containing an alginate and a diphosphonic acid

Info

Publication number: CA1041013A
Authority: CA; Canada
Prior art keywords: composition; alginic; compound; appetite; curbing
Prior art date: 1974-03-16
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

CA221,248A

Other languages

English (en)

French (fr)

Other versions

CA221248S (en

Inventor

Christian Heine

Karl-Heinz Worms

Helmut Blum

Christian Gloxhuber

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Henkel AG and Co KGaA

Original Assignee

Henkel AG and Co KGaA

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1974-03-16

Filing date

1975-03-04

Publication date

1978-10-24

1975-03-04 Application filed by Henkel AG and Co KGaA filed Critical Henkel AG and Co KGaA

1978-10-24 Application granted granted Critical

1978-10-24 Publication of CA1041013A publication Critical patent/CA1041013A/en

Status Expired legal-status Critical Current

Links

230000036528 appetite Effects 0.000 title claims abstract description 26
235000019789 appetite Nutrition 0.000 title claims abstract description 26
235000010443 alginic acid Nutrition 0.000 title claims abstract description 8
229920000615 alginic acid Polymers 0.000 title claims abstract description 8
238000002360 preparation method Methods 0.000 title abstract description 22
XQRLCLUYWUNEEH-UHFFFAOYSA-N diphosphonic acid Chemical compound OP(=O)OP(O)=O XQRLCLUYWUNEEH-UHFFFAOYSA-N 0.000 title abstract description 5
FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 title abstract description 3
229940072056 alginate Drugs 0.000 title abstract description 3
150000003839 salts Chemical class 0.000 claims abstract description 17
241001465754 Metazoa Species 0.000 claims abstract description 13
231100000252 nontoxic Toxicity 0.000 claims abstract description 13
230000003000 nontoxic effect Effects 0.000 claims abstract description 13
239000000203 mixture Substances 0.000 claims description 27
150000001875 compounds Chemical class 0.000 claims description 24
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 5
239000000783 alginic acid Substances 0.000 claims description 5
229960001126 alginic acid Drugs 0.000 claims description 5
150000004781 alginic acids Chemical class 0.000 claims description 5
239000011575 calcium Substances 0.000 claims description 5
229910052791 calcium Inorganic materials 0.000 claims description 5
229910052783 alkali metal Inorganic materials 0.000 claims description 4
229910052739 hydrogen Inorganic materials 0.000 claims description 4
239000001257 hydrogen Substances 0.000 claims description 4
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 4
239000006187 pill Substances 0.000 claims description 4
230000036961 partial effect Effects 0.000 claims description 3
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 3
QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims description 2
150000003863 ammonium salts Chemical class 0.000 claims description 2
239000007864 aqueous solution Substances 0.000 claims description 2
125000004435 hydrogen atom Chemical group [H]* 0.000 claims 2
FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims 1
150000001340 alkali metals Chemical class 0.000 claims 1
LDTZSTJLVYBEKB-UHFFFAOYSA-N butedronic acid Chemical class OC(=O)CC(C(O)=O)C(P(O)(O)=O)P(O)(O)=O LDTZSTJLVYBEKB-UHFFFAOYSA-N 0.000 claims 1
229910052749 magnesium Inorganic materials 0.000 claims 1
239000011777 magnesium Substances 0.000 claims 1
238000001556 precipitation Methods 0.000 abstract description 18
239000003112 inhibitor Substances 0.000 abstract description 17
159000000007 calcium salts Chemical class 0.000 abstract description 5
238000001879 gelation Methods 0.000 description 14
BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 9
229910001424 calcium ion Inorganic materials 0.000 description 9
239000002253 acid Substances 0.000 description 7
238000012360 testing method Methods 0.000 description 6
IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 5
235000010413 sodium alginate Nutrition 0.000 description 5
239000000661 sodium alginate Substances 0.000 description 5
229940005550 sodium alginate Drugs 0.000 description 5
UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 4
239000003795 chemical substances by application Substances 0.000 description 4
230000000694 effects Effects 0.000 description 4
210000001035 gastrointestinal tract Anatomy 0.000 description 4
239000004615 ingredient Substances 0.000 description 4
238000000034 method Methods 0.000 description 4
239000000243 solution Substances 0.000 description 4
239000003826 tablet Substances 0.000 description 4
ABLZXFCXXLZCGV-UHFFFAOYSA-N Phosphorous acid Chemical compound OP(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 description 3
150000007513 acids Chemical class 0.000 description 3
-1 alkali metal salts Chemical class 0.000 description 3
230000000578 anorexic effect Effects 0.000 description 3
239000000843 powder Substances 0.000 description 3
239000003352 sequestering agent Substances 0.000 description 3
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 2
241000124008 Mammalia Species 0.000 description 2
239000000654 additive Substances 0.000 description 2
230000037396 body weight Effects 0.000 description 2
235000010410 calcium alginate Nutrition 0.000 description 2
239000000648 calcium alginate Substances 0.000 description 2
229960002681 calcium alginate Drugs 0.000 description 2
OKHHGHGGPDJQHR-YMOPUZKJSA-L calcium;(2s,3s,4s,5s,6r)-6-[(2r,3s,4r,5s,6r)-2-carboxy-6-[(2r,3s,4r,5s,6r)-2-carboxylato-4,5,6-trihydroxyoxan-3-yl]oxy-4,5-dihydroxyoxan-3-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylate Chemical compound [Ca+2].O[C@@H]1[C@H](O)[C@H](O)O[C@@H](C([O-])=O)[C@H]1O[C@H]1[C@@H](O)[C@@H](O)[C@H](O[C@H]2[C@H]([C@@H](O)[C@H](O)[C@H](O2)C([O-])=O)O)[C@H](C(O)=O)O1 OKHHGHGGPDJQHR-YMOPUZKJSA-L 0.000 description 2
230000000052 comparative effect Effects 0.000 description 2
239000012141 concentrate Substances 0.000 description 2
BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 2
229910000397 disodium phosphate Inorganic materials 0.000 description 2
235000019800 disodium phosphate Nutrition 0.000 description 2
235000013399 edible fruits Nutrition 0.000 description 2
150000002500 ions Chemical class 0.000 description 2
239000007788 liquid Substances 0.000 description 2
230000014759 maintenance of location Effects 0.000 description 2
235000012054 meals Nutrition 0.000 description 2
125000000325 methylidene group Chemical group [H]C([H])=* 0.000 description 2
238000012986 modification Methods 0.000 description 2
230000004048 modification Effects 0.000 description 2
150000003009 phosphonic acids Chemical class 0.000 description 2
229910000030 sodium bicarbonate Inorganic materials 0.000 description 2
235000017557 sodium bicarbonate Nutrition 0.000 description 2
SXGRAKNNKBAFML-UHFFFAOYSA-N 1,3-diphosphonopropan-2-ylphosphonic acid Chemical compound OP(O)(=O)CC(P(O)(O)=O)CP(O)(O)=O SXGRAKNNKBAFML-UHFFFAOYSA-N 0.000 description 1
GAPYCUKJBQZFAZ-UHFFFAOYSA-N 2-(1,1-diphosphonoethyl)butanedioic acid Chemical compound OP(=O)(O)C(P(O)(O)=O)(C)C(C(O)=O)CC(O)=O GAPYCUKJBQZFAZ-UHFFFAOYSA-N 0.000 description 1
INJFRROOFQOUGJ-UHFFFAOYSA-N 2-[hydroxy(methoxy)phosphoryl]butanedioic acid Chemical compound COP(O)(=O)C(C(O)=O)CC(O)=O INJFRROOFQOUGJ-UHFFFAOYSA-N 0.000 description 1
BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 1
101100283604 Caenorhabditis elegans pigk-1 gene Proteins 0.000 description 1
206010053567 Coagulopathies Diseases 0.000 description 1
KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
241000282414 Homo sapiens Species 0.000 description 1
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
229910019142 PO4 Inorganic materials 0.000 description 1
NBIIXXVUZAFLBC-UHFFFAOYSA-L Phosphate ion(2-) Chemical compound OP([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-L 0.000 description 1
102000004160 Phosphoric Monoester Hydrolases Human genes 0.000 description 1
108090000608 Phosphoric Monoester Hydrolases Proteins 0.000 description 1
229920000388 Polyphosphate Polymers 0.000 description 1
ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
YSMRWXYRXBRSND-UHFFFAOYSA-N TOTP Chemical compound CC1=CC=CC=C1OP(=O)(OC=1C(=CC=CC=1)C)OC1=CC=CC=C1C YSMRWXYRXBRSND-UHFFFAOYSA-N 0.000 description 1
YJNBCJLDSPNBOH-UHFFFAOYSA-N [[carboxy(hydroxy)phosphoryl]oxy-hydroxyphosphoryl]formic acid Chemical class OC(=O)P(O)(=O)OP(O)(=O)C(O)=O YJNBCJLDSPNBOH-UHFFFAOYSA-N 0.000 description 1
BFDMEODWJJUORJ-UHFFFAOYSA-N [dimethylamino(phosphono)methyl]phosphonic acid Chemical compound CN(C)C(P(O)(O)=O)P(O)(O)=O BFDMEODWJJUORJ-UHFFFAOYSA-N 0.000 description 1
230000002378 acidificating effect Effects 0.000 description 1
235000010407 ammonium alginate Nutrition 0.000 description 1
239000000728 ammonium alginate Substances 0.000 description 1
KPGABFJTMYCRHJ-YZOKENDUSA-N ammonium alginate Chemical compound [NH4+].[NH4+].O1[C@@H](C([O-])=O)[C@@H](OC)[C@H](O)[C@H](O)[C@@H]1O[C@@H]1[C@@H](C([O-])=O)O[C@@H](O)[C@@H](O)[C@H]1O KPGABFJTMYCRHJ-YZOKENDUSA-N 0.000 description 1
230000008901 benefit Effects 0.000 description 1
PZVXRVSZEYPTCG-UHFFFAOYSA-N benzyl-[chloro(hydroxy)phosphoryl]oxyphosphinic acid Chemical compound ClP(OP(=O)(O)CC1=CC=CC=C1)(=O)O PZVXRVSZEYPTCG-UHFFFAOYSA-N 0.000 description 1
NRIMHVFWRMABGJ-UHFFFAOYSA-N bicyclo[2.2.1]hepta-2,5-diene-2,3-dicarboxylic acid Chemical compound C1C2C(C(=O)O)=C(C(O)=O)C1C=C2 NRIMHVFWRMABGJ-UHFFFAOYSA-N 0.000 description 1
239000011230 binding agent Substances 0.000 description 1
230000015572 biosynthetic process Effects 0.000 description 1
DLEPCXYNAPUMDZ-UHFFFAOYSA-N butan-2-ylphosphonic acid Chemical compound CCC(C)P(O)(O)=O DLEPCXYNAPUMDZ-UHFFFAOYSA-N 0.000 description 1
235000014171 carbonated beverage Nutrition 0.000 description 1
NHWZQIYTQZEOSJ-UHFFFAOYSA-N carbonic acid;phosphoric acid Chemical compound OC(O)=O.OP(O)(O)=O NHWZQIYTQZEOSJ-UHFFFAOYSA-N 0.000 description 1
150000001768 cations Chemical class 0.000 description 1
230000035602 clotting Effects 0.000 description 1
239000013068 control sample Substances 0.000 description 1
239000013078 crystal Substances 0.000 description 1
WLWKIJKUDWYINL-UHFFFAOYSA-N cyclohexane-1,1,2,2,3,3-hexacarboxylic acid Chemical compound OC(=O)C1(C(O)=O)CCCC(C(O)=O)(C(O)=O)C1(C(O)=O)C(O)=O WLWKIJKUDWYINL-UHFFFAOYSA-N 0.000 description 1
230000007812 deficiency Effects 0.000 description 1
235000005911 diet Nutrition 0.000 description 1
230000037213 diet Effects 0.000 description 1
235000001916 dieting Nutrition 0.000 description 1
230000037228 dieting effect Effects 0.000 description 1
235000019621 digestibility Nutrition 0.000 description 1
230000035622 drinking Effects 0.000 description 1
238000002474 experimental method Methods 0.000 description 1
235000015203 fruit juice Nutrition 0.000 description 1
235000011389 fruit/vegetable juice Nutrition 0.000 description 1
239000011521 glass Substances 0.000 description 1
239000008233 hard water Substances 0.000 description 1
230000006872 improvement Effects 0.000 description 1
238000010348 incorporation Methods 0.000 description 1
230000002401 inhibitory effect Effects 0.000 description 1
230000000968 intestinal effect Effects 0.000 description 1
230000000670 limiting effect Effects 0.000 description 1
159000000003 magnesium salts Chemical class 0.000 description 1
238000004519 manufacturing process Methods 0.000 description 1
239000000463 material Substances 0.000 description 1
MBKDYNNUVRNNRF-UHFFFAOYSA-N medronic acid Chemical compound OP(O)(=O)CP(O)(O)=O MBKDYNNUVRNNRF-UHFFFAOYSA-N 0.000 description 1
230000004060 metabolic process Effects 0.000 description 1
235000013336 milk Nutrition 0.000 description 1
239000008267 milk Substances 0.000 description 1
210000004080 milk Anatomy 0.000 description 1
150000004712 monophosphates Chemical class 0.000 description 1
MGFYIUFZLHCRTH-UHFFFAOYSA-N nitrilotriacetic acid Chemical compound OC(=O)CN(CC(O)=O)CC(O)=O MGFYIUFZLHCRTH-UHFFFAOYSA-N 0.000 description 1
235000021317 phosphate Nutrition 0.000 description 1
150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
230000004962 physiological condition Effects 0.000 description 1
230000035790 physiological processes and functions Effects 0.000 description 1
239000001205 polyphosphate Substances 0.000 description 1
235000011176 polyphosphates Nutrition 0.000 description 1
229910052700 potassium Inorganic materials 0.000 description 1
239000011591 potassium Substances 0.000 description 1
235000010408 potassium alginate Nutrition 0.000 description 1
239000000737 potassium alginate Substances 0.000 description 1
MZYRDLHIWXQJCQ-YZOKENDUSA-L potassium alginate Chemical compound [K+].[K+].O1[C@@H](C([O-])=O)[C@@H](OC)[C@H](O)[C@H](O)[C@@H]1O[C@@H]1[C@@H](C([O-])=O)O[C@@H](O)[C@@H](O)[C@H]1O MZYRDLHIWXQJCQ-YZOKENDUSA-L 0.000 description 1
230000008569 process Effects 0.000 description 1
230000002829 reductive effect Effects 0.000 description 1
239000000523 sample Substances 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
239000011734 sodium Substances 0.000 description 1
159000000000 sodium salts Chemical class 0.000 description 1
210000002784 stomach Anatomy 0.000 description 1
229940088594 vitamin Drugs 0.000 description 1
239000011782 vitamin Substances 0.000 description 1
229930003231 vitamin Natural products 0.000 description 1
235000013343 vitamin Nutrition 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/20—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents
- A23L29/206—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents of vegetable origin
- A23L29/256—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents of vegetable origin from seaweeds, e.g. alginates, agar or carrageenan
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/20—Reducing nutritive value; Dietetic products with reduced nutritive value
- A23L33/21—Addition of substantially indigestible substances, e.g. dietary fibres
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K3/00—Use of inorganic substances as compounding ingredients
- C08K3/18—Oxygen-containing compounds, e.g. metal carbonyls
- C08K3/24—Acids; Salts thereof
- C08K3/26—Carbonates; Bicarbonates
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K3/00—Use of inorganic substances as compounding ingredients
- C08K3/32—Phosphorus-containing compounds
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K5/00—Use of organic ingredients
- C08K5/49—Phosphorus-containing compounds
- C08K5/51—Phosphorus bound to oxygen
- C08K5/53—Phosphorus bound to oxygen bound to oxygen and to carbon only

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Polymers & Plastics (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Food Science & Technology (AREA)
Nutrition Science (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Molecular Biology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Dispersion Chemistry (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Mycology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Non-Alcoholic Beverages (AREA)

CA221,248A 1974-03-16 1975-03-04 Appetite curbing preparation containing an alginate and a diphosphonic acid Expired CA1041013A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE2412827A DE2412827A1 (de)	1974-03-16	1974-03-16	Alginatpraeparationen

Publications (1)

Publication Number	Publication Date
CA1041013A true CA1041013A (en)	1978-10-24

Family

ID=5910341

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA221,248A Expired CA1041013A (en)	1974-03-16	1975-03-04	Appetite curbing preparation containing an alginate and a diphosphonic acid

Country Status (9)

Country	Link
AT (1)	AT347037B (da)
BE (1)	BE826675A (da)
CA (1)	CA1041013A (da)
DE (1)	DE2412827A1 (da)
DK (1)	DK61775A (da)
FR (1)	FR2263704B1 (da)
GB (1)	GB1480967A (da)
NL (1)	NL7501972A (da)
SE (1)	SE404289B (da)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US8283338B2 (en)	2007-11-30	2012-10-09	Kao Corporation	GIP secretion inhibitor
JP5581129B2 (ja)	2009-06-17	2014-08-27	花王株式会社	肥満予防・改善剤

1974
- 1974-03-16 DE DE2412827A patent/DE2412827A1/de active Pending
1975
- 1975-02-19 NL NL7501972A patent/NL7501972A/xx unknown
- 1975-02-19 SE SE7501886A patent/SE404289B/xx unknown
- 1975-02-19 DK DK61775*#A patent/DK61775A/da unknown
- 1975-03-04 CA CA221,248A patent/CA1041013A/en not_active Expired
- 1975-03-12 GB GB10225/75A patent/GB1480967A/en not_active Expired
- 1975-03-14 FR FR7507977A patent/FR2263704B1/fr not_active Expired
- 1975-03-14 AT AT197375A patent/AT347037B/de not_active IP Right Cessation
- 1975-03-14 BE BE154319A patent/BE826675A/xx unknown

Also Published As

Publication number	Publication date
GB1480967A (en)	1977-07-27
FR2263704A1 (da)	1975-10-10
NL7501972A (nl)	1975-09-18
FR2263704B1 (da)	1978-12-08
AT347037B (de)	1978-12-11
ATA197375A (de)	1978-04-15
DK61775A (da)	1975-09-17
SE7501886L (da)	1975-09-17
DE2412827A1 (de)	1975-09-25
BE826675A (fr)	1975-09-15
SE404289B (sv)	1978-10-02

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Thomas et al.	1963	Some concepts concerning the genesis of urinary calculi
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