CA1045978A - Vehicule a compression directe - Google Patents

Vehicule a compression directe

Info

Publication number: CA1045978A
Authority: CA; Canada
Prior art keywords: weight; tricalcium phosphate; parts; locust bean; bean gum
Prior art date: 1975-05-06
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

CA226,420A

Other languages

English (en)

Inventor

Anthony Monti

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Sucrest Corp

Original Assignee

Sucrest Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1975-05-06

Filing date

1975-05-06

Publication date

1979-01-09

1975-05-06 Application filed by Sucrest Corp filed Critical Sucrest Corp

1975-05-06 Priority to CA226,420A priority Critical patent/CA1045978A/fr

1979-01-09 Application granted granted Critical

1979-01-09 Publication of CA1045978A publication Critical patent/CA1045978A/fr

Status Expired legal-status Critical Current

Links

238000007907 direct compression Methods 0.000 title claims abstract description 28
239000000203 mixture Substances 0.000 claims abstract description 58
239000001506 calcium phosphate Substances 0.000 claims abstract description 43
229920000161 Locust bean gum Polymers 0.000 claims abstract description 39
239000000711 locust bean gum Substances 0.000 claims abstract description 39
235000010420 locust bean gum Nutrition 0.000 claims abstract description 39
QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims abstract description 37
229910000391 tricalcium phosphate Inorganic materials 0.000 claims abstract description 35
229940078499 tricalcium phosphate Drugs 0.000 claims abstract description 35
235000019731 tricalcium phosphate Nutrition 0.000 claims abstract description 34
239000011363 dried mixture Substances 0.000 claims abstract description 10
239000003795 chemical substances by application Substances 0.000 claims abstract description 9
239000000314 lubricant Substances 0.000 claims abstract description 7
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 30
239000000463 material Substances 0.000 claims description 20
230000002378 acidificating effect Effects 0.000 claims description 11
VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims description 4
FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims description 4
WNLRTRBMVRJNCN-UHFFFAOYSA-N adipic acid Chemical compound OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 claims description 4
YYRMJZQKEFZXMX-UHFFFAOYSA-L calcium bis(dihydrogenphosphate) Chemical compound [Ca+2].OP(O)([O-])=O.OP(O)([O-])=O YYRMJZQKEFZXMX-UHFFFAOYSA-L 0.000 claims description 4
229910000150 monocalcium phosphate Inorganic materials 0.000 claims description 4
235000019691 monocalcium phosphate Nutrition 0.000 claims description 4
239000011975 tartaric acid Substances 0.000 claims description 4
235000002906 tartaric acid Nutrition 0.000 claims description 4
BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 claims description 3
FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 3
BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims description 2
KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 claims description 2
239000001361 adipic acid Substances 0.000 claims description 2
235000011037 adipic acid Nutrition 0.000 claims description 2
BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims description 2
DIZPMCHEQGEION-UHFFFAOYSA-H aluminium sulfate (anhydrous) Chemical compound [Al+3].[Al+3].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O DIZPMCHEQGEION-UHFFFAOYSA-H 0.000 claims description 2
KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 claims description 2
239000001530 fumaric acid Substances 0.000 claims description 2
235000011087 fumaric acid Nutrition 0.000 claims description 2
239000001630 malic acid Substances 0.000 claims description 2
235000011090 malic acid Nutrition 0.000 claims description 2
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims description 2
240000008375 Hymenaea courbaril Species 0.000 claims 1
239000011790 ferrous sulphate Substances 0.000 claims 1
235000003891 ferrous sulphate Nutrition 0.000 claims 1
BAUYGSIQEAFULO-UHFFFAOYSA-L iron(2+) sulfate (anhydrous) Chemical compound [Fe+2].[O-]S([O-])(=O)=O BAUYGSIQEAFULO-UHFFFAOYSA-L 0.000 claims 1
229910000359 iron(II) sulfate Inorganic materials 0.000 claims 1
238000000034 method Methods 0.000 abstract description 11
239000011149 active material Substances 0.000 abstract description 4
239000000945 filler Substances 0.000 abstract description 2
238000009491 slugging Methods 0.000 abstract description 2
238000005469 granulation Methods 0.000 abstract 1
230000003179 granulation Effects 0.000 abstract 1
239000003826 tablet Substances 0.000 description 36
HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 22
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 14
235000019359 magnesium stearate Nutrition 0.000 description 11
238000007906 compression Methods 0.000 description 8
230000006835 compression Effects 0.000 description 8
239000002245 particle Substances 0.000 description 6
240000008886 Ceratonia siliqua Species 0.000 description 5
235000013912 Ceratonia siliqua Nutrition 0.000 description 5
229910019142 PO4 Inorganic materials 0.000 description 5
235000021317 phosphate Nutrition 0.000 description 5
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 5
239000010452 phosphate Substances 0.000 description 5
244000046052 Phaseolus vulgaris Species 0.000 description 4
235000010627 Phaseolus vulgaris Nutrition 0.000 description 4
238000002474 experimental method Methods 0.000 description 4
239000000843 powder Substances 0.000 description 4
235000009754 Vitis X bourquina Nutrition 0.000 description 3
235000012333 Vitis X labruscana Nutrition 0.000 description 3
240000006365 Vitis vinifera Species 0.000 description 3
235000014787 Vitis vinifera Nutrition 0.000 description 3
239000011575 calcium Substances 0.000 description 3
229910052791 calcium Inorganic materials 0.000 description 3
229910000389 calcium phosphate Inorganic materials 0.000 description 3
235000011010 calcium phosphates Nutrition 0.000 description 3
239000003085 diluting agent Substances 0.000 description 3
238000002036 drum drying Methods 0.000 description 3
238000001035 drying Methods 0.000 description 3
238000002156 mixing Methods 0.000 description 3
239000000725 suspension Substances 0.000 description 3
NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 2
CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
244000299461 Theobroma cacao Species 0.000 description 2
235000009470 Theobroma cacao Nutrition 0.000 description 2
239000002253 acid Substances 0.000 description 2
230000002411 adverse Effects 0.000 description 2
OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 description 2
235000009508 confectionery Nutrition 0.000 description 2
239000006185 dispersion Substances 0.000 description 2
239000007788 liquid Substances 0.000 description 2
QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 2
239000011236 particulate material Substances 0.000 description 2
150000003839 salts Chemical class 0.000 description 2
238000012360 testing method Methods 0.000 description 2
244000075850 Avena orientalis Species 0.000 description 1
235000007319 Avena orientalis Nutrition 0.000 description 1
BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
235000005979 Citrus limon Nutrition 0.000 description 1
244000131522 Citrus pyriformis Species 0.000 description 1
229920002261 Corn starch Polymers 0.000 description 1
ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
235000019739 Dicalciumphosphate Nutrition 0.000 description 1
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
FZERHIULMFGESH-UHFFFAOYSA-N N-phenylacetamide Chemical compound CC(=O)NC1=CC=CC=C1 FZERHIULMFGESH-UHFFFAOYSA-N 0.000 description 1
241000212342 Sium Species 0.000 description 1
UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 description 1
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
229930003268 Vitamin C Natural products 0.000 description 1
238000009825 accumulation Methods 0.000 description 1
125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 description 1
229960001138 acetylsalicylic acid Drugs 0.000 description 1
239000004480 active ingredient Substances 0.000 description 1
239000000654 additive Substances 0.000 description 1
WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 1
229910000329 aluminium sulfate Inorganic materials 0.000 description 1
235000011128 aluminium sulphate Nutrition 0.000 description 1
BIIVYFLTOXDAOV-YVEFUNNKSA-N alvocidib Chemical compound O[C@@H]1CN(C)CC[C@@H]1C1=C(O)C=C(O)C2=C1OC(C=1C(=CC=CC=1)Cl)=CC2=O BIIVYFLTOXDAOV-YVEFUNNKSA-N 0.000 description 1
235000019270 ammonium chloride Nutrition 0.000 description 1
229940069428 antacid Drugs 0.000 description 1
239000003159 antacid agent Substances 0.000 description 1
239000012736 aqueous medium Substances 0.000 description 1
239000007900 aqueous suspension Substances 0.000 description 1
230000009286 beneficial effect Effects 0.000 description 1
108010051210 beta-Fructofuranosidase Proteins 0.000 description 1
SXDBWCPKPHAZSM-UHFFFAOYSA-M bromate Inorganic materials [O-]Br(=O)=O SXDBWCPKPHAZSM-UHFFFAOYSA-M 0.000 description 1
SXDBWCPKPHAZSM-UHFFFAOYSA-N bromic acid Chemical compound OBr(=O)=O SXDBWCPKPHAZSM-UHFFFAOYSA-N 0.000 description 1
FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 description 1
CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical compound [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 description 1
235000013539 calcium stearate Nutrition 0.000 description 1
239000008116 calcium stearate Substances 0.000 description 1
239000001913 cellulose Substances 0.000 description 1
229920002678 cellulose Polymers 0.000 description 1
239000007958 cherry flavor Substances 0.000 description 1
238000007796 conventional method Methods 0.000 description 1
239000008120 corn starch Substances 0.000 description 1
229910000390 dicalcium phosphate Inorganic materials 0.000 description 1
229940038472 dicalcium phosphate Drugs 0.000 description 1
GXGAKHNRMVGRPK-UHFFFAOYSA-N dimagnesium;dioxido-bis[[oxido(oxo)silyl]oxy]silane Chemical compound [Mg+2].[Mg+2].[O-][Si](=O)O[Si]([O-])([O-])O[Si]([O-])=O GXGAKHNRMVGRPK-UHFFFAOYSA-N 0.000 description 1
BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 1
229910000397 disodium phosphate Inorganic materials 0.000 description 1
235000019800 disodium phosphate Nutrition 0.000 description 1
238000009826 distribution Methods 0.000 description 1
238000007908 dry granulation Methods 0.000 description 1
235000013399 edible fruits Nutrition 0.000 description 1
238000007429 general method Methods 0.000 description 1
239000008187 granular material Substances 0.000 description 1
239000001573 invertase Substances 0.000 description 1
235000011073 invertase Nutrition 0.000 description 1
150000002500 ions Chemical class 0.000 description 1
239000008101 lactose Substances 0.000 description 1
230000001050 lubricating effect Effects 0.000 description 1
239000011777 magnesium Substances 0.000 description 1
229910052749 magnesium Inorganic materials 0.000 description 1
ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 description 1
239000001095 magnesium carbonate Substances 0.000 description 1
229910000021 magnesium carbonate Inorganic materials 0.000 description 1
239000000391 magnesium silicate Substances 0.000 description 1
229940099273 magnesium trisilicate Drugs 0.000 description 1
229910000386 magnesium trisilicate Inorganic materials 0.000 description 1
235000019793 magnesium trisilicate Nutrition 0.000 description 1
238000004519 manufacturing process Methods 0.000 description 1
239000011159 matrix material Substances 0.000 description 1
239000001525 mentha piperita l. herb oil Substances 0.000 description 1
229910000403 monosodium phosphate Inorganic materials 0.000 description 1
235000019799 monosodium phosphate Nutrition 0.000 description 1
238000000465 moulding Methods 0.000 description 1
150000007524 organic acids Chemical class 0.000 description 1
235000019477 peppermint oil Nutrition 0.000 description 1
239000008194 pharmaceutical composition Substances 0.000 description 1
AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
239000001488 sodium phosphate Substances 0.000 description 1
238000001694 spray drying Methods 0.000 description 1
239000007916 tablet composition Substances 0.000 description 1
238000001665 trituration Methods 0.000 description 1
238000009827 uniform distribution Methods 0.000 description 1
235000019154 vitamin C Nutrition 0.000 description 1
239000011718 vitamin C Substances 0.000 description 1
238000005550 wet granulation Methods 0.000 description 1

Landscapes

Medicinal Preparation (AREA)

CA226,420A 1975-05-06 1975-05-06 Vehicule a compression directe Expired CA1045978A (fr)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
CA226,420A CA1045978A (fr)	1975-05-06	1975-05-06	Vehicule a compression directe

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
CA226,420A CA1045978A (fr)	1975-05-06	1975-05-06	Vehicule a compression directe

Publications (1)

Publication Number	Publication Date
CA1045978A true CA1045978A (fr)	1979-01-09

Family

ID=4103018

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA226,420A Expired CA1045978A (fr)	1975-05-06	1975-05-06	Vehicule a compression directe

Country Status (1)

Country	Link
CA (1)	CA1045978A (fr)

1975
- 1975-05-06 CA CA226,420A patent/CA1045978A/fr not_active Expired

Publication	Publication Date	Title
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US3655866A (en)	1972-04-11	Sugarless gum containing dicalcium phosphate dihydrate
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HU216339B (hu)	1999-06-28	Formázott tejszínpótló, valamint eljárás előállítására
JP3230814B2 (ja)	2001-11-19	炭酸マグネシウムおよびオイルタブレット形成助剤
CA2007494A1 (fr)	1990-07-16	Methode de production de soudre de chocolat et poudre de chocolat
JPH03123729A (ja)	1991-05-27	パントテン酸カルシウム組成物およびその製造方法
EP1659878A2 (fr)	2006-05-31	Formulation a base de phospholipides