CA1046410A - Compose cardiotonique - Google Patents

Compose cardiotonique

Info

Publication number: CA1046410A
Authority: CA; Canada
Prior art keywords: composition; weight; cardiotonic; gelatine capsule; polyethylene glycol
Prior art date: 1974-04-01
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

CA223,484A

Other languages

English (en)

Inventor

Carlo Fadda

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Catalent UK Swindon Encaps Ltd

Original Assignee

Catalent UK Swindon Encaps Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1974-04-01

Filing date

1975-04-01

Publication date

1979-01-16

1975-04-01 Application filed by Catalent UK Swindon Encaps Ltd filed Critical Catalent UK Swindon Encaps Ltd

1979-01-16 Application granted granted Critical

1979-01-16 Publication of CA1046410A publication Critical patent/CA1046410A/fr

Status Expired legal-status Critical Current

Links

239000000203 mixture Substances 0.000 title claims abstract description 27
230000003177 cardiotonic effect Effects 0.000 title claims abstract description 8
ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims abstract description 21
239000002775 capsule Substances 0.000 claims abstract description 18
229940097217 cardiac glycoside Drugs 0.000 claims abstract description 17
239000002368 cardiac glycoside Substances 0.000 claims abstract description 17
229930002534 steroid glycoside Natural products 0.000 claims abstract description 17
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims abstract description 15
LPMXVESGRSUGHW-HBYQJFLCSA-N ouabain Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1O[C@@H]1C[C@@]2(O)CC[C@H]3[C@@]4(O)CC[C@H](C=5COC(=O)C=5)[C@@]4(C)C[C@@H](O)[C@@H]3[C@@]2(CO)[C@H](O)C1 LPMXVESGRSUGHW-HBYQJFLCSA-N 0.000 claims abstract description 14
239000001828 Gelatine Substances 0.000 claims abstract description 11
229920000159 gelatin Polymers 0.000 claims abstract description 11
235000019322 gelatine Nutrition 0.000 claims abstract description 11
FXHOOIRPVKKKFG-UHFFFAOYSA-N N,N-Dimethylacetamide Chemical compound CN(C)C(C)=O FXHOOIRPVKKKFG-UHFFFAOYSA-N 0.000 claims abstract description 9
229940113088 dimethylacetamide Drugs 0.000 claims abstract description 9
239000002202 Polyethylene glycol Substances 0.000 claims abstract description 8
229920001223 polyethylene glycol Polymers 0.000 claims abstract description 8
LTMHDMANZUZIPE-AMTYYWEZSA-N Digoxin Natural products O([C@H]1[C@H](C)O[C@H](O[C@@H]2C[C@@H]3[C@@](C)([C@@H]4[C@H]([C@]5(O)[C@](C)([C@H](O)C4)[C@H](C4=CC(=O)OC4)CC5)CC3)CC2)C[C@@H]1O)[C@H]1O[C@H](C)[C@@H](O[C@H]2O[C@@H](C)[C@H](O)[C@@H](O)C2)[C@@H](O)C1 LTMHDMANZUZIPE-AMTYYWEZSA-N 0.000 claims abstract description 6
229960005156 digoxin Drugs 0.000 claims abstract description 6
LTMHDMANZUZIPE-PUGKRICDSA-N digoxin Chemical compound C1[C@H](O)[C@H](O)[C@@H](C)O[C@H]1O[C@@H]1[C@@H](C)O[C@@H](O[C@@H]2[C@H](O[C@@H](O[C@@H]3C[C@@H]4[C@]([C@@H]5[C@H]([C@]6(CC[C@@H]([C@@]6(C)[C@H](O)C5)C=5COC(=O)C=5)O)CC4)(C)CC3)C[C@@H]2O)C)C[C@@H]1O LTMHDMANZUZIPE-PUGKRICDSA-N 0.000 claims abstract description 6
LTMHDMANZUZIPE-UHFFFAOYSA-N digoxine Natural products C1C(O)C(O)C(C)OC1OC1C(C)OC(OC2C(OC(OC3CC4C(C5C(C6(CCC(C6(C)C(O)C5)C=5COC(=O)C=5)O)CC4)(C)CC3)CC2O)C)CC1O LTMHDMANZUZIPE-UHFFFAOYSA-N 0.000 claims abstract description 6
239000007788 liquid Substances 0.000 claims abstract description 6
WDJUZGPOPHTGOT-OAXVISGBSA-N Digitoxin Natural products O([C@H]1[C@@H](C)O[C@@H](O[C@@H]2C[C@@H]3[C@@](C)([C@@H]4[C@H]([C@]5(O)[C@@](C)([C@H](C6=CC(=O)OC6)CC5)CC4)CC3)CC2)C[C@H]1O)[C@H]1O[C@@H](C)[C@H](O[C@H]2O[C@@H](C)[C@@H](O)[C@@H](O)C2)[C@@H](O)C1 WDJUZGPOPHTGOT-OAXVISGBSA-N 0.000 claims abstract description 5
229960000648 digitoxin Drugs 0.000 claims abstract description 4
WDJUZGPOPHTGOT-XUDUSOBPSA-N digitoxin Chemical compound C1[C@H](O)[C@H](O)[C@@H](C)O[C@H]1O[C@@H]1[C@@H](C)O[C@@H](O[C@@H]2[C@H](O[C@@H](O[C@@H]3C[C@@H]4[C@]([C@@H]5[C@H]([C@]6(CC[C@@H]([C@@]6(C)CC5)C=5COC(=O)C=5)O)CC4)(C)CC3)C[C@@H]2O)C)C[C@@H]1O WDJUZGPOPHTGOT-XUDUSOBPSA-N 0.000 claims abstract description 4
125000003827 glycol group Chemical group 0.000 claims abstract description 3
230000000747 cardiac effect Effects 0.000 claims abstract 2
125000005456 glyceride group Chemical group 0.000 claims abstract 2
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 abstract description 12
235000011187 glycerol Nutrition 0.000 abstract description 6
FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 5
239000004480 active ingredient Substances 0.000 description 5
239000000600 sorbitol Substances 0.000 description 5
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
229920002565 Polyethylene Glycol 400 Polymers 0.000 description 3
MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 description 3
239000004615 ingredient Substances 0.000 description 3
239000004014 plasticizer Substances 0.000 description 3
150000008143 steroidal glycosides Chemical class 0.000 description 3
238000009472 formulation Methods 0.000 description 2
239000007791 liquid phase Substances 0.000 description 2
MCJGNVYPOGVAJF-UHFFFAOYSA-N quinolin-8-ol Chemical compound C1=CN=C2C(O)=CC=CC2=C1 MCJGNVYPOGVAJF-UHFFFAOYSA-N 0.000 description 2
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
HPMZBILYSWLILX-UMDUKNJSSA-N 3'''-O-acetyldigitoxin Chemical compound C1[C@H](OC(C)=O)[C@H](O)[C@@H](C)O[C@H]1O[C@@H]1[C@@H](C)O[C@@H](O[C@@H]2[C@H](O[C@@H](O[C@@H]3C[C@@H]4[C@]([C@@H]5[C@H]([C@]6(CC[C@@H]([C@@]6(C)CC5)C=5COC(=O)C=5)O)CC4)(C)CC3)C[C@@H]2O)C)C[C@@H]1O HPMZBILYSWLILX-UMDUKNJSSA-N 0.000 description 1
HPMZBILYSWLILX-UHFFFAOYSA-N Acetyl-digitoxine Natural products C1C(OC(C)=O)C(O)C(C)OC1OC1C(C)OC(OC2C(OC(OC3CC4C(C5C(C6(CCC(C6(C)CC5)C=5COC(=O)C=5)O)CC4)(C)CC3)CC2O)C)CC1O HPMZBILYSWLILX-UHFFFAOYSA-N 0.000 description 1
FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
CKNOLMVLQUPVMU-XOMFLMSUSA-N Digitalin Natural products O(C)[C@H]1[C@@H](O[C@H]2[C@H](O)[C@@H](O)[C@@H](O)[C@H](CO)O2)[C@H](C)O[C@H](O[C@@H]2C[C@@H]3[C@@](C)([C@@H]4[C@H]([C@]5(O)[C@@](C)([C@@H]([C@H](O)C5)C5=CC(=O)OC5)CC4)CC3)CC2)[C@@H]1O CKNOLMVLQUPVMU-XOMFLMSUSA-N 0.000 description 1
241000208011 Digitalis Species 0.000 description 1
240000001879 Digitalis lutea Species 0.000 description 1
JAYAGJDXJIDEKI-UHFFFAOYSA-N Lanatoside C Natural products CC1OC(OC2CC3C(C4C(C5(CCC(C5(C)C(O)C4)C=4COC(=O)C=4)O)CC3)(C)CC2)CC(O)C1OC(OC1C)CC(O)C1OC(OC1C)CC(OC(C)=O)C1OC1OC(CO)C(O)C(O)C1O JAYAGJDXJIDEKI-UHFFFAOYSA-N 0.000 description 1
JAYAGJDXJIDEKI-PTGWOZRBSA-N Lanatoside C Chemical compound O([C@H]1[C@@H](OC(C)=O)C[C@@H](O[C@@H]1C)O[C@H]1[C@@H](O)C[C@@H](O[C@@H]1C)O[C@H]1[C@@H](O)C[C@@H](O[C@@H]1C)O[C@@H]1C[C@@H]2[C@]([C@@H]3[C@H]([C@]4(CC[C@@H]([C@@]4(C)[C@H](O)C3)C=3COC(=O)C=3)O)CC2)(C)CC1)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O JAYAGJDXJIDEKI-PTGWOZRBSA-N 0.000 description 1
CPFNIKYEDJFRAT-UHFFFAOYSA-N Strospasid Natural products OC1C(OC)C(O)C(C)OC1OC1CC(CCC2C3(CC(O)C(C3(C)CCC32)C=2COC(=O)C=2)O)C3(C)CC1 CPFNIKYEDJFRAT-UHFFFAOYSA-N 0.000 description 1
CKNOLMVLQUPVMU-UHFFFAOYSA-N UNPD183315 Natural products O1C(C)C(OC2C(C(O)C(O)C(CO)O2)O)C(OC)C(O)C1OC(C1)CCC2(C)C1CCC(C1(CC3O)O)C2CCC1(C)C3C1=CC(=O)OC1 CKNOLMVLQUPVMU-UHFFFAOYSA-N 0.000 description 1
229960003635 acetyldigitoxin Drugs 0.000 description 1
229960003304 acetyldigoxin Drugs 0.000 description 1
HWKJSYYYURVNQU-DXJNJSHLSA-N acetyldigoxin Chemical compound C1[C@H](OC(C)=O)[C@H](O)[C@@H](C)O[C@H]1O[C@@H]1[C@@H](C)O[C@@H](O[C@@H]2[C@H](O[C@@H](O[C@@H]3C[C@@H]4[C@]([C@@H]5[C@H]([C@]6(CC[C@@H]([C@@]6(C)[C@H](O)C5)C=5COC(=O)C=5)O)CC4)(C)CC3)C[C@@H]2O)C)C[C@@H]1O HWKJSYYYURVNQU-DXJNJSHLSA-N 0.000 description 1
MGVYFNHJWXJYBE-UHFFFAOYSA-N alpha-Acetyl-digoxin Natural products CC1OC(CC(O)C1O)OC2C(O)CC(OC3C(C)OC(CC3OC(=O)C)OC4CCC5(C)C(CCC6C5CCC7(C)C(C(O)CC67O)C8=CC(=O)OC8)C4)OC2C MGVYFNHJWXJYBE-UHFFFAOYSA-N 0.000 description 1
239000000496 cardiotonic agent Substances 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
238000013329 compounding Methods 0.000 description 1
229950004590 digitalin Drugs 0.000 description 1
CKNOLMVLQUPVMU-YMMLYESFSA-N digitalin Chemical compound C1([C@@H]2[C@@]3(C)CC[C@H]4[C@H]([C@]3(C[C@@H]2O)O)CC[C@H]2[C@]4(C)CC[C@@H](C2)O[C@H]2[C@H](O)[C@H]([C@H]([C@@H](C)O2)O[C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)OC)=CC(=O)OC1 CKNOLMVLQUPVMU-YMMLYESFSA-N 0.000 description 1
125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 description 1
239000006185 dispersion Substances 0.000 description 1
239000002552 dosage form Substances 0.000 description 1
230000002496 gastric effect Effects 0.000 description 1
-1 gl~cerine Substances 0.000 description 1
TZMQHOJDDMFGQX-UHFFFAOYSA-N hexane-1,1,1-triol Chemical compound CCCCCC(O)(O)O TZMQHOJDDMFGQX-UHFFFAOYSA-N 0.000 description 1
229960002614 lanatoside c Drugs 0.000 description 1
239000000463 material Substances 0.000 description 1
229960003746 metildigoxin Drugs 0.000 description 1
IYJMSDVSVHDVGT-PEQKVOOWSA-N metildigoxin Chemical compound O1[C@H](C)[C@@H](OC)[C@@H](O)C[C@@H]1O[C@@H]1[C@@H](C)O[C@@H](O[C@@H]2[C@H](O[C@@H](O[C@@H]3C[C@@H]4[C@]([C@@H]5[C@H]([C@]6(CC[C@@H]([C@@]6(C)[C@H](O)C5)C=5COC(=O)C=5)O)CC4)(C)CC3)C[C@@H]2O)C)C[C@@H]1O IYJMSDVSVHDVGT-PEQKVOOWSA-N 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Cardiology (AREA)
Hospice & Palliative Care (AREA)
Heart & Thoracic Surgery (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Molecular Biology (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

CA223,484A 1974-04-01 1975-04-01 Compose cardiotonique Expired CA1046410A (fr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB14265/74A GB1508770A (en)	1974-04-01	1974-04-01	Pharmaceutical compositions

Publications (1)

Publication Number	Publication Date
CA1046410A true CA1046410A (fr)	1979-01-16

Family

ID=10038031

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA223,484A Expired CA1046410A (fr)	1974-04-01	1975-04-01	Compose cardiotonique

Country Status (12)

Country	Link
JP (1)	JPS5644045B2 (fr)
AT (1)	AT342777B (fr)
AU (1)	AU500001B2 (fr)
BE (1)	BE827349A (fr)
CA (1)	CA1046410A (fr)
DE (1)	DE2513601A1 (fr)
DK (1)	DK137436B (fr)
FI (1)	FI63671C (fr)
FR (1)	FR2265353B1 (fr)
GB (1)	GB1508770A (fr)
NL (1)	NL7503881A (fr)
SE (1)	SE408687B (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2805165A1 (de) *	1977-02-09	1978-08-10	Christiaens Sa A	Gitoxin enthaltendes arzneimittel und verfahren zu seiner herstellung
ATE398448T1 (de)	1993-09-28	2008-07-15	Scherer Gmbh R P	Herstellung von weichgelatinekapseln

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1481411A (en) *	1973-07-20	1977-07-27	Scherer Ltd R	Pharmaceutical compositions
FI750489A7 (fr) *	1974-02-22	1975-08-23	Wellcome Found

1974
- 1974-04-01 GB GB14265/74A patent/GB1508770A/en not_active Expired
1975
- 1975-03-27 DE DE19752513601 patent/DE2513601A1/de active Granted
- 1975-03-27 SE SE7503592A patent/SE408687B/xx not_active IP Right Cessation
- 1975-03-28 BE BE154915A patent/BE827349A/fr not_active IP Right Cessation
- 1975-04-01 FR FR7510180A patent/FR2265353B1/fr not_active Expired
- 1975-04-01 NL NL7503881A patent/NL7503881A/xx not_active Application Discontinuation
- 1975-04-01 FI FI750964A patent/FI63671C/fi not_active IP Right Cessation
- 1975-04-01 DK DK138675AA patent/DK137436B/da not_active IP Right Cessation
- 1975-04-01 AT AT244575A patent/AT342777B/de not_active IP Right Cessation
- 1975-04-01 JP JP3968275A patent/JPS5644045B2/ja not_active Expired
- 1975-04-01 AU AU79663/75A patent/AU500001B2/en not_active Expired
- 1975-04-01 CA CA223,484A patent/CA1046410A/fr not_active Expired

Also Published As

Publication number	Publication date
FR2265353B1 (fr)	1980-02-15
AU7966375A (en)	1976-10-07
FI750964A7 (fr)	1975-10-02
AT342777B (de)	1978-04-25
DE2513601C2 (fr)	1988-05-26
SE7503592L (fr)	1975-10-02
GB1508770A (en)	1978-04-26
DK137436B (da)	1978-03-06
AU500001B2 (en)	1979-05-10
NL7503881A (nl)	1975-10-03
DK137436C (fr)	1978-08-21
DE2513601A1 (de)	1975-10-02
JPS517117A (fr)	1976-01-21
BE827349A (fr)	1975-09-29
FI63671B (fi)	1983-04-29
FI63671C (fi)	1983-08-10
SE408687B (sv)	1979-07-02
DK138675A (fr)	1975-10-02
JPS5644045B2 (fr)	1981-10-16
ATA244575A (de)	1977-08-15
FR2265353A1 (fr)	1975-10-24

Publication	Publication Date	Title
US4198391A (en)	1980-04-15	Pharmaceutical compositions
US3344029A (en)	1967-09-26	Sustained release composition
US4235870A (en)	1980-11-25	Slow release pharmaceutical compositions
US3965256A (en)	1976-06-22	Slow release pharmaceutical compositions
CA2210985C (fr)	2007-01-09	Composition pharmaceutique contenant du fenofibrate et des glycerides polyglycolyses
DE2336218C3 (de)	1985-11-14	Orale Arzneiform
FI84783B (fi)	1991-10-15	Foerfarande foer framstaellning av ett farmaceutiskt preparat i enhetsdosform.
US4067960A (en)	1978-01-10	Pharmaceutical compositions containing cardiac glycoside
US6387400B1 (en)	2002-05-14	Process for preparing pharmaceutical compositions for use with soft gelatin formulations
US3789119A (en)	1974-01-29	Stabilized molded sublingual nitroglycerin tablets
JPS6028810B2 (ja)	1985-07-06	医薬用フオイルの製法
JPS63162627A (ja)	1988-07-06	徐放性医薬製剤
US3755575A (en)	1973-08-28	Pharmaceutical compositions
US4088750A (en)	1978-05-09	Method and preparation for increasing bioavailability of digoxin
CA2011943A1 (fr)	1990-09-13	Compose pour la preparation d'une forme posologique active de vitamine d3 et methode de preparation
CA1095411A (fr)	1981-02-10	Cardiotonique en capsules de gelatine
DE2940905A1 (de)	1980-04-30	Pulver aus gleichmaessigen, kugelfoermigen teilchen, verfahren zur herstellung und arzneimittel
Kochakian	1946	The effect of dose and nutritive state on the renotrophic and androgenic activities of various steroids
CA1046410A (fr)	1979-01-16	Compose cardiotonique
KR860006265A (ko)	1986-09-09	9,10-디하이드로 에르고트 알카로이드를 함유하는 서방성 제재의 제조방법
UA57725C2 (uk)	2003-07-15	Композиція, що містить циклоспорин, спосіб одержання желатинових капсул, що містять циклоспорин, та спосіб лікування станів чи симптомів з його використанням
US3873727A (en)	1975-03-25	Stabilization of molded sublingual nitroglycerin tablets
US3197370A (en)	1965-07-27	Pyrilamine tannate compositions
US3326760A (en)	1967-06-20	Choline salicylate polygalacturonate therapy
US2910403A (en)	1959-10-27	Anti hypertensive compositions comprising 2-methyl-5, 8-dimethoxychromone and acetamides