CA1062501A - Methode et appareil pour depister les deficiences au niveau des reactions enzymatiques et particullerement les taux de facteurs de coagulation dans le plasma sanguin - Google Patents
Methode et appareil pour depister les deficiences au niveau des reactions enzymatiques et particullerement les taux de facteurs de coagulation dans le plasma sanguinInfo
- Publication number
- CA1062501A CA1062501A CA257,483A CA257483A CA1062501A CA 1062501 A CA1062501 A CA 1062501A CA 257483 A CA257483 A CA 257483A CA 1062501 A CA1062501 A CA 1062501A
- Authority
- CA
- Canada
- Prior art keywords
- standard
- blood plasma
- plasma
- time
- factor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
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- 238000000034 method Methods 0.000 title claims abstract description 40
- 239000003114 blood coagulation factor Substances 0.000 title claims abstract description 34
- 102000015081 Blood Coagulation Factors Human genes 0.000 title claims abstract description 33
- 108010039209 Blood Coagulation Factors Proteins 0.000 title claims abstract description 33
- 230000007812 deficiency Effects 0.000 title abstract description 45
- 238000006911 enzymatic reaction Methods 0.000 title abstract 2
- 108010049003 Fibrinogen Proteins 0.000 claims abstract description 65
- 102000008946 Fibrinogen Human genes 0.000 claims abstract description 65
- 229940012952 fibrinogen Drugs 0.000 claims abstract description 65
- 230000003287 optical effect Effects 0.000 claims abstract description 65
- 230000000694 effects Effects 0.000 claims description 115
- 206010053567 Coagulopathies Diseases 0.000 claims description 53
- 230000035602 clotting Effects 0.000 claims description 53
- 238000005065 mining Methods 0.000 claims 1
- 230000002950 deficient Effects 0.000 abstract description 23
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- 238000012360 testing method Methods 0.000 description 103
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- 239000003153 chemical reaction reagent Substances 0.000 description 26
- 238000003556 assay Methods 0.000 description 25
- 229960004072 thrombin Drugs 0.000 description 19
- 102100022641 Coagulation factor IX Human genes 0.000 description 18
- 108010076282 Factor IX Proteins 0.000 description 18
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- 229960004222 factor ix Drugs 0.000 description 18
- 108010054218 Factor VIII Proteins 0.000 description 17
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- 229960000301 factor viii Drugs 0.000 description 17
- 102000009123 Fibrin Human genes 0.000 description 13
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- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 description 13
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- PGOHTUIFYSHAQG-LJSDBVFPSA-N (2S)-6-amino-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-1-[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-4-methylsulfanylbutanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-5-carbamimidamidopentanoyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]acetyl]amino]-3-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]-3-sulfanylpropanoyl]amino]-4-methylsulfanylbutanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-hydroxybutanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxypropanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-oxopentanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxypropanoyl]amino]-3-carboxypropanoyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoyl]amino]-5-oxopentanoyl]amino]-3-phenylpropanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-4-oxobutanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-4-carboxybutanoyl]amino]-5-oxopentanoyl]amino]hexanoic acid Chemical compound CSCC[C@H](N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(O)=O PGOHTUIFYSHAQG-LJSDBVFPSA-N 0.000 description 11
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- 239000001110 calcium chloride Substances 0.000 description 9
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- 230000000994 depressogenic effect Effects 0.000 description 8
- 238000005259 measurement Methods 0.000 description 8
- 239000003146 anticoagulant agent Substances 0.000 description 6
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 description 6
- 230000002159 abnormal effect Effects 0.000 description 5
- 229940127219 anticoagulant drug Drugs 0.000 description 5
- 230000023555 blood coagulation Effects 0.000 description 5
- 238000007689 inspection Methods 0.000 description 5
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- 208000009292 Hemophilia A Diseases 0.000 description 4
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- 238000012216 screening Methods 0.000 description 4
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- 210000003813 thumb Anatomy 0.000 description 4
- CFWRDBDJAOHXSH-SECBINFHSA-N 2-azaniumylethyl [(2r)-2,3-diacetyloxypropyl] phosphate Chemical compound CC(=O)OC[C@@H](OC(C)=O)COP(O)(=O)OCCN CFWRDBDJAOHXSH-SECBINFHSA-N 0.000 description 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 3
- 229960000182 blood factors Drugs 0.000 description 3
- 230000035945 sensitivity Effects 0.000 description 3
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
- 102100023804 Coagulation factor VII Human genes 0.000 description 2
- 108010023321 Factor VII Proteins 0.000 description 2
- 201000003542 Factor VIII deficiency Diseases 0.000 description 2
- 108010071289 Factor XIII Proteins 0.000 description 2
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- 239000001509 sodium citrate Substances 0.000 description 2
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 2
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- 101100438378 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) fac-1 gene Proteins 0.000 description 1
- 238000012274 Preoperative evaluation Methods 0.000 description 1
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- 230000036760 body temperature Effects 0.000 description 1
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- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000007819 clotting time assay Methods 0.000 description 1
- AGVAZMGAQJOSFJ-WZHZPDAFSA-M cobalt(2+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+2].N#[C-].[N-]([C@@H]1[C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP(O)(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O AGVAZMGAQJOSFJ-WZHZPDAFSA-M 0.000 description 1
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- 208000009429 hemophilia B Diseases 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 238000011005 laboratory method Methods 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
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- 230000002035 prolonged effect Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
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- 230000009467 reduction Effects 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 230000035939 shock Effects 0.000 description 1
- ZNCPFRVNHGOPAG-UHFFFAOYSA-L sodium oxalate Chemical compound [Na+].[Na+].[O-]C(=O)C([O-])=O ZNCPFRVNHGOPAG-UHFFFAOYSA-L 0.000 description 1
- 229940039790 sodium oxalate Drugs 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
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Landscapes
- Investigating Or Analysing Biological Materials (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA257,483A CA1062501A (fr) | 1976-07-21 | 1976-07-21 | Methode et appareil pour depister les deficiences au niveau des reactions enzymatiques et particullerement les taux de facteurs de coagulation dans le plasma sanguin |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA257,483A CA1062501A (fr) | 1976-07-21 | 1976-07-21 | Methode et appareil pour depister les deficiences au niveau des reactions enzymatiques et particullerement les taux de facteurs de coagulation dans le plasma sanguin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1062501A true CA1062501A (fr) | 1979-09-18 |
Family
ID=4106476
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA257,483A Expired CA1062501A (fr) | 1976-07-21 | 1976-07-21 | Methode et appareil pour depister les deficiences au niveau des reactions enzymatiques et particullerement les taux de facteurs de coagulation dans le plasma sanguin |
Country Status (1)
| Country | Link |
|---|---|
| CA (1) | CA1062501A (fr) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3225998A1 (fr) * | 2016-03-31 | 2017-10-04 | Siemens Healthcare Diagnostics Products GmbH | Procede de determination de fibrinogenes |
| CN108872619A (zh) * | 2017-04-24 | 2018-11-23 | 希森美康株式会社 | 血液样本的分析方法以及分析装置 |
| EP4394045A1 (fr) | 2022-12-28 | 2024-07-03 | Siemens Healthcare Diagnostics Products GmbH | Procédé de détermination du fibrinogène |
-
1976
- 1976-07-21 CA CA257,483A patent/CA1062501A/fr not_active Expired
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3225998A1 (fr) * | 2016-03-31 | 2017-10-04 | Siemens Healthcare Diagnostics Products GmbH | Procede de determination de fibrinogenes |
| WO2017167706A1 (fr) | 2016-03-31 | 2017-10-05 | Siemens Healthcare Diagnostics Products Gmbh | Procédé de dosage de fibrinogène |
| CN108139411A (zh) * | 2016-03-31 | 2018-06-08 | 西门子医学诊断产品有限责任公司 | 用于确定纤维蛋白原的方法 |
| JP2019502094A (ja) * | 2016-03-31 | 2019-01-24 | シーメンス ヘルスケア ダイアグノスティクス プロダクツ ゲゼルシヤフト ミツト ベシユレンクテル ハフツング | フィブリノゲンを決定する方法 |
| US10822636B2 (en) | 2016-03-31 | 2020-11-03 | Siemens Healthcare Diagnostics Products Gmbh | Method for determining fibrinogen and automatic analyzer |
| CN108872619A (zh) * | 2017-04-24 | 2018-11-23 | 希森美康株式会社 | 血液样本的分析方法以及分析装置 |
| US10739360B2 (en) | 2017-04-24 | 2020-08-11 | National University Corporation Nagoya University | Method for analyzing blood specimen, and analyzer |
| EP3396384B1 (fr) * | 2017-04-24 | 2020-11-18 | Sysmex Corporation | Procédé et appareil pour déterminer un échantillon sanguin |
| CN108872619B (zh) * | 2017-04-24 | 2024-06-11 | 希森美康株式会社 | 血液样本的分析方法以及分析装置 |
| EP4394045A1 (fr) | 2022-12-28 | 2024-07-03 | Siemens Healthcare Diagnostics Products GmbH | Procédé de détermination du fibrinogène |
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