CA1064903A - Saponine acide soluble dans l'eau - Google Patents

Saponine acide soluble dans l'eau

Info

Publication number: CA1064903A
Authority: CA; Canada
Prior art keywords: escin; nozzle; solution; spray drying; spray
Prior art date: 1975-07-11
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

CA256,650A

Other languages

English (en)

Inventor

Rolf Madaus

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Madaus Holding GmbH

Original Assignee

Dr Madaus GmbH and Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1975-07-11

Filing date

1976-07-09

Publication date

1979-10-23

1976-07-09 Application filed by Dr Madaus GmbH and Co filed Critical Dr Madaus GmbH and Co

1979-10-23 Application granted granted Critical

1979-10-23 Publication of CA1064903A publication Critical patent/CA1064903A/fr

Status Expired legal-status Critical Current

Links

230000002378 acidificating effect Effects 0.000 title description 11
SYXUBXTYGFJFEH-UHFFFAOYSA-N oat triterpenoid saponin Chemical compound CNC1=CC=CC=C1C(=O)OC1C(C=O)(C)CC2C3(C(O3)CC3C4(CCC5C(C)(CO)C(OC6C(C(O)C(OC7C(C(O)C(O)C(CO)O7)O)CO6)OC6C(C(O)C(O)C(CO)O6)O)CCC53C)C)C4(C)CC(O)C2(C)C1 SYXUBXTYGFJFEH-UHFFFAOYSA-N 0.000 title description 3
229940011399 escin Drugs 0.000 claims abstract description 40
229930186222 escin Natural products 0.000 claims abstract description 40
238000000034 method Methods 0.000 claims abstract description 11
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 15
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 12
238000001694 spray drying Methods 0.000 claims description 8
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 6
CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims description 6
239000007921 spray Substances 0.000 claims description 5
239000011261 inert gas Substances 0.000 claims description 4
238000005507 spraying Methods 0.000 claims description 4
229910002092 carbon dioxide Inorganic materials 0.000 claims description 3
239000001569 carbon dioxide Substances 0.000 claims description 3
150000001768 cations Chemical class 0.000 claims description 3
238000000605 extraction Methods 0.000 claims description 3
235000010181 horse chestnut Nutrition 0.000 claims description 3
239000002904 solvent Substances 0.000 claims description 3
241000157280 Aesculus hippocastanum Species 0.000 claims description 2
JCXJVPUVTGWSNB-UHFFFAOYSA-N nitrogen dioxide Inorganic materials O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 claims 2
DNIAPMSPPWPWGF-GSVOUGTGSA-N (R)-(-)-Propylene glycol Chemical compound C[C@@H](O)CO DNIAPMSPPWPWGF-GSVOUGTGSA-N 0.000 claims 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 9
238000002360 preparation method Methods 0.000 abstract description 3
239000008194 pharmaceutical composition Substances 0.000 abstract 1
239000000243 solution Substances 0.000 description 6
239000008298 dragée Substances 0.000 description 4
238000001035 drying Methods 0.000 description 3
238000004519 manufacturing process Methods 0.000 description 3
239000000203 mixture Substances 0.000 description 3
KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
239000002253 acid Substances 0.000 description 2
-1 aliphatic alcohols Chemical class 0.000 description 2
239000003814 drug Substances 0.000 description 2
238000011156 evaluation Methods 0.000 description 2
238000002347 injection Methods 0.000 description 2
239000007924 injection Substances 0.000 description 2
HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
238000005259 measurement Methods 0.000 description 2
229910052757 nitrogen Inorganic materials 0.000 description 2
241000157282 Aesculus Species 0.000 description 1
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
206010037549 Purpura Diseases 0.000 description 1
LBPGGVGNNLPHBO-UHFFFAOYSA-N [N].OC Chemical compound [N].OC LBPGGVGNNLPHBO-UHFFFAOYSA-N 0.000 description 1
238000009825 accumulation Methods 0.000 description 1
239000000443 aerosol Substances 0.000 description 1
230000002322 anti-exudative effect Effects 0.000 description 1
239000007864 aqueous solution Substances 0.000 description 1
239000013078 crystal Substances 0.000 description 1
238000011161 development Methods 0.000 description 1
238000010586 diagram Methods 0.000 description 1
229940079593 drug Drugs 0.000 description 1
210000004051 gastric juice Anatomy 0.000 description 1
239000000499 gel Substances 0.000 description 1
150000002500 ions Chemical class 0.000 description 1
239000008101 lactose Substances 0.000 description 1
239000007788 liquid Substances 0.000 description 1
235000019359 magnesium stearate Nutrition 0.000 description 1
239000002674 ointment Substances 0.000 description 1
239000003960 organic solvent Substances 0.000 description 1
206010034754 petechiae Diseases 0.000 description 1
229920000058 polyacrylate Polymers 0.000 description 1
229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
239000001267 polyvinylpyrrolidone Substances 0.000 description 1
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
239000000126 substance Substances 0.000 description 1
239000003826 tablet Substances 0.000 description 1
238000012360 testing method Methods 0.000 description 1
238000004809 thin layer chromatography Methods 0.000 description 1
238000005303 weighing Methods 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C07H15/256—Polyterpene radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Genetics & Genomics (AREA)
Diabetes (AREA)
Pain & Pain Management (AREA)
Molecular Biology (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Rheumatology (AREA)
Hematology (AREA)
Obesity (AREA)
Saccharide Compounds (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Plant Substances (AREA)

CA256,650A 1975-07-11 1976-07-09 Saponine acide soluble dans l'eau Expired CA1064903A (fr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE2530953A DE2530953C3 (de)	1975-07-11	1975-07-11	Verfahren zur Herstellung von röntgenamorphem Aescin, nach diesem Verfahren erhältliches röntgenamorphes Aescin und dieses enthaltende Arzneimittel

Publications (1)

Publication Number	Publication Date
CA1064903A true CA1064903A (fr)	1979-10-23

Family

ID=5951225

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA256,650A Expired CA1064903A (fr)	1975-07-11	1976-07-09	Saponine acide soluble dans l'eau

Country Status (20)

Country	Link
JP (2)	JPS5234915A (fr)
AU (1)	AU510463B2 (fr)
BE (1)	BE844053A (fr)
BG (1)	BG27379A3 (fr)
CA (1)	CA1064903A (fr)
CS (1)	CS208184B2 (fr)
DE (1)	DE2530953C3 (fr)
ES (1)	ES449748A1 (fr)
FI (1)	FI62099C (fr)
FR (1)	FR2316961A1 (fr)
GB (1)	GB1550845A (fr)
HK (1)	HK33681A (fr)
HU (1)	HU174603B (fr)
PH (1)	PH13989A (fr)
PL (1)	PL99028B1 (fr)
PT (1)	PT65302B (fr)
RO (1)	RO70354A (fr)
SU (1)	SU786857A3 (fr)
YU (1)	YU41812B (fr)
ZA (1)	ZA764065B (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1252201B (it) *	1991-12-12	1995-06-05	Dompe Farmaceutici Spa	S-carbossimetilcisteina sale di lisina monoidrato e procedimento per la sua preparazione.

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE302543C (fr) *
NL301747A (fr) *	1962-12-14
YU37063B (en) *	1971-12-06	1984-08-31	Lek Tovarna Farmacevtskih	Process for preparing x-ray amorphous water-sulubleascin
DE2357226A1 (de) *	1973-11-16	1975-05-28	Merck Patent Gmbh	Verfahren zur herstellung von wasserloeslichem beta-aescin

1975
- 1975-07-11 DE DE2530953A patent/DE2530953C3/de not_active Expired - Lifetime
1976
- 1976-06-30 FI FI761895A patent/FI62099C/fi not_active IP Right Cessation
- 1976-06-30 PT PT65302A patent/PT65302B/pt unknown
- 1976-07-05 BG BG033673A patent/BG27379A3/xx unknown
- 1976-07-07 SU SU762377645A patent/SU786857A3/ru active
- 1976-07-07 GB GB28233/76A patent/GB1550845A/en not_active Expired
- 1976-07-08 AU AU15729/76A patent/AU510463B2/en not_active Expired
- 1976-07-08 YU YU1670/76A patent/YU41812B/xx unknown
- 1976-07-08 ZA ZA764065A patent/ZA764065B/xx unknown
- 1976-07-09 CS CS764567A patent/CS208184B2/cs unknown
- 1976-07-09 HU HU76MA2797A patent/HU174603B/hu not_active IP Right Cessation
- 1976-07-09 CA CA256,650A patent/CA1064903A/fr not_active Expired
- 1976-07-10 PL PL1976191114A patent/PL99028B1/pl unknown
- 1976-07-10 ES ES449748A patent/ES449748A1/es not_active Expired
- 1976-07-10 RO RO7686932A patent/RO70354A/fr unknown
- 1976-07-12 PH PH18678A patent/PH13989A/en unknown
- 1976-07-12 JP JP51082846A patent/JPS5234915A/ja active Granted
- 1976-07-12 FR FR7621313A patent/FR2316961A1/fr active Granted
- 1976-07-12 BE BE168849A patent/BE844053A/fr not_active IP Right Cessation
1981
- 1981-07-16 HK HK336/81A patent/HK33681A/xx unknown
1986
- 1986-12-22 JP JP61304058A patent/JPS6366127A/ja active Granted

Also Published As

Publication number	Publication date
AU1572976A (en)	1978-01-12
FR2316961B1 (fr)	1984-04-20
PT65302B (de)	1977-12-13
ZA764065B (en)	1977-07-27
PH13989A (en)	1980-11-28
SU786857A3 (ru)	1980-12-07
JPS5234915A (en)	1977-03-17
JPS6366127A (ja)	1988-03-24
CS208184B2 (en)	1981-08-31
RO70354A (fr)	1982-03-24
FI62099B (fi)	1982-07-30
AU510463B2 (en)	1980-06-26
HK33681A (en)	1981-07-24
YU167076A (en)	1983-06-30
FI62099C (fi)	1982-11-10
FI761895A7 (fr)	1977-01-12
DE2530953A1 (de)	1977-01-27
GB1550845A (en)	1979-08-22
YU41812B (en)	1988-02-29
HU174603B (hu)	1980-02-28
DE2530953C2 (de)	1994-07-07
DE2530953C3 (de)	1994-07-07
PT65302A (de)	1976-07-01
BG27379A3 (bg)	1979-10-12
BE844053A (fr)	1977-01-12
PL99028B1 (pl)	1978-06-30
FR2316961A1 (fr)	1977-02-04
JPH0336808B2 (fr)	1991-06-03
ES449748A1 (es)	1977-08-16
JPS6221765B2 (fr)	1987-05-14

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Zhang et al.	1997	Glycolipids from Mirabilis himalaica
Ford	1981	A new lactone from water-stressed chickpea
Van Puyvelde et al.	1989	The hepatoprotective principle of Hypoestes triflora leaves
Sciuto et al.	1974	Biosynthesis of amaranthin in Celosia plumosa
US4137231A (en)	1979-01-30	Process for the isolation of 2-hydroxymethyl-3,4,5-trihydroxypiperidine from plant material
EP0932409B1 (fr)	2003-03-26	Procede de production d'une extrait de valeriane officinale contenant des taux eleves d'acide valerique
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IE38120B1 (en)	1978-01-04	Pharmaceutically active derivatives of glycyrrhizinic acid and their preparation
US4132782A (en)	1979-01-02	Method for suppressing herpes simplex virus
Kutney et al.	1982	Studies on natural products from Cuban plants. Alkaloids from Tabernaemontana citrifolia
El Abbadi et al.	1989	New alkaloids of Chiococca alba
SU786857A3 (ru)	1980-12-07	Способ получени рентгеноаморфного эсцина
GB1559275A (en)	1980-01-16	Process for the preparation of a stable beta vulgaris extrct
Pérez et al.	1994	The monoterpene 9-hydroxythymol from Bahia schaffneri var. aristata
KR820002108B1 (ko)	1982-11-10	수용성 산성 사포닌의 제조 방법
GB970894A (en)	1964-09-23	Analgesic preparation
JPS57128632A (en)	1982-08-10	Addition product of saponin in medicinal ginseng with nannitol and its preparation
Asante‐Poku et al.	1974	Site of decomposition of methyl bromide in cocoa beans
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