CA1070628A - Procede pour la regeneration d'une isomerase du glucose rendue insoluble - Google Patents

Procede pour la regeneration d'une isomerase du glucose rendue insoluble

Info

Publication number: CA1070628A
Authority: CA; Canada
Prior art keywords: aqueous; glucose isomerase; insolubilized; renewal; mineral acid
Prior art date: 1977-03-23
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

CA274,613A

Other languages

English (en)

Inventor

Yoshimasa Fujita

Nobuo Imai

Isao Kawakami

Isao Miyachi

Akiyoshi Matsumoto

Akira Kamata

Tadashi Hishida

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Mitsubishi Chemical Corp

Seikagaku Corp

Original Assignee

Seikagaku Corp

Mitsubishi Chemical Industries Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1977-03-23

Filing date

1977-03-23

Publication date

1980-01-29

1977-03-23 Application filed by Seikagaku Corp, Mitsubishi Chemical Industries Ltd filed Critical Seikagaku Corp

1977-03-23 Priority to CA274,613A priority Critical patent/CA1070628A/fr

1980-01-29 Application granted granted Critical

1980-01-29 Publication of CA1070628A publication Critical patent/CA1070628A/fr

Status Expired legal-status Critical Current

Links

108700040099 Xylose isomerases Proteins 0.000 title claims abstract description 91
238000000034 method Methods 0.000 title claims abstract description 45
239000011347 resin Substances 0.000 claims abstract description 54
229920005989 resin Polymers 0.000 claims abstract description 54
239000002253 acid Substances 0.000 claims abstract description 36
229910052500 inorganic mineral Inorganic materials 0.000 claims abstract description 35
239000011707 mineral Substances 0.000 claims abstract description 35
239000000243 solution Substances 0.000 claims abstract description 35
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims abstract description 30
239000003957 anion exchange resin Substances 0.000 claims abstract description 30
239000008103 glucose Substances 0.000 claims abstract description 29
150000003839 salts Chemical class 0.000 claims abstract description 25
238000006317 isomerization reaction Methods 0.000 claims abstract description 20
239000000463 material Substances 0.000 claims abstract description 20
239000000203 mixture Substances 0.000 claims abstract description 20
238000011282 treatment Methods 0.000 claims abstract description 20
239000012266 salt solution Substances 0.000 claims abstract description 15
229930091371 Fructose Natural products 0.000 claims abstract description 12
RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 claims abstract description 12
239000005715 Fructose Substances 0.000 claims abstract description 12
108090000769 Isomerases Proteins 0.000 claims description 53
102000004195 Isomerases Human genes 0.000 claims description 53
235000010755 mineral Nutrition 0.000 claims description 33
235000002639 sodium chloride Nutrition 0.000 claims description 28
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 18
QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims description 18
239000003513 alkali Substances 0.000 claims description 14
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 10
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 10
KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 claims description 9
WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims description 8
239000011780 sodium chloride Substances 0.000 claims description 5
235000011121 sodium hydroxide Nutrition 0.000 claims description 5
239000001103 potassium chloride Substances 0.000 claims description 4
235000011164 potassium chloride Nutrition 0.000 claims description 4
PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 claims description 3
229910052938 sodium sulfate Inorganic materials 0.000 claims description 3
235000011152 sodium sulphate Nutrition 0.000 claims description 3
235000011118 potassium hydroxide Nutrition 0.000 claims description 2
OTYBMLCTZGSZBG-UHFFFAOYSA-L potassium sulfate Chemical compound [K+].[K+].[O-]S([O-])(=O)=O OTYBMLCTZGSZBG-UHFFFAOYSA-L 0.000 claims 2
229910052939 potassium sulfate Inorganic materials 0.000 claims 2
235000011151 potassium sulphates Nutrition 0.000 claims 2
230000000977 initiatory effect Effects 0.000 claims 1
230000000694 effects Effects 0.000 abstract description 47
230000007423 decrease Effects 0.000 abstract description 5
239000012670 alkaline solution Substances 0.000 abstract description 2
229940000425 combination drug Drugs 0.000 abstract description 2
238000001179 sorption measurement Methods 0.000 description 16
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 15
229920002307 Dextran Polymers 0.000 description 14
238000003795 desorption Methods 0.000 description 11
230000014759 maintenance of location Effects 0.000 description 9
239000007864 aqueous solution Substances 0.000 description 8
238000005342 ion exchange Methods 0.000 description 8
102000004169 proteins and genes Human genes 0.000 description 7
108090000623 proteins and genes Proteins 0.000 description 7
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
239000004793 Polystyrene Substances 0.000 description 6
229920002223 polystyrene Polymers 0.000 description 6
230000008929 regeneration Effects 0.000 description 6
238000011069 regeneration method Methods 0.000 description 6
102000004190 Enzymes Human genes 0.000 description 5
108090000790 Enzymes Proteins 0.000 description 5
229940088598 enzyme Drugs 0.000 description 5
XEEYBQQBJWHFJM-UHFFFAOYSA-N iron Substances [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 5
PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 description 4
238000006243 chemical reaction Methods 0.000 description 4
229910052742 iron Inorganic materials 0.000 description 4
-1 iron ion Chemical class 0.000 description 4
229920000447 polyanionic polymer Polymers 0.000 description 4
MYRTYDVEIRVNKP-UHFFFAOYSA-N 1,2-Divinylbenzene Chemical compound C=CC1=CC=CC=C1C=C MYRTYDVEIRVNKP-UHFFFAOYSA-N 0.000 description 3
QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 3
238000013019 agitation Methods 0.000 description 3
238000005349 anion exchange Methods 0.000 description 3
238000000149 argon plasma sintering Methods 0.000 description 3
238000004040 coloring Methods 0.000 description 3
239000003456 ion exchange resin Substances 0.000 description 3
229920003303 ion-exchange polymer Polymers 0.000 description 3
239000000178 monomer Substances 0.000 description 3
239000011148 porous material Substances 0.000 description 3
230000001172 regenerating effect Effects 0.000 description 3
239000000126 substance Substances 0.000 description 3
238000005406 washing Methods 0.000 description 3
NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 description 2
QCVGEOXPDFCNHA-UHFFFAOYSA-N 5,5-dimethyl-2,4-dioxo-1,3-oxazolidine-3-carboxamide Chemical compound CC1(C)OC(=O)N(C(N)=O)C1=O QCVGEOXPDFCNHA-UHFFFAOYSA-N 0.000 description 2
UJOBWOGCFQCDNV-UHFFFAOYSA-N 9H-carbazole Chemical compound C1=CC=C2C3=CC=CC=C3NC2=C1 UJOBWOGCFQCDNV-UHFFFAOYSA-N 0.000 description 2
QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 2
KAKZBPTYRLMSJV-UHFFFAOYSA-N Butadiene Chemical group C=CC=C KAKZBPTYRLMSJV-UHFFFAOYSA-N 0.000 description 2
VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 2
102000002322 Egg Proteins Human genes 0.000 description 2
108010000912 Egg Proteins Proteins 0.000 description 2
CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 2
102000016943 Muramidase Human genes 0.000 description 2
108010014251 Muramidase Proteins 0.000 description 2
108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 description 2
238000010306 acid treatment Methods 0.000 description 2
150000001720 carbohydrates Chemical class 0.000 description 2
229920001429 chelating resin Polymers 0.000 description 2
239000003795 chemical substances by application Substances 0.000 description 2
238000000354 decomposition reaction Methods 0.000 description 2
238000009826 distribution Methods 0.000 description 2
235000014103 egg white Nutrition 0.000 description 2
210000000969 egg white Anatomy 0.000 description 2
238000000605 extraction Methods 0.000 description 2
239000012535 impurity Substances 0.000 description 2
229910010272 inorganic material Inorganic materials 0.000 description 2
239000011147 inorganic material Substances 0.000 description 2
239000007788 liquid Substances 0.000 description 2
229960000274 lysozyme Drugs 0.000 description 2
235000010335 lysozyme Nutrition 0.000 description 2
239000004325 lysozyme Substances 0.000 description 2
229910052751 metal Inorganic materials 0.000 description 2
239000002184 metal Substances 0.000 description 2
244000005700 microbiome Species 0.000 description 2
VLTRZXGMWDSKGL-UHFFFAOYSA-N perchloric acid Chemical compound OCl(=O)(=O)=O VLTRZXGMWDSKGL-UHFFFAOYSA-N 0.000 description 2
125000001453 quaternary ammonium group Chemical group 0.000 description 2
239000002904 solvent Substances 0.000 description 2
BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 2
PRPINYUDVPFIRX-UHFFFAOYSA-N 1-naphthaleneacetic acid Chemical compound C1=CC=C2C(CC(=O)O)=CC=CC2=C1 PRPINYUDVPFIRX-UHFFFAOYSA-N 0.000 description 1
GZSUIHUAFPHZSU-UHFFFAOYSA-N 9-ethyl-2,3-dihydro-1h-carbazol-4-one Chemical compound C12=CC=CC=C2N(CC)C2=C1C(=O)CCC2 GZSUIHUAFPHZSU-UHFFFAOYSA-N 0.000 description 1
101150034533 ATIC gene Proteins 0.000 description 1
241000186361 Actinobacteria <class> Species 0.000 description 1
VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 1
241000193830 Bacillus <bacterium> Species 0.000 description 1
241000894006 Bacteria Species 0.000 description 1
241000186146 Brevibacterium Species 0.000 description 1
GUBGYTABKSRVRQ-WFVLMXAXSA-N DEAE-cellulose Chemical compound OC1C(O)C(O)C(CO)O[C@H]1O[C@@H]1C(CO)OC(O)C(O)C1O GUBGYTABKSRVRQ-WFVLMXAXSA-N 0.000 description 1
241000186660 Lactobacillus Species 0.000 description 1
FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
229910019142 PO4 Inorganic materials 0.000 description 1
ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
229910052774 Proactinium Inorganic materials 0.000 description 1
241000589516 Pseudomonas Species 0.000 description 1
240000004808 Saccharomyces cerevisiae Species 0.000 description 1
208000036366 Sensation of pressure Diseases 0.000 description 1
241000187747 Streptomyces Species 0.000 description 1
229910052783 alkali metal Inorganic materials 0.000 description 1
150000001340 alkali metals Chemical class 0.000 description 1
QGZKDVFQNNGYKY-UHFFFAOYSA-N ammonia Natural products N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 1
239000011260 aqueous acid Substances 0.000 description 1
238000010923 batch production Methods 0.000 description 1
239000007795 chemical reaction product Substances 0.000 description 1
150000001868 cobalt Chemical class 0.000 description 1
229910017052 cobalt Inorganic materials 0.000 description 1
239000010941 cobalt Substances 0.000 description 1
GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 description 1
239000000356 contaminant Substances 0.000 description 1
229920001577 copolymer Polymers 0.000 description 1
XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 1
230000003247 decreasing effect Effects 0.000 description 1
230000002255 enzymatic effect Effects 0.000 description 1
238000001914 filtration Methods 0.000 description 1
239000012847 fine chemical Substances 0.000 description 1
150000002303 glucose derivatives Chemical class 0.000 description 1
XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 description 1
125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
238000007654 immersion Methods 0.000 description 1
230000001771 impaired effect Effects 0.000 description 1
229910017053 inorganic salt Inorganic materials 0.000 description 1
150000002505 iron Chemical class 0.000 description 1
229910000358 iron sulfate Inorganic materials 0.000 description 1
BAUYGSIQEAFULO-UHFFFAOYSA-L iron(2+) sulfate (anhydrous) Chemical compound [Fe+2].[O-]S([O-])(=O)=O BAUYGSIQEAFULO-UHFFFAOYSA-L 0.000 description 1
229940039696 lactobacillus Drugs 0.000 description 1
239000011777 magnesium Substances 0.000 description 1
229910052749 magnesium Inorganic materials 0.000 description 1
159000000003 magnesium salts Chemical class 0.000 description 1
229910052943 magnesium sulfate Inorganic materials 0.000 description 1
235000019341 magnesium sulphate Nutrition 0.000 description 1
239000011159 matrix material Substances 0.000 description 1
229910021645 metal ion Inorganic materials 0.000 description 1
STZCRXQWRGQSJD-GEEYTBSJSA-M methyl orange Chemical compound [Na+].C1=CC(N(C)C)=CC=C1\N=N\C1=CC=C(S([O-])(=O)=O)C=C1 STZCRXQWRGQSJD-GEEYTBSJSA-M 0.000 description 1
229940012189 methyl orange Drugs 0.000 description 1
238000002156 mixing Methods 0.000 description 1
230000007935 neutral effect Effects 0.000 description 1
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
239000010452 phosphate Substances 0.000 description 1
239000008363 phosphate buffer Substances 0.000 description 1
239000008055 phosphate buffer solution Substances 0.000 description 1
235000020004 porter Nutrition 0.000 description 1
229910052700 potassium Inorganic materials 0.000 description 1
239000011591 potassium Substances 0.000 description 1
235000007686 potassium Nutrition 0.000 description 1
238000000790 scattering method Methods 0.000 description 1
YPNVIBVEFVRZPJ-UHFFFAOYSA-L silver sulfate Chemical compound [Ag+].[Ag+].[O-]S([O-])(=O)=O YPNVIBVEFVRZPJ-UHFFFAOYSA-L 0.000 description 1
229910000367 silver sulfate Inorganic materials 0.000 description 1
239000007787 solid Substances 0.000 description 1
239000012265 solid product Substances 0.000 description 1
229910021653 sulphate ion Inorganic materials 0.000 description 1
239000000725 suspension Substances 0.000 description 1
230000002195 synergetic effect Effects 0.000 description 1
238000009210 therapy by ultrasound Methods 0.000 description 1
238000004448 titration Methods 0.000 description 1
125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
229920002554 vinyl polymer Polymers 0.000 description 1
239000011800 void material Substances 0.000 description 1

Landscapes

Preparation Of Compounds By Using Micro-Organisms (AREA)

CA274,613A 1977-03-23 1977-03-23 Procede pour la regeneration d'une isomerase du glucose rendue insoluble Expired CA1070628A (fr)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
CA274,613A CA1070628A (fr)	1977-03-23	1977-03-23	Procede pour la regeneration d'une isomerase du glucose rendue insoluble

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
CA274,613A CA1070628A (fr)	1977-03-23	1977-03-23	Procede pour la regeneration d'une isomerase du glucose rendue insoluble

Publications (1)

Publication Number	Publication Date
CA1070628A true CA1070628A (fr)	1980-01-29

Family

ID=4108227

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA274,613A Expired CA1070628A (fr)	1977-03-23	1977-03-23	Procede pour la regeneration d'une isomerase du glucose rendue insoluble

Country Status (1)

Country	Link
CA (1)	CA1070628A (fr)

1977
- 1977-03-23 CA CA274,613A patent/CA1070628A/fr not_active Expired

Legal Events

Date	Code	Title	Description
1997-01-29	MKEX	Expiry

Publication	Publication Date	Title
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CA1070628A (fr)	1980-01-29	Procede pour la regeneration d'une isomerase du glucose rendue insoluble
US4205127A (en)	1980-05-27	Process for the renewal of an insolubilized glucose isomerase
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US3684574A (en)	1972-08-15	Method of producing sweet syrup by resin isomerization of dextrose syrup
US4252899A (en)	1981-02-24	Process for immobilizing glucose isomerase and a method of continuous isomerization of glucose
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CA1159785A (fr)	1984-01-03	Methode de production de glucose isomerase immobilisee
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JP2524984B2 (ja)	1996-08-14	固定化酵素