CA1083041A - Dispositif pour la dispensation continue de medicaments et procede de fabrication - Google Patents

Dispositif pour la dispensation continue de medicaments et procede de fabrication

Info

Publication number: CA1083041A
Authority: CA; Canada
Prior art keywords: solute; drug; polymer; mixture; depots
Prior art date: 1975-07-28
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

CA257,322A

Other languages

English (en)

Inventor

Robert M. Gale

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Alza Corp

Original Assignee

Alza Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1975-07-28

Filing date

1976-07-20

Publication date

1980-08-05

1976-07-20 Application filed by Alza Corp filed Critical Alza Corp

1980-08-05 Application granted granted Critical

1980-08-05 Publication of CA1083041A publication Critical patent/CA1083041A/fr

Status Expired legal-status Critical Current

Links

238000000034 method Methods 0.000 title claims abstract description 20
238000013268 sustained release Methods 0.000 title claims abstract description 7
239000012730 sustained-release form Substances 0.000 title claims abstract description 7
238000012377 drug delivery Methods 0.000 title abstract 3
239000003814 drug Substances 0.000 claims abstract description 81
229940079593 drug Drugs 0.000 claims abstract description 77
229920000642 polymer Polymers 0.000 claims abstract description 66
239000000203 mixture Substances 0.000 claims abstract description 45
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 37
239000007787 solid Substances 0.000 claims abstract description 17
238000011065 in-situ storage Methods 0.000 claims abstract description 9
239000011148 porous material Substances 0.000 claims abstract description 8
230000014759 maintenance of location Effects 0.000 claims abstract description 6
JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 claims description 26
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical group [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 24
229960000890 hydrocortisone Drugs 0.000 claims description 13
239000011780 sodium chloride Substances 0.000 claims description 12
229920001200 poly(ethylene-vinyl acetate) Polymers 0.000 claims description 9
XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 claims description 8
238000009792 diffusion process Methods 0.000 claims description 8
229960004716 idoxuridine Drugs 0.000 claims description 8
239000005038 ethylene vinyl acetate Substances 0.000 claims description 7
230000003204 osmotic effect Effects 0.000 claims description 7
239000002245 particle Substances 0.000 claims description 7
238000004519 manufacturing process Methods 0.000 claims description 2
239000000306 component Substances 0.000 description 8
238000012360 testing method Methods 0.000 description 7
230000000694 effects Effects 0.000 description 6
239000011159 matrix material Substances 0.000 description 6
230000035699 permeability Effects 0.000 description 6
238000002360 preparation method Methods 0.000 description 6
238000002560 therapeutic procedure Methods 0.000 description 5
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 4
239000011734 sodium Substances 0.000 description 4
229910052708 sodium Inorganic materials 0.000 description 4
229940124597 therapeutic agent Drugs 0.000 description 4
229920001577 copolymer Polymers 0.000 description 3
230000001419 dependent effect Effects 0.000 description 3
239000002609 medium Substances 0.000 description 3
238000002156 mixing Methods 0.000 description 3
SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 2
NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 2
VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 2
TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 2
CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 2
CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
239000012736 aqueous medium Substances 0.000 description 2
230000015572 biosynthetic process Effects 0.000 description 2
DQXBYHZEEUGOBF-UHFFFAOYSA-N but-3-enoic acid;ethene Chemical compound C=C.OC(=O)CC=C DQXBYHZEEUGOBF-UHFFFAOYSA-N 0.000 description 2
OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 description 2
229920001971 elastomer Polymers 0.000 description 2
KWGKDLIKAYFUFQ-UHFFFAOYSA-M lithium chloride Chemical compound [Li+].[Cl-] KWGKDLIKAYFUFQ-UHFFFAOYSA-M 0.000 description 2
239000000463 material Substances 0.000 description 2
229940023490 ophthalmic product Drugs 0.000 description 2
-1 psychic energi~ers Substances 0.000 description 2
GEHJYWRUCIMESM-UHFFFAOYSA-L sodium sulfite Chemical compound [Na+].[Na+].[O-]S([O-])=O GEHJYWRUCIMESM-UHFFFAOYSA-L 0.000 description 2
150000003431 steroids Chemical class 0.000 description 2
230000001225 therapeutic effect Effects 0.000 description 2
229920002554 vinyl polymer Polymers 0.000 description 2
QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
229920003345 Elvax® Polymers 0.000 description 1
101100001675 Emericella variicolor andJ gene Proteins 0.000 description 1
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 description 1
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
229930195725 Mannitol Natural products 0.000 description 1
229920012485 Plasticized Polyvinyl chloride Polymers 0.000 description 1
MUPFEKGTMRGPLJ-RMMQSMQOSA-N Raffinose Natural products O(C[C@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](O[C@@]2(CO)[C@H](O)[C@@H](O)[C@@H](CO)O2)O1)[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 MUPFEKGTMRGPLJ-RMMQSMQOSA-N 0.000 description 1
108091006629 SLC13A2 Proteins 0.000 description 1
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
229930006000 Sucrose Natural products 0.000 description 1
QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
239000000150 Sympathomimetic Substances 0.000 description 1
FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
MUPFEKGTMRGPLJ-UHFFFAOYSA-N UNPD196149 Natural products OC1C(O)C(CO)OC1(CO)OC1C(O)C(O)C(O)C(COC2C(C(O)C(O)C(CO)O2)O)O1 MUPFEKGTMRGPLJ-UHFFFAOYSA-N 0.000 description 1
XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 description 1
239000013543 active substance Substances 0.000 description 1
239000000654 additive Substances 0.000 description 1
230000000996 additive effect Effects 0.000 description 1
150000005215 alkyl ethers Chemical class 0.000 description 1
229940121363 anti-inflammatory agent Drugs 0.000 description 1
239000002260 anti-inflammatory agent Substances 0.000 description 1
230000000845 anti-microbial effect Effects 0.000 description 1
239000004599 antimicrobial Substances 0.000 description 1
239000003096 antiparasitic agent Substances 0.000 description 1
229940125687 antiparasitic agent Drugs 0.000 description 1
229940125688 antiparkinson agent Drugs 0.000 description 1
239000000939 antiparkinson agent Substances 0.000 description 1
239000003699 antiulcer agent Substances 0.000 description 1
WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
239000011575 calcium Substances 0.000 description 1
229910052791 calcium Inorganic materials 0.000 description 1
NKWPZUCBCARRDP-UHFFFAOYSA-L calcium bicarbonate Chemical compound [Ca+2].OC([O-])=O.OC([O-])=O NKWPZUCBCARRDP-UHFFFAOYSA-L 0.000 description 1
229910000020 calcium bicarbonate Inorganic materials 0.000 description 1
229940125692 cardiovascular agent Drugs 0.000 description 1
239000002327 cardiovascular agent Substances 0.000 description 1
229920002301 cellulose acetate Polymers 0.000 description 1
230000006835 compression Effects 0.000 description 1
238000007906 compression Methods 0.000 description 1
239000003433 contraceptive agent Substances 0.000 description 1
230000002254 contraceptive effect Effects 0.000 description 1
238000007796 conventional method Methods 0.000 description 1
239000003179 convulsant agent Substances 0.000 description 1
238000005520 cutting process Methods 0.000 description 1
239000002934 diuretic Substances 0.000 description 1
229940030606 diuretics Drugs 0.000 description 1
210000003717 douglas' pouch Anatomy 0.000 description 1
238000001647 drug administration Methods 0.000 description 1
238000005538 encapsulation Methods 0.000 description 1
230000001076 estrogenic effect Effects 0.000 description 1
JEIPFZHSYJVQDO-UHFFFAOYSA-N ferric oxide Chemical compound O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 description 1
210000001035 gastrointestinal tract Anatomy 0.000 description 1
239000008103 glucose Substances 0.000 description 1
230000002641 glycemic effect Effects 0.000 description 1
229940125697 hormonal agent Drugs 0.000 description 1
150000004677 hydrates Chemical class 0.000 description 1
239000003326 hypnotic agent Substances 0.000 description 1
230000000147 hypnotic effect Effects 0.000 description 1
238000005213 imbibition Methods 0.000 description 1
229910017053 inorganic salt Inorganic materials 0.000 description 1
238000003780 insertion Methods 0.000 description 1
230000037431 insertion Effects 0.000 description 1
150000002500 ions Chemical class 0.000 description 1
239000008101 lactose Substances 0.000 description 1
239000007788 liquid Substances 0.000 description 1
INHCSSUBVCNVSK-UHFFFAOYSA-L lithium sulfate Inorganic materials [Li+].[Li+].[O-]S([O-])(=O)=O INHCSSUBVCNVSK-UHFFFAOYSA-L 0.000 description 1
238000011068 loading method Methods 0.000 description 1
239000003589 local anesthetic agent Substances 0.000 description 1
229960005015 local anesthetics Drugs 0.000 description 1
229910001629 magnesium chloride Inorganic materials 0.000 description 1
229910052943 magnesium sulfate Inorganic materials 0.000 description 1
235000019341 magnesium sulphate Nutrition 0.000 description 1
239000000594 mannitol Substances 0.000 description 1
235000010355 mannitol Nutrition 0.000 description 1
239000000155 melt Substances 0.000 description 1
210000003205 muscle Anatomy 0.000 description 1
229940035363 muscle relaxants Drugs 0.000 description 1
239000003158 myorelaxant agent Substances 0.000 description 1
150000002894 organic compounds Chemical class 0.000 description 1
239000012466 permeate Substances 0.000 description 1
239000000049 pigment Substances 0.000 description 1
229920000515 polycarbonate Polymers 0.000 description 1
239000004417 polycarbonate Substances 0.000 description 1
229920000728 polyester Polymers 0.000 description 1
229920001296 polysiloxane Polymers 0.000 description 1
229920002689 polyvinyl acetate Polymers 0.000 description 1
239000011118 polyvinyl acetate Substances 0.000 description 1
229920002620 polyvinyl fluoride Polymers 0.000 description 1
GNSKLFRGEWLPPA-UHFFFAOYSA-M potassium dihydrogen phosphate Chemical compound [K+].OP(O)([O-])=O GNSKLFRGEWLPPA-UHFFFAOYSA-M 0.000 description 1
OTYBMLCTZGSZBG-UHFFFAOYSA-L potassium sulfate Chemical compound [K+].[K+].[O-]S([O-])(=O)=O OTYBMLCTZGSZBG-UHFFFAOYSA-L 0.000 description 1
229910052939 potassium sulfate Inorganic materials 0.000 description 1
235000011151 potassium sulphates Nutrition 0.000 description 1
230000001072 progestational effect Effects 0.000 description 1
230000003236 psychic effect Effects 0.000 description 1
238000004080 punching Methods 0.000 description 1
230000001047 pyretic effect Effects 0.000 description 1
MUPFEKGTMRGPLJ-ZQSKZDJDSA-N raffinose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)O)O1 MUPFEKGTMRGPLJ-ZQSKZDJDSA-N 0.000 description 1
239000012047 saturated solution Substances 0.000 description 1
229940125723 sedative agent Drugs 0.000 description 1
239000000932 sedative agent Substances 0.000 description 1
229910000029 sodium carbonate Inorganic materials 0.000 description 1
235000010265 sodium sulphite Nutrition 0.000 description 1
239000000243 solution Substances 0.000 description 1
239000000600 sorbitol Substances 0.000 description 1
239000003381 stabilizer Substances 0.000 description 1
239000000126 substance Substances 0.000 description 1
239000005720 sucrose Substances 0.000 description 1
239000004094 surface-active agent Substances 0.000 description 1
229940127230 sympathomimetic drug Drugs 0.000 description 1
230000009885 systemic effect Effects 0.000 description 1
235000002906 tartaric acid Nutrition 0.000 description 1
239000011975 tartaric acid Substances 0.000 description 1
OKUCEQDKBKYEJY-UHFFFAOYSA-N tert-butyl 3-(methylamino)pyrrolidine-1-carboxylate Chemical compound CNC1CCN(C(=O)OC(C)(C)C)C1 OKUCEQDKBKYEJY-UHFFFAOYSA-N 0.000 description 1
RBTVSNLYYIMMKS-UHFFFAOYSA-N tert-butyl 3-aminoazetidine-1-carboxylate;hydrochloride Chemical compound Cl.CC(C)(C)OC(=O)N1CC(N)C1 RBTVSNLYYIMMKS-UHFFFAOYSA-N 0.000 description 1
210000001519 tissue Anatomy 0.000 description 1
231100000331 toxic Toxicity 0.000 description 1
230000002588 toxic effect Effects 0.000 description 1
239000003204 tranquilizing agent Substances 0.000 description 1
230000002936 tranquilizing effect Effects 0.000 description 1
210000004291 uterus Anatomy 0.000 description 1
210000001215 vagina Anatomy 0.000 description 1
125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
239000011800 void material Substances 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas

Landscapes

Health & Medical Sciences (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

CA257,322A 1975-07-28 1976-07-20 Dispositif pour la dispensation continue de medicaments et procede de fabrication Expired CA1083041A (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US59979575A	1975-07-28	1975-07-28
US599,795		1975-07-28

Publications (1)

Publication Number	Publication Date
CA1083041A true CA1083041A (fr)	1980-08-05

Family

ID=24401120

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA257,322A Expired CA1083041A (fr)	1975-07-28	1976-07-20	Dispositif pour la dispensation continue de medicaments et procede de fabrication

Country Status (8)

Country	Link
JP (1)	JPS5215810A (fr)
CA (1)	CA1083041A (fr)
CH (1)	CH623232A5 (fr)
DE (1)	DE2633987A1 (fr)
FR (1)	FR2319380A1 (fr)
GB (1)	GB1503116A (fr)
IT (1)	IT1069521B (fr)
SE (1)	SE7608161L (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB2048710B (en) *	1979-05-07	1983-03-09	Alza Corp	Osmotically driven fluid dispenser
GB2109237B (en) *	1981-11-18	1985-12-18	Standard Telephones Cables Ltd	Composite materials
JPS60139222U (ja) *	1984-02-28	1985-09-14	株式会社東芝	折りたたみ式記録計
DE19537090A1 (de) *	1995-10-05	1997-04-10	Lohmann Therapie Syst Lts	Osmotische Vorrichtung zur kontinuierlichen Freisetzung von Wirkstoffen in die Flüssigkeiten des Gastrointestinaltraktes
ZA97976B (en) *	1996-04-05	1997-08-18	Alza Corp	Uniform drug delivery theraphy.
US6096339A (en) *	1997-04-04	2000-08-01	Alza Corporation	Dosage form, process of making and using same

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3892842A (en) *	1971-09-01	1975-07-01	Alza Corp	Intrauterine contraceptive device for releasing steroid having double bond functionality
GB1425550A (en) *	1973-04-25	1976-02-18	Alza Corp	Device for releasing active agent and process for producing the same

1976
- 1976-07-06 GB GB2809376A patent/GB1503116A/en not_active Expired
- 1976-07-16 SE SE7608161A patent/SE7608161L/ not_active Application Discontinuation
- 1976-07-20 CA CA257,322A patent/CA1083041A/fr not_active Expired
- 1976-07-27 JP JP8960076A patent/JPS5215810A/ja active Pending
- 1976-07-27 FR FR7622829A patent/FR2319380A1/fr active Granted
- 1976-07-27 IT IT6887676A patent/IT1069521B/it active
- 1976-07-28 CH CH967576A patent/CH623232A5/de not_active IP Right Cessation
- 1976-07-28 DE DE19762633987 patent/DE2633987A1/de not_active Withdrawn

Also Published As

Publication number	Publication date
IT1069521B (it)	1985-03-25
FR2319380B1 (fr)	1978-11-17
GB1503116A (en)	1978-03-08
SE7608161L (sv)	1977-01-29
DE2633987A1 (de)	1977-02-10
CH623232A5 (en)	1981-05-29
FR2319380A1 (fr)	1977-02-25
JPS5215810A (en)	1977-02-05

Legal Events

Date	Code	Title	Description
1997-08-05	MKEX	Expiry

Publication	Publication Date	Title
EP0669129B1 (fr)	2001-10-31	Médicaments expansibles à libération contrôlée
CA1318825C (fr)	1993-06-08	Multitude de mini-pilules sous forme posologique liquide
US4127127A (en)	1978-11-28	Therapeutic systems made from certain segmented copolyesters
US3926188A (en)	1975-12-16	Laminated drug dispenser
JP2527713B2 (ja)	1996-08-28	薬物放出調節製剤
US5004614A (en)	1991-04-02	Controlled release device with an impermeable coating having an orifice for release of drug
CA1265449A (fr)	1990-02-06	Dispositifs a debitage temporise de substances actives, et preparation desdits dispositifs
US4911707A (en)	1990-03-27	Monolithic user-activated transdermal therapeutic system
CA1189754A (fr)	1985-07-02	Liberation simultanee de deux medicaments d'un dispositif dispensateur
US4439196A (en)	1984-03-27	Osmotic drug delivery system
EP1499289B1 (fr)	2008-07-23	Forme de dosage a liberation controlee a volume efficace
EP0089548B1 (fr)	1987-01-28	Dispositif osmotique pour libérer une substance active
JP3973684B2 (ja)	2007-09-12	口腔の苦痛状態を治療するための経口投与および方法
US4917676A (en)	1990-04-17	User-activated transdermal therapeutic system
DE69531216T2 (de)	2004-05-27	Verabreichungssystem mit gesteuerter freisetzung einer arzneistoffsuspension
US4475916A (en)	1984-10-09	Osmotic drug delivery system
US4439194A (en)	1984-03-27	Water and drug delivery system for suppository use
EP0010876A1 (fr)	1980-05-14	Dispositif agissant par osmose pour libérer des substances
IL92966A (en)	1995-07-31	Dispensing devices powered by hydrogel
JPS6043327B2 (ja)	1985-09-27	薬品放出体の製造法
DK162470B (da)	1991-11-04	Osmotisk praeparat med oejeblikkelig tilgaengelighed af laegemiddel
EP0100424A2 (fr)	1984-02-15	Anhydrides d'acides en tant qu'agents de contrôle de vitesse de l'érosion de polymères, ces polymèrs comprenant des agents actifs dispersés dans leur matrice, ou l'agent actif étant revêtu de la matrice polymère
DD278720A5 (de)	1990-05-16	Schwimmfaehiges orales therapeutisches system
EP0907358B1 (fr)	2001-12-12	Traitement par administration uniforme de medicaments
PT88565B (pt)	1993-03-31	Dispositivo para fornecimento de droga de solubilidade modulada