CA1094930A - Reactif contenant un lysat de limulus amelocyte - Google Patents

Reactif contenant un lysat de limulus amelocyte

Info

Publication number: CA1094930A
Authority: CA; Canada
Prior art keywords: lysate; endotoxin; composition; limulus amebocyte; stabilizing agent
Prior art date: 1976-07-23
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

CA282,252A

Other languages

English (en)

Inventor

Donald F. Mills

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Mallinckrodt Inc

Original Assignee

Mallinckrodt Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1976-07-23

Filing date

1977-07-07

Publication date

1981-02-03

1977-07-07 Application filed by Mallinckrodt Inc filed Critical Mallinckrodt Inc

1981-02-03 Application granted granted Critical

1981-02-03 Publication of CA1094930A publication Critical patent/CA1094930A/fr

Status Expired legal-status Critical Current

Links

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JYJIGFIDKWBXDU-MNNPPOADSA-N inulin Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)OC[C@]1(OC[C@]2(OC[C@]3(OC[C@]4(OC[C@]5(OC[C@]6(OC[C@]7(OC[C@]8(OC[C@]9(OC[C@]%10(OC[C@]%11(OC[C@]%12(OC[C@]%13(OC[C@]%14(OC[C@]%15(OC[C@]%16(OC[C@]%17(OC[C@]%18(OC[C@]%19(OC[C@]%20(OC[C@]%21(OC[C@]%22(OC[C@]%23(OC[C@]%24(OC[C@]%25(OC[C@]%26(OC[C@]%27(OC[C@]%28(OC[C@]%29(OC[C@]%30(OC[C@]%31(OC[C@]%32(OC[C@]%33(OC[C@]%34(OC[C@]%35(OC[C@]%36(O[C@@H]%37[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O%37)O)[C@H]([C@H](O)[C@@H](CO)O%36)O)[C@H]([C@H](O)[C@@H](CO)O%35)O)[C@H]([C@H](O)[C@@H](CO)O%34)O)[C@H]([C@H](O)[C@@H](CO)O%33)O)[C@H]([C@H](O)[C@@H](CO)O%32)O)[C@H]([C@H](O)[C@@H](CO)O%31)O)[C@H]([C@H](O)[C@@H](CO)O%30)O)[C@H]([C@H](O)[C@@H](CO)O%29)O)[C@H]([C@H](O)[C@@H](CO)O%28)O)[C@H]([C@H](O)[C@@H](CO)O%27)O)[C@H]([C@H](O)[C@@H](CO)O%26)O)[C@H]([C@H](O)[C@@H](CO)O%25)O)[C@H]([C@H](O)[C@@H](CO)O%24)O)[C@H]([C@H](O)[C@@H](CO)O%23)O)[C@H]([C@H](O)[C@@H](CO)O%22)O)[C@H]([C@H](O)[C@@H](CO)O%21)O)[C@H]([C@H](O)[C@@H](CO)O%20)O)[C@H]([C@H](O)[C@@H](CO)O%19)O)[C@H]([C@H](O)[C@@H](CO)O%18)O)[C@H]([C@H](O)[C@@H](CO)O%17)O)[C@H]([C@H](O)[C@@H](CO)O%16)O)[C@H]([C@H](O)[C@@H](CO)O%15)O)[C@H]([C@H](O)[C@@H](CO)O%14)O)[C@H]([C@H](O)[C@@H](CO)O%13)O)[C@H]([C@H](O)[C@@H](CO)O%12)O)[C@H]([C@H](O)[C@@H](CO)O%11)O)[C@H]([C@H](O)[C@@H](CO)O%10)O)[C@H]([C@H](O)[C@@H](CO)O9)O)[C@H]([C@H](O)[C@@H](CO)O8)O)[C@H]([C@H](O)[C@@H](CO)O7)O)[C@H]([C@H](O)[C@@H](CO)O6)O)[C@H]([C@H](O)[C@@H](CO)O5)O)[C@H]([C@H](O)[C@@H](CO)O4)O)[C@H]([C@H](O)[C@@H](CO)O3)O)[C@H]([C@H](O)[C@@H](CO)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 JYJIGFIDKWBXDU-MNNPPOADSA-N 0.000 description 1
229940029339 inulin Drugs 0.000 description 1
238000011835 investigation Methods 0.000 description 1
238000012454 limulus amebocyte lysate test Methods 0.000 description 1
GZQKNULLWNGMCW-PWQABINMSA-N lipid A (E. coli) Chemical compound O1[C@H](CO)[C@@H](OP(O)(O)=O)[C@H](OC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCCCC)[C@@H](NC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCC)[C@@H]1OC[C@@H]1[C@@H](O)[C@H](OC(=O)C[C@H](O)CCCCCCCCCCC)[C@@H](NC(=O)C[C@H](O)CCCCCCCCCCC)[C@@H](OP(O)(O)=O)O1 GZQKNULLWNGMCW-PWQABINMSA-N 0.000 description 1
229920006008 lipopolysaccharide Polymers 0.000 description 1
239000007788 liquid Substances 0.000 description 1
230000004807 localization Effects 0.000 description 1
230000002934 lysing effect Effects 0.000 description 1
239000011777 magnesium Substances 0.000 description 1
229910001425 magnesium ion Inorganic materials 0.000 description 1
239000011572 manganese Substances 0.000 description 1
WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 description 1
238000004519 manufacturing process Methods 0.000 description 1
239000000463 material Substances 0.000 description 1
QWIZNVHXZXRPDR-WSCXOGSTSA-N melezitose Chemical compound O([C@@]1(O[C@@H]([C@H]([C@@H]1O[C@@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)O)CO)CO)[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O QWIZNVHXZXRPDR-WSCXOGSTSA-N 0.000 description 1
238000002844 melting Methods 0.000 description 1
230000008018 melting Effects 0.000 description 1
238000002156 mixing Methods 0.000 description 1
150000002772 monosaccharides Chemical class 0.000 description 1
239000006259 organic additive Substances 0.000 description 1
230000003204 osmotic effect Effects 0.000 description 1
239000008188 pellet Substances 0.000 description 1
150000002972 pentoses Chemical class 0.000 description 1
229920001282 polysaccharide Polymers 0.000 description 1
239000005017 polysaccharide Substances 0.000 description 1
239000000843 powder Substances 0.000 description 1
QYNRIDLOTGRNML-UHFFFAOYSA-N primeverose Natural products OC1C(O)C(O)COC1OCC1C(O)C(O)C(O)C(O)O1 QYNRIDLOTGRNML-UHFFFAOYSA-N 0.000 description 1
238000000746 purification Methods 0.000 description 1
238000011046 pyrogen test Methods 0.000 description 1
239000012217 radiopharmaceutical Substances 0.000 description 1
229940121896 radiopharmaceutical Drugs 0.000 description 1
230000002799 radiopharmaceutical effect Effects 0.000 description 1
MUPFEKGTMRGPLJ-ZQSKZDJDSA-N raffinose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)O)O1 MUPFEKGTMRGPLJ-ZQSKZDJDSA-N 0.000 description 1
238000011160 research Methods 0.000 description 1
HEBKCHPVOIAQTA-ZXFHETKHSA-N ribitol Chemical compound OC[C@H](O)[C@H](O)[C@H](O)CO HEBKCHPVOIAQTA-ZXFHETKHSA-N 0.000 description 1
CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 description 1
239000011734 sodium Substances 0.000 description 1
229910001415 sodium ion Inorganic materials 0.000 description 1
239000000600 sorbitol Substances 0.000 description 1
241000894007 species Species 0.000 description 1
239000005720 sucrose Substances 0.000 description 1
230000001550 time effect Effects 0.000 description 1
239000003053 toxin Substances 0.000 description 1
231100000765 toxin Toxicity 0.000 description 1
150000004043 trisaccharides Chemical class 0.000 description 1
229940073585 tromethamine hydrochloride Drugs 0.000 description 1
QYNRIDLOTGRNML-ULAALWPKSA-N vicianose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)CO[C@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)C(O)O1 QYNRIDLOTGRNML-ULAALWPKSA-N 0.000 description 1
239000000811 xylitol Substances 0.000 description 1
235000010447 xylitol Nutrition 0.000 description 1
HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
229960002675 xylitol Drugs 0.000 description 1

Classifications

- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/579—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving limulus lysate

Landscapes

Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Biomedical Technology (AREA)
Chemical & Material Sciences (AREA)
Hematology (AREA)
Immunology (AREA)
Urology & Nephrology (AREA)
Cell Biology (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Food Science & Technology (AREA)
Medicinal Chemistry (AREA)
Physics & Mathematics (AREA)
Analytical Chemistry (AREA)
Microbiology (AREA)
General Health & Medical Sciences (AREA)
General Physics & Mathematics (AREA)
Pathology (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Investigating Or Analysing Biological Materials (AREA)
Saccharide Compounds (AREA)

CA282,252A 1976-07-23 1977-07-07 Reactif contenant un lysat de limulus amelocyte Expired CA1094930A (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US70798276A	1976-07-23	1976-07-23
US707,982		1976-07-23

Publications (1)

Publication Number	Publication Date
CA1094930A true CA1094930A (fr)	1981-02-03

Family

ID=24843927

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA282,252A Expired CA1094930A (fr)	1976-07-23	1977-07-07	Reactif contenant un lysat de limulus amelocyte

Country Status (9)

Country	Link
JP (1)	JPS5363092A (fr)
BE (1)	BE857020A (fr)
CA (1)	CA1094930A (fr)
DE (1)	DE2729618C2 (fr)
FR (1)	FR2359423A1 (fr)
GB (1)	GB1522127A (fr)
IT (1)	IT1083542B (fr)
NL (1)	NL7707024A (fr)
SE (1)	SE7708473L (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4273557A (en)	1980-03-31	1981-06-16	Mallinckrodt, Inc.	Limulus lysate procedure for determining endotoxins
US4322217A (en)	1980-06-27	1982-03-30	Mallinckrodt, Inc.	Process for preparing Limulus lysate
US5648230A (en) *	1994-06-30	1997-07-15	Seikagaku Kogyo Kabushiki Kaisha (Seikagaku Corporation)	Endotoxin stabilizing agent, endotoxin composition and method for assaying endotoxin
US20140295477A1 (en) *	2011-09-01	2014-10-02	Fresenius Medical Care Holdings, Inc	Kit For Sampling And Detection Of Endotoxin In Aqueous Solution

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BE790338A (fr) *	1971-10-20	1973-04-20	Mallinckrodt Chemical Works	Compositions reactives de recherche sur des echantillons biologiques, et leurs procedes de preparation et d'utilisation
US4096091A (en) *	1974-07-17	1978-06-20	Baxter Travenol Laboratories, Inc.	Limulus lysate having improved capacity to precipitate in the presence of low endotoxin concentrations, and reconstituting solutions therefor

1977
- 1977-06-02 GB GB23462/77A patent/GB1522127A/en not_active Expired
- 1977-06-22 IT IT68449/77A patent/IT1083542B/it active
- 1977-06-24 NL NL7707024A patent/NL7707024A/xx not_active Application Discontinuation
- 1977-06-30 DE DE2729618A patent/DE2729618C2/de not_active Expired
- 1977-07-07 CA CA282,252A patent/CA1094930A/fr not_active Expired
- 1977-07-14 JP JP8362777A patent/JPS5363092A/ja active Pending
- 1977-07-22 FR FR7722617A patent/FR2359423A1/fr not_active Withdrawn
- 1977-07-22 BE BE179527A patent/BE857020A/fr unknown
- 1977-07-22 SE SE7708473A patent/SE7708473L/xx unknown

Also Published As

Publication number	Publication date
FR2359423A1 (fr)	1978-02-17
NL7707024A (nl)	1978-01-25
IT1083542B (it)	1985-05-21
GB1522127A (en)	1978-08-23
JPS5363092A (en)	1978-06-06
DE2729618C2 (de)	1982-04-01
DE2729618A1 (de)	1978-02-02
SE7708473L (sv)	1978-01-24
BE857020A (fr)	1978-01-23

Legal Events

Date	Code	Title	Description
1998-02-03	MKEX	Expiry

Publication	Publication Date	Title
Reinhold et al.	1971	A technique for quantitative measurement of endotoxin in human plasma
Yin et al.	1972	Picogram-sensitive assay for endotoxin: Gelation of Limulus polyphemus blood cell lysate induced lipopolysaccharides and lipid A from gram-negative bacteria
US5702882A (en)	1997-12-30	Reagent for endotoxin-specific assay
Sonntag et al.	1999	Pyrogens Using Human whole Blood
NL192139C (fr)	1997-02-04
JPH02265984A (ja)	1990-10-30	物質の貯蔵
EP1092157B1 (fr)	2005-03-02	Regulateurs de la coagulation pour des essais pt et aptt
Jeffery et al.	1961	Deacetylcephalosporin C
EP0426395A1 (fr)	1991-05-08	Essai cinétique pour endotoxine utilisant un lysat d'amoebocyte de limulus et substrat chromogénique
CA1160549A (fr)	1984-01-17	Methode utilisant un lysat d'amybocytes de limulus
Miller et al.	1982	Fatal hemolytic anemia in the black rhinoceros: case report and a survey
CA1094930A (fr)	1981-02-03	Reactif contenant un lysat de limulus amelocyte
Walz	1984	Platelet-released proteins as molecular markers for the activation process
US4447527A (en)	1984-05-08	Single test formulations for enzyme immunoassays and method for preparation
ES2322931T3 (es)	2009-07-02	Preparacion de esferas para pruebas de diagnostico.
KR900002840B1 (ko)	1990-05-01	안정화된 효소 결합체 조성물
US3778352A (en)	1973-12-11	Plasminogen assay system
IE42640B1 (en)	1980-09-24	Compositions for the detection of fibrinogen, fibrinogen split products and/or fibrin split products
CA1159754A (fr)	1984-01-03	Procede pour la preparation des lysats de limulus
JP2003155298A (ja)	2003-05-27	（１→３）−β−Ｄ−グルカン結合ドメインタンパク質、該物質を使用した測定法及び測定キット
Skarnes	1967	Leukin, a bactericidal agent from rabbit polymorphonuclear leucocytes
Champlin et al.	2002	Prevalence of a novel capsule-associated lipoprotein among Pasteurellaceae pathogenic in animals
Vanhaecke et al.	1987	Endotoxin testing
Genton et al.	1964	Assay of plasma thrombolytic activity with fluorescein-labeled clots
Tsitouris et al.	1967	Serum inhibition of plasmin and of plasminogen activation in thrombotic diseases