CA1098826A - Chlorhexidine and/or salt thereof hydrophobic ointments - Google Patents

Chlorhexidine and/or salt thereof hydrophobic ointments

Info

Publication number: CA1098826A
Authority: CA; Canada
Prior art keywords: composition; chlorhexidine; surfactant; salt; weight
Prior art date: 1977-02-08
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

CA296,603A

Other languages

English (en)

French (fr)

Inventor

Edward A. D. Richards

James A. Stead

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Sanofi Aventis France

Original Assignee

Roussel Uclaf SA

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1977-02-08

Filing date

1978-02-07

Publication date

1981-04-07

1978-02-07 Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA

1981-04-07 Application granted granted Critical

1981-04-07 Publication of CA1098826A publication Critical patent/CA1098826A/en

Status Expired legal-status Critical Current

Links

GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 title claims abstract description 21
229960003260 chlorhexidine Drugs 0.000 title claims abstract description 19
239000002674 ointment Substances 0.000 title claims abstract description 18
230000002209 hydrophobic effect Effects 0.000 title claims abstract description 13
150000003839 salts Chemical class 0.000 title claims abstract description 12
239000000203 mixture Substances 0.000 claims abstract description 27
239000004094 surface-active agent Substances 0.000 claims abstract description 27
230000000845 anti-microbial effect Effects 0.000 claims abstract description 9
239000003883 ointment base Substances 0.000 claims abstract description 6
206010052428 Wound Diseases 0.000 claims abstract description 5
239000012188 paraffin wax Substances 0.000 claims description 9
150000002148 esters Chemical class 0.000 claims description 6
239000004744 fabric Substances 0.000 claims description 5
150000005846 sugar alcohols Chemical class 0.000 claims description 5
235000000346 sugar Nutrition 0.000 claims description 3
FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 2
FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 2
FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 2
229930195725 Mannitol Natural products 0.000 claims description 2
125000004432 carbon atom Chemical group C* 0.000 claims description 2
239000000594 mannitol Substances 0.000 claims description 2
235000010355 mannitol Nutrition 0.000 claims description 2
239000000600 sorbitol Substances 0.000 claims description 2
235000014113 dietary fatty acids Nutrition 0.000 claims 1
239000000194 fatty acid Substances 0.000 claims 1
229930195729 fatty acid Natural products 0.000 claims 1
150000004665 fatty acids Chemical class 0.000 claims 1
210000002966 serum Anatomy 0.000 description 9
239000000126 substance Substances 0.000 description 5
239000003814 drug Substances 0.000 description 4
238000010348 incorporation Methods 0.000 description 4
229940079593 drug Drugs 0.000 description 3
230000000694 effects Effects 0.000 description 3
IYFATESGLOUGBX-YVNJGZBMSA-N Sorbitan monopalmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O IYFATESGLOUGBX-YVNJGZBMSA-N 0.000 description 2
238000010521 absorption reaction Methods 0.000 description 2
239000002253 acid Substances 0.000 description 2
239000003242 anti bacterial agent Substances 0.000 description 2
229940088710 antibiotic agent Drugs 0.000 description 2
230000002401 inhibitory effect Effects 0.000 description 2
244000005700 microbiome Species 0.000 description 2
-1 organic acid salts Chemical class 0.000 description 2
239000001570 sorbitan monopalmitate Substances 0.000 description 2
235000011071 sorbitan monopalmitate Nutrition 0.000 description 2
229940031953 sorbitan monopalmitate Drugs 0.000 description 2
ZORQXIQZAOLNGE-UHFFFAOYSA-N 1,1-difluorocyclohexane Chemical compound FC1(F)CCCCC1 ZORQXIQZAOLNGE-UHFFFAOYSA-N 0.000 description 1
IECPWNUMDGFDKC-UHFFFAOYSA-N Fusicsaeure Natural products C12C(O)CC3C(=C(CCC=C(C)C)C(O)=O)C(OC(C)=O)CC3(C)C1(C)CCC1C2(C)CCC(O)C1C IECPWNUMDGFDKC-UHFFFAOYSA-N 0.000 description 1
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
229930193140 Neomycin Natural products 0.000 description 1
241000191967 Staphylococcus aureus Species 0.000 description 1
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
229930006000 Sucrose Natural products 0.000 description 1
208000027418 Wounds and injury Diseases 0.000 description 1
150000007513 acids Chemical class 0.000 description 1
239000004599 antimicrobial Substances 0.000 description 1
WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
229960002152 chlorhexidine acetate Drugs 0.000 description 1
WDRFFJWBUDTUCA-UHFFFAOYSA-N chlorhexidine acetate Chemical compound CC(O)=O.CC(O)=O.C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 WDRFFJWBUDTUCA-UHFFFAOYSA-N 0.000 description 1
229960001884 chlorhexidine diacetate Drugs 0.000 description 1
150000001875 compounds Chemical class 0.000 description 1
230000003247 decreasing effect Effects 0.000 description 1
238000009472 formulation Methods 0.000 description 1
229960003704 framycetin Drugs 0.000 description 1
PGBHMTALBVVCIT-VCIWKGPPSA-N framycetin Chemical compound N[C@@H]1[C@@H](O)[C@H](O)[C@H](CN)O[C@@H]1O[C@H]1[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](N)C[C@@H](N)[C@@H]2O)O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CN)O2)N)O[C@@H]1CO PGBHMTALBVVCIT-VCIWKGPPSA-N 0.000 description 1
229940048400 fucidin Drugs 0.000 description 1
239000008103 glucose Substances 0.000 description 1
ACGUYXCXAPNIKK-UHFFFAOYSA-N hexachlorophene Chemical compound OC1=C(Cl)C=C(Cl)C(Cl)=C1CC1=C(O)C(Cl)=CC(Cl)=C1Cl ACGUYXCXAPNIKK-UHFFFAOYSA-N 0.000 description 1
229960004068 hexachlorophene Drugs 0.000 description 1
230000000415 inactivating effect Effects 0.000 description 1
230000002779 inactivation Effects 0.000 description 1
208000015181 infectious disease Diseases 0.000 description 1
238000013101 initial test Methods 0.000 description 1
229910052500 inorganic mineral Inorganic materials 0.000 description 1
230000002366 lipolytic effect Effects 0.000 description 1
239000000463 material Substances 0.000 description 1
230000000813 microbial effect Effects 0.000 description 1
239000011707 mineral Substances 0.000 description 1
229960004927 neomycin Drugs 0.000 description 1
239000003921 oil Substances 0.000 description 1
ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid group Chemical group C(CCCCCCC\C=C/CCCCCCCC)(=O)O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
239000005416 organic matter Substances 0.000 description 1
125000006353 oxyethylene group Chemical group 0.000 description 1
IPCSVZSSVZVIGE-UHFFFAOYSA-N palmitic acid group Chemical group C(CCCCCCCCCCCCCCC)(=O)O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 1
235000019809 paraffin wax Nutrition 0.000 description 1
230000001717 pathogenic effect Effects 0.000 description 1
235000019271 petrolatum Nutrition 0.000 description 1
ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
230000001766 physiological effect Effects 0.000 description 1
230000003389 potentiating effect Effects 0.000 description 1
MCSINKKTEDDPNK-UHFFFAOYSA-N propyl propionate Chemical compound CCCOC(=O)CC MCSINKKTEDDPNK-UHFFFAOYSA-N 0.000 description 1
HJHVQCXHVMGZNC-JCJNLNMISA-M sodium;(2z)-2-[(3r,4s,5s,8s,9s,10s,11r,13r,14s,16s)-16-acetyloxy-3,11-dihydroxy-4,8,10,14-tetramethyl-2,3,4,5,6,7,9,11,12,13,15,16-dodecahydro-1h-cyclopenta[a]phenanthren-17-ylidene]-6-methylhept-5-enoate Chemical compound [Na+].O[C@@H]([C@@H]12)C[C@H]3\C(=C(/CCC=C(C)C)C([O-])=O)[C@@H](OC(C)=O)C[C@]3(C)[C@@]2(C)CC[C@@H]2[C@]1(C)CC[C@@H](O)[C@H]2C HJHVQCXHVMGZNC-JCJNLNMISA-M 0.000 description 1
239000001593 sorbitan monooleate Substances 0.000 description 1
235000011069 sorbitan monooleate Nutrition 0.000 description 1
229940035049 sorbitan monooleate Drugs 0.000 description 1
238000001228 spectrum Methods 0.000 description 1
238000003756 stirring Methods 0.000 description 1
239000005720 sucrose Substances 0.000 description 1
150000008163 sugars Chemical class 0.000 description 1
239000000725 suspension Substances 0.000 description 1
230000000699 topical effect Effects 0.000 description 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/43—Guanidines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16L—PIPES; JOINTS OR FITTINGS FOR PIPES; SUPPORTS FOR PIPES, CABLES OR PROTECTIVE TUBING; MEANS FOR THERMAL INSULATION IN GENERAL
- F16L59/00—Thermal insulation in general
- F16L59/08—Means for preventing radiation, e.g. with metal foil

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
Dermatology (AREA)
Pharmacology & Pharmacy (AREA)
General Engineering & Computer Science (AREA)
Birds (AREA)
Molecular Biology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Oil, Petroleum & Natural Gas (AREA)
Biochemistry (AREA)
Mechanical Engineering (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

CA296,603A 1977-02-08 1978-02-07 Chlorhexidine and/or salt thereof hydrophobic ointments Expired CA1098826A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB5159/77		1977-02-08
GB5159/77A GB1599159A (en)	1977-02-08	1977-02-08	Pharmaceutical compositions containing chlorhexidine

Publications (1)

Publication Number	Publication Date
CA1098826A true CA1098826A (en)	1981-04-07

Family

ID=9790803

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA296,603A Expired CA1098826A (en)	1977-02-08	1978-02-07	Chlorhexidine and/or salt thereof hydrophobic ointments

Country Status (10)

Country	Link
JP (1)	JPS53101520A (da)
AU (1)	AU3306478A (da)
BE (1)	BE863723A (da)
CA (1)	CA1098826A (da)
DE (1)	DE2805248A1 (da)
DK (1)	DK55378A (da)
FR (1)	FR2379284A1 (da)
GB (1)	GB1599159A (da)
NL (1)	NL7801464A (da)
ZA (1)	ZA78387B (da)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US10016537B2 (en)	2012-08-28	2018-07-10	3M Innovative Properties Company	Chlorhexidine gluconate compositions, resin systems and article

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0053754B1 (de) *	1980-12-06	1986-04-23	Reichert, Dietrich, Dr. med.	Mittel zur Bekämpfung des Schnarchens und Verfahren zu dessen Anwendung
EP0065399B1 (en) *	1981-05-09	1984-12-12	Smith and Nephew Associated Companies p.l.c.	Dressings, manufacture and use
JPS62500240A (ja) *	1984-09-26	1987-01-29	グラツク，ブルノ　アントニ−	殺菌洗浄用配合物
US4920145A (en) *	1988-02-29	1990-04-24	Gaf Chemical Corporation	Water-soluble complexes of water-insoluble pharmaceutical compounds and preparation thereof
FR2806629B1 (fr) *	2000-03-22	2003-01-24	Lhd Lab Hygiene Dietetique	Compresse antiseptique
WO2014035971A2 (en) *	2012-08-28	2014-03-06	3M Innovative Properties Company	Chlorhexidine gluconate solubilized in a hydrophobic monoacylglyceride

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB901659A (en) *	1959-11-25	1962-07-25	Carolina Julia Cornelia Vintge	Ointment for the treatment of acne vulgaris
GB1040733A (en) *	1964-04-22	1966-09-01	Monsanto Chemicals	Mycobacteriostatic compositions
US3856931A (en) *	1972-08-01	1974-12-24	Schering Ag	Medicated stick
US3919430A (en) *	1974-01-28	1975-11-11	Akzona Inc	Water absorption base

1977
- 1977-02-08 GB GB5159/77A patent/GB1599159A/en not_active Expired
1978
- 1978-01-11 FR FR7800660A patent/FR2379284A1/fr active Granted
- 1978-01-20 ZA ZA00780387A patent/ZA78387B/xx unknown
- 1978-02-07 BE BE184962A patent/BE863723A/xx unknown
- 1978-02-07 CA CA296,603A patent/CA1098826A/en not_active Expired
- 1978-02-07 DK DK55378A patent/DK55378A/da not_active Application Discontinuation
- 1978-02-07 AU AU33064/78A patent/AU3306478A/en active Pending
- 1978-02-08 JP JP1253678A patent/JPS53101520A/ja active Pending
- 1978-02-08 DE DE19782805248 patent/DE2805248A1/de not_active Withdrawn
- 1978-02-08 NL NL7801464A patent/NL7801464A/xx not_active Application Discontinuation

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US10016537B2 (en)	2012-08-28	2018-07-10	3M Innovative Properties Company	Chlorhexidine gluconate compositions, resin systems and article
US10232093B2 (en)	2012-08-28	2019-03-19	3M Innovative Properties Company	Chlorhexidine gluconate compositions, resin systems and article
US10456509B2 (en)	2012-08-28	2019-10-29	3M Innovative Properties Company	Chlorhexidine gluconate compositions, resin systems and articles

Also Published As

Publication number	Publication date
AU3306478A (en)	1979-08-16
FR2379284A1 (fr)	1978-09-01
JPS53101520A (en)	1978-09-05
NL7801464A (nl)	1978-08-10
DK55378A (da)	1978-08-09
DE2805248A1 (de)	1978-08-10
BE863723A (fr)	1978-08-07
GB1599159A (en)	1981-09-30
FR2379284B1 (da)	1981-07-10
ZA78387B (en)	1979-02-28

Legal Events

Date	Code	Title	Description
1998-04-07	MKEX	Expiry

Publication	Publication Date	Title
US5374432A (en)	1994-12-20	Topical anti-infective ointment containing silver or silver salts and antibiotics
DE69921867T2 (de)	2005-12-22	Mikrobizide Zusammensetzung
US6638978B1 (en)	2003-10-28	Antimicrobial preservative compositions and methods
AU2008347253B2 (en)	2012-04-19	Antimicrobial compositions
US5945110A (en)	1999-08-31	Composition for the prevention or treatment of nappy rash
DE60101269T2 (de)	2004-09-16	Antiseptische kompresse
CA1098826A (en)	1981-04-07	Chlorhexidine and/or salt thereof hydrophobic ointments
JPH10513192A (ja)	1998-12-15	放出制御ガラスから構成された抗菌組成物
CA2751386A1 (en)	2010-08-12	Bismuth-thiols as antiseptics for epithelial tissues, acute and chronic wounds, bacterial biofilms and other indications
EP0480189B1 (en)	1996-03-20	Pharmaceutical compositions for topical use comprising hyaluronic acid sodium salt and disinfectant substances
US20080286346A1 (en)	2008-11-20	Wound Dressing
DE3850535T2 (de)	1995-01-12	Topisch aktive Doppelstrang-RNS-Zusammensetzungen.
DE69623485T2 (de)	2003-01-09	Inhibierung von exoprotein in absorbierenden produkten
Andrews et al.	1977	Influence of antioxidants on the bioactivity of amphotericin B
DE102006015271A1 (de)	2007-10-11	Biguanidhaltige Liposomen
US4535078A (en)	1985-08-13	Antibacterial composition comprising silver sulfadiazine and sodium piperacillin
US5370875A (en)	1994-12-06	Topical, antimicobial powders of chloroxylenol and chlorhexidine diacetate
US5080902A (en)	1992-01-14	Article and a prophylactic composition containing a microbicide
US3836672A (en)	1974-09-17	Topical antifungal 1,3-diols
DE69816620T2 (de)	2004-02-19	Hautschutzmittel
US3102840A (en)	1963-09-03	Method of controlling fungi with esters of o-phenyl phenol
CA2072460A1 (en)	1992-12-28	Use of acid derivatives for pediculicidal medicament production
Robb et al.	1980	Delivery of the topical antimicrobial agents silver sulfadiazine, gentamicin and nystatin to infected burn wounds in rats from preloaded synthetic dressings
US3595956A (en)	1971-07-27	Compositions containing 2,4,5-trichlorophenol and polymyxin b and neomycin
GB2186486A (en)	1987-08-19	Antibacterial dressing