CA1113005A - Excipient composition for creams - Google Patents

Excipient composition for creams

Info

Publication number: CA1113005A
Authority: CA; Canada
Prior art keywords: microfibres; base composition; cream; composition according; creams
Prior art date: 1977-12-06
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

CA316,390A

Other languages

English (en)

French (fr)

Inventor

Pierluigi Vanoni

Vincenzo Foti

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Anic SpA

Original Assignee

Anic SpA

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1977-12-06

Filing date

1978-11-17

Publication date

1981-11-24

1977-12-06 Priority claimed from IT3041177A external-priority patent/IT1089625B/it

1978-09-29 Priority claimed from IT2825078A external-priority patent/IT1159150B/it

1978-11-17 Application filed by Anic SpA filed Critical Anic SpA

1981-11-24 Application granted granted Critical

1981-11-24 Publication of CA1113005A publication Critical patent/CA1113005A/en

Status Expired legal-status Critical Current

Links

239000006071 cream Substances 0.000 title claims abstract description 27
239000000203 mixture Substances 0.000 title claims description 41
239000000546 pharmaceutical excipient Substances 0.000 title description 8
239000003658 microfiber Substances 0.000 claims abstract description 46
229920001410 Microfiber Polymers 0.000 claims abstract description 45
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 15
229920001169 thermoplastic Polymers 0.000 claims description 7
239000004416 thermosoftening plastic Substances 0.000 claims description 7
239000000080 wetting agent Substances 0.000 claims description 4
239000004700 high-density polyethylene Substances 0.000 claims description 3
229920001684 low density polyethylene Polymers 0.000 claims description 3
239000004702 low-density polyethylene Substances 0.000 claims description 3
239000004519 grease Substances 0.000 claims description 2
230000000887 hydrating effect Effects 0.000 claims description 2
125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 2
229920001903 high density polyethylene Polymers 0.000 claims 2
230000003111 delayed effect Effects 0.000 abstract description 3
JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 description 40
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 30
229960000890 hydrocortisone Drugs 0.000 description 20
238000009472 formulation Methods 0.000 description 19
239000000499 gel Substances 0.000 description 16
238000012360 testing method Methods 0.000 description 13
230000000694 effects Effects 0.000 description 9
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 8
239000002674 ointment Substances 0.000 description 8
239000002904 solvent Substances 0.000 description 5
229920002134 Carboxymethyl cellulose Polymers 0.000 description 4
-1 Carboxymethyl- Chemical group 0.000 description 4
239000001768 carboxy methyl cellulose Substances 0.000 description 4
235000010948 carboxy methyl cellulose Nutrition 0.000 description 4
239000008112 carboxymethyl-cellulose Substances 0.000 description 4
238000009792 diffusion process Methods 0.000 description 4
239000010410 layer Substances 0.000 description 4
238000003756 stirring Methods 0.000 description 4
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
229920002125 Sokalan® Polymers 0.000 description 3
238000001035 drying Methods 0.000 description 3
238000000338 in vitro Methods 0.000 description 3
238000001727 in vivo Methods 0.000 description 3
238000000034 method Methods 0.000 description 3
241000700198 Cavia Species 0.000 description 2
239000005662 Paraffin oil Substances 0.000 description 2
239000004698 Polyethylene Substances 0.000 description 2
GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 2
238000010521 absorption reaction Methods 0.000 description 2
239000002775 capsule Substances 0.000 description 2
238000011156 evaluation Methods 0.000 description 2
239000008240 homogeneous mixture Substances 0.000 description 2
230000036571 hydration Effects 0.000 description 2
238000006703 hydration reaction Methods 0.000 description 2
239000000463 material Substances 0.000 description 2
239000004584 polyacrylic acid Substances 0.000 description 2
229920000573 polyethylene Polymers 0.000 description 2
229920001451 polypropylene glycol Polymers 0.000 description 2
238000002360 preparation method Methods 0.000 description 2
FUFLCEKSBBHCMO-UHFFFAOYSA-N 11-dehydrocorticosterone Natural products O=C1CCC2(C)C3C(=O)CC(C)(C(CC4)C(=O)CO)C4C3CCC2=C1 FUFLCEKSBBHCMO-UHFFFAOYSA-N 0.000 description 1
WLAMNBDJUVNPJU-UHFFFAOYSA-N 2-methylbutyric acid Chemical compound CCC(C)C(O)=O WLAMNBDJUVNPJU-UHFFFAOYSA-N 0.000 description 1
HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 description 1
MFYSYFVPBJMHGN-ZPOLXVRWSA-N Cortisone Chemical compound O=C1CC[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 MFYSYFVPBJMHGN-ZPOLXVRWSA-N 0.000 description 1
MFYSYFVPBJMHGN-UHFFFAOYSA-N Cortisone Natural products O=C1CCC2(C)C3C(=O)CC(C)(C(CC4)(O)C(=O)CO)C4C3CCC2=C1 MFYSYFVPBJMHGN-UHFFFAOYSA-N 0.000 description 1
206010013786 Dry skin Diseases 0.000 description 1
239000001856 Ethyl cellulose Substances 0.000 description 1
ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 1
HSRJKNPTNIJEKV-UHFFFAOYSA-N Guaifenesin Chemical compound COC1=CC=CC=C1OCC(O)CO HSRJKNPTNIJEKV-UHFFFAOYSA-N 0.000 description 1
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
241001465754 Metazoa Species 0.000 description 1
239000004372 Polyvinyl alcohol Substances 0.000 description 1
239000000654 additive Substances 0.000 description 1
150000001298 alcohols Chemical class 0.000 description 1
238000010171 animal model Methods 0.000 description 1
230000006399 behavior Effects 0.000 description 1
WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
239000001913 cellulose Substances 0.000 description 1
229920002678 cellulose Polymers 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
229960004544 cortisone Drugs 0.000 description 1
239000002537 cosmetic Substances 0.000 description 1
239000008278 cosmetic cream Substances 0.000 description 1
238000010586 diagram Methods 0.000 description 1
239000006185 dispersion Substances 0.000 description 1
239000012153 distilled water Substances 0.000 description 1
230000037336 dry skin Effects 0.000 description 1
230000007613 environmental effect Effects 0.000 description 1
229920001249 ethyl cellulose Polymers 0.000 description 1
235000019325 ethyl cellulose Nutrition 0.000 description 1
150000002191 fatty alcohols Chemical class 0.000 description 1
238000001914 filtration Methods 0.000 description 1
229940063583 high-density polyethylene Drugs 0.000 description 1
238000010348 incorporation Methods 0.000 description 1
239000004615 ingredient Substances 0.000 description 1
150000002500 ions Chemical class 0.000 description 1
239000007788 liquid Substances 0.000 description 1
230000005923 long-lasting effect Effects 0.000 description 1
208000020442 loss of weight Diseases 0.000 description 1
239000012907 medicinal substance Substances 0.000 description 1
238000002844 melting Methods 0.000 description 1
230000008018 melting Effects 0.000 description 1
239000004570 mortar (masonry) Substances 0.000 description 1
QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
230000003287 optical effect Effects 0.000 description 1
229920003023 plastic Polymers 0.000 description 1
239000004033 plastic Substances 0.000 description 1
229920002451 polyvinyl alcohol Polymers 0.000 description 1
230000001681 protective effect Effects 0.000 description 1
230000002441 reversible effect Effects 0.000 description 1
238000005070 sampling Methods 0.000 description 1
230000028327 secretion Effects 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
239000011734 sodium Substances 0.000 description 1
235000010268 sodium methyl p-hydroxybenzoate Nutrition 0.000 description 1
239000004290 sodium methyl p-hydroxybenzoate Substances 0.000 description 1
PESXGULMKCKJCC-UHFFFAOYSA-M sodium;4-methoxycarbonylphenolate Chemical compound [Na+].COC(=O)C1=CC=C([O-])C=C1 PESXGULMKCKJCC-UHFFFAOYSA-M 0.000 description 1
239000002344 surface layer Substances 0.000 description 1
150000003536 tetrazoles Chemical class 0.000 description 1
238000011282 treatment Methods 0.000 description 1
229940099259 vaseline Drugs 0.000 description 1
238000013022 venting Methods 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0241—Containing particulates characterized by their shape and/or structure
- A61K8/027—Fibers; Fibrils
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8105—Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers
- A61K8/8111—Homopolymers or copolymers of aliphatic olefines, e.g. polyethylene, polyisobutene; Compositions of derivatives of such polymers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Chemical & Material Sciences (AREA)
Birds (AREA)
Dermatology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Inorganic Chemistry (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Cosmetics (AREA)

CA316,390A 1977-12-06 1978-11-17 Excipient composition for creams Expired CA1113005A (en)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
IT3041177A IT1089625B (it)	1977-12-06	1977-12-06	Composizione eccipiente per creme
IT30411A/77		1977-12-06
IT2825078A IT1159150B (it)	1978-09-29	1978-09-29	Composizione eccipiente per creme
IT28250A/78		1978-09-29

Publications (1)

Publication Number	Publication Date
CA1113005A true CA1113005A (en)	1981-11-24

Family

ID=26328775

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA316,390A Expired CA1113005A (en)	1977-12-06	1978-11-17	Excipient composition for creams

Country Status (10)

Country	Link
JP (1)	JPS5486610A (no)
BE (1)	BE872562A (no)
CA (1)	CA1113005A (no)
DE (1)	DE2852809C3 (no)
DK (1)	DK549078A (no)
FR (1)	FR2411005A1 (no)
GB (1)	GB2008947B (no)
NL (1)	NL7811876A (no)
NO (1)	NO148731C (no)
SE (1)	SE433173B (no)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5489017A (en) *	1977-12-26	1979-07-14	Lion Dentifrice Co Ltd	Ointment agent
IT1125491B (it) *	1979-10-18	1986-05-14	Anic Spa	Preparato per il trattamento di ferite,piaghe,ulcerazioni ed altre affezioni cutanee essudative
KR830005852A (ko) *	1980-07-18	1983-09-14	미첼 페터 잭슨	피부와 점막의 비루스 감염치료에 적합한 국소치료제의 제조방법

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE387596C (de) *	1922-05-04	1923-12-29	Ernst Schaufler	Verfahren zur Verbesserung von Schmelzstaebchen, Salben, Seifen und aehnlichen Mitteln
NL219299A (no) *	1956-07-26
US2915475A (en) *	1958-12-29	1959-12-01	Du Pont	Fibrous alumina monohydrate and its production
DK103797C (da) *	1963-05-01	1966-02-21	Barnes Hind Lab Inc	Kosmetisk middel.
US3265571A (en) *	1965-04-08	1966-08-09	Barnes Hind Pharm Inc	Thixotropic acne vulgaris composition

1978
- 1978-11-17 CA CA316,390A patent/CA1113005A/en not_active Expired
- 1978-12-04 DK DK549078A patent/DK549078A/da not_active Application Discontinuation
- 1978-12-05 GB GB7847256A patent/GB2008947B/en not_active Expired
- 1978-12-05 FR FR7834270A patent/FR2411005A1/fr active Granted
- 1978-12-05 SE SE7812512A patent/SE433173B/sv unknown
- 1978-12-05 NL NL7811876A patent/NL7811876A/xx not_active Application Discontinuation
- 1978-12-05 JP JP14976478A patent/JPS5486610A/ja active Pending
- 1978-12-05 NO NO784086A patent/NO148731C/no unknown
- 1978-12-06 BE BE192167A patent/BE872562A/xx not_active IP Right Cessation
- 1978-12-06 DE DE2852809A patent/DE2852809C3/de not_active Expired

Also Published As

Publication number	Publication date
DE2852809C3 (de)	1981-01-08
NO784086L (no)	1979-06-07
DE2852809A1 (de)	1979-06-07
SE433173B (sv)	1984-05-14
BE872562A (fr)	1979-06-06
GB2008947B (en)	1982-04-21
NO148731C (no)	1983-12-07
GB2008947A (en)	1979-06-13
DK549078A (da)	1979-06-07
SE7812512L (sv)	1979-06-07
FR2411005B1 (no)	1982-11-26
DE2852809B2 (de)	1980-04-10
NO148731B (no)	1983-08-29
FR2411005A1 (fr)	1979-07-06
NL7811876A (nl)	1979-06-08
JPS5486610A (en)	1979-07-10

Legal Events

Date	Code	Title	Description
1998-11-24	MKEX	Expiry

Publication	Publication Date	Title
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KR100507022B1 (ko)	2005-08-09	전달가능한 통기성 피부 관리 조성물을 갖는 제품
DE68907362T2 (de)	1993-10-14	Hydrophile Schaumzusammensetzungen.
KR100722894B1 (ko)	2007-05-30	로션처리된 신체측 라이너를 갖는 흡수용품
US6402408B1 (en)	2002-06-11	Composition containing a liquid fatty phase gelled with a polyamide containing ester end groups
US4291025A (en)	1981-09-22	Agar gel topical dressing
US20090220616A1 (en)	2009-09-03	Moisturizing and lubricating compositions
US20050101927A1 (en)	2005-05-12	Absorbent products comprising a moisturizing and lubricating composition
JP2001515760A (ja)	2001-09-25	皮膚の健康を維持または向上させるための方法
NZ193221A (en)	1984-08-24	Controlled release composition
US7144582B1 (en)	2006-12-05	Compositions structured with at least one polymer and methods of using the same
CA1113005A (en)	1981-11-24	Excipient composition for creams
KR20230071704A (ko)	2023-05-23	히드로퀴논을 포함하는 하이드로겔 패치 및 패치를 이용하는 방법
GB2163956A (en)	1986-03-12	Percutaneous anaesthetic composition for topical application
CN115093617B (zh)	2023-01-06	一种水凝胶基膜及其制备方法和应用
JPS6081120A (ja)	1985-05-09	メーキャップ化粧料
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EP0745392A1 (en)	1996-12-04	Wound covering material
WO2023054797A1 (ko)	2023-04-06	수상 및 유상의 적절한 비율을 갖는 유중수형 고형 화장료 조성물
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EP1243260B1 (en)	2005-06-15	Cicatrizant hydrocolloidal patch containing hyaluronic acid and chondroitin sulphate
WO2023063475A1 (ko)	2023-04-20	식물 유래 성분을 포함하는 비수계 오일밤 화장료 조성물
JPS61236711A (ja)	1986-10-22	アロエ含有パツク剤