CA1113257A - Procede d'obtention de technetium-99 radioactif - Google Patents

Procede d'obtention de technetium-99 radioactif

Info

Publication number: CA1113257A
Authority: CA; Canada
Prior art keywords: technetium; molybdenum; solvent; yes; produced
Prior art date: 1978-03-14
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

CA322,216A

Other languages

English (en)

Inventor

Hampar L. Karageozian

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Individual

Original Assignee

Individual

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1978-03-14

Filing date

1979-02-23

Publication date

1981-12-01

1978-03-14 Priority claimed from US05/886,404 external-priority patent/US4158700A/en

1979-02-23 Application filed by Individual filed Critical Individual

1981-12-01 Application granted granted Critical

1981-12-01 Publication of CA1113257A publication Critical patent/CA1113257A/fr

Status Expired legal-status Critical Current

Links

229940056501 technetium 99m Drugs 0.000 title claims abstract description 55
GKLVYJBZJHMRIY-OUBTZVSYSA-N Technetium-99 Chemical compound [99Tc] GKLVYJBZJHMRIY-OUBTZVSYSA-N 0.000 title claims abstract description 54
238000000034 method Methods 0.000 title claims abstract description 27
230000002285 radioactive effect Effects 0.000 title abstract description 7
239000002904 solvent Substances 0.000 claims abstract description 41
ZOKXTWBITQBERF-AKLPVKDBSA-N Molybdenum Mo-99 Chemical compound [99Mo] ZOKXTWBITQBERF-AKLPVKDBSA-N 0.000 claims abstract description 24
229950009740 molybdenum mo-99 Drugs 0.000 claims abstract description 24
239000000463 material Substances 0.000 claims abstract description 14
239000003960 organic solvent Substances 0.000 claims abstract description 12
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 12
230000007935 neutral effect Effects 0.000 claims abstract description 8
238000004519 manufacturing process Methods 0.000 claims abstract description 6
125000004432 carbon atom Chemical group C* 0.000 claims abstract description 4
ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 claims description 16
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 14
235000019441 ethanol Nutrition 0.000 claims description 9
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 8
PNEYBMLMFCGWSK-UHFFFAOYSA-N Alumina Chemical compound [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 claims description 7
XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims description 6
229960004756 ethanol Drugs 0.000 claims description 6
FDPIMTJIUBPUKL-UHFFFAOYSA-N pentan-3-one Chemical compound CCC(=O)CC FDPIMTJIUBPUKL-UHFFFAOYSA-N 0.000 claims description 6
239000000203 mixture Substances 0.000 claims description 4
DNIAPMSPPWPWGF-GSVOUGTGSA-N (R)-(-)-Propylene glycol Chemical compound C[C@@H](O)CO DNIAPMSPPWPWGF-GSVOUGTGSA-N 0.000 claims description 3
238000001704 evaporation Methods 0.000 claims description 2
230000008020 evaporation Effects 0.000 claims description 2
-1 aliphatic alcohols Chemical class 0.000 abstract description 7
238000000605 extraction Methods 0.000 abstract description 3
239000003125 aqueous solvent Substances 0.000 abstract description 2
239000003153 chemical reaction reagent Substances 0.000 abstract description 2
238000002360 preparation method Methods 0.000 abstract description 2
230000005258 radioactive decay Effects 0.000 abstract description 2
238000000926 separation method Methods 0.000 abstract description 2
230000002269 spontaneous effect Effects 0.000 abstract description 2
239000000032 diagnostic agent Substances 0.000 abstract 1
ZOKXTWBITQBERF-UHFFFAOYSA-N Molybdenum Chemical compound [Mo] ZOKXTWBITQBERF-UHFFFAOYSA-N 0.000 description 12
229910052750 molybdenum Inorganic materials 0.000 description 11
239000011733 molybdenum Substances 0.000 description 11
239000000243 solution Substances 0.000 description 11
238000010828 elution Methods 0.000 description 9
KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 6
238000011109 contamination Methods 0.000 description 6
230000000694 effects Effects 0.000 description 6
238000012856 packing Methods 0.000 description 6
239000000126 substance Substances 0.000 description 5
JKQOBWVOAYFWKG-UHFFFAOYSA-N molybdenum trioxide Chemical compound O=[Mo](=O)=O JKQOBWVOAYFWKG-UHFFFAOYSA-N 0.000 description 4
239000012085 test solution Substances 0.000 description 4
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
239000004743 Polypropylene Substances 0.000 description 3
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 3
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
239000002253 acid Substances 0.000 description 3
229940024548 aluminum oxide Drugs 0.000 description 3
239000007788 liquid Substances 0.000 description 3
TWNQGVIAIRXVLR-UHFFFAOYSA-N oxo(oxoalumanyloxy)alumane Chemical compound O=[Al]O[Al]=O TWNQGVIAIRXVLR-UHFFFAOYSA-N 0.000 description 3
229920001155 polypropylene Polymers 0.000 description 3
230000005855 radiation Effects 0.000 description 3
238000011084 recovery Methods 0.000 description 3
239000011780 sodium chloride Substances 0.000 description 3
MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 2
239000005708 Sodium hypochlorite Substances 0.000 description 2
150000001875 compounds Chemical class 0.000 description 2
239000011521 glass Substances 0.000 description 2
239000007800 oxidant agent Substances 0.000 description 2
239000011734 sodium Substances 0.000 description 2
229910052708 sodium Inorganic materials 0.000 description 2
SUKJFIGYRHOWBL-UHFFFAOYSA-N sodium hypochlorite Chemical compound [Na+].Cl[O-] SUKJFIGYRHOWBL-UHFFFAOYSA-N 0.000 description 2
239000011684 sodium molybdate Substances 0.000 description 2
235000015393 sodium molybdate Nutrition 0.000 description 2
TVXXNOYZHKPKGW-UHFFFAOYSA-N sodium molybdate (anhydrous) Chemical compound [Na+].[Na+].[O-][Mo]([O-])(=O)=O TVXXNOYZHKPKGW-UHFFFAOYSA-N 0.000 description 2
ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
101100536354 Drosophila melanogaster tant gene Proteins 0.000 description 1
101150039033 Eci2 gene Proteins 0.000 description 1
241000364027 Sinoe Species 0.000 description 1
239000004809 Teflon Substances 0.000 description 1
229920006362 Teflon® Polymers 0.000 description 1
YKTSYUJCYHOUJP-UHFFFAOYSA-N [O--].[Al+3].[Al+3].[O-][Si]([O-])([O-])[O-] Chemical compound [O--].[Al+3].[Al+3].[O-][Si]([O-])([O-])[O-] YKTSYUJCYHOUJP-UHFFFAOYSA-N 0.000 description 1
230000002378 acidificating effect Effects 0.000 description 1
238000013019 agitation Methods 0.000 description 1
150000001298 alcohols Chemical class 0.000 description 1
239000003513 alkali Substances 0.000 description 1
229910052782 aluminium Inorganic materials 0.000 description 1
XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
235000010210 aluminium Nutrition 0.000 description 1
WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 1
SNAAJJQQZSMGQD-UHFFFAOYSA-N aluminum magnesium Chemical compound [Mg].[Al] SNAAJJQQZSMGQD-UHFFFAOYSA-N 0.000 description 1
APUPEJJSWDHEBO-UHFFFAOYSA-P ammonium molybdate Chemical compound [NH4+].[NH4+].[O-][Mo]([O-])(=O)=O APUPEJJSWDHEBO-UHFFFAOYSA-P 0.000 description 1
239000011609 ammonium molybdate Substances 0.000 description 1
235000018660 ammonium molybdate Nutrition 0.000 description 1
229940010552 ammonium molybdate Drugs 0.000 description 1
239000007864 aqueous solution Substances 0.000 description 1
230000001580 bacterial effect Effects 0.000 description 1
RQPZNWPYLFFXCP-UHFFFAOYSA-L barium dihydroxide Chemical compound [OH-].[OH-].[Ba+2] RQPZNWPYLFFXCP-UHFFFAOYSA-L 0.000 description 1
229910001863 barium hydroxide Inorganic materials 0.000 description 1
239000000440 bentonite Substances 0.000 description 1
229910000278 bentonite Inorganic materials 0.000 description 1
SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 1
BRPQOXSCLDDYGP-UHFFFAOYSA-N calcium oxide Chemical compound [O-2].[Ca+2] BRPQOXSCLDDYGP-UHFFFAOYSA-N 0.000 description 1
239000000292 calcium oxide Substances 0.000 description 1
ODINCKMPIJJUCX-UHFFFAOYSA-N calcium oxide Inorganic materials [Ca]=O ODINCKMPIJJUCX-UHFFFAOYSA-N 0.000 description 1
239000000969 carrier Substances 0.000 description 1
230000015556 catabolic process Effects 0.000 description 1
238000005119 centrifugation Methods 0.000 description 1
230000001143 conditioned effect Effects 0.000 description 1
230000003247 decreasing effect Effects 0.000 description 1
238000006731 degradation reaction Methods 0.000 description 1
238000003745 diagnosis Methods 0.000 description 1
238000012631 diagnostic technique Methods 0.000 description 1
238000001914 filtration Methods 0.000 description 1
239000007789 gas Substances 0.000 description 1
238000010438 heat treatment Methods 0.000 description 1
239000012535 impurity Substances 0.000 description 1
229910052500 inorganic mineral Inorganic materials 0.000 description 1
239000011630 iodine Substances 0.000 description 1
229910052740 iodine Inorganic materials 0.000 description 1
238000005342 ion exchange Methods 0.000 description 1
238000004255 ion exchange chromatography Methods 0.000 description 1
150000002576 ketones Chemical class 0.000 description 1
VTHJTEIRLNZDEV-UHFFFAOYSA-L magnesium dihydroxide Chemical compound [OH-].[OH-].[Mg+2] VTHJTEIRLNZDEV-UHFFFAOYSA-L 0.000 description 1
239000000347 magnesium hydroxide Substances 0.000 description 1
229910001862 magnesium hydroxide Inorganic materials 0.000 description 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
239000011707 mineral Substances 0.000 description 1
235000010755 mineral Nutrition 0.000 description 1
ZOKXTWBITQBERF-OIOBTWANSA-N molybdenum-93 Chemical compound [93Mo] ZOKXTWBITQBERF-OIOBTWANSA-N 0.000 description 1
VLAPMBHFAWRUQP-UHFFFAOYSA-L molybdic acid Chemical compound O[Mo](O)(=O)=O VLAPMBHFAWRUQP-UHFFFAOYSA-L 0.000 description 1
239000012074 organic phase Substances 0.000 description 1
230000003647 oxidation Effects 0.000 description 1
238000007254 oxidation reaction Methods 0.000 description 1
RVTZCBVAJQQJTK-UHFFFAOYSA-N oxygen(2-);zirconium(4+) Chemical compound [O-2].[O-2].[Zr+4] RVTZCBVAJQQJTK-UHFFFAOYSA-N 0.000 description 1
239000002245 particle Substances 0.000 description 1
150000002978 peroxides Chemical class 0.000 description 1
238000001556 precipitation Methods 0.000 description 1
238000011160 research Methods 0.000 description 1
239000012266 salt solution Substances 0.000 description 1
150000003839 salts Chemical class 0.000 description 1
229920006395 saturated elastomer Polymers 0.000 description 1
229910001220 stainless steel Inorganic materials 0.000 description 1
239000010935 stainless steel Substances 0.000 description 1
229910001928 zirconium oxide Inorganic materials 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01G—COMPOUNDS CONTAINING METALS NOT COVERED BY SUBCLASSES C01D OR C01F
- C01G99/00—Subject matter not provided for in other groups of this subclass
- C01G99/003—Preparation involving a liquid-liquid extraction, an adsorption or an ion-exchange
- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
- G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
- G21G1/04—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes outside nuclear reactors or particle accelerators

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Inorganic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Physics & Mathematics (AREA)
Engineering & Computer Science (AREA)
General Engineering & Computer Science (AREA)
High Energy & Nuclear Physics (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Manufacture And Refinement Of Metals (AREA)

CA322,216A 1978-03-14 1979-02-23 Procede d'obtention de technetium-99 radioactif Expired CA1113257A (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US05/886,404 US4158700A (en)	1976-03-08	1978-03-14	Method of producing radioactive technetium-99M
US886,404		1978-03-14

Publications (1)

Publication Number	Publication Date
CA1113257A true CA1113257A (fr)	1981-12-01

Family

ID=25388994

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA322,216A Expired CA1113257A (fr)	1978-03-14	1979-02-23	Procede d'obtention de technetium-99 radioactif

Country Status (6)

Country	Link
JP (1)	JPS54133295A (fr)
CA (1)	CA1113257A (fr)
DE (1)	DE2909648A1 (fr)
FR (1)	FR2420190A1 (fr)
GB (1)	GB2016796B (fr)
IT (1)	IT1166691B (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US9576690B2 (en)	2012-06-15	2017-02-21	Dent International Research, Inc.	Apparatus and methods for transmutation of elements

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5215281A (en) *	1991-09-27	1993-06-01	Zsi, Inc.	Two-piece cushion insert for U-bolt clamp assembly
DE102010006435B3 (de) *	2010-02-01	2011-07-21	Siemens Aktiengesellschaft, 80333	Verfahren und Vorrichtung zur Produktion von 99mTc
JP5817977B2 (ja) *	2011-08-08	2015-11-18	国立研究開発法人日本原子力研究開発機構	高濃度かつ高放射能をもつテクネチウム−９９ｍ溶液の製造方法
JPWO2014057900A1 (ja) *	2012-10-10	2016-09-05	国立大学法人大阪大学	Ｒｉの単離装置

1979
- 1979-02-23 CA CA322,216A patent/CA1113257A/fr not_active Expired
- 1979-02-28 GB GB7906990A patent/GB2016796B/en not_active Expired
- 1979-03-12 DE DE19792909648 patent/DE2909648A1/de not_active Withdrawn
- 1979-03-13 FR FR7906371A patent/FR2420190A1/fr active Granted
- 1979-03-14 JP JP2880079A patent/JPS54133295A/ja active Pending
- 1979-03-14 IT IT20973/79A patent/IT1166691B/it active

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US9576690B2 (en)	2012-06-15	2017-02-21	Dent International Research, Inc.	Apparatus and methods for transmutation of elements

Also Published As

Publication number	Publication date
IT7920973A0 (it)	1979-03-14
FR2420190B3 (fr)	1981-12-31
FR2420190A1 (fr)	1979-10-12
GB2016796B (en)	1982-07-07
DE2909648A1 (de)	1979-10-18
IT1166691B (it)	1987-05-06
GB2016796A (en)	1979-09-26
JPS54133295A (en)	1979-10-16

Legal Events

Date	Code	Title	Description
1998-12-01	MKEX	Expiry

Publication	Publication Date	Title
Kraus et al.	1954	Anion exchange studies. IX. Adsorbability of a number of metals in hydrochloric acid solutions
Figgins	1960	The radiochemistry of polonium
Strelow	1960	An ion exchange selectivity scale of cations based on equilibrium distribution coefficients
US4158700A (en)	1979-06-19	Method of producing radioactive technetium-99M
WO1989003434A1 (fr)	1989-04-20	Composes heteropolycycliques supportes utilises dans la separation et l'extraction de metaux a transition tardive
US3936440A (en)	1976-02-03	Method of labeling complex metal chelates with radioactive metal isotopes
CA1245456A (fr)	1988-11-29	Recuperation de molbdene-99 a partir d'une cible d'alliage d'uranium irradiee
Goble et al.	1958	Protactinium—III solvent extraction from halide solutions
CA1113257A (fr)	1981-12-01	Procede d'obtention de technetium-99 radioactif
US3468808A (en)	1969-09-23	Production of high purity radioactive technetium-99m
Kopecký et al.	1974	68Ge 68Ga generator for the production of 68Ga in an ionic form
Bauman et al.	1967	Coupled ligand chromatography, applications to trace element collection and characterization
Mitchell	1982	Purification of analytical reagents
Byrne et al.	1974	Rapid neutron activation analysis of arsenic in a wide range of samples by solvent extraction of the iodide
Lewis	1971	Production of high specific activity molybdenum-99 for preparation of technetium-99m generators
Braun et al.	1975	Plasticized open-cell polyurethane foam as a universal matrix for organic reagents in trace element preconcentration: part III. Collection of cobalt traces on 1-nitroso-2-naphthol and diethyldithiocarbamate foams
Kawabuchi et al.	1973	A neutron activation procedure for the determination of dissolved silver in sea water
Maddock et al.	1955	The chemical effects of radiative thermal neutron capture. Part 3.—Triphenylarsine and triphenylstibine
US4248730A (en)	1981-02-03	Evaporation-based Ge/68 Ga Separation
Testa	1970	Column reversed-phase partition chromatography for the isolation of some radionuclides from biological materials
Arino et al.	1973	A new 137Cs/137Ba radioisotope generator system
Egger et al.	1986	Neutron activation analysis of aluminium with radiochemical separation of 24Na
Sekine et al.	1969	Studies of actinium (III) in various solutions. II. Distribution behavior of lanthanum (III) and actinium (III) in some chelate extraction systems
Tait et al.	1997	Rapid and efficient separation of strontium from liquid milk with a cation exchange resin Dowex 50WX8 treated with cryptand 222
Ramaniah et al.	1975	Studies on electrodeposition of actinide elements from non-aqueous medium

CA1113257A - Procede d'obtention de technetium-99 radioactif - Google Patents

Info

Links

Classifications

Landscapes

Applications Claiming Priority (2)

Publications (1)

Family

ID=25388994

Family Applications (1)

Country Status (6)

Cited By (1)

Families Citing this family (4)

Cited By (1)

Also Published As

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