CA1116605A - Bis (2-imidazolin-2-ylhydrazone)-9,10-dihydro-9,10- anthracenedicarboxaldehydes - Google Patents

Bis (2-imidazolin-2-ylhydrazone)-9,10-dihydro-9,10- anthracenedicarboxaldehydes

Info

Publication number: CA1116605A
Authority: CA; Canada
Prior art keywords: dihydro; dihydrochloride; bis; imidazolin; ylhydrazone
Prior art date: 1978-10-24
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

CA000314064A

Other languages

English (en)

Inventor

Ralph G. Child

Ving J. Lee

Stanley A. Lang, Jr.

Yang-I Lin

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Wyeth Holdings LLC

Original Assignee

American Cyanamid Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1978-10-24

Filing date

1978-10-24

Publication date

1982-01-19

1978-10-24 Application filed by American Cyanamid Co filed Critical American Cyanamid Co

1978-10-24 Priority to CA000314064A priority Critical patent/CA1116605A/fr

1982-01-19 Application granted granted Critical

1982-01-19 Publication of CA1116605A publication Critical patent/CA1116605A/fr

Status Expired legal-status Critical Current

Links

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125000004432 carbon atom Chemical group C* 0.000 claims description 16
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238000002360 preparation method Methods 0.000 claims description 11
-1 chloro, methyl Chemical group 0.000 claims description 10
229910052757 nitrogen Inorganic materials 0.000 claims description 8
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RQNKXAIJVOBSJY-UHFFFAOYSA-N 2-methyl-9,10-dihydroanthracene-9,10-dicarbaldehyde Chemical compound C1=CC=C2C(C=O)C3=CC(C)=CC=C3C(C=O)C2=C1 RQNKXAIJVOBSJY-UHFFFAOYSA-N 0.000 claims description 3
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NBSHFBANNVIIGL-UHFFFAOYSA-N 2-chloro-9,10-dihydroanthracene-9,10-dicarbaldehyde Chemical compound C1=CC=C2C(C=O)C3=CC(Cl)=CC=C3C(C=O)C2=C1 NBSHFBANNVIIGL-UHFFFAOYSA-N 0.000 claims description 2
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SBRUFOSORMQHES-UHFFFAOYSA-N anthracene-9,10-dialdehyde Chemical compound C1=CC=C2C(C=O)=C(C=CC=C3)C3=C(C=O)C2=C1 SBRUFOSORMQHES-UHFFFAOYSA-N 0.000 claims 1
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229960003742 phenol Drugs 0.000 description 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 description 1
239000003495 polar organic solvent Substances 0.000 description 1
229920005862 polyol Polymers 0.000 description 1
150000003077 polyols Chemical class 0.000 description 1
229910000027 potassium carbonate Inorganic materials 0.000 description 1
238000001556 precipitation Methods 0.000 description 1
239000003755 preservative agent Substances 0.000 description 1
230000002335 preservative effect Effects 0.000 description 1
230000002265 prevention Effects 0.000 description 1
230000002035 prolonged effect Effects 0.000 description 1
229960005335 propanol Drugs 0.000 description 1
238000001953 recrystallisation Methods 0.000 description 1
230000000979 retarding effect Effects 0.000 description 1
239000004334 sorbic acid Substances 0.000 description 1
229940075582 sorbic acid Drugs 0.000 description 1
235000010199 sorbic acid Nutrition 0.000 description 1
238000001228 spectrum Methods 0.000 description 1
238000010561 standard procedure Methods 0.000 description 1
230000001954 sterilising effect Effects 0.000 description 1
238000004659 sterilization and disinfection Methods 0.000 description 1
235000000346 sugar Nutrition 0.000 description 1
150000008163 sugars Chemical class 0.000 description 1
125000000446 sulfanediyl group Chemical group *S* 0.000 description 1
239000000725 suspension Substances 0.000 description 1
YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
229940033663 thimerosal Drugs 0.000 description 1
125000000464 thioxo group Chemical group S=* 0.000 description 1
231100000331 toxic Toxicity 0.000 description 1
230000002588 toxic effect Effects 0.000 description 1
238000005292 vacuum distillation Methods 0.000 description 1
238000001291 vacuum drying Methods 0.000 description 1
235000015112 vegetable and seed oil Nutrition 0.000 description 1
239000008158 vegetable oil Substances 0.000 description 1
239000003981 vehicle Substances 0.000 description 1

Landscapes

Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

CA000314064A 1978-10-24 1978-10-24 Bis (2-imidazolin-2-ylhydrazone)-9,10-dihydro-9,10- anthracenedicarboxaldehydes Expired CA1116605A (fr)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
CA000314064A CA1116605A (fr)	1978-10-24	1978-10-24	Bis (2-imidazolin-2-ylhydrazone)-9,10-dihydro-9,10- anthracenedicarboxaldehydes

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
CA000314064A CA1116605A (fr)	1978-10-24	1978-10-24	Bis (2-imidazolin-2-ylhydrazone)-9,10-dihydro-9,10- anthracenedicarboxaldehydes

Publications (1)

Publication Number	Publication Date
CA1116605A true CA1116605A (fr)	1982-01-19

Family

ID=4112674

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA000314064A Expired CA1116605A (fr)	1978-10-24	1978-10-24	Bis (2-imidazolin-2-ylhydrazone)-9,10-dihydro-9,10- anthracenedicarboxaldehydes

Country Status (1)

Country	Link
CA (1)	CA1116605A (fr)

1978
- 1978-10-24 CA CA000314064A patent/CA1116605A/fr not_active Expired

Legal Events

Date	Code	Title	Description
1999-01-19	MKEX	Expiry

Publication	Publication Date	Title
SU1535377A3 (ru)	1990-01-07	Способ получени производных ароматических аминоспиртов или их фармакологически приемлемых солей
KR840001965B1 (ko)	1984-10-26	안트라센-9,10-비스-카르보닐-히드라존 유도체 제조방법
EP0037486B1 (fr)	1984-01-25	Chélates de métaux de 1,4-bis(amino substitué)-5,8-dihydroxyanthraquinones
JPS62246589A (ja)	1987-10-27	〔２，２−ビス（アミノメチル）−１，３−プロパンジオ−ル−ｎ，ｎ’〕白金錯塩
KR900001194B1 (ko)	1990-02-28	N-아미노피리디늄 베타인 유도체의 제조방법
Lalezari et al.	1990	Synthesis of 1‐aryl‐1, 2, 3‐triazole‐4, 5‐dimethanol‐4, 5‐bis (isopropylcarbamates) as potential antineoplastic agents
HUT67899A (en)	1995-05-29	Thioxanthenone antitumor agents
US4275192A (en)	1981-06-23	Bis(4-demethoxydaunorubicin)dihydrazone derivatives and pharmacologically acceptable salts thereof
US4389399A (en)	1983-06-21	Thiocarbamoyl heterocycle-anthraquinone derivatives
EP0011747B1 (fr)	1982-05-19	Dérivés aminopropanols de 6-hydroxy-2,3,4,5-tétrahydro-1H-1-benzazépin-2-ones, procédé pour leur préparation, et compositions pharmaceutiques les contenant
US4187373A (en)	1980-02-05	Novel dihydrobenzanthracene derivatives
US4235996A (en)	1980-11-25	Bis(2-imidazolin-2-ylhydrazone)-9,10-dihydro-9,10-anthracenedicarboxaldehydes
JPS63264580A (ja)	1988-11-01	３−（２−ハロアルキル）−１，４−オキサチインおよび２−（２−ハロアルキル）−１，４−ジチイン
US3535317A (en)	1970-10-20	3-hydrazinopyridazines having hypotensive activity
KR100209826B1 (ko)	1999-07-15	티옥산테논 항종양제
US2663710A (en)	1953-12-22	Series of nitrofuran compounds comprising 5-nitro-2-furyl 2-dialkyl-aminoalkyl ketone semicarbazone salts
IE47633B1 (en)	1984-05-16	Novel anthracene-9, 10-bis-carbonyl hydrazones and derivatives
CA1117535A (fr)	1982-02-02	Anthracene-9,10-bis-carbonyl-hydrazones
US2681911A (en)	1954-06-22	1, 2, 3, 4-tetrahydroisoquinolinalkanol esters of aromatically substituted aliphaticacids and their derivatives
AU538905B2 (en)	1984-08-30	Substituted 9,10-anthracene-byshydrazones
US4698343A (en)	1987-10-06	(Alkoxy-2)phenylpiperazines having alpha-1 and beta blocking properties
JPH01279864A (ja)	1989-11-10	新規の１，２―ジヒドロピリド〔３，４―ｂ〕―ピラジン類製造用の中間体
CA1194868A (fr)	1985-10-08	1-4-bis(substituant-amino),5,8- dihydroxyanthraquinones et leucobases derivees
KR830000466B1 (ko)	1983-03-09	안트라센-9, 10-비스-카보닐히드라존 유도체의 제조방법
Relyea et al.	1963	3, 6-Disubstituted Pyridazines1