CA1118410A - 19-nor-pregnahexenes, methode de preparation, et compositions pharmaceutiques qui en renferment - Google Patents

19-nor-pregnahexenes, methode de preparation, et compositions pharmaceutiques qui en renferment

Info

Publication number
CA1118410A
CA1118410A CA000307894A CA307894A CA1118410A CA 1118410 A CA1118410 A CA 1118410A CA 000307894 A CA000307894 A CA 000307894A CA 307894 A CA307894 A CA 307894A CA 1118410 A CA1118410 A CA 1118410A
Authority
CA
Canada
Prior art keywords
hydrogen
pregna
methyl
alpha
process according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA000307894A
Other languages
English (en)
Inventor
Richard W. Draper
Charles J. Casmer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MSD International Holdings GmbH
Original Assignee
Scherico Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scherico Ltd filed Critical Scherico Ltd
Priority to CA374,650A priority Critical patent/CA1123337A/fr
Application granted granted Critical
Publication of CA1118410A publication Critical patent/CA1118410A/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0053—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa not substituted in position 16
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/005—Ketals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0061—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
    • C07J5/0069—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group
    • C07J5/0076—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group by an alkyl group

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA000307894A 1977-07-26 1978-07-21 19-nor-pregnahexenes, methode de preparation, et compositions pharmaceutiques qui en renferment Expired CA1118410A (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA374,650A CA1123337A (fr) 1977-07-26 1981-04-03 Compositions pharmaceutiques antimitotiques

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US81918277A 1977-07-26 1977-07-26
US819,182 1977-07-26

Publications (1)

Publication Number Publication Date
CA1118410A true CA1118410A (fr) 1982-02-16

Family

ID=25227423

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000307894A Expired CA1118410A (fr) 1977-07-26 1978-07-21 19-nor-pregnahexenes, methode de preparation, et compositions pharmaceutiques qui en renferment

Country Status (13)

Country Link
EP (1) EP0000609B1 (fr)
JP (1) JPS5424864A (fr)
AT (1) ATA532778A (fr)
AU (1) AU518819B2 (fr)
CA (1) CA1118410A (fr)
DE (1) DE2861112D1 (fr)
DK (1) DK326478A (fr)
FI (1) FI782305A7 (fr)
GR (1) GR73119B (fr)
NO (1) NO782538L (fr)
NZ (1) NZ187926A (fr)
PT (1) PT68338A (fr)
ZA (1) ZA784081B (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4897290A (en) * 1986-09-26 1990-01-30 Konishiroku Photo Industry Co., Ltd. Method for manufacturing the substrate for liquid crystal display

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3410879A (en) * 1967-04-12 1968-11-12 American Home Prod Process for preparing gonahexaenes

Also Published As

Publication number Publication date
JPS5424864A (en) 1979-02-24
DE2861112D1 (en) 1981-12-10
ATA532778A (de) 1982-12-15
EP0000609B1 (fr) 1981-09-23
GR73119B (fr) 1984-02-03
AU518819B2 (en) 1981-10-22
NO782538L (no) 1979-01-29
NZ187926A (en) 1980-10-08
ZA784081B (en) 1979-07-25
DK326478A (da) 1979-01-27
PT68338A (en) 1978-08-01
AU3824878A (en) 1980-01-24
FI782305A7 (fi) 1979-01-27
EP0000609A1 (fr) 1979-02-07

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Legal Events

Date Code Title Description
MKEX Expiry