CA1137468A - Peptide anitbacterien - Google Patents

Peptide anitbacterien

Info

Publication number: CA1137468A
Authority: CA; Canada
Prior art keywords: group; peptide; formula; configuration; prepared
Prior art date: 1978-10-23
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

CA000338128A

Other languages

English (en)

Inventor

Daniel T. Chu

Jerry R. Martin

Alford M. Thomas

Norman E. Wideburg

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Abbott Laboratories

Original Assignee

Abbott Laboratories

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1978-10-23

Filing date

1979-10-22

Publication date

1982-12-14

1979-10-22 Application filed by Abbott Laboratories filed Critical Abbott Laboratories

1982-12-14 Application granted granted Critical

1982-12-14 Publication of CA1137468A publication Critical patent/CA1137468A/fr

Status Expired legal-status Critical Current

Links

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150000004702 methyl esters Chemical class 0.000 description 1
239000006186 oral dosage form Substances 0.000 description 1
125000000636 p-nitrophenyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)[N+]([O-])=O 0.000 description 1
238000007911 parenteral administration Methods 0.000 description 1
150000002960 penicillins Chemical class 0.000 description 1
238000005897 peptide coupling reaction Methods 0.000 description 1
COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 1
NMHMNPHRMNGLLB-UHFFFAOYSA-N phloretic acid Chemical compound OC(=O)CCC1=CC=C(O)C=C1 NMHMNPHRMNGLLB-UHFFFAOYSA-N 0.000 description 1
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
235000021317 phosphate Nutrition 0.000 description 1
239000010452 phosphate Substances 0.000 description 1
239000006187 pill Substances 0.000 description 1
229920002223 polystyrene Polymers 0.000 description 1
238000002360 preparation method Methods 0.000 description 1
239000003755 preservative agent Substances 0.000 description 1
125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
238000001953 recrystallisation Methods 0.000 description 1
238000013207 serial dilution Methods 0.000 description 1
238000005245 sintering Methods 0.000 description 1
229910000029 sodium carbonate Inorganic materials 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
239000007909 solid dosage form Substances 0.000 description 1
239000002904 solvent Substances 0.000 description 1
238000000935 solvent evaporation Methods 0.000 description 1
239000003381 stabilizer Substances 0.000 description 1
238000010561 standard procedure Methods 0.000 description 1
229960005322 streptomycin Drugs 0.000 description 1
125000001424 substituent group Chemical group 0.000 description 1
KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
KZNICNPSHKQLFF-UHFFFAOYSA-N succinimide Chemical class O=C1CCC(=O)N1 KZNICNPSHKQLFF-UHFFFAOYSA-N 0.000 description 1
229930101283 tetracycline Natural products 0.000 description 1
OFVLGDICTFRJMM-WESIUVDSSA-N tetracycline Chemical compound C1=CC=C2[C@](O)(C)[C@H]3C[C@H]4[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O OFVLGDICTFRJMM-WESIUVDSSA-N 0.000 description 1
YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
FGMPLJWBKKVCDB-UHFFFAOYSA-N trans-L-hydroxy-proline Natural products ON1CCCC1C(O)=O FGMPLJWBKKVCDB-UHFFFAOYSA-N 0.000 description 1
229960004799 tryptophan Drugs 0.000 description 1
239000004474 valine Substances 0.000 description 1
235000012431 wafers Nutrition 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Gastroenterology & Hepatology (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Pharmacology & Pharmacy (AREA)
Molecular Biology (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)

CA000338128A 1978-10-23 1979-10-22 Peptide anitbacterien Expired CA1137468A (fr)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date
US95351678A	1978-10-23	1978-10-23
US953,516		1978-10-23
US4167979A	1979-05-23	1979-05-23
US41,679		1979-05-23

Publications (1)

Publication Number	Publication Date
CA1137468A true CA1137468A (fr)	1982-12-14

Family

ID=26718400

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA000338128A Expired CA1137468A (fr)	1978-10-23	1979-10-22	Peptide anitbacterien

Country Status (14)

Country	Link
EP (1)	EP0020481A4 (fr)
JP (1)	JPS55500821A (fr)
AR (1)	AR229015A1 (fr)
AU (1)	AU528165B2 (fr)
CA (1)	CA1137468A (fr)
DK (1)	DK208680A (fr)
ES (1)	ES8100250A1 (fr)
GR (1)	GR73145B (fr)
IL (1)	IL58487A (fr)
IT (1)	IT1125557B (fr)
NZ (1)	NZ191839A (fr)
PH (1)	PH14917A (fr)
PT (1)	PT70319A (fr)
WO (1)	WO1980000789A1 (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1984002905A1 (fr) *	1983-01-26	1984-08-02	University Patents Inc	Peptides antibacteriens
AU742278B2 (en) *	1996-10-29	2001-12-20	Graeme Smith	A stump
US20040052928A1 (en)	2002-09-06	2004-03-18	Ehud Gazit	Peptides and methods using same for diagnosing and treating amyloid-associated diseases
US7491699B2 (en)	2002-12-09	2009-02-17	Ramot At Tel Aviv University Ltd.	Peptide nanostructures and methods of generating and using the same
EP1583713B1 (fr)	2003-01-07	2009-03-25	Ramot at Tel Aviv University Ltd.	Nanostructures de peptides encapsulant une matiere etrangere ainsi que procede de fabrication correspondant
JP2007527728A (ja)	2003-04-03	2007-10-04	ガリルメディカルリミテッド	正確に画定された冷凍切除のための装置及び方法
CN101415724B (zh)	2003-06-30	2015-12-02	特拉维夫大学未来科技开发有限公司	肽、抗肽抗体以及用它们来诊断和治疗淀粉样蛋白相关疾病的方法
WO2005027901A1 (fr)	2003-09-25	2005-03-31	Tel Aviv University Future Technology Development L.P.	Compositions et methodes d'utilisation de ces compositions pour le traitement des maladies associees a la substance amyloide
WO2005031362A2 (fr)	2003-10-02	2005-04-07	Ramot At Tel Aviv University Ltd.	Nouveaux agents antibacteriens et procedes permettant de les identifier et de les utiliser
US20090156471A1 (en) *	2004-07-15	2009-06-18	Ramot At Tel Aviv University Ltd.	Use of anti-amyloid agents for treating and typing pathogen infections
WO2006013552A2 (fr)	2004-08-02	2006-02-09	Ramot At Tel Aviv University Ltd.	Articles de nanostructures a base de peptides et leur procede de formation
US7732479B2 (en)	2004-08-19	2010-06-08	Tel Aviv University Future Technology Development L.P.	Compositions for treating amyloid associated diseases
US7786086B2 (en)	2004-09-08	2010-08-31	Ramot At Tel-Aviv University Ltd.	Peptide nanostructures containing end-capping modified peptides and methods of generating and using the same
EP1973928A2 (fr)	2005-10-11	2008-10-01	Ramot at Tel-Aviv University Ltd.	Hydrogels auto-assembles a base de fmoc-ff
BR112013012033A2 (pt)	2010-11-15	2016-08-09	Merz Pharma Gmbh & Co Kgaa	análogos de dipeptídeos para o tratamento de condições associadas com a formação de fibrila amiloide

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3956367A (en) *	1972-02-03	1976-05-11	Merck & Co., Inc.	3-Fluoro-D-alanine and pharmacologically acceptable esters, and pharmacologically acceptable salts thereof
US4031231A (en) *	1974-06-13	1977-06-21	Merck & Co., Inc.	Antibacterial composition comprising 3-fluoro-D-alanine or deutero analog in combination with auto-antagonist inhibitor
US4028405A (en) *	1974-10-15	1977-06-07	Merck & Co., Inc.	Fluorinated amino acids

1975
- 1975-10-15 PH PH23169A patent/PH14917A/en unknown
1979
- 1979-09-17 WO PCT/US1979/000752 patent/WO1980000789A1/fr not_active Ceased
- 1979-09-17 JP JP50168679A patent/JPS55500821A/ja active Pending
- 1979-10-12 NZ NZ191839A patent/NZ191839A/xx unknown
- 1979-10-16 PT PT70319A patent/PT70319A/pt unknown
- 1979-10-17 GR GR60286A patent/GR73145B/el unknown
- 1979-10-18 IL IL7958487A patent/IL58487A/xx unknown
- 1979-10-22 IT IT7926703A patent/IT1125557B/it active
- 1979-10-22 ES ES485269A patent/ES8100250A1/es not_active Expired
- 1979-10-22 CA CA000338128A patent/CA1137468A/fr not_active Expired
- 1979-10-23 AR AR278595A patent/AR229015A1/es active
- 1979-10-23 AU AU52040/79A patent/AU528165B2/en not_active Expired - Fee Related
1980
- 1980-05-07 EP EP19790901311 patent/EP0020481A4/fr not_active Withdrawn
- 1980-05-13 DK DK208680A patent/DK208680A/da not_active Application Discontinuation

Also Published As

Publication number	Publication date
IL58487A0 (en)	1980-01-31
ES485269A0 (es)	1980-11-01
IT1125557B (it)	1986-05-14
GR73145B (fr)	1984-02-09
ES8100250A1 (es)	1980-11-01
DK208680A (da)	1980-05-13
AU528165B2 (en)	1983-04-14
AU5204079A (en)	1980-05-01
JPS55500821A (fr)	1980-10-23
IT7926703A0 (it)	1979-10-22
IL58487A (en)	1982-09-30
EP0020481A1 (fr)	1981-01-07
PH14917A (en)	1982-01-29
EP0020481A4 (fr)	1981-04-24
AR229015A1 (es)	1983-05-31
PT70319A (en)	1979-11-01
WO1980000789A1 (fr)	1980-05-01
NZ191839A (en)	1983-02-15

Legal Events

Date	Code	Title	Description
1999-12-14	MKEX	Expiry

Publication	Publication Date	Title
RU2105010C1 (ru)	1998-02-20	Трипептид или его фармацевтически приемлемые соли или сольваты, фармацевтическая композиция, обладающая ингибирующей активностью в отношении амидазы тромбина
Diddens et al.	1976	On the transport of tripeptide antibiotics in bacteria
WO1980000789A1 (fr)	1980-05-01	Peptide anti-bacterien
NZ245039A (en)	1994-12-22	N-phenylalanyl and n-phenylglycyl derivatives of the dipeptide of l-azetidine-2-carboxylic acid and l-arginine aldehyde; anti-blood clotting compositions
JPH05170794A (ja)	1993-07-09	タチキニン由来の新規ぺプチドおよび医薬組成物
SE452326B (sv)	1987-11-23	Salter av agmatinderivat och farmaceutiska preparat innehallande desamma
US4386073A (en)	1983-05-31	Tripeptides acting on the central nervous system and a process for the preparation thereof
EP1515983A1 (fr)	2005-03-23	Macrocycles d'amide antibacteriens
KR960014104B1 (ko)	1996-10-14	테이코플라닌 화합물의 치환 알킬아미드
US4322340A (en)	1982-03-30	Pharmacologically active peptides
US4264590A (en)	1981-04-28	Antibacterial peptide
EP0030847B1 (fr)	1984-05-30	Peptides à activité pharmacologique, leur préparation et compositions pharmaceutiques les contenant
US4333873A (en)	1982-06-08	Pharmacologically active peptides
US4143134A (en)	1979-03-06	Halo-phosphonopeptides
US4134972A (en)	1979-01-16	Compositions having antibiotic properties
JPH0570495A (ja)	1993-03-23	環式ヘキサペプチド化合物
KR840001720B1 (ko)	1984-10-17	펩타이드의 제조방법
HU185022B (en)	1984-11-28	Process for the preparation of biologically active tetrapeptide derivatives
CA1178610A (fr)	1984-11-27	Composes de structure apparentee a celle du bestatin utilises comme stimulateurs de l'immunite
US4309342A (en)	1982-01-05	Antibacterial peptides
US4100275A (en)	1978-07-11	Compositions having antibiotic properties
IE42785B1 (en)	1980-10-22	L-3-(3,4-dihydroxyphenyl)-2-methyl-alanine peptides
US4127649A (en)	1978-11-28	Compositions having antibiotic properties
GB1582420A (en)	1981-01-07	Phenylamino phenylacetic acid amide compounds and processes for their preparation
US4473554A (en)	1984-09-25	Bestatin-related compounds as immunopotentiator